Yue Wang, PhD
Associate Research Professor of Medical & Molecular Genetics
- Phone
- (317) 278-3851
- Address
-
975 W. Walnut street
Medical Research&Library Building, Room 244A
Indianapolis, IN 46202-5120 - PubMed:
Bio
Dr. Wang received her PhD in the Department of Pharmacology and Toxicology at Indiana University in 2006, working in the laboratory of Dr. Grant Nicol on the role of Neurofibromine, nerve growth factor and Ras signaling cascade in controlling the excitability of sensory neurons. Postdoctoral training with Dr. Daniel Meldrum (Indiana University) focused on progenitor cell therapy against acute myocardial ischemia and reperfusion injury. She joined the Department of Medical and Molecular Genetics at the Indiana University School of Medicine in 2011, continuing to study the mechanisms and action of progenitor cells in tissue protection. She became interested in the biology of different types of stem cells and the underlying mechanisms involved in cardiac repair and wound healing. She has continued to study the paracrine factors/exosomes regulate pro-survival and pro-angiogenesis signaling with potential implication for tissue repair and regeneration.
Year | Degree | Institution |
---|---|---|
2006 | PhD | Indiana University |
2000 | MS | Harbin Medical University |
1994 | AS | Harbin Medical University |
Bone-marrow derived mesenchymal stem cells (MSCs) have emerged as a promising candidate for cell-based therapy of ischemic heart disease. MSCs are safe, can be easily isolated and amplified from patients’ bone marrow, are immunologically tolerated as transplants, and possess multilineage differentiation potential. Intramyocardial injection of MSCs reduces inflammation, fibrosis, infarct size, ventricular remodeling, and therefore, improves cardiac function. However, these benefits are modest and may have limited duration. Dr. Wang’s laboratory is interested in understanding how MSCs function to protect heart from ischemia and how to maximize their therapeutic potential by developing novel and effective pharmacological and molecular interventions. Such knowledge could lead to better therapies for the ischemic heart diseases and the ischemic insult of other organ systems.
Zhang X; Li M; Lin H; Rao X; Feng W; Yang Y; Mort M; Cooper DN; Wang Y; Wang Y; Wells C; Zhou Y; Liu Y; Human genetics 2017 Apr 8
Xie JY; Chew LA; Yang X; Wang Y; Qu C; Wang Y; Federici LM; Fitz SD; Ripsch MS; Due MR; Moutal A; Khanna M; White FA; Vanderah TW; Johnson PL; Porreca F; Khanna R; Pain 2016 Sep
Li M; Feng W; Zhang X; Yang Y; Wang K; Mort M; Cooper DN; Wang Y; Zhou Y; Liu Y; Human mutation 2016 Oct 3
Li J; Wang Y; Wang L; Dai X; Cong W; Feng W; Xu C; Deng Y; Wang Y; Skaar TC; Liang H; Liu Y; BMC genomics 2016 Aug 22
Zhou A; Li M; He B; Feng W; Huang F; Xu B; Dunker AK; Balch C; Li B; Liu Y; Wang Y; BMC genomics 2016 Aug 22
Xu B; Luo Y; Liu Y; Li BY; Wang Y; American journal of physiology. Heart and circulatory physiology 2015 Feb 27
Herrmann JL; Abarbanell AM; Wang Y; Weil BR; Poynter JA; Manukyan MC; Meldrum DR; The Annals of thoracic surgery 2011 Sep 23
Wannemuehler TJ; Manukyan MC; Brewster BD; Rouch J; Poynter JA; Wang Y; Meldrum DR; The Journal of surgical research 2011 Oct 24
Luo Y; Wang Y; Poynter JA; Manukyan MC; Herrmann JL; Abarbanell AM; Weil BR; Meldrum DR; Surgery 2011 Nov 16
Poynter JA; Herrmann JL; Manukyan MC; Wang Y; Abarbanell AM; Weil BR; Brewster BD; Meldrum DR; Journal of the American College of Surgeons 2011 May 5
Herrmann JL; Weil BR; Abarbanell AM; Wang Y; Poynter JA; Manukyan MC; Meldrum DR; Shock (Augusta, Ga.) 2011 May
Manukyan MC; Weil BR; Wang Y; Abarbanell AM; Herrmann JL; Poynter JA; Brewster BD; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2011 Mar 30
Manukyan MC; Alvernaz CH; Poynter JA; Wang Y; Brewster BD; Weil BR; Abarbanell AM; Herrmann JL; Crowe BJ; Keck AC; Meldrum DR; Surgery 2011 Jun 30
Herrmann JL; Fiege JW; Abarbanell AM; Weil BR; Wang Y; Poynter JA; Manukyan MC; Brewster BD; Meldrum DR; The Journal of surgical research 2011 Dec 14
Manukyan MC; Keck AC; Poynter JA; Wang Y; Weil BR; Abarbanell AM; Herrmann JL; Crowe BJ; Alvernaz C; Meldrum DR; Surgery 2011 Aug
Poynter JA; Manukyan MC; Wang Y; Brewster BD; Herrmann JL; Weil BR; Abarbanell AM; Meldrum DR; Surgery 2011 Aug
Crowe B; Poynter JA; Manukyan MC; Wang Y; Brewster BD; Herrmann JL; Abarbanell AM; Weil BR; Meldrum DR; Surgery 2011 Aug
Duan JH; Wang Y; Duarte D; Vasko MR; Nicol GD; Hingtgen CM; Neuroscience letters 2011 Apr 8
Tan J; Weil BR; Abarbanell AM; Wang Y; Herrmann JL; Dake ML; Meldrum DR; Shock (Augusta, Ga.) 2010 Sep
Manukyan MC; Weil BR; Wang Y; Abarbanell AM; Herrmann JL; Poynter JA; Meldrum DR; Shock (Augusta, Ga.) 2010 Nov
Herrmann JL; Abarbanell AM; Weil BR; Wang Y; Poynter JA; Manukyan MC; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2010 May 19
Herrmann JL; Abarbanell AM; Weil BR; Manukyan MC; Poynter JA; Brewster BJ; Wang Y; Meldrum DR; The Journal of surgical research 2010 Jun 16
Herrmann JL; Wang Y; Abarbanell AM; Weil BR; Tan J; Meldrum DR; Shock (Augusta, Ga.) 2010 Jan
Abarbanell AM; Wang Y; Herrmann JL; Weil BR; Poynter JA; Manukyan MC; Meldrum DR; American journal of physiology. Heart and circulatory physiology 2010 Feb 19
Wang Y; Duan JH; Hingtgen CM; Nicol GD; Journal of neurophysiology 2010 Feb 17
Wang Y; Abarbanell AM; Herrmann JL; Weil BR; Manukyan MC; Poynter JA; Meldrum DR; PloS one 2010 Dec 3
Wang Y; Abarbanell AM; Herrmann JL; Weil BR; Poynter J; Manukyan MC; Crisostomo PR; Meldrum DR; Shock (Augusta, Ga.) 2010 Dec
Weil BR; Manukyan MC; Herrmann JL; Abarbanell AM; Poynter JA; Wang Y; Meldrum DR; The Journal of surgical research 2010 Aug 6
Abarbanell AM; Hartley JA; Herrmann JL; Weil BR; Wang Y; Manukyan MC; Poynter JA; Meldrum DR; Surgery 2010 Aug 19
Weil BR; Manukyan MC; Herrmann JL; Wang Y; Abarbanell AM; Poynter JA; Meldrum DR; Surgery 2010 Aug
Weil BR; Manukyan MC; Herrmann JL; Wang Y; Abarbanell AM; Poynter JA; Meldrum DR; Surgery 2010 Aug
Herrmann JL; Abarbanell AM; Weil BR; Manukyan MC; Poynter JA; Wang Y; Coffey AC; Meldrum DR; Journal of cardiovascular translational research 2010 Apr
Wang M; Tan J; Wang Y; Meldrum KK; Dinarello CA; Meldrum DR; Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 25
Herrmann JL; Abarbanell AM; Weil BR; Wang Y; Wang M; Tan J; Meldrum DR; The Annals of thoracic surgery 2009 Nov
Zeller CN; Wang Y; Markel TA; Weil B; Abarbanell A; Herrmann JL; Kelly ML; Coffey A; Meldrum DR; The Annals of thoracic surgery 2009 Mar
Wang Y; Wang M; Abarbanell AM; Weil BR; Herrmann JL; Tan J; Novotny NM; Coffey AC; Meldrum DR; Surgery 2009 Jun 25
Wang M; Wang Y; Abarbanell A; Tan J; Weil B; Herrmann J; Meldrum DR; Surgery 2009 Jun 25
Abarbanell AM; Herrmann JL; Weil BR; Wang Y; Tan J; Moberly SP; Fiege JW; Meldrum DR; The Journal of surgical research 2009 Jul 17
Wang M; Wang Y; Weil B; Abarbanell A; Herrmann J; Tan J; Kelly M; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2009 Feb 11
Novotny NM; Lahm T; Markel TA; Crisostomo PR; Wang M; Wang Y; Ray R; Tan J; Al-Azzawi D; Meldrum DR; Shock (Augusta, Ga.) 2009 Feb
Wang Y; Weil BR; Herrmann JL; Abarbanell AM; Tan J; Markel TA; Kelly ML; Meldrum DR; American journal of physiology. Cell physiology 2009 Aug 19
Vornehm ND; Wang M; Abarbanell A; Herrmann J; Weil B; Tan J; Wang Y; Kelly M; Meldrum DR; Surgery 2009 Aug
Herrmann JL; Markel TA; Abarbanell AM; Weil BR; Wang M; Wang Y; Tan J; Meldrum DR; Antioxidants & redox signaling 2009 Aug
Weil BR; Abarbanell AM; Herrmann JL; Wang Y; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2009 Apr 22
Novotny NM; Lahm T; Markel TA; Crisostomo PR; Wang M; Wang Y; Tan J; Meldrum DR; Shock (Augusta, Ga.) 2009 Apr
Wang M; Crisostomo PR; Markel TA; Wang Y; Meldrum DR; Circulation 2008 Sep 30
Sharma R; Markel TA; Wang Y; Crisostomo PR; Wang M; Sando IC; Weil BR; Meldrum DR; Shock (Augusta, Ga.) 2008 Sep
Markel TA; Wang Y; Herrmann JL; Crisostomo PR; Wang M; Novotny NM; Herring CM; Tan J; Lahm T; Meldrum DR; American journal of physiology. Heart and circulatory physiology 2008 Oct 10
Lahm T; Crisostomo PR; Markel TA; Wang M; Wang Y; Tan J; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2008 Oct 1
Wang Y; Crisostomo PR; Wang M; Weil B; Abarbanell A; Poynter J; Manukyan MC; Meldrum DR; Shock (Augusta, Ga.) 2008 Nov
Wang M; Crisostomo PR; Markel T; Wang Y; Lillemoe KD; Meldrum DR; Surgery 2008 May 9
Novotny NM; Ray R; Markel TA; Crisostomo PR; Wang M; Wang Y; Meldrum DR; Journal of the American College of Surgeons 2008 May 19
Erwin GS; Crisostomo PR; Wang Y; Wang M; Markel TA; Guzman M; Sando IC; Sharma R; Meldrum DR; The Journal of surgical research 2008 Mar 13
Crisostomo PR; Markel TA; Wang Y; Meldrum DR; Surgery 2008 Jan 30
Crisostomo PR; Wang Y; Markel TA; Wang M; Lahm T; Meldrum DR; American journal of physiology. Cell physiology 2008 Jan 30
Sando IC; Wang Y; Crisostomo PR; Markel TA; Sharma R; Erwin GS; Guzman MJ; Meldrum DR; Wang M; The Journal of surgical research 2008 Jan 17
Guzman MJ; Crisostomo PR; Wang M; Markel TA; Wang Y; Meldrum DR; The Journal of surgical research 2008 Jan 16
Lahm T; Crisostomo PR; Markel TA; Wang M; Wang Y; Weil B; Meldrum DR; Shock (Augusta, Ga.) 2008 Dec
Wang Y; Crisostomo PR; Wang M; Markel TA; Novotny NM; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2008 Aug 6
Markel TA; Crisostomo PR; Wang M; Wang Y; Lahm T; Novotny NM; Tan J; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2008 Aug 6
Crisostomo PR; Abarbanell AM; Wang M; Lahm T; Wang Y; Meldrum DR; American journal of physiology. Heart and circulatory physiology 2008 Aug 22
Wang Y; Nicol GD; Clapp DW; Hingtgen CM; Journal of neurophysiology 2005 Aug 10