The research laboratory of Matthew Turner, MD, PhD, focuses on the interaction between skin injury, inflammation and wound healing. These interactions are important for inflammatory skin diseases such as atopic dermatitis (atopic eczema) and conditions that impair the wound healing, such as diabetes mellitus. The goal of the Turner Lab is to discover new molecular pathways that promote inflammatory skin diseases and impair wound healing and translate these discoveries into improved novel treatments for patients.
The Turner Lab studies mechanisms of skin inflammation that contribute to atopic dermatitis (AD), one of the most common inflammatory diseases in humans and one that disproportionately affects children (up to 1 in 5 children). Atopic dermatitis is associated with significant morbidity due to severe itching, poor sleep and secondary skin infections—all of which can dramatically impair quality of life and productivity for patients and their caregivers. Treatment options for atopic dermatitis are limited and often ineffective. A better understanding of the mechanisms that cause and perpetuate atopic dermatitis is needed in order to identify new cellular and molecular targets for therapy. The Turner Lab is contributing to the understanding of the causes of atopic dermatitis through research with vitro systems, mouse models of atopic dermatitis and healthy and diseased human subjects.