13386-Vidal, Ruben
Faculty

Ruben Vidal, PhD

Luella McWhirter Martin Professor of Clinical Alzheimer's Research

Address
Van Nuys Medical Science Building
635 Barnhill Drive, Room A128

Indianapolis, IN 46202

Bio

EDUCATION:

Undergraduate/Graduate

1989 M.S. National University at Rosario, Argentina. (Clinical Laboratories)

1992 Ph.D. National University at Rosario, Argentina. "Hereditary Cerebral Hemorrhage with Amyloidosis, Dutch Type. Cloning and sequence of the Alzheimer's disease gene that encodes the Amyloid Precursor Protein of the amyloid deposited in cerebral vessel walls."  Thesis Advisor: Blas Frangione, M.D., Ph.D., Department of Pathology, New York University School of Medicine, New York, NY

Postdoctoral Training

1992-1994 Department of Dermatology, New York University School of Medicine, New York, NY

1995-1996 Department of Pathology, New York University School of Medicine, New York, NY

ACADEMIC APPOINTMENTS:

1985-1989 Teaching Assistant, Biology I/II, Department of Biology, National University at Rosario, Argentina

1989-1990 Instructor in Immunology, Department of Pathology, National University at Rosario, Argentina

1990-1992 Assistant Researcher, Department of Pathology, New York University School of Medicine, New York, NY

1992-1994 Post-Doctoral Fellow, Department of Dermatology, New York University School of Medicine, New York, NY

1995-2000 Assistant Researcher, Department of Pathology, New York University School of Medicine, New York, NY

1996-2000 Instructor in Pathology, Department of Pathology, New York University School of Medicine, New York, NY

2000 Research Assistant Professor, Department of Pathology, New York University School of Medicine, New York, NY

2000-2006 Assistant Professor, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

2006-2014 Associate Professor (with tenure), Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

2000-present Primary investigator. Neuropathology Core. Indiana Alzheimer Disease Center. Indiana University School of Medicine, Indianapolis, IN

2006-present Primary investigator. Stark Neurosciences Research Institute. Indiana University School of Medicine, Indianapolis, IN

2014-present Professor, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

2017-present Director of Neurodegenerative Disease Research, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 

2017-present  Luella Mc Whirter Martin Professor in Alzheimer's Disease Research. Indiana University School of Medicine, Indianapolis, IN 

 

Key Publications

1. Y. Shi, A. G. Murzin, B. Falcon, A. Epstein, J. Machin, P. Tempest, K. L. Newell, R. Vidal, H. G. Garringer, N. Sahara, M. Higuchi, B. Ghetti, M-K. Jang, S. H.W. Scheres, and M. Goedert. Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607. (2021) Acta Neuropathol. Mar 16. doi: 10.1007/s00401-021-02294-3.
 
2. X. Taylor, P. Cisternas, Y. You, Y. You, S. Xiang, J. Zhang, R. Vidal, and C. A. Lasagna-Reeves. A1-Reactive Astrocytes and a loss of TREM2 are associated to an early state of pathology in a mouse model of cerebral amyloid angiopathy. (2020) J. Neuroinflammation. 17(1):223. doi: 10.1186/s12974-020-01900-7.
 
3. P. Cisternas, X. Taylor, A. Perkins, O. Maldonado, E. Allman, R. Cordova, Y. Marambio, B. Munoz, T. Pennington, S. Xiang, J. Zhang, R. Vidal, B. Atwood, and C. A. Lasagna-Reeves. Vascular amyloid accumulation alters the Gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy. (2020) Aging Cell. Sep 10:e13233. doi: 10.1111/acel.132)
 
4. J. Irimia-Dominguez, C. Sun, K. Li, B. B. Muhoberac, G. I. Hallinan, H. J. Garringer, B. Ghetti, W. Jiang, and R. Vidal. Cryo-EM structures and functional characterization of homo- and heteropolymers of human ferritin variants. (2020) Sci. Rep. 10(1):20666. doi: 10.1038/s41598-020-77717-4.
 
5. W. Zhang, A. Tarutani, K. L. Newell, A. G. Murzin, T. Matsubara, B. Falcon, R. Vidal, H, J. Garringer, Y. Shi, T. Ikeuchi, S. Murayama, B. Ghetti, M. Hasegawa, M. Goedert and S. H.W. Scheres. Novel tau filament fold in corticobasal degeneration. (2020) Nature. 580:283-287. doi: 10.1038/s41586-020-2043-0.
 
6. K. Li, C. Sun, T. Klose, J. Irimia-Dominguez, F. S Vago, R. Vidal, and W. Jiang. Sub-3?Å apoferritin structure determined with full range of phase shifts using a single position of volta phase plate. (2019) J Struct Biol. 206(2):225-232. doi: 10.1016/j.jsb.2019.03.007
 
7. B. Falcon, J. Zivanov, W. Zhang, A. G. Murzin, H. J. Garringer, R. Vidal, R. A. Crowther, K. L. Newell, B. Ghetti, M. Goedert and S. H.W. Scheres. Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic cofactors. (2019) Nature. 568(7752):420-423. doi: 10.1038/s41586-019-1026-5.
 
8. Y. You, A. Perkins, P. Cisternas, B. Muñoz, X. Taylor, Y. You, H. J. Garringer, A. L. Oblak, B. Atwood, R. Vidal, and C. A. Lasagna-Reeves. Tau as a mediator of neurotoxicity associated to Cerebral Amyloid Angiopathy. (2019) Acta Neuropathol Commun. 26;7(1):26. doi: 10.1186/s40478-019-0680-z.
 
9. B. Falcon, W. Zhang, M. Schweighauser, R. Vidal, H. J. Garringer, B. Ghetti, S. Scheres, and M. Goedert. Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold. (2018) Acta Neuropathol. 136(5):699-708. doi: 10.1007/s00401-018-1914-z. Epub 2018 Oct 1.
 
10. B. Falcon, W. Zhang, A. G. Murzin, G. Murshudov, H. J. Garringer, R. Vidal, R. A. Crowther, B. Ghetti, S. Scheres, and M. Goedert. Structures of filaments from Pick's disease reveal a novel tau protein fold. (2018) Nature. 561(7721):137-140. doi: 10.1038/s41586-018-0454-y.
 
11. M. A. Pappolla, E. Matsubara, R. Vidal, J. Pacheco-Quinto, B. Poeggeler, M. Zagorski, and K. Sambamurti. Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis. (2018) Curr Alzheimer Res. 15(7):637-642. doi: 10.2174/1567205015666180411092551.
 
12. H. J. Garringer. N. Sammeta, A. Oblak, B. Ghetti, and R. Vidal. Amyloid and intracellular accumulation of BRI2. (2017) Neurobiol Aging 52:90-97.  
 
13. H. J. Garringer, J. Irimia-Dominguez, W. Li, C. B. Goodwin, B. Richine, A. Acton, R. J. Chan, M. Peacock, B. B. Muhoberac, B. Ghetti, and R. Vidal. Effect of systemic iron overload and a chelation therapy in a mouse model of the neurodegenerative disease Hereditary Ferritinopathy. (2016) PLoS One 11(8):e0161341. 
 
14. Y. Levites, B. O’Nuallain, R. Devudu Puligedda, T. Ondrejcak, S. P. Adekar, C. Chen, P. E. Cruz, A. M. Rosario, S. Macy, R. Vidal, A. Solomon, D. Brown, M. J. Rowan, T. E. Golde, and S. K. Dessain. A human monoclonal IgG that binds Aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. (2015) J. Neurosci. 35(16):6265-6276.
 
15. W. Li, H. J. Garringer, C. B. Goodwin, B. Richine, A. Acton, N. VanDuyn, B. B. Muhoberac, J. Irimia-Dominguez, R. J. Chan, M. Peacock, R. Nass, B. Ghetti, and R. Vidal. Systemic and cerebral iron homeostasis in ferritin knock-out mice. (2015) PLoS One 10(1):e0117435.
 
16. M. Pappolla, K. Sambamurti, R. Vidal, J. Pacheco, B. Poeggeler, and E. Matsubara. Evidence for Lymphatic Ab Clearance in Alzheimer’s Transgenic Mice. (2014) Neurobiol Dis 71:215-219. (Published article online: Aug 4, 2014).  
 
17. K. Nishida, H. J. Garringer, N. Futamura, I. Funakawa, K. Jinnai, R. Vidal, and M. Takao. A novel ferritin light chain mutation in neuroferritinopathy with an atypical presentation. (2014) J Neurol Sci. 342(1-2):173-7. (Published article online: Apr 12, 2014).  
 
18. M. S. Marcora, A. C. Fernández-Gamba, L. A. Avendaño, C. Rotondaro, O. L. Podhajcer, R. Vidal, L. Morelli, M. F. Ceriani, and E. M. Castaño. Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia. (2014) Mol Neurodegener. 9(1):5. 
 
19. H. J. Garringer, J. Murrell, N. Sammeta, A. Gnezda, B. Ghetti, and R. Vidal. Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. (2013) PLoS One 8(2):e56426. (Published article online: Feb 13, 2013).   
 
20. R. Vidal, N. Sammeta, H. J. Garringer, K. Sambamurti, L. Miravalle, B. T. Lamb, and B. Ghetti. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice. (2012) FASEB J. 26(7):2899-2910. (Published article online: Mar 29, 2012). 
 
21. M. A. Baraibar, G. Barbeito, B. B. Muhoberac, and R. Vidal. A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage. Free Radic. Biol. Med. (2012) 52(9):1692-7. (Published article online: Feb 17, 2012).
 
22. E. G. Farrow, X. Yu, L. J. Summers, S. I. Davis, J. C. Fleet, M. R. Allen, A. G. Robling, K. R. Stayrook, V. Jideonwo, M. J. Magers, H. J. Garringer, R. Vidal, R. J. Chan, C. B. Goodwin, S. L. Hui, M. Peacock, and K. E. White. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc. Natl. Acad. Sci. U. S. A. (2011) 108(46):E1146-55. (Published article online: Oct 17, 2011).
 
23. B. B. Muhoberac, M. A. Baraibar, and R. Vidal. Iron-loading induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration. (2011) Biochim. Biophys. Acta. 1812(4):544-8 (Published article online: Oct 26, 2010).  
 
24. R. Tamayev, L. Giliberto, W. Li, C. D'Abramo, O. Arancio, R. Vidal, and L. D'Adamio.  Memory deficits due to Familial British Dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. (2010) J. Neurosci. 30(44):14915-4.
 
25. G. Barbeito, T. Levade, M.B. Delisle, B.Ghetti, and R. Vidal. Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy. (2010) Mol. Neurodegener. 5:50.  
 
26. X. Deng, R. Vidal, and E. W. Englander. Accumulation of oxidative DNA damage in brain mitochondria in mouse model of Hereditary Ferritinopathy. (2010) Neurosci Lett. 479(1):44-8. (Published article online: May 15, 2010).
 
27. M. A. Baraibar, B. M. Muhoberac, H. J. Garringer, T. D. Hurley, and R. Vidal. Unraveling of the E helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration. (2010) J. Biol. Chem. 285(3):1950-6. (Published article online: Nov 18, 2009) 
 
28. L. Giliberto, S. Matsuda, R. Vidal, and L. D'Adamio. Generation and initial characterization of FDD knock in mice. (2009) PLoS One 4(11):e7900. 
 
29. F. Ory-Magne, C. Brefel-Courbon, P. Payoux, S. Debruxelles, I. Sibon, C. Goizet, P. Labauge, P. Menegon, E. Uro-Coste, B. Ghetti, M. B. Delisle, R. Vidal, and O. Rascol. Clinical phenotype and neuroimaging findings in a French family with hereditary ferritinopathy (FTL498-499InsTC). (2009) Mov. Disord. 24(11):1676-83. (Published article online: Jun 9, 2009).
 
30. X. Xiao, L. Miravalle, J. Yuan, J. McGeehan, Z. Dong, R. Wyza, G. T. MacLennan, A. M. Golichowski, G. Kneale, N. King, Q. Kong, S. Spina, R. Vidal, B. Ghetti, K. Roos, P. Gambetti, and W.-Q. Zou. Failure to detect the presence of prions in the uterine and gestational tissues from a gravida with Creutzfeldt-Jakob disease. (2009) Am.J. Pathol. 174(5):1602-8. (Published article online: Apr 6, 2009). 
 
31. A. G. Barbeito, H. J. Garringer, M. A. Baraibar, X. Gao, M. Arredondo, M. T. Núñez, M. A. Smith, B. Ghetti, and R. Vidal. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. (2009) J. Neurochem. 109:1067-1078 (Published article Online: Mar 30, 2009)
 
32. R. Vidal, A. G. Barbeito, L. Miravalle, and B. Ghetti. Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2. (2009) Brain Pathol. 19:58–68 (Published article online: Apr 10, 2008). 
 
33. R. Vidal, L. Miravalle, X. Gao, A. Barbeito, M. Baraibar, S. K. Hekmatyar, M. Widel, N. Bansal, M. B. Delisle, and B. Ghetti. Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice. (2008) J. Neurosci. 28(1):60-7.
 
34. G. D. Van Vickle, C. L. Esh, T. A. Kokjohn, R. L. Patton, W. M. Kalback, D. C. Luehrs, T. G. Beach, A. J. Newel, F. Lopera, B. Ghetti, R. Vidal, E. M. Castaño, and A. E. Roher. The Presenilin-1 280 Glu→Ala mutation alters C-terminal APP processing to yield elongated Aβ peptides: implications for Alzheimer's disease. (2008) Mol. Med. 14(3-4):184-194.
 
35. M. A. Baraibar, A. G. Barbeito, B. M. Muhoberac, and R. Vidal. Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration. (2008) J. Biol. Chem. 283(46): 31679-89 (Published article online: Aug 28, 2008). 
 
36. L. Maarouf, I. D. Daugs, S. Spina, R. Vidal, T. A. Kokjohn, R. L. Patton, W. M. Kalback, D. C. Luehrs, D. G. Walker, E. M. Castaño, T. G. Beach, B. Ghetti, and A. E. Roher. Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations. (2008) Mol. Neurodegener. 3:20. 
 
37. S. Spina, J. R. Murrell, E. D. Huey, E. M. Wassermann, P. Pietrini, M. A. Baraibar, A. G. Barbeito, J. C. Troncoso, R. Vidal, B. Ghetti, and J. Grafman. (2007) Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation. (2007) Neurology. 68:820-827. 
 
38. L. Miravalle, M. Calero, M. Takao, A. E. Roher, B. Ghetti, and R. Vidal. Amino-terminally truncated Ab peptide species are the main component of cotton wool plaques. (2005) Biochemistry. 44:10810-10821. 
 
39. T. Foroud, N. Pankratz, A. P. Batchman, M. W. Pauciulo, R. Vidal, L. Miravalle, H. H. Goebel, L. J. Cushman, B. Azzarelli, H. Horak, M. Farlow, and W. C. Nichols. A mutation in myotilin causes spheroid body myopathy. (2005) Neurology. 65:1936-1940.  
 
40. A. Roher, T. Kokjohn, C. Esh, N. Weiss, J. Childress, W. Kalback, D. C. Luehrs, J. Lopez, D. Brune, Y.-M. Kuo, M. Farlow, J. Murrell, R. Vidal, and B. Ghetti. The human amyloid-beta precursor protein770 mutation 717 Val-Phe generates peptides longer than Ab42 and flocculent amyloid aggregates. (2004) J. Biol. Chem. 279:5829-5836.
 
41. S.-I. Choi, R. Vidal, B. Frangione, and E. Levy. Axonal transport of British and Danish amyloid peptides via secretory vesicles. (2004) FASEB J. 18:373-5.  
 
42. B. Azzarelli, L. Miravalle, and R. Vidal. Polyclonal antibodies raised against the Oligodendrocyte Transcription Factor 1 (Olig1) recognize neoplastic oligodendrocytes. (2004) J. Neuropathol. Exp. Neurol. 63:170-179.
 
43. R. Vidal, B. Ghetti, M. Takao, C. Brefel-Courbon, E. Uro-Coste, B.S. Glazier, V. Siani, M.D. Benson, P. Calvas, L. Miravalle, O. Rascol, and M.B. Delisle. Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the Ferritin Light Polypeptide gene. (2004) J. Neuropathol. Exp. Neurol. 63:363-80.
 
44. M. Takao, B. Ghetti, H. Yoshida, P. Piccardo, Y. Narain, J. R. Murrell, R. Vidal, B. S. Glazier, R. Jakes, M. Tsutsui, M. G. Spillantini, R. A. Crowther, M. Goedert, and A. Koto. Early-onset dementia with Lewy bodies. (2004) Brain Pathol. 14:137-147.
 
45. R. Vidal, M. B. Delisle, O. Rascol, and B. Ghetti. Hereditary ferritinopathy. (2003) J. Neurol. Sci. 207:110-111.
 
46. J. L. Holton, T. Lashley, J. Ghiso, H. Braendgaard, R. Vidal, C. Guerin, G. Gibb, D. P. Hanger, A. Rostagno, B. H. Anderton, C. Strand, H. Ayling, G. Plant, B. Frangione, M. Bojsen-Møller, and T. Revesz. Familial Danish dementia: A novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta. (2002) J. Neuropathol. Exp. Neurol. 61(3):254-267. 
 
47. J. L. Holton, J. Ghiso, T. Lashley, A. Rostagno, C. J. Guerin, G. Gibb, H. Houlden, H. Ayling, L. Martinian, B. H. Anderton, N. W. Wood, R. Vidal, G. Plant, B. Frangione, T. Revesz. Regional distribution of ABri deposition and its association with neurofibrillary degeneration in familial British dementia. (2001) Am.J. Pathol. 158:515-526. 
 
48. M-H.Teng, J-Y Yin, R. Vidal, J. Ghiso, A. Kumar, R. Rabenou, A. Shah, D. Jacobson, C. Tagoe, G. Gallo, and J. Buxbaum. Amyloid and non-fibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis. (2001) Lab. Invest. 81:385-396. (Article Featured on Cover. Editorial). 
49. R. Vidal, M. Calero T. Révész, G. Plant, J. Ghiso and B. Frangione. Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family. (2001) Gene. 266:95-102. 
 
50. J. Ghiso,  J. Holton, L. Miravalle , M. Calero, T. Lashley, R.Vidal, H. Houlden, N. Wood, T. A. Neubert, A. Rostagno, G. Plant, T. Révész, and B. Frangione. Systemic amyloid deposits in familial British dementia. (2001) J. Biol. Chem. 276:43909-43914. 
 
51. B. Poeggeler, L. Miravalle, M. G. Zagorski, T. Wisniewski, Y. J. Chyan, Y. Zhang, H. Shao, T. Bryant-Thomas, R. Vidal, B. Frangione, J. Ghiso, and M. A. Pappolla. Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Aβ Peptide. (2001) Biochemistry 40:14995-5001. 
 
52. V. Askanas, W. King Engel, R. B. Alvarez, B. Frangione, J. Ghiso, and R. Vidal. Inclusion-body myositis accompanied by muscle blood-vessel and cardiac amyloidosis in a black patient homozygous for the transthyretin Val122Ile allele. (2000) Ann. Neurol. 47:544-549.
 
53. R. Vidal, T. Révész, A. Rostagno, E. Kim, J. L. Holton, T. Bek, M. Bojsen-Møller, H. Braendgaard, G. Plant, J. Ghiso and B. Frangione. A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. (2000) Proc. Natl. Acad. Sci. U. S. A. 97: 4920-4925.
 
54. T. Tokuda, M. Calero, E. Matsubara, R. Vidal, A. Kumar, B. Permanne, B. Zlokovic, J. Smith, M. J. LaDu, A. Rostagno, B. Frangione, and J. Ghiso.  Lipidation of Apolipoprotein E influences its isoform specific interaction with Alzheimer's amyloid β-peptides. (2000) Biochem. J. 348:359-365.
 
55. R. Vidal, M. Calero, P. Piccardo, M. R. Farlow, F.W. Unverzagt, E. Méndez, A.Jiménez-Huete, R. Beavis, G. Gallo, E. Gomez-Tortosa,  J. Ghiso, B. T. Hyman,  B. Frangione, and B. Ghetti.  Senile dementia associated with Aß angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-ε4 allele. (2000) Acta Neuropathol. 100:1-12. 
 
56. B. Kaplan, R. Vidal, A. Kumar, J. Ghiso, and G. Gallo. Immunochemical microanalysis of amyloid proteins in fine-needle aspirates of abdominal fat. (1999) Am. J. Clin. Pathol. 112:403-407.
 
57. S. Derét, L. Denoroy, M. Lamarine, R. Vidal, B. Mougenot, B. Frangione, F. Stevens, P.M. Ronco, and P. Aucouturier. Kappa light chain-associated Fanconi's syndrome: Molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular crystals. (1999) Protein Eng. 12:363-369.
 
58. R. Vidal, F. Goñi, F. Stevens, P. Aucouturier, A. Kumar, B. Frangione, J. Ghiso, and G. Gallo. Somatic mutations of the L12a gene in V-κI light chain deposition disease: Potential effects on aberrant protein conformation and deposition. (1999) Am. J. Pathol. 155:2009-2018. 
 
59. A. Rostagno, R. Vidal, B. Kaplan, J. Chuba, A. Kumar, J. Elliot, B. Frangione, G. Gallo, and J. Ghiso. pH-dependent fibrillogenesis of a VκIII Bence Jones protein. (1999) Br. J. Haematol. 107:835-843. 
 
60. R. Vidal, B. Frangione, A. Rostagno, S. Mead, T. Revesz, G. Plant, and J. Ghiso. A stop-codon mutation in the BRI gene associated with familial British dementia. (1999) Nature 399:776-781.
 
61. C. Decourt, G. Touchard, J.L. Preud'homme, R. Vidal, H. Beaufils, M.C. Diemert, and M. Cogné. Complete primary sequence of two λ immunoglobulin light chains in myelomas with non-amyloid (Randall type) light chain deposition disease. (1998) Am. J. Pathol. 153:313-318. 
 
62. A. Jimenez-Huete, P. M. J. Lievens, R. Vidal, P. Piccardo, B. Ghetti, F. Tagliavini, B. Frangione, and F. Prelli. Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues. (1998) Am. J. Pathol. 153:1561-1572. 
 
63. M. Pizzolato, G. Bragantini, P. Bresciani, S. Pavlovski, J. Chuba, R. Vidal, A. Rostagno, and J. Ghiso. IgG1-κ biclonal gammopathy associated with multiple myeloma suggests a regulatory mechanism. (1998) Br. J. Haematol. 102:503-508.   
 
64. R. Vidal, B. Kaplan, A. Kumar, J. Ghiso, B. Frangione, and G. Gallo. Amino-terminal identity of co-existent amyloid and nonamyloid immunoglobulin kappa light chain deposits. A human model to study alterations of protein conformation. (1997) Clin. Exp. Immunol. 110:464-471.
 
65. R. Vidal, F. Garzuly, H. Budka, M. Lalowski, R. Linke, F. Britting, B. Frangione, and T. Wisniewski. Meningocerebrovascular Amyloidosis Associated with a Novel Transthyretin (TTR) Missense Mutation at Codon 18 (TTRD18G). (1996) Am. J. Pathol. 148:361-366. (Article Featured on Cover. Editorial).
 
66. Garzuly, R. Vidal, T. Wisniewski, F. Britting, and H. Budka. Familial meningo-cerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTRAsp18Gly). (1996) Neurology 47:1562-1567.
 
67. G. Gallo, F. Goñi, F. Boctor, R. Vidal, A. Kumar, B. Frangione, and J. Ghiso. Light chain cardiomyopathy: Immunohistochemical and biochemical analysis of the light chain deposits. (1996) Am. J. Pathol. 148:1397-1406. (Article Featured on Cover. Editorial).
 
68. Perini, R. Vidal, B. Ghetti, F. Tagliavini, B. Frangione, and F. Prelli. PrP27-30 is a normal soluble Prion protein fragment released by human platelets. (1996) Biochem. Biophys. Res. Comm. 223:572-577.
 
69. R. Vidal, J. Ghiso, T. Wisniewski, and B. Frangione. Alzheimer’s Presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant. (1996) FEBS Lett. 393:19-23.
 
70. A.Rostagno, R. Vidal, A. Kumar, J. Chuba, G. Niederman, L. Gold, B. Frangione, J. Ghiso,and G. Gallo. Fibrillary Glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes. (1996) Am. J. Kidney Dis. 28:676-684. (Article Featured on Cover. Editorial). 
 
71. R. Vidal, I. Fernandez-Madrid, B. Frangione, and E. Levy. Sequencing of the Alzheimer's APP gene Dutch Variant (APP-D). (1993) Hum. Mutat. 2:495.
 
72. T. Magnaldo, R. Vidal, M. Ohtsuki, I. Freedberg, and M. Blumenberg. On the role of AP2 in epithelial-specific gene expression. (1993) Gene Expr. 3:307-315.
 
73. J. Ghiso, T. Wisniewski, R. Vidal, A. Rostagno, and B. Frangione. Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer’s disease. (1992) Biochem. J. 282:517-522.
 
74. R. Vidal, J. Ghiso, G. Gallo, M. Cohen, P.-L Gambetti, and B. Frangione. Amyloidoma of the CNS. II. Immunohistochemical and biochemical study. (1992) Neurology 42:2024-2028.
 

Titles & Appointments

  • Luella McWhirter Martin Professor of Clinical Alzheimer's Research
  • Professor of Pathology & Laboratory Medicine
  • Luella Mc Whirter Martin Professor in Alzheimer's Disease Research
  • Education
    1992 PhD National University of Rosario
    1989 BS National University of Rosario
    1989 MS National University of Rosario
  • Research

    Abnormal protein deposition in the brain and neurodegeneration

  • Professional Organizations
    American Association of Neuropathologists
    International Society for Frontotemporal Dementias
    Society for Neuroscience
  • Awards
    Org: Alzheimer's Association
    Desc: Traveling Award
    Scope: International
    Date:
    Org: American Association of Neuropathologists.
    Desc: Moore Award
    Scope: International
    Date:
    Org: Alzheimer's Association
    Desc: Investigator Initiated Research Award.
    Scope: National
    Date:
    Org: Department of Clinical Medicine. National University of La Plata School of Medicine, La Plata, Argentina
    Desc: Guest of Honor
    Scope: University
    Date:
    Org: National Institutes of Health/National Institute of Neurological Disorders and Stroke
    Desc: Award
    Scope: National
    Date:
    Org: Alzheimer's Association
    Desc: Investigator Initiated Research Award
    Scope: National
    Date:
    Org: National Institutes of Health/National Institute of Neurological Disorders and Stroke
    Desc: Supplementary Award
    Scope: National
    Date:
    Org: American Health Assistance Foundation (AHAF)
    Desc: Award
    Scope: National
    Date:
    Org: National Institutes of Health/National Institute of Neurological Disorders and Stroke
    Desc: Award
    Scope: National
    Date:
    Org: National Institutes of Health/National Institute of Aging
    Desc: Award
    Scope: National
    Date:
    Org: National Institutes of Health/National Institute of Neurological Disorders and Stroke
    Desc: Award
    Scope: National
    Date:
    Org: Alzheimer's Association
    Desc: Zenith Fellows Award.
    Scope: National
    Date:
    Org: Luella Mc Whirter Martin Professor in Alzheimer's Disease Research
    Desc: Luella Mc Whirter Martin Professor in Alzheimer's Disease Research
    Scope: National
    Date:

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