9738-Hurley, Thomas

Thomas D. Hurley, PhD

Associate Dean for Graduate Education

Chancellor's Professor, IUPUI

Professor of Biochemistry & Molecular Biology

Director, Indiana CTSI TL1 Training Program

Phone
(317) 278-2008
Address
635 Barnhill Drive
Medical Science, Room MS4019
Indianapolis, IN 46202
PubMed:

Bio

Dr. Hurley received his PhD in Biochemistry from Indiana University in 1990.   Dr. Hurley received post-doctoral training at the Johns Hopkins School of Medicine in the Biophysics and Biophysical Chemistry Department where he pursued training in the application of X-ray crystallography to understand enzyme structure and function. He joined the faculty within the Department of Biochemistry and Molecular Biology at Indiana University School of Medicine in 1992. His research focus is to apply kinetic and biophysical techniques to understand enzyme structure and function, as well as applying High-Throughput screening approaches to discover and develop inhibitors for enzyme targets relevant to human disease.
He has twice served as the Interim-Chair of the Department of Biochemistry and Molecular Biology. He accepted the role as Associate Dean for Graduate Education within the School of Medicine in the Fall of 2017.  Since taking this role, the number of applications to the School of Medicine Graduate programs has more than doubled, as has the diversity of our applicant pool and the diversity of our incoming graduate student cohorts.

Key Publications

For a complete list of publications, visit PubMed

Tang B, Frasinyuk MS, Chikwana VM, Mahalingan KK, Morgan CA, Segvich DM, Bondarenko SP, Mrug GP, Wyrebek P, Watt DS, DePaoli-Roach AA, Roach PJ, Hurley TD. (2020) Discovery and development of small-molecule inhibitors of glycogen synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551. doi: 10.1021/acs.jmedchem.9b01851. Epub 2020 Mar 23. PMCID: PMC7233370

Huddle, BC, Grimley, E, Chtcherbinine, M., Buchman, CD, Takahashi, C, Debnath, B, McGonigal, SC, Mao, S, Li, S, Felton,J, Pan, S, Wen, B, Sun, D, Neamati, N, Buckanovich, RJ, Hurley, TD, Larsen, SD. (2020) Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of Aldehyde Dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy. Eur J Med Chem. 2021 Feb 5;211:113060. doi: 10.1016/j.ejmech.2020.113060. Epub 2020 Dec 3. PMCID: PMC7855449

Muralikrishnan V, Fang F, Given TC, Podicheti R, Chtcherbinine M, Metcalfe TX, Sriramkumar S, O'Hagan HM, Hurley TD, Nephew KP. A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer. Cancers (Basel). 2022 Jul 15;14(14):3437. doi: 10.3390/cancers14143437. PMID: 35884498; PubMed Central PMCID: PMC9318275

Takahashi, C, Chtcherbinine, M, Huddle, BC, Wilson, MW, Emmel, T, Hohlman, RM, McGonigal, S, Buckanovich, RJ, Larsen, SD, and Hurley, TD. (2024) Development of substituted benzimidazoles as inhibitors of Human Aldehyde Dehydrogenase 1A Isoenzymes. Chem Biol Interact. 2024 Feb 14, 391:110910. doi: 10.1016/j.cbi.2024.110910. PMCID: PMC11062403

Skurat, AV, Segvich, DM, Contreas, CJ, Hu, YC, Hurley, TD, DePaoli-Roach, AA and Roach, PJ. (2024) Impaired malin expression and interaction with partner proteins in Lafora disease. J. Biol. Chem. 300(5):107271 doi: https://doi.org/10.1016/j.jbc.2024.107271. PMCID: PMC11063907

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