Jeffrey Elmendorf earned his B.S. degree in Chemistry from the State University of New York at Oneonta, NY in 1991 and Ph.D. degree under the mentorship of Dr. Jiri Turinsky within the Department of Physiology and Cell Biology from Albany Medical College in Albany, NY in 1996. He then completed three years of post-doctoral research in the laboratory of Dr. Jeffrey Pessin at the University of Iowa, Iowa City, IA. In 2000, he joined the Department of Cellular & Integrative Physiology at Indiana University School of Medicine. He holds an adjunct appointment in the Department of Biochemistry & Molecular Biology.
Dr. Elmendorf’s primary research is in the field of insulin action and glucose transport. His laboratory has pioneered the discovery of membrane and cytoskeletal aspects of insulin resistance. A major novel finding of his laboratory is that excess plasma membrane cholesterol critically impairs glucose transporter GLUT4/glucose transport regulation by insulin. Ongoing studies are asking novel questions about cellular cholesterol accumulation and GLUT4 dysregulation, what mechanisms are involved, and the impact of targeting this toxicity on preventing and/or improving insulin resistance.
In addition to being active in diabetes and metabolic disease research his entire career, Dr. Elmendorf has been active in scientist training. His laboratory has supported the training of numerous MS, PhD, MD, and MD/PhD predoctoral and postdoctoral fellows, as well as high school and undergraduate students. Dr. Elmendorf sits on the executive committee of a P30 NIDDK-supported Indiana Diabetes Research Center (IDRC) where he serves as the Director of the Center’s Pilot and Feasibility Program and the Associate Director of Faculty/Trainee Development for the Indiana Center for Diabetes and Metabolic Diseases (CDMD). He also serves on the American Diabetes Association Research Grant Review Committee and is an Editorial Board Member of the American Journal of Physiology-Endocrinology & Metabolism.