6507-Yu, Andy

Andy Q. Yu, MD, PhD

Professor of Microbiology & Immunology

Professor of Medicine

Address
MS 267
635 Barnhill Dr.
Indianapolis , IN 46202
PubMed:

Bio

Professor Yu received his graduate training in immunology and virology at the Fourth Military Medical University and completed his postdoctoral fellowship at the University of Toronto. In 2005, he became an Assistant Professor at the University of Hawaii. He joined the faculty at the Indiana University School of Medicine in 2008 as an Assistant Professor of Microbiology and Immunology, was promoted to Associate Professor with tenure in 2014, and became a tenured Professor in 2019. Professor Yu’s research focuses on the immune and inflammatory mechanisms underlying complex human diseases, including HIV-associated neurocognitive disorder (HAND), persistent HIV reservoirs, traumatic brain and spinal cord injuries, metabolic and immune dysregulation in alcohol-associated liver disease (ALD), and immune modulation in pain management for sickle cell disease (SCD). In addition to his research, he serves as director of the graduate course “Introduction to Immunology” and is a member of both the Radionuclide Radiation Safety Committee (RRSC) and the Radioactive Drug Research Committee (RDRC) at Indiana University.

Key Publications

 

1.    Li W, Pucka AQ, Debats C, Reyes BA, Syed F, O'Brien ARW, Mehta R, Manchanda N, Jacob SA, Hardesty BM, Greist A, Harte SE, Harris RE, Yu Q, Wang Y. Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity. Front Immunol. 2024;15:1288187. doi: 10.3389/fimmu.2024.1288187. eCollection 2024. PubMed PMID: 38361924; PubMed Central PMCID: PMC10867278.

2.    Li W, Xia Y, Yang J, Sanyal AJ, Shah VH, Chalasani NP, Yu Q. Disrupted balance between pro-inflammatory lipid mediators and anti-inflammatory specialized pro-resolving mediators is linked to hyperinflammation in patients with alcoholic hepatitis. medRxiv. 2023 Dec 17;. doi: 10.1101/2023.12.15.23300034. PubMed PMID: 38168393; PubMed Central PMCID: PMC10760266.

3.    Wu X, Liu J, Li W, Khan MF, Dai H, Tian J, Priya R, Tian DJ, Wu W, Yaacoub A, Gu J, Syed F, Yu CH, Gao X, Yu Q, Xu XM, Brutkiewicz RR. CD1d-dependent neuroinflammation impairs tissue repair and functional recovery following a spinal cord injury. bioRxiv. 2023 Oct 17;. doi: 10.1101/2023.10.13.562047. PubMed PMID: 37905092; PubMed Central PMCID: PMC10614755.

4.    Awosanya OD, Dadwal UC, Imel EA, Yu Q, Kacena MA. The Impacts of COVID-19 on Musculoskeletal Health. Curr Osteoporos Rep. 2022 Aug;20(4):213-225. doi: 10.1007/s11914-022-00734-x. Epub 2022 Jun 20. Review. PubMed PMID: 35723777; PubMed Central PMCID: PMC9207429.

5.    Li W, Syed F, Yu R, Yang J, Xia Y, Relich RF, Russell PM, Zhang S, Khalili M, Huang L, Kacena MA, Zheng X, Yu Q. Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection. Front Immunol. 2022;13:833310. doi: 10.3389/fimmu.2022.833310. eCollection 2022. Review. PubMed PMID: 35281051; PubMed Central PMCID: PMC8904355.

6.    Gao X, Li W, Syed F, Yuan F, Li P, Yu Q. PD-L1 signaling in reactive astrocytes counteracts neuroinflammation and ameliorates neuronal damage after traumatic brain injury. J Neuroinflammation. 2022 Feb 8;19(1):43. doi: 10.1186/s12974-022-02398-x. PubMed PMID: 35135580; PubMed Central PMCID: PMC8822654.

7.    Syed F, Li W, Relich RF, Russell PM, Zhang S, Zimmerman MK, Yu Q. Excessive Matrix Metalloproteinase-1 and Hyperactivation of Endothelial Cells Occurred in COVID-19 Patients and Were Associated With the Severity of COVID-19. J Infect Dis. 2021 Jul 2;224(1):60-69. doi: 10.1093/infdis/jiab167. PubMed PMID: 33885811; PubMed Central PMCID: PMC8083685.

8.    Yang J, Syed F, Xia Y, Sanyal AJ, Shah VH, Chalasani N, Zheng X, Yu Q, Lou Y, Li W. Blood Biomarkers of Intestinal Epithelium Damage Regenerating Islet-derived Protein 3α and Trefoil Factor 3 Are Persistently Elevated in Patients with Alcoholic Hepatitis. Alcohol Clin Exp Res. 2021 Apr;45(4):720-731. doi: 10.1111/acer.14579. Epub 2021 Mar 11. PubMed PMID: 33587293; PubMed Central PMCID: PMC8076084.

9.    Xia Y, Yang J, Sanyal AJ, Shah VH, Chalasani NP, Yu Q, Zheng X, Li W. Persistent Hyperactivation of Endothelial Cells in Patients with Alcoholic Hepatitis. Alcohol Clin Exp Res. 2020 May;44(5):1075-1087. doi: 10.1111/acer.14331. Epub 2020 Apr 21. PubMed PMID: 32246771; PubMed Central PMCID: PMC7255105.

10.  Li W, Xia Y, Yang J, Guo H, Sun G, Sanyal AJ, Shah VH, Lou Y, Zheng X, Chalasani N, Yu Q. Immune Checkpoint Axes Are Dysregulated in Patients With Alcoholic Hepatitis. Hepatol Commun. 2020 Apr;4(4):588-605. doi: 10.1002/hep4.1475. eCollection 2020 Apr. PubMed PMID: 32258953; PubMed Central PMCID: PMC7109345.

11.  Agrawal N, Rowe J, Lan J, Yu Q, Hrycyna CA, Chmielewski J. Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity. J Med Chem. 2020 Mar 12;63(5):2131-2138. doi: 10.1021/acs.jmedchem.9b00779. Epub 2019 Sep 20. PubMed PMID: 31505928; PubMed Central PMCID: PMC7073916.

12.  Syed F, Yu Q. Cofilin, an intracellular marker for HIV-associated CD4 T-cell motility dysregulation, shed light on the mechanisms of incomplete immune reconstitution in the patients with HIV. J Med Virol. 2020 Jan;92(1):1-3. doi: 10.1002/jmv.25577. Epub 2019 Sep 9. PubMed PMID: 31502247; PubMed Central PMCID: PMC6842407.

13.  Li W, Lin EL, Liangpunsakul S, Lan J, Chalasani S, Rane S, Puri P, Kamath PS, Sanyal AJ, Shah VH, Radaeva S, Crabb DW, Chalasani N, Yu Q. Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis. Clin Transl Gastroenterol. 2019 Jun;10(6):e00052. doi: 10.14309/ctg.0000000000000052. PubMed PMID: 31211759; PubMed Central PMCID: PMC6613857.

14.  Puri P, Liangpunsakul S, Christensen JE, Shah VH, Kamath PS, Gores GJ, Walker S, Comerford M, Katz B, Borst A, Yu Q, Kumar DP, Mirshahi F, Radaeva S, Chalasani NP, Crabb DW, Sanyal AJ. The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis. Hepatology. 2018 Apr;67(4):1284-1302. doi: 10.1002/hep.29623. Epub 2018 Feb 22. PubMed PMID: 29083504; PubMed Central PMCID: PMC5867221.

15.  Xing Y, Shepherd N, Lan J, Li W, Rane S, Gupta SK, Zhang S, Dong J, Yu Q. MMPs/TIMPs imbalances in the peripheral blood and cerebrospinal fluid are associated with the pathogenesis of HIV-1-associated neurocognitive disorders. Brain Behav Immun. 2017 Oct;65:161-172. doi: 10.1016/j.bbi.2017.04.024. Epub 2017 May 6. PubMed PMID: 28487203; PubMed Central PMCID: PMC5793222.

16.  Amet T, Son YM, Jiang L, Cheon IS, Huang S, Gupta SK, Dent AL, Montaner LJ, Yu Q, Sun J. BCL6 represses antiviral resistance in follicular T helper cells. J Leukoc Biol. 2017 Aug;102(2):527-536. doi: 10.1189/jlb.4A1216-513RR. Epub 2017 May 26. PubMed PMID: 28550121; PubMed Central PMCID: PMC5505751.

17.  Li W, Amet T, Xing Y, Yang D, Liangpunsakul S, Puri P, Kamath PS, Sanyal AJ, Shah VH, Katz BP, Radaeva S, Crabb DW, Chalasani N, Yu Q. Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study. Hepatology. 2017 Aug;66(2):575-590. doi: 10.1002/hep.29242. Epub 2017 Jun 30. PubMed PMID: 28466561; PubMed Central PMCID: PMC5548491.

18.  Xie MM, Amet T, Liu H, Yu Q, Dent AL. AMP kinase promotes Bcl6 expression in both mouse and human T cells. Mol Immunol. 2017 Jan;81:67-75. doi: 10.1016/j.molimm.2016.11.020. Epub 2016 Nov 26. PubMed PMID: 27898346; PubMed Central PMCID: PMC5772768.

19.  Amet T, Lan J, Shepherd N, Yang K, Byrd D, Xing Y, Yu Q. Glycosylphosphatidylinositol Anchor Deficiency Attenuates the Production of Infectious HIV-1 and Renders Virions Sensitive to Complement Attack. AIDS Res Hum Retroviruses. 2016 Oct/Nov;32(10-11):1100-1112. doi: 10.1089/AID.2016.0046. Epub 2016 Jul 27. PubMed PMID: 27231035; PubMed Central PMCID: PMC5067833.

20.  Meng Z, Du L, Hu N, Byrd D, Amet T, Desai M, Shepherd N, Lan J, Han R, Yu Q. Antiretroviral Therapy Normalizes Autoantibody Profile of HIV Patients by Decreasing CD33?CD11b?HLA-DR? Cells: A Cross-Sectional Study. Medicine (Baltimore). 2016 Apr;95(15):e3285. doi: 10.1097/MD.0000000000003285. PubMed PMID: 27082567; PubMed Central PMCID: PMC4839811.

21.  Yang K, Lan J, Shepherd N, Hu N, Xing Y, Byrd D, Amet T, Jewell C, Gupta S, Kounga C, Gao J, Yu Q. Blockage of CD59 Function Restores Activities of Neutralizing and Nonneutralizing Antibodies in Triggering Antibody-Dependent Complement-Mediated Lysis of HIV-1 Virions and Provirus-Activated Latently Infected Cells. J Virol. 2015 Sep;89(18):9393-406. doi: 10.1128/JVI.01614-15. Epub 2015 Jul 1. PubMed PMID: 26136568; PubMed Central PMCID: PMC4542366.

22.  Wang T, Green LA, Gupta SK, Amet T, Byrd DJ, Yu Q, Twigg HL 3rd, Clauss M. Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients. AIDS Res Hum Retroviruses. 2015 Feb;31(2):217-20. doi: 10.1089/AID.2013.0250. Epub 2014 Sep 4. PubMed PMID: 25062432; PubMed Central PMCID: PMC4313413.

23.  Liu Z, Zhang X, Yu Q, He JJ. Exosome-associated hepatitis C virus in cell cultures and patient plasma. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):218-22. doi: 10.1016/j.bbrc.2014.10.146. Epub 2014 Nov 4. PubMed PMID: 25449270.

24.  Lan J, Yang K, Byrd D, Hu N, Amet T, Shepherd N, Desai M, Gao J, Gupta S, Sun Y, Yu Q. Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells. J Immunol. 2014 Oct 1;193(7):3577-89. doi: 10.4049/jimmunol.1303030. Epub 2014 Aug 22. PubMed PMID: 25149467; PubMed Central PMCID: PMC4170029.

25.  Byrd D, Shepherd N, Lan J, Hu N, Amet T, Yang K, Desai M, Yu Q. Primary human macrophages serve as vehicles for vaccinia virus replication and dissemination. J Virol. 2014 Jun;88(12):6819-31. doi: 10.1128/JVI.03726-13. Epub 2014 Apr 2. PubMed PMID: 24696488; PubMed Central PMCID: PMC4054380.

26.  Amet T, Byrd D, Hu N, Sun Q, Li F, Zhao Y, Hu S, Grantham A, Yu Q. BST-2 expression in human hepatocytes is inducible by all three types of interferons and restricts production of hepatitis C virus. Curr Mol Med. 2014 Mar;14(3):349-60. doi: 10.2174/1566524013666131118111719. PubMed PMID: 24236455.

27.  Hu S, Ghabril M, Amet T, Hu N, Byrd D, Yang K, Vuppalanchi R, Saxena R, Desai M, Lan J, Johnson R, Gupta S, Chalasani N, Yu Q. HIV-1 coinfection profoundly alters intrahepatic chemokine but not inflammatory cytokine profiles in HCV-infected subjects. PLoS One. 2014;9(2):e86964. doi: 10.1371/journal.pone.0086964. eCollection 2014. PubMed PMID: 24516541; PubMed Central PMCID: PMC3916319.

28.  Byrd D, Amet T, Hu N, Lan J, Hu S, Yu Q. Primary human leukocyte subsets differentially express vaccinia virus receptors enriched in lipid rafts. J Virol. 2013 Aug;87(16):9301-12. doi: 10.1128/JVI.01545-13. Epub 2013 Jun 19. PubMed PMID: 23785200; PubMed Central PMCID: PMC3754057.

29.  Yu Q, Chow EM, McCaw SE, Hu N, Byrd D, Amet T, Hu S, Ostrowski MA, Gray-Owen SD. Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response. PLoS One. 2013;8(2):e56705. doi: 10.1371/journal.pone.0056705. Epub 2013 Feb 12. PubMed PMID: 23424672; PubMed Central PMCID: PMC3570455.

30.  Amet T, Ghabril M, Chalasani N, Byrd D, Hu N, Grantham A, Liu Z, Qin X, He JJ, Yu Q. CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology. 2012 Feb;55(2):354-63. doi: 10.1002/hep.24686. Epub 2011 Dec 16. PubMed PMID: 21932413; PubMed Central PMCID: PMC3417136.

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