10576-Yoder, Mervin

Mervin C. Yoder, MD

Distinguished Professor Emeritus

Phone 317-274-9787
975 W. Walnut Street

Indianapolis, IN 46202
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Dr. Yoder currently serves as Director Emeritus, Indiana Center for Regenerative Medicine and Engineering. Dr. Yoder received his medical degree from Indiana University School of Medicine.

Prior to joining Indiana University, Dr. Yoder served as an Instructor in Pediatrics at the Children’s Hospital of Philadelphia.

He retired and relinquished clinical duties in Neonatal-Perinatal Medicine in 2018 to focus on basic research.

Dr. Yoder’s research focus is in developmental biology of hematopoietic and endothelial stem and progenitor cell emergence, maintenance and regenerative properties. He has served as principle/co-investigator on more than thirty extramural foundation/NIH grants that have led to more than 304 peer reviewed publications, 55 books/book chapters, 30,425 citations and an h-index of 89.

Key Publications

Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice.

Gil CH, Chakraborty D, Vieira CP, Prasain N, Li Calzi S, Fortmann SD, Hu P, Banno K, Jamal M, Huang C, Sielski MS, Lin Y, Huang X, Dupont MD, Floyd JL, Prasad R, Longhini ALF, McGill TJ, Chung HM, Murphy MP, Kotton DN, Boulton ME, Yoder MC, Grant MB.Sci Adv. 2022 Mar 4;8(9):eabm5559. doi: 10.1126/sciadv.abm5559. Epub 2022 Mar 4.PMID: 35245116 Free PMC article

Isolation of tissue-resident vascular endothelial stem cells from mouse liver.

Naito H, Wakabayashi T, Ishida M, Gil CH, Iba T, Rahmawati FN, Shimizu S, Yoder MC, Takakura N.Nat Protoc. 2020 Mar;15(3):1066-1081. doi: 10.1038/s41596-019-0276-x. Epub 2020 Jan 31.PMID: 32005982

Titles & Appointments

  • Distinguished Professor Emeritus
  • Richard and Pauline Klingler Professor Emeritus of Pediatrics
  • Professor Emeritus of Biochemistry & Molecular Biology
  • Professor Emeritus of Ophthalmology
  • Professor Emeritus of Cellular & Integrative Physiology
  • Director Emeritus, Indiana Center for Regenerative Medicine and Engineering
  • Education
    1985 Fellowship The Children's Hospital of Philadelphia
    1983 Residency The Children's Hospital of Philadelphia
    1980 MD Indiana University
    1976 MA Indiana State University
    1975 BA Malone College
  • Research

    While it is well founded that all hematopoietic cells circulating in blood or present in tissues are derived from bone marrow resident hematopoietic stem cells (HSC) in adult subjects, Dr. Yoder has contributed to the more recent understanding that there are multiple waves of hematopoiesis that emerge throughout embryonic and fetal development in mouse and man. The first wave of blood cells are derived from hemogenic endothelial cells within the yolk sac. During this wave, primitive red blood cells, macrophages and megakaryocytes are the first to emerge in the bloodstream (in that order).

    Subsequently, in the second wave, erythroid-myeloid progenitor cells, B1B and T cells, and NK cells emerge from hemogenic endothelial cells. Finally, in the third wave, HSC emerge from specific hemogenic endothelium in the aorta. These HSC migrate to fetal liver, expand, and subsequently migrate again into the bone marrow sites of hematopoiesis that persist throughout the life of the subject.

    In related studies, Dr. Yoder contributed to clarifying the identity, source and function of circulating and resident vascular endothelial progenitor cells. Human cord blood was found to be enriched in circulating endothelial cells that displayed clonal proliferative potential (named endothelial colony forming cells:ECFC). ECFC are present not only in cord blood, but also within the endothelial intima of umbilical artery and vein, adult mammary artery, saphenous vein and aortic vessels. ECFC upon isolation display a hierarchy of proliferative potential with some individual cells giving rise to >2,000 progeny in 14 days. Recently, cells resembling ECFC have been identified upon specific differentiation of induced pluripotent stem cells and such cells integrate into damaged diabetic murine retinal vasculature to restore retinal perfusion, diminish retinal hypoxia and stimulate recovery of retinal neuronal functions.

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  • Professional Organizations
    American Pediatric Society
    Association of American Physicians
    International Society for Experimental Hematology
  • Board Certifications
    American Board of Pediatrics - Pediatrics
    American Board of Pediatrics - Neonatal-Perinatal Medicine
  • Awards
    Org: American Academy of Pediatrics
    Desc: Edward L. Gresham Recognition Award
    Scope: State
    Date: 1995-01-01
    Org: Alpha Omega Alpha Medical Honor Society
    Desc: Alpha Omega Alpha
    Scope: National
    Date: 1979-01-01

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