The research lab of Clark D. Wells, PhD investigates the changes in cell morphology and cell growth that lead to cancer development. The major focus is on the coordination between cell polarity proteins and HIPPO signaling during the early progression of breast and brain cancer. Both pathways have been shown by work from the Wells Laboratory to be coordinated by the Amot family of adaptor proteins. Dysregulation in expression of members of the Amot family have also been shown to promote the malignant potential of cancer cells. These basic science discoveries are being actively pursued for novel avenues for drug development.