Kelly N. Nudelman, PhD

Bio

Kelly Nudelman, PhD, is an Assistant Research Professor of Medical and Molecular Genetics at Indiana University School of Medicine (IUSM). Her research is focused on elucidating the genetics and biomarkers of Alzheimer’s and Parkinson’s disease, related dementias, and brain injury.

 Dr. Nudelman is the co-lead for the Genetics and Biomarker Core of the IU Alzheimer’s Disease Research Center (P30) and is a co-investigator on projects studying the genetics and biomarkers of Alzheimer’s and Parkinson’s disease, including the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS, U01), the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD, U24), and projects funded by the Michael J. Fox Foundation to collaboratively investigate the genetics and biomarkers of Parkinson's disease.

Dr. Nudelman has served on national committees for organizations including the Alzheimer's Disease Sequencing Project and the ClinGen Parkinson's Disease Gene Curation Expert Panel, and is a member of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART).

Key Publications

Carroll JE, Small BJ, Tometich DB, Zhai W, Zhou X, Luta G, Ahles TA, Saykin AJ, Nudelman KNH, Clapp JD, Jim HS, Jacobsen PB, Hurria A, Graham D, McDonald BC, Denduluri N, Extermann M, Isaacs C, Dilawari AA, Root J, Stern RA, Mandelblatt JS. Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype. Cancer. 2019 Dec 15;125(24):4516-4524. doi: 10.1002/cncr.32489. Epub 2019 Sep 25. PubMed PMID: 31553501; PubMed Central PMCID: PMC6891125.

Simuni T, Brumm MC, Uribe L, Caspell-Garcia C, Coffey CS, Siderowf A, Alcalay RN, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Nudelman K, Tosun-Turgut D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten S, Bressman S, Marek K. Clinical and Dopamine Transporter Imaging Characteristics of Leucine Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study. Mov Disord. 2020 May;35(5):833-844. doi: 10.1002/mds.27989. Epub 2020 Feb 19. PubMed PMID: 32073681; PubMed Central PMCID: PMC7231646.

Apostolova LG, Aisen P, Eloyan A, Fagan A, Fargo KN, Foroud T, Gatsonis C, Grinberg LT, Jack CR Jr, Kramer J, Koeppe R, Kukull WA, Murray ME, Nudelman K, Rumbaugh M, Toga A, Vemuri P, Trullinger A, Iaccarino L, Day GS, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez M, Musiek E, Onyike CU, Rogalski E, Salloway S, Wolk DA, Wingo TS, Carrillo MC, Dickerson BC, Rabinovici GD. The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology. Alzheimers Dement. 2021 Dec;17(12):2043-2055. doi: 10.1002/alz.12350. Epub 2021 May 21. PubMed PMID: 34018654; PubMed Central PMCID: PMC8939858.

Simuni T, Merchant K, Brumm MC, Cho H, Caspell-Garcia C, Coffey CS, Chahine LM, Alcalay RN, Nudelman K, Foroud T, Mollenhauer B, Siderowf A, Tanner C, Iwaki H, Sherer T, Marek K. Longitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort. NPJ Parkinsons Dis. 2022 Oct 22;8(1):140. doi: 10.1038/s41531-022-00404-w. PubMed PMID: 36273008; PubMed Central PMCID: PMC9588016.

Simpson E, Reiter JL, Ren J, Zhang Z, Nudelman KN, Riggen LD Jr, Menser MD, Harezlak J, Foroud TM, Saykin AJ, Brooks A, Cameron KL, Duma SM, McGinty G, Rowson S, Svoboda SJ, Broglio SP, McCrea MA, Pasquina PF, McAllister TW, Liu Y. Gene Expression Alterations in Peripheral Blood Following Sport-Related Concussion in a Prospective Cohort of Collegiate Athletes: A Concussion Assessment, Research and Education (CARE) Consortium Study. Sports Med. 2024 Apr;54(4):1021-1032. doi: 10.1007/s40279-023-01951-9. Epub 2023 Nov 8. PubMed PMID: 37938533.

Simuni T, Chahine LM, Poston K, Brumm M, Buracchio T, Campbell M, Chowdhury S, Coffey C, Concha-Marambio L, Dam T, DiBiaso P, Foroud T, Frasier M, Gochanour C, Jennings D, Kieburtz K, Kopil CM, Merchant K, Mollenhauer B, Montine T, Nudelman K, Pagano G, Seibyl J, Sherer T, Singleton A, Stephenson D, Stern M, Soto C, Tanner CM, Tolosa E, Weintraub D, Xiao Y, Siderowf A, Dunn B, Marek K. A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research. Lancet Neurol. 2024 Feb;23(2):178-190. doi: 10.1016/S1474-4422(23)00405-2. Review. PubMed PMID: 38267190.