Yue Wang, PhD, MS
Associate Research Professor of Medical & Molecular Genetics
Phone
(317) 278-3851
Address
975 W. Walnut street
Medical Research&Library Building, Room 244A
Indianapolis, IN 46202-5120
Medical Research&Library Building, Room 244A
Indianapolis, IN 46202-5120
Bio
Dr. Wang received her PhD in the Department of Pharmacology and Toxicology at Indiana University in 2006, working in the laboratory of Dr. Grant Nicol on the role of Neurofibromine, nerve growth factor and Ras signaling cascade in controlling the excitability of sensory neurons. Postdoctoral training with Dr. Daniel Meldrum (Indiana University) focused on progenitor cell therapy against acute myocardial ischemia and reperfusion injury. She joined the Department of Medical and Molecular Genetics at the Indiana University School of Medicine in 2011, continuing to study the mechanisms and action of progenitor cells in tissue protection. She became interested in the biology of different types of stem cells and the underlying mechanisms involved in cardiac repair and wound healing. She has continued to study the paracrine factors/exosomes regulate pro-survival and pro-angiogenesis signaling with potential implication for tissue repair and regeneration.
Titles & Appointments
- Associate Research Professor of Medical & Molecular Genetics
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Education2006 PhD Indiana University2000 MS Harbin Medical University1994 AS Harbin Medical University
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Research
Bone-marrow derived mesenchymal stem cells (MSCs) have emerged as a promising candidate for cell-based therapy of ischemic heart disease. MSCs are safe, can be easily isolated and amplified from patients’ bone marrow, are immunologically tolerated as transplants, and possess multilineage differentiation potential. Intramyocardial injection of MSCs reduces inflammation, fibrosis, infarct size, ventricular remodeling, and therefore, improves cardiac function. However, these benefits are modest and may have limited duration. Dr. Wang’s laboratory is interested in understanding how MSCs function to protect heart from ischemia and how to maximize their therapeutic potential by developing novel and effective pharmacological and molecular interventions. Such knowledge could lead to better therapies for the ischemic heart diseases and the ischemic insult of other organ systems.
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PublicationsregSNPs-splicing: a tool for prioritizing synonymous single-nucleotide substitution.
Zhang X; Li M; Lin H; Rao X; Feng W; Yang Y; Mort M; Cooper DN; Wang Y; Wang Y; Wells C; Zhou Y; Liu Y; Human genetics 2017 Apr 8Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.
Xie JY; Chew LA; Yang X; Wang Y; Qu C; Wang Y; Federici LM; Fitz SD; Ripsch MS; Due MR; Moutal A; Khanna M; White FA; Vanderah TW; Johnson PL; Porreca F; Khanna R; Pain 2016 SepExonImpact: Prioritizing Pathogenic Alternative Splicing Events.
Li M; Feng W; Zhang X; Yang Y; Wang K; Mort M; Cooper DN; Wang Y; Zhou Y; Liu Y; Human mutation 2016 Oct 3Identification of rifampin-regulated functional modules and related microRNAs in human hepatocytes based on the protein interaction network.
Li J; Wang Y; Wang L; Dai X; Cong W; Feng W; Xu C; Deng Y; Wang Y; Skaar TC; Liang H; Liu Y; BMC genomics 2016 Aug 22Lipopolysaccharide treatment induces genome-wide pre-mRNA splicing pattern changes in mouse bone marrow stromal stem cells.
Zhou A; Li M; He B; Feng W; Huang F; Xu B; Dunker AK; Balch C; Li B; Liu Y; Wang Y; BMC genomics 2016 Aug 22Platelet-derived growth factor-BB enhances MSC-mediated cardioprotection via suppression of miR-320 expression.
Xu B; Luo Y; Liu Y; Li BY; Wang Y; American journal of physiology. Heart and circulatory physiology 2015 Feb 27Transforming growth factor-a enhances stem cell-mediated postischemic myocardial protection.
Herrmann JL; Abarbanell AM; Wang Y; Weil BR; Poynter JA; Manukyan MC; Meldrum DR; The Annals of thoracic surgery 2011 Sep 23Advances in mesenchymal stem cell research in sepsis.
Wannemuehler TJ; Manukyan MC; Brewster BD; Rouch J; Poynter JA; Wang Y; Meldrum DR; The Journal of surgical research 2011 Oct 24Pretreating mesenchymal stem cells with interleukin-1ß and transforming growth factor-ß synergistically increases vascular endothelial growth factor production and improves mesenchymal stem cell-mediated myocardial protection after acute ischemia.
Luo Y; Wang Y; Poynter JA; Manukyan MC; Herrmann JL; Abarbanell AM; Weil BR; Meldrum DR; Surgery 2011 Nov 16Intracoronary mesenchymal stem cells promote postischemic myocardial functional recovery, decrease inflammation, and reduce apoptosis via a signal transducer and activator of transcription 3 mechanism.
Poynter JA; Herrmann JL; Manukyan MC; Wang Y; Abarbanell AM; Weil BR; Brewster BD; Meldrum DR; Journal of the American College of Surgeons 2011 May 5IL-6 and TGF-a costimulate mesenchymal stem cell vascular endothelial growth factor production by ERK-, JNK-, and PI3K-mediated mechanisms.
Herrmann JL; Weil BR; Abarbanell AM; Wang Y; Poynter JA; Manukyan MC; Meldrum DR; Shock (Augusta, Ga.) 2011 MayFemale stem cells are superior to males in preserving myocardial function following endotoxemia.
Manukyan MC; Weil BR; Wang Y; Abarbanell AM; Herrmann JL; Poynter JA; Brewster BD; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2011 Mar 30Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway.
Manukyan MC; Alvernaz CH; Poynter JA; Wang Y; Brewster BD; Weil BR; Abarbanell AM; Herrmann JL; Crowe BJ; Keck AC; Meldrum DR; Surgery 2011 Jun 30TGF-a equalizes age disparities in stem cell-mediated cardioprotection.
Herrmann JL; Fiege JW; Abarbanell AM; Weil BR; Wang Y; Poynter JA; Manukyan MC; Brewster BD; Meldrum DR; The Journal of surgical research 2011 Dec 14Transforming growth factor-alpha does not protect myocardium during acute ischemia/reperfusion.
Manukyan MC; Keck AC; Poynter JA; Wang Y; Weil BR; Abarbanell AM; Herrmann JL; Crowe BJ; Alvernaz C; Meldrum DR; Surgery 2011 AugSystemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1a and VEGF production and improves functional recovery after acute ischemia/reperfusion.
Poynter JA; Manukyan MC; Wang Y; Brewster BD; Herrmann JL; Weil BR; Abarbanell AM; Meldrum DR; Surgery 2011 AugPretreatment with intracoronary mimosine improves postischemic myocardial functional recovery.
Crowe B; Poynter JA; Manukyan MC; Wang Y; Brewster BD; Herrmann JL; Abarbanell AM; Weil BR; Meldrum DR; Surgery 2011 AugRas signaling pathways mediate NGF-induced enhancement of excitability of small-diameter capsaicin-sensitive sensory neurons from wildtype but not Nf1+/- mice.
Duan JH; Wang Y; Duarte D; Vasko MR; Nicol GD; Hingtgen CM; Neuroscience letters 2011 Apr 8Ablation of TNF-alpha receptors influences mesenchymal stem cell-mediated cardiac protection against ischemia.
Tan J; Weil BR; Abarbanell AM; Wang Y; Herrmann JL; Dake ML; Meldrum DR; Shock (Augusta, Ga.) 2010 SepThe phosphoinositide-3 kinase survival signaling mechanism in sepsis.
Manukyan MC; Weil BR; Wang Y; Abarbanell AM; Herrmann JL; Poynter JA; Meldrum DR; Shock (Augusta, Ga.) 2010 NovPostinfarct intramyocardial injection of mesenchymal stem cells pretreated with TGF-alpha improves acute myocardial function.
Herrmann JL; Abarbanell AM; Weil BR; Wang Y; Poynter JA; Manukyan MC; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2010 May 19Optimizing stem cell function for the treatment of ischemic heart disease.
Herrmann JL; Abarbanell AM; Weil BR; Manukyan MC; Poynter JA; Brewster BJ; Wang Y; Meldrum DR; The Journal of surgical research 2010 Jun 16Preconditioning mesenchymal stem cells with transforming growth factor-alpha improves mesenchymal stem cell-mediated cardioprotection.
Herrmann JL; Wang Y; Abarbanell AM; Weil BR; Tan J; Meldrum DR; Shock (Augusta, Ga.) 2010 JanToll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury.
Abarbanell AM; Wang Y; Herrmann JL; Weil BR; Poynter JA; Manukyan MC; Meldrum DR; American journal of physiology. Heart and circulatory physiology 2010 Feb 19Augmented sodium currents contribute to the enhanced excitability of small diameter capsaicin-sensitive sensory neurons isolated from Nf1+/? mice.
Wang Y; Duan JH; Hingtgen CM; Nicol GD; Journal of neurophysiology 2010 Feb 17TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection.
Wang Y; Abarbanell AM; Herrmann JL; Weil BR; Manukyan MC; Poynter JA; Meldrum DR; PloS one 2010 Dec 3Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury.
Wang Y; Abarbanell AM; Herrmann JL; Weil BR; Poynter J; Manukyan MC; Crisostomo PR; Meldrum DR; Shock (Augusta, Ga.) 2010 DecThe immunomodulatory properties of mesenchymal stem cells: implications for surgical disease.
Weil BR; Manukyan MC; Herrmann JL; Abarbanell AM; Poynter JA; Wang Y; Meldrum DR; The Journal of surgical research 2010 Aug 6Exogenous high-mobility group box 1 improves myocardial recovery after acute global ischemia/reperfusion injury.
Abarbanell AM; Hartley JA; Herrmann JL; Weil BR; Wang Y; Manukyan MC; Poynter JA; Meldrum DR; Surgery 2010 Aug 19Mesenchymal stem cells attenuate myocardial functional depression and reduce systemic and myocardial inflammation during endotoxemia.
Weil BR; Manukyan MC; Herrmann JL; Wang Y; Abarbanell AM; Poynter JA; Meldrum DR; Surgery 2010 AugSignaling via GPR30 protects the myocardium from ischemia/reperfusion injury.
Weil BR; Manukyan MC; Herrmann JL; Wang Y; Abarbanell AM; Poynter JA; Meldrum DR; Surgery 2010 AugGender dimorphisms in progenitor and stem cell function in cardiovascular disease.
Herrmann JL; Abarbanell AM; Weil BR; Manukyan MC; Poynter JA; Wang Y; Coffey AC; Meldrum DR; Journal of cardiovascular translational research 2010 AprIL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.
Wang M; Tan J; Wang Y; Meldrum KK; Dinarello CA; Meldrum DR; Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 25Cell-based therapy for ischemic heart disease: a clinical update.
Herrmann JL; Abarbanell AM; Weil BR; Wang Y; Wang M; Tan J; Meldrum DR; The Annals of thoracic surgery 2009 NovRole of tumor necrosis factor receptor 1 in sex differences of stem cell mediated cardioprotection.
Zeller CN; Wang Y; Markel TA; Weil B; Abarbanell A; Herrmann JL; Kelly ML; Coffey A; Meldrum DR; The Annals of thoracic surgery 2009 MarMEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells.
Wang Y; Wang M; Abarbanell AM; Weil BR; Herrmann JL; Tan J; Novotny NM; Coffey AC; Meldrum DR; Surgery 2009 Jun 25Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion.
Wang M; Wang Y; Abarbanell A; Tan J; Weil B; Herrmann J; Meldrum DR; Surgery 2009 Jun 25Animal models of myocardial and vascular injury.
Abarbanell AM; Herrmann JL; Weil BR; Wang Y; Tan J; Moberly SP; Fiege JW; Meldrum DR; The Journal of surgical research 2009 Jul 17Estrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia.
Wang M; Wang Y; Weil B; Abarbanell A; Herrmann J; Tan J; Kelly M; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2009 Feb 11beta-Blockers in sepsis: reexamining the evidence.
Novotny NM; Lahm T; Markel TA; Crisostomo PR; Wang M; Wang Y; Ray R; Tan J; Al-Azzawi D; Meldrum DR; Shock (Augusta, Ga.) 2009 FebMEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells.
Wang Y; Weil BR; Herrmann JL; Abarbanell AM; Tan J; Markel TA; Kelly ML; Meldrum DR; American journal of physiology. Cell physiology 2009 Aug 19Acute postischemic treatment with estrogen receptor-alpha agonist or estrogen receptor-beta agonist improves myocardial recovery.
Vornehm ND; Wang M; Abarbanell A; Herrmann J; Weil B; Tan J; Wang Y; Kelly M; Meldrum DR; Surgery 2009 AugProinflammatory stem cell signaling in cardiac ischemia.
Herrmann JL; Markel TA; Abarbanell AM; Weil BR; Wang M; Wang Y; Tan J; Meldrum DR; Antioxidants & redox signaling 2009 AugHigh glucose concentration in cell culture medium does not acutely affect human mesenchymal stem cell growth factor production or proliferation.
Weil BR; Abarbanell AM; Herrmann JL; Wang Y; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2009 Apr 22Angiopoietin-1 in the treatment of ischemia and sepsis.
Novotny NM; Lahm T; Markel TA; Crisostomo PR; Wang M; Wang Y; Tan J; Meldrum DR; Shock (Augusta, Ga.) 2009 AprMechanisms of sex differences in TNFR2-mediated cardioprotection.
Wang M; Crisostomo PR; Markel TA; Wang Y; Meldrum DR; Circulation 2008 Sep 30Proestrus female rats are more resistant to right ventricular pressure overload.
Sharma R; Markel TA; Wang Y; Crisostomo PR; Wang M; Sando IC; Weil BR; Meldrum DR; Shock (Augusta, Ga.) 2008 SepVEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function.
Markel TA; Wang Y; Herrmann JL; Crisostomo PR; Wang M; Novotny NM; Herring CM; Tan J; Lahm T; Meldrum DR; American journal of physiology. Heart and circulatory physiology 2008 Oct 10Selective estrogen receptor-alpha and estrogen receptor-beta agonists rapidly decrease pulmonary artery vasoconstriction by a nitric oxide-dependent mechanism.
Lahm T; Crisostomo PR; Markel TA; Wang M; Wang Y; Tan J; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2008 Oct 1Nitric oxide suppresses the secretion of vascular endothelial growth factor and hepatocyte growth factor from human mesenchymal stem cells.
Wang Y; Crisostomo PR; Wang M; Weil B; Abarbanell A; Poynter J; Manukyan MC; Meldrum DR; Shock (Augusta, Ga.) 2008 NovEstrogen receptor beta mediates acute myocardial protection following ischemia.
Wang M; Crisostomo PR; Markel T; Wang Y; Lillemoe KD; Meldrum DR; Surgery 2008 May 9Stem cell therapy in myocardial repair and remodeling.
Novotny NM; Ray R; Markel TA; Crisostomo PR; Wang M; Wang Y; Meldrum DR; Journal of the American College of Surgeons 2008 May 19Estradiol-treated mesenchymal stem cells improve myocardial recovery after ischemia.
Erwin GS; Crisostomo PR; Wang Y; Wang M; Markel TA; Guzman M; Sando IC; Sharma R; Meldrum DR; The Journal of surgical research 2008 Mar 13Surgically relevant aspects of stem cell paracrine effects.
Crisostomo PR; Markel TA; Wang Y; Meldrum DR; Surgery 2008 Jan 30Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism.
Crisostomo PR; Wang Y; Markel TA; Wang M; Lahm T; Meldrum DR; American journal of physiology. Cell physiology 2008 Jan 30Females exhibit relative resistance to depressive effects of tumor necrosis factor-alpha on the myocardium.
Sando IC; Wang Y; Crisostomo PR; Markel TA; Sharma R; Erwin GS; Guzman MJ; Meldrum DR; Wang M; The Journal of surgical research 2008 Jan 17Vascular endothelial growth factor improves myocardial functional recovery following ischemia/reperfusion injury.
Guzman MJ; Crisostomo PR; Wang M; Markel TA; Wang Y; Meldrum DR; The Journal of surgical research 2008 Jan 16Exogenous estrogen rapidly attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction.
Lahm T; Crisostomo PR; Markel TA; Wang M; Wang Y; Weil B; Meldrum DR; Shock (Augusta, Ga.) 2008 DecTGF-alpha increases human mesenchymal stem cell-secreted VEGF by MEK- and PI3-K- but not JNK- or ERK-dependent mechanisms.
Wang Y; Crisostomo PR; Wang M; Markel TA; Novotny NM; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2008 Aug 6TNFR1 signaling resistance associated with female stem cell cytokine production is independent of TNFR2-mediated pathways.
Markel TA; Crisostomo PR; Wang M; Wang Y; Lahm T; Novotny NM; Tan J; Meldrum DR; American journal of physiology. Regulatory, integrative and comparative physiology 2008 Aug 6Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions.
Crisostomo PR; Abarbanell AM; Wang M; Lahm T; Wang Y; Meldrum DR; American journal of physiology. Heart and circulatory physiology 2008 Aug 22Sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability.
Wang Y; Nicol GD; Clapp DW; Hingtgen CM; Journal of neurophysiology 2005 Aug 10
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