6622-Wen, Qiuting
Faculty

Qiuting Wen, PhD

Assistant Professor of Radiology & Imaging Sciences

Address
GH 4100


Indianapolis, IN 46202

Bio

Dr. Wen obtained her Ph.D from UCSF-UC Berkeley Joint PhD Program in Bioengineering, where she conducted her research in brain tumor imaging (advisor: Dr. Sarah Nelson) and developed a keen interest in MRI. After graduation, she moved to Indiana University to continue her research as a postdoc with a focus in advanced diffusion MRI (PI: Dr. Yu-Chien Wu). She is the developer of dynamic Diffusion-Weighting Imaging (dDWI) for measuring the paravascular cerebrospinal fluid (pCSF) dynamics - a key component of the brain's waste clearance function (glymphatic system).  Her current research is applying dDWI to understand dysfunctional pCSF clearance in aging, Alzheimer's Disease (AD), and other neurodegenerative and cerebrovascular diseases.  Another focus of her research is developing multimodal imaging analytical frameworks to understand brain's regional vulnearability to tauopathy in aging/AD. 

Lab website: https://sites.google.com/view/wenlab/home



Key Publications

  1. Wen Q*, Tong Y, Zhou X, Dzemidzic M, Ho CY, Wu YC. Assessing Pulsatile Waveforms of Paravascular Cerebrospinal Fluid Dynamics within the Glymphatic Pathways using Dynamic Diffusion-weighted Imaging (dDWI). Neuroimage, 2022.
  2. Shahid SS, Wen Q, Risacher SL, Farlow MR, Unverzagt FW, Apostolova LG, Foroud TM, Zetterberg H, Blennow K, Saykin AJ, Wu YC. Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease. Brain.  2022 Jun 30;145(6):2149-2160. 
  3. Hall Z, Chien B, Risacher SL, Saykin AJ, Wu YC, Wen Q*. Tau deposition and structural connectivity demonstrate differential association patterns with neurocognitive tests. Brain Imaging and Behavior 2021 Sep 17 (Cover article)
  4. Wen Q*, Risacher SL, Xie L, Li J, Harezlak J, Tallman E, Farlow MR, Unverzagt FW, Gao S, Apostolova LG, Saykin AJ, and Wu YC. Tau-related white-matter alterations along spatially selective pathways. Neuroimage. 2021 Feb 1;226:117560.
  5. Wen Q*, Feng L, Zhou K, Wu Y-C. Rapid golden-angle diffusion-weighted propeller MRI for simultaneous assessment of ADC and IVIM. Neuroimage. 2020 Dec;223:117327
  6. Wen Q, Mustafi SM, Harezlak J, Li J, Risacher SL, West JD, Tallman E, Farlow MR, Unverzagt FW, Apostolova LG, Saykin AJ, and Wu YC. White-matter alterations in early-stage Alzheimer’s disease: A tract-specific study. Alzheimers Dement (Amst). 2019 Dec; 11: 576–587
  7. Wen Q, Kodiweera C, Dale BM, Shivraman G, Wu Y-C. Rotating single-shot acquisition (RoSA) with composite reconstruction for fast high-resolution diffusion imaging. Magnetic Resonance in Medicine 2018 Jan,79(1):264-275
  8. Wen Q, Kelley D, Banerjee S, Xu D, Lupo JM, Hess C, Nelson SJ. Clinically feasible NODDI characterization of brain tumor using an optimized multiband EPI at 7T. Neuroimage Clin. 2015, 9: 291–299.
  9. Wen Q, Jalilian L, Lupo JM, Molinaro AM., Chang SM, Clarke J, Prados M, Nelson SJ. Comparison of ADC metrics and their association with outcome for patients with newly diagnosed glioblastoma being treated with radiation therapy, temozolomide, erlotinib and bevacizumab, J Neurooncol. 2015 Jan,121(2):331-9.
  10. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. Association between diffusion and clinical outcome varies with treatment regimen for patients with newly diagnosed glioblastoma. Transl Oncol. 2015 Dec,8(6):446-55.

Titles & Appointments

  • Assistant Professor of Radiology & Imaging Sciences
  • Education
    2015 PhD University of California, San Francisco
    2009 MS Tsinghua University
    2007 BS Tsinghua University
  • Research

    My research focuses on the development of novel MR imaging techniques to understand neurophysiology and to address unmet clinical needs. I also develop image analytical approaches to study neurodegenerative diseases (e.g. Alzheimer's disease).

  • Clinical Interests

    Alzheimer's disease; Aging; Mild traumatic brain injury; Brain tumor; 

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