The primary focus of the Gingery Lab (Indianapolis) is on musculoskeletal pathology injury, repair, regeneration and therapeutics.

Gingery Lab

The primary focus of the Gingery Lab is on musculoskeletal pathology injury, repair, regeneration and therapeutics. The lab focuses on an integrated systems approach to clinical pathologies found in the musculoskeletal system which inform both understanding of disease etiology and the development of therapeutics.

Current projects in the laboratory explore the role of cellular senescence in carpal tunnel syndrome, where cellular senescence drives fibrosis in the subsynovial connective tissue. As a direct outcome of this work, Anne Gingery, PhD, and her collaborators have begun the first clinical trial investigating the efficacy of using senolytic drugs that specifically target senescent cells to treat carpal tunnel syndrome.

Another project area of the laboratory is investigating the role of senescent cell accumulation in aging and pathologic tendon disorders. The laboratory is systemically evaluating how metabolic syndrome drives musculoskeletal pathology in many tissues including bone, cartilage, fat, muscle and tendon. Further, the laboratory studies immune system dysfunction at both the systemic and tissue level as a driver of musculoskeletal disease.

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Anne Gingery, PhD, and two of her research staff work in their lab.

Led by Anne Gingery, PhD

Gingery is an Assistant Professor in the Department of Orthopaedic Surgery at the IU School of Medicine. She received her PhD in biochemistry, molecular biology and biophysics from the University of Minnesota. She completed post-doctoral training at the University of Minnesota and at Mayo Clinic in the Department of Biochemistry and Molecular Biology.
Prior to joining the faculty at IU, Gingery was an assistant professor at Mayo Clinic in the Department of Orthopedic Surgery and Biochemistry. Gingery is a member of the Orthopaedic Research Society, American Society of Bone and Mineral Research and the Indiana Center for Musculoskeletal Health.