7391-Duman Scheel, Molly
Faculty

Molly Duman Scheel, PhD

Navari Family Professor

Address
Raclin-Carmichael Hall
1234 Notre Dame Ave.

South Bend, IN 46617

Bio

2013-Present, Associate Professor, Department of Medical and Molecular Genetics, IU School of Medicine-South Bend

 

2013-Present, Adjunct Associate Professor, Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame

 

2007-2013, Assistant Professor, Department of Medical and Molecular Genetics, IU School of Medicine-South Bend

 

2007-2013, Adjunct Assistant Professor, Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame

 

2002-2007,  Assistant Professor, Biology Department, Albion College

 

1999-2002,  Postdoctoral Fellow, University of Chicago, Ben May Institute for Cancer Research, University of Chicago     

Key Publications

Hapairai et al.  2017.  Lure and kill yeast interfering RNA larvicides targeting neural genes in the human disease vector mosquito Aedes aegypti.  Sci Rep 7(1):13223.  doi: 10.1038/s41598-017-13566-y.  Free text is available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643370/

Mysore et al.  2017.  Yeast interfering RNA larvicides targeting neural genes induce high rates of Anopheles larval mortality.  Malar J. 16(1):461.  doi: 10.1186/s12936-017-2112-5.  Free text is available at: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-2112-5

Titles & Appointments

  • Navari Family Professor
  • Professor of Medical & Molecular Genetics
  • Education
    1999 PhD University of Chicago
    1994 BS University of Notre Dame
  • Research

         Vector mosquitoes inflict more human suffering than any other organism—and kill more than one million people each year.  Despite the devastating impact of these insects on human society, we know very little about mosquito developmental biology.  Our laboratory’s in-depth analysis of mosquito developmental genetics aims to promote the elucidation of tools to target mosquitoes before they are disease-transmitting adults.  Research in our lab, which has primarily focused on analysis of mosquito central and sensory nervous system development, has included the first-ever targeted genetic knockdown studies of mosquito neural development.  In recent years, we have begun a large-scale effort to develop species-specific interfering RNA insecticides, a promising new tool for the biorational control of mosquitoes.  

    Lab members and Contact Information:

    Keshava Mysore, Postdoctoral Fellow, kmysore@iu.edu

    Limb Hapairai, Postdoctoral Fellow, lhapaira@nd.edu

    Ping Li, Research Technician, pli@nd.edu

    Jacob Realey, Research Technician, jsrealey@iu.edu

    Alexandra Lesnik, Undergraduate, Alexandra.M.Lesnik.1@nd.edu

    Laboratory phone:  (574) 631-7194

  • Professional Organizations
    American Committee on Medical Entomology
    American Mosquito Control Association
    American Society of Tropical Medicine and Hygiene
    Genetics Society of America
    Society for Developmental Biology
  • Awards
    Org: National Institutes of Health
    Desc: Development of yeast interfering RNA larvicides targeting Aedes aegypti, 1 R21 AI128116-01
    Scope: National
    Date: 2017-07-21
    Org: Deployed Warfighter Protection Program (DoD)
    Desc: Dual action larvicidal/adulticidal siRNA insecticides for biorational mosquito control, W911QY-17-1-0002
    Scope: National
    Date: 2017-07-10
    Org: Department of Defense
    Desc: Effective interfering RNA lure and kill baited ovitraps for biorational Aedes Zika vector mosquito control, PR161211.
    Scope: National
    Date: 2017-07-01
    Org: Department of Defense
    Desc: Effective interfering RNA lure and kill baited ovitraps for biorational Aedes Zika vector mosquito control, PR161211.
    Scope: National
    Date: 2017-07-01
    Org: USAID
    Desc: Combating Zika and Future Threats, A Grand Challenge for Development
    Scope: International
    Date: 2016-10-01
    Org: Showalter Trust
    Desc: Showalter Scholar Award
    Scope: University
    Date: 2015-08-01
    Org: Bill and Melinda Gates Foundation
    Desc: Grand Challenges and Explorations Phase 1 Grant Award (Completed)
    Scope: International
    Date: 2015-06-01
    Org: IUPUI
    Desc: Trailblazer Award
    Scope: University
    Date: 2015-04-01
    Org: NIH/NIAID
    Desc: Active R21-Cis-regulatory element discovery in a sequenced mosquito genome
    Scope: National
    Date: 2015-01-01
    Org: NIH/NIAID
    Desc: R01AI081795-01 (Completed)
    Scope: National
    Date: 2009-08-01

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