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Nelson Lab

The lab of David E. Nelson, PhD is focused on chlamydial pathogenesis, microbiome pathogen interactions and pathogen discovery.

Active Research

The Nelson laboratory works in two distinct but sometimes overlapping areas of microbial pathogenesis. One focus is utilization of emerging genetic tools to identify virulence factors that dictate how genetically similar intracellular pathogens in the genus Chlamydia infect different tissues, evade local and systemic immunity and cause distinct disease states. Long-term goals of this project are identification of suitable antigens for use in recombinant anti-chlamydial vaccines and generation and testing of live-attenuated anti-chlamydial vaccines.

The second major focus of the laboratory is discovery of novel urogenital tract pathogens and disease syndromes. This project utilizes cutting-edge metagenomic approaches to identify disease-associated microorganisms in patients with idiopathic urogenital tract disease.

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To stay up-to-date on the medical research work at IU School of Medicine, follow the IU School of Medicine research blog, where investigators throughout the school’s academic departments statewide post updates about their work.

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Research Funding

Genetic Analysis of Mechanisms of Chlamydial Immune Evasion. NIH/NIAID.
2R56AI099278-06.

The Role of the Urethral Microbiome in Idiopathic Urethritis in Men. NIH/NIAID.
5R01AI116706-02.

Recent Publications

Faculty Research Team

5018-Nelson, David

David E. Nelson, PhD

Associate Professor of Microbiology & Immunology

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Additional Research Team Members

Other research team members in the Nelson Lab include Amanda Giebel, PhD (Post-doctoral Fellow), Yuan Sun, PhD (Post-doctoral Fellow), Evelyn Toh, PhD (Senior Research Associate) and Xiaoli Zhang (Research Associate).