67374-Sayed, Marawan

Marawan A. Sayed, PhD

Postdoctoral Fellow in Neurology

Address
GH 4700
NEUR
IN
Indianapolis, IN

Bio

 

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Marawan has been a member of the pharmacology department staff at Egypt's National Research Center (NRC), where she holds the title of experienced pharmacologist and toxicologist. His primary focus has been on repurposing therapeutics and conducting preclinical and clinical research to address diseases common in Egypt. Marawan has been an experienced pharmacologist and toxicologist at Egypt's National Research Center (NRC), the country's primary research institution. He is skilled in pharmacology, laboratory work, animal modeling, statistics, scientific teaching, and scientific writing. In addition, he has contributed to clinical trials and the development of the COVID-19 vaccine, and he has held various roles within the medical division of the NRC. 

 Furthermore, Marawan received a certificate of completion from King's College in London, England, for excelling in their Clinical Development Modules and achieving first place. Thereafter, Marawan possesses preclinical and clinical studies skills, as well as extensive statistical analysis expertise. He used to work in diabetes, cancer, and epilepsy. Additionally, He is now conducting research at the Indiana University School of Medicine, focusing on the mechanisms of epileptogenesis following traumatic brain injury in rodent models or hippocampal injection of an epileptogenic drug. Using live brain imaging to study inflammatory mediators and bioluminescence via IVIS and EEG recording. Hopefully, these findings will help uncover the paradigm of epileptogenesis. 

Education: 

2024-2025 

Fellowship 

Department of Neurology, Indiana University, Indiana, USA 

2023 

Diploma 

King’s College, U.K 

2020 

PhD 

Cairo University 

2013 

MS 

Cairo University 

2005 

BS 

Cairo University 

Awards: 

1. First place in Clinical Development Modules, King's College in London, England. 

2: Awarded the National Research Center prize for the best master thesis in the Medical Division. 

Key Publications

  1. Seddiek, H., Hanna, M., Hamoud, A. E. M., Elbaset, M. A., Akabawy, A. M. A., Kotb, M. Z., & Khalifa, M. M. (2025). Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment. Scientific Reports, 15(1), 4485. https://doi.org/10.1038/s41598-025-87628-x. 
  2. Hanna, M., Akabawy, A. M. A., Khalifa, M. M., Elbaset, M. A., Imam, R. A., & Seddiek, H. (2025). Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage. Frontiers in Physiology, 16. https://doi.org/10.3389/fphys.2025.1430946
  3. Elbaset, M. A., Afifi, S. M., Esatbeyoglu, T., Abdelrahman, S. S., & Saleh, D. O. (2024). Neuroprotective Effects of Trimetazidine against Cisplatin-Induced Peripheral Neuropathy: Involvement of AMPK-Mediated PI3K/mTOR, Nrf2, and NF-κB Signaling Axes. Oxidative Medicine and Cellular Longevity, 2024(1). https://doi.org/10.1155/2024/6612009.
  4. Saleh, D. O., Abo El Nasr, N. M. E., Hussien, Y. A., El-Baset, M. A., & Ahmed, K. A. (2024). Cyclophosphamide-induced testicular injury: the role of chrysin in mitigating iron overload and ferroptosis. Naunyn-Schmiedeberg’s Archives of Pharmacology. https://doi.org/10.1007/s00210-024-03519-4
  5. Mahmoud, N. S., Elbaset, M. A., Mohawed, O. A. M., & Ahmed, H. H. (2024). Trimetazidine attenuates neuroinflammation via TLR4/NF-KB pathway inhibition in lipopolysaccharides-induced dementia in rats. Journal of Applied Pharmaceutical Science. https://doi.org/10.7324/JAPS.2024.166458.
  6. Salem, E. M., Dawaba, H. M., Elbaset, M. A., Gad, S., & Hassan, T. H. (2024). Optimizing bioavailability and antihypertensive activity of Carvedilol cubosomes using D-optimal design: Comparative analysis of Cremophor RH 40 and Polyvinyl alcohol as secondary stabilizers. Journal of Drug Delivery Science and Technology, 97, 105817. https://doi.org/10.1016/j.jddst.2024.105817.
  7. Hanna, M., Elnassag, S. S., Mohamed, D. H., Elbaset, M. A., Shaker, O., Khowailed, E. A., & Gouda, S. A. A. (2024). Melatonin and mesenchymal stem cells co-administration alleviates chronic obstructive pulmonary disease via modulation of angiogenesis at the vascular-alveolar unit. Pflügers Archiv - European Journal of Physiology, 476(7), 1155–1168. https://doi.org/10.1007/s00424-024-02968-3.
  8. S.A.E. Bashandy, A.M.A. El-Seidy, F.A.A. Ibrahim, S.S. Abdelrahman, S.A. Abdelmottaleb Moussa, M.A. ElBaset, Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload, Sci. Rep. 13 (2023) 16010. https://doi.org/10.1038/s41598-023-42550-y.
  9. N.F. Abdelkader, S.M. Ibrahim, P.E. Moustafa, M.A. Elbaset, Inosine mitigated diabetic peripheral neuropathy via modulating GLO1/AGEs/RAGE/NF-κB/Nrf2 and TGF-β/PKC/TRPV1 signaling pathways, Biomed. Pharmacother. 145 (2022) 112395. https://doi.org/10.1016/j.biopha.2021.112395.
  10. N.F. Abdelkader, M.A. Elbaset, P.E. Moustafa, S.M. Ibrahim, Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK. signaling, Arch. Pharm. Res. 45 (2022) 475–493. https://doi.org/10.1007/s12272-022-01391-5.
  11. M. Hanna, H. Seddiek, B.E. Aboulhoda, G.N.B. Morcos, A.M.A. Akabawy, M.A. Elbaset, A.A. Ibrahim, M.M. Khalifa, I.M. Khalifah, M.S. Fadel, T. Shoukry, Synergistic cardioprotective effects of melatonin and deferoxamine through the improvement of ferritinophagy in doxorubicin-induced acute cardiotoxicity, Front. Physiol. 13 (2022). https://doi.org/10.3389/fphys.2022.1050598.
  12. N. Sharawy, A.A.A. Imam, B.E. Aboulhoda, M.M. Khalifa, G.N.B. Morcos, W.A. Abd Algaleel, P.E. Moustafa, M.A. Abdelbaset, T. Shoukry, Iron dyshomeostasis and time-course changes in iron-uptake systems and ferritin level in relation to pro-inflammatory microglia polarization in sepsis-induced encephalopathy, Front. Physiol. 13 (2022). https://doi.org/10.3389/fphys.2022.953206.

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