Dent Lab

Research Funding

• Allergy Control
  NIH R01 AI132771-01 “The control of allergic immune responses by follicular regulatory T cells”, 6/01/17 – 5/30/22. Principal Investigator.

  This study analyzes the development of follicular repressor T cells and their function in controlling IgE production during allergic immune responses.

• HIV-1 Cure
  NIH R01 AI117835-01 “Targeting latently infected Tfh cells to achieving a functional cure of HIV-1”, 3/01/15 – 2/29/20. Co-investigator (PI Yu).

  The goal of this grant is to assess Tfh cell characteristics that lead to latent infection with HIV-1.

• 2017

  Xie, M.M., Amet, T., Liu, H., Yu, Q., Dent, A.L. “AMP Kinase Promotes Bcl6 Expression in both Mouse and Human T cells”, Mol. Immunol. 81:67-75 (2017)

  Jandl, C., Liu, S. , Canete, P., Warren, J., Hughes, W., Vogelzang, A., Webster, A., Craig, M., Uzel, G., Dent, A. , Stepnesky, P., Keller, B., Warnatz, K., Sprent, J., King. C. “IL-21 restricts regulatory T cells through Bcl-6 mediated inhibition of responsiveness to IL-2″ Nature Comm. 8:14647 DOI: 10.1038 (2017)\

  Olson, M.R., Ulrich, B.J., Hummel, S.A., Khan, I., Meuris, B., Cherukuri, Y., Dent, A.L., Janga, S.C., Kaplan, M.H. “Paracrine IL-2 is required for optimal type 2 effector cytokine production”, J. Immunol. 198:4352-4359 (2017)

  Xie, M.M., Koh, B.-H., Hollister, K., Wu, H., Sun, J., Kaplan, M.H., Dent, A.L. “Bcl6 Promotes Follicular Helper T-Cell Differentiation and PD-1 Expression in a Blimp1-independent Manner”, Eur. J. Immunol. doi: 10.1002/eji.201747034 (2017)

• 2016

  Wu, H., Chen, Y., Liu, H., Xu, L-L, Teuscher, P., Wang, S., Lu, S., Dent, A.L. “Follicular Regulatory T cells Repress Cytokine Production by Follicular Helper T cells and Optimize IgG Responses in Mice”, Eur. J. Immunol. doi: 10.1002/eji.201546094 (2016)

  Olson, M.R., Verdan, F.F., Hufford, M.M., Dent, A.L., Kaplan, M.H. “STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells”, J. Immunol. 196:3297-304 (2016)

  Wu, H., Xie, M.M., Liu, H., Dent, A.L. “STAT3 is Important for Follicular Regulatory T cell Differentiation”, PLOSone, 11(5):e0155040. doi: 10.1371/journal.pone.0155040(2016)

  Kobayashi, T., Iijima K., Dent, A.L., Kita, H. “IL-4-Producing Follicular Helper T (Tfh) Cells Mediate IgE Antibody Response to Airborne Allergens Independently of Th2 Cells”, J. Allergy Clin. Immunol., pii: S0091-6749(16)30289-5 (2016)

  Leong, Y.A., Chen, Y,. Ong, H.S., Wu, D., Man, K., Deleage, C., Minnich, M., Meckiff, B.J., Wei, Y., Hou, Z., Zotos, D., Fenix, K.A., Atnerkar, A., Preston, S., Chipman, J.G., Beilman, G.J., Allison, C.C., Sun, L., Wang, P., Xu, J., Toe, J.G., Lu, H.K., Tao, Y., Palendira, U., Dent, A.L., Landay, A.L., Pellegrini, M., Comerford, I., McColl, S.R., Schacker, T.W., Long, H.M., Estes, J.D., Busslinger, M., Belz, G.T., Lewin, S.R., Kallies, A., Yu, D. “CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles”, Nat. Immunol. doi: 10.1038/ni.3543 (2016)