The laboratory of Patricia Silveyra, PhD, studies the cellular and molecular mechanisms underlying sex differences in lung inflammation and lung disease triggered by various environmental exposures. With an interdisciplinary focus on respiratory physiology, molecular endocrinology, and cellular and molecular immunology, the Silveyra laboratory investigates the effects of air pollutants, cigarette smoke, e-cigarettes, and other environmental exposures in the male and female lung.
Active Research
We are currently investigating the following areas of research:
- Sex differences in lung inflammatory responses to environmental exposures (ambient ozone, particulate matter, allergens, smoking, e-cigarettes, phthalates).
- The effects of the female reproductive cycle in lung inflammatory responses and asthma exacerbations.
- Circulating sex hormone's effects on air pollution-induced lung inflammation.
- Mechanisms of estrogen receptor regulation in the context of lung inflammation.
- Sex differences in airway remodeling during asthma and ozone-induced asthma exacerbations.
- Sex differences in the effects of e-cigs and ENDS exposure, including second and third hand exposures across the life span.
- The effects of environmental exposures such as endocrine disruptors in the lung's response to allergens and pollutants.
- The interplay of the lung and gut microbiomes in the context of lung health and disease.
- The effects of diet and exercise modifications in lung immunology.
Current Research Funding
R01HL159764 (PI: Silveyra)
Gonadal hormones as mediators of sex and gender influences in asthma
R01HL159764-03S2 (PI: Silveyra; Commodore Diversity Supplement)
Gonadal hormones as mediators of sex and gender influences in asthma
R01HL159764-03S1 (PI: Silveyra; Administrative Supplement)
Promoting DEIA in Lung Disease Research Through a Mentored Training Experience at IUB-SPH
P01HL158507 (PI: Gaston; Silveyra Scientific Advisor)
Scientific innovation for personalized severe asthma management
K01HL149989 (PI: Turi; Silveyra primary mentor)
Identification of Early Metabolomic and Immune Endotypes of Allergy and Asthma: An Integrated Multiomics Approach
K23HD109727 (PI: Siddaiah, Silveyra co-mentor)
Salivary miRNAs as prognostic markers of pulmonary hyper-tension associated with Bronchopulmonary Dysplasia in extremely low gestational age infants
K08HL169727 (PI: Gandhi; Silveyra Advisory Board)
The role of surfactant protein-A genetic variant and sex in pathogenesis of neonatal respiratory syncytial virus infection
Recent Publications
Ekpruke CD, Alford R, Rousselle D, Babayev M, Sharma S, Commodore S, Buechlein A, Rusch DB, Silveyra P. Transcriptomics analysis of allergen-induced inflammatory gene expression in the Four-Core Genotype mouse model. Physiol Genomics. 2023 Dec 4. doi: 10.1152/physiolgenomics.00112.2023.
Commodore S, Ekpruke CD, Rousselle D, Alford R, Babayev M, Sharma S, Buechlein A, Rusch DB, Silveyra P. Lung pro-inflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones. Physiol Genomics. 2023 Dec 4. doi: 10.1152/physiolgenomics.00049.2023.
Alam F, Silveyra P. Sex differences in e-cigarette use and related health effects. Int J Environ Res Public Health. 2023 Nov 18;20(22):7079. doi: 10.3390/ijerph20227079.
Commodore S, Sharma S, Ekpruke CD, Pepin R, Hansen A, Rousselle D, Babayev M, Ndeke JM, Alford R, Parker E, Dickinson S, Sharma S, Silveyra P. Thirdhand vaping exposures are associated with pulmonary and systemic inflammation in a mouse model. J Environ Expo Assess 2023;2:22, doi: 10.20517/jeea.2023.27
Sundar IK, Duraisamy SK, Choudhary I, Saini Y, Silveyra P. Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice. Adv Biol (Weinh). 2023 Nov;7(11):e2300045. doi: 10.1002/adbi.202300045.
