The research laboratory of Karen E. Pollok, PhD, focuses on the development of new combination therapies for solid tumors such as glioblastoma and pediatric sarcoma. The overall strategy is to use precision genomics to guide prioritization of targets for study. Emphasis is on investigations that evaluate the therapeutic effect of blocking DNA damage and repair pathways in the context of front-line therapies.
The Pollok Laboratory is heavily invested in team science that integrates bench research with the clinic. The research team represents a highly integrated, collaborative, and dynamic training environment to advance discovery and create pathways cures of adult and pediatric cancers.
Pollok’s expertise and many designations are a strong foundation for synergistic study. She serves as the basic science leader of the Brain Tumor Working Group (BTWG) and the director of the In Vivo Therapeutics (IVT) Core for the NCI-designated Indiana University Simon Cancer Center. She is also the co-director of the Indiana University Purdue University-Indianapolis (IUPUI) Signature Center for Brain and Neurological Tumors.
In addition, Pollok is the associate director (Administrative Core) and an MPD/PI for Project 1 of the U54 Eunice Kennedy Shriver NICHD Specialized Centers in Research in Pediatric Developmental Pharmacology, the co-leader for the summer enrichment program and project leader of the Experimental Mouse Resources Core on the U54 NIDDK Cooperative Centers of Excellence in Hematology. She has also directed the development of ectopic and orthotopic models (brain, ovarian, breast, sarcoma, lung and pancreatic cancers) at IU School of Medicine to streamline resources and processes for multiple investigators.