The Kline Lab is led by Jeff Kline, MD, a translational researcher in the area of venous thromboembolism. This lab performs clinical and applied laboratory research intended to improve the therapeutic index of all steps of venous thromboembolism diagnosis and treatment.
Located in the Medical Science Building on the IU School of Medicine—Indianapolis campus, the Kline Lab spans 850 square feet of laboratory space and connects via corridor to IU Health University Hospital, where investigators collect samples from patients, which are analyzed in this lab. The three rooms of this lab include a biochemistry/protein production and purification laboratory; a lab equipped to measure hemostasis, coagulation, NOx and cellular metabolism; and a rat surgery area, with dander abatement equipment.
Investigators in this lab work with many different organisms—from an e coli expression vector used to make a mutant plasmin for dissolving blood clots to rats, pigs and humans with pulmonary embolism. The main therapeutic goals are to produce clot lysis while not increasing the bleeding risk and to protect the right ventricle from damage.