13352-Ghetti, Bernardino

Bernardino Ghetti, MD

Distinguished Professor

Van Nuys Medical Science Building
635 Barnhill Drive, Room A128

Indianapolis, IN 46202
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Dr. Bernardino Ghetti, MD, obtained a Doctorate in Medicine and completed the Specialization in Mental and Nervous Diseases at the University of Pisa, Italy. At the Albert Einstein College of Medicine, Bronx, New York, he received training as a research fellow in experimental Neuropathology and then as a resident in Pathology and Neuropathology.

Throughout his career, Dr. Ghetti has investigated neurodegenerative dementias, using human tissue and animal models. Dr. Ghetti's approach begins with the neuropathologic analysis: the identification of the brain's neurodegenerative changes determines the direction of the molecular investigations at the protein and DNA levels and has led to the identification of the etiological basis of several forms of dementia. In 1989, he discovered the first hereditary dementia, characterized by the coexistence of prion protein amyloid and neurofibrillary tangles. Subsequently, Dr. Ghetti's team identified genetic mutations in the APP, PSEN1, PRNP, and other genes causing neurodegeneration. In 1993, Dr. Ghetti began studying a hereditary form of frontotemporal dementia, characterized by tau deposits in neurons and glia. In 1998, by identifying the genetic defect, causing that disorder, Dr. Ghetti's international team was among the first to discover mutations in the MAPTgene. Dr. Ghetti, Distinguished Professor at Indiana University, is the founder of the Indiana Alzheimer Disease Center and served as its first Director (1991–2013). Dr. Ghetti served as President of the American Association of Neuropathologists, the International Society of Neuropathology. He is the Founder and served as the first President of the International Society for Frontotemporal Dementias.

Resident in Pathology, Albert Einstein College of Medicine

Fellow in Neuropathology, Albert Einstein College of Medicine

Diplomate of the American Board of Pathology in Neuropathology 

Key Publications

Titles & Appointments

  • Distinguished Professor
  • Chancellor’s Professor, IUPUI
  • Professor of Pathology & Laboratory Medicine
  • Professor of Psychiatry
  • Professor of Medical & Molecular Genetics
  • Professor of Neurology
  • Division Chief
  • Education
    1966 MD University of Pisa
  • Research

    Alzheimer's and other degenerative brain diseases 

  • Awards
    Org: Indiana University
    Desc: Bicentennial Medal
    Scope: University
    Date: 1905-07-14
    Org: American Association for the Advancement of Science
    Desc: Fellow (Neuroscience)
    Scope: National
    Date: 1905-07-07
    Org: Indiana University
    Desc: Distinguished Professor
    Scope: University
    Date: 1905-06-21

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