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Clinkenbeard Lab

The Clinkenbeard lab led by Erica Clinkenbeard, PhD, is focused on understanding the molecular mechanism driving bone loss in chronic kidney disease – mineral and bone disorder (CKD-MBD). Dovetailed studies in animal models of CKD and tissue culture work to identify novel targets for therapeutic interventions.

Disrupted mineral metabolism in CKD-MBD is linked to bone fragility and increased fracture risk leading to morbidity and mortality in these patients. Unfortunately, there are no current therapeutics to dramatically improve fracture risk; thus, the underlying effects of CKD on bone homeostasis are not fully understood. The lab uses a mouse model of induced CKD to recapitulate both the metabolic and bone phenotypes observed in CKD patients as well as understand the molecular pathways involved through genetic manipulations. These studies coupled with in vitro techniques serve to elucidate uremic factors that contribute to bone loss and how they alter the differentiation and function of osteoblasts, the bone forming cells.

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Active Research

Co-PI: Erica Clinkenbeard, Kenneth White

Agency: Keryx Biopharmaceuticals, Inc.

Recent Publications

Clinkenbeard EL, Noonan M, Thomas J, Ni P, Hum JM, Aref M, Swallow E, Moe S, Allen MR. White EK. Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD. JCI Inisght (accepted).

Hum JM, O’Bryan LM, Tatiparthi AK, Clinkenbeard EL, Ni P, Cramer MS, Bhaskaran M, Johnson RL, Wilson JM, Smith RC, White KE. Sustained Klotho delivery reduces serum phosphate in a model of diabetic nephropathy. Journal of Applied Physiology (accepted)

Research Team

21750-Clinkenbeard, Erica

Erica L. Clinkenbeard, PhD

Assistant Professor of Medical and Molecular Genetics

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The lab team also includes Daniel Edwards III (Research Technician).