6507-Yu, Andy

Andy Q. Yu, MD, PhD

Professor of Microbiology & Immunology

MS 420
635 Barnhill Dr.

Indianapolis , IN 46202-5120
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Research in Yu laboratory is centered on HIV immunopathogenesis, latency, and eradication, and the clinical and immunological interactions between HIV and other human persistent viruses like HBV and HCV. 

Key Publications

Li Wei, Amet T, Xing Y, Liangpunsakul S, Puri P, Kamath P, Sanyal Arun, Katz B, Radaeva S, Crabb D, Chalasani Naga, Yu Q. Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: a prospective observational study. Hepatology. 2017 Aug;66(2):575-590. doi: 10.1002/hep.29242. Epub 2017 Jun 30.


Puri P, Liangpunsakul S, Christensen JE, Shah VH, Kamath PS, Gores GJ, Walker S, Comerford M, Katz B, Borst A, Yu Q, Kumar DP, Mirshahi F, Radaeva S, Chalasani NP, Crabb DW, Sanyal AJ; TREAT Consortium. The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis. Hepatology. 2017 Oct 30. doi: 10.1002/hep.29623. [Epub ahead of print]


Xing Y, Shepherd N, Lan Jie, Li Wei, Rane S, Gupta SK, Zhang S, Dong Jun, Yu Q. MMPs/TIMPs imbalances in the peripheral blood and cerebrospinal fluid are associated with the pathogenesis of HIV-1-associated neurocognitive disorders. Brain Behav Immun. 2017 Oct;65:161-172. doi: 10.1016/j.bbi.2017.04.024. Epub 2017 May 6.


Amet T, Lan J, Shepherd N, Yang K, Byrd D, Xing Y, Yu Q. Glycosylphosphatidylinositol Anchor Deficiency Attenuates the Production of Infectious HIV-1 and Renders Virions Sensitive to Complement Attack. AIDS Res Hum Retroviruses. 2016 Oct/Nov;32(10-11):1100-1112. Epub 2016 Jul 27.


Meng Z, Du L, Hu N, Byrd D, Amet T, Desai M, Shepherd N, Lan J, Han R, Yu Q. Antiretroviral Therapy Normalizes Autoantibody Profile of HIV Patients by Decreasing CD33+CD11b+HLA-DR+ Cells: A Cross-Sectional Study. Medicine (Baltimore). 2016 Apr;95(15):e3285.


Yang K, Lan J, Shepherd N, Hu N, Xing Y, Byrd D, Amet T, Jewell C, Gupta S, Kounga C, Gao J, Yu Q. Blockage of CD59 Function Restores Activities of Neutralizing and Nonneutralizing Antibodies in Triggering Antibody-Dependent Complement-Mediated Lysis of HIV-1 Virions and Provirus-Activated Latently Infected Cells. J Virol. 2015 Sep;89(18):9393-406. Epub 2015 Jul 1.


Lan J, Yang K, Byrd D, Hu N, Amet T, Shepherd N, Desai M, Gao J, Gupta S, Sun Y, Yu Q. Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells. J Immunol. 2014 Oct 1;193(7):3577-89. Epub 2014 Aug 22.


Byrd D, Shepherd N, Lan J, Hu N, Amet T, Yang K, Desai M, Yu Q. Primary human macrophages serve as vehicles for vaccinia virus replication and dissemination. J Virol. 2014 Jun;88(12):6819-31. Epub 2014 Apr 2.


Amet T, Byrd D, Hu N, Sun Q, Li F, Zhao Y, Hu S, Grantham A, Yu Q. BST-2 expression in human hepatocytes is inducible by all three types of interferons and restricts production of hepatitis C virus. Curr Mol Med. 2014 Mar;14(3):349-60.


Byrd D, Amet T, Hu N, Lan J, Hu S, Yu Q. Primary human leukocyte subsets differentially express vaccinia virus receptors enriched in lipid rafts. J Virol. 2013 Aug;87(16):9301-12. Epub 2013 Jun 19.


Amet T, Ghabril M, Chalasani N, Byrd D, Hu N, Grantham A, Liu Z, Qin X, He JJ, Yu Q. CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology. 2012 Feb;55(2):354-63. Epub 2011 Dec 16.

Titles & Appointments

  • Professor of Microbiology & Immunology
  • Professor of Medicine
  • Education
    1995 PhD Fourth Military Medical University
    1989 MS Fourth Military Medical University
    1986 MD Wannan Medical College
  • Research

    Research in Yu laboratory is centered on HIV immunopathogenesis, latency, and eradication, and the clinical and immunological interactions between HIV and other human persistent viruses like HBV and HCV.

  • Publications
    Post-Injury Treatment of 7,8-Dihydroxyflavone Promotes Neurogenesis in the Hippocampus of the Adult Mouse.
    Zhao S; Yu A; Wang X; Gao X; Chen J; Journal of neurotrauma 2016 Apr 28
  • Awards
    Org: Indiana University
    Desc: Teaching Trustee Award of Indiana University
    Scope: University
    Org: Showalter
    Desc: Showalter Scholar
    Scope: University
    Org: Indiana University
    Desc: Research Frontiers Trailblazer Award
    Scope: University

Research Labs

Faculty research at IU School of Medicine is transforming health. Details about the medical research being conducted in faculty labs throughout IU School of Medicine are available in the Research section of this site.

Faculty Labs