65063-Pease, Matthew

Matthew W. Pease, MD

Assistant Professor of Neurological Surgery

355 W. 16th Street, Suite 5100
Indianapolis, IN


Matthew Pease, MD is a neurosurgeon who specializes in care for patients with cancer and trauma. He joined the Department of Neurological Surgery at Indiana University School of Medicine in August 2023.

Dr. Pease graduated with high distinction in economics from Duke University where he developed models to better understand how the brain is structured to make economic decisions. After graduating, he completed medical school at the University of Southern California and trained in clinical neurosurgery at the University of Pittsburgh Medical Center. There, Dr. Pease developed an interest in better understanding how to predict outcomes for trauma patients, communicate expected outcomes to families, and better prevent complications during the course of recovery.

After residency, Dr. Pease completed a fellowship in neurosurgical oncology at Memorial Sloan Kettering Cancer Center, the first institution in the U.S. devoted solely to treating cancer. “For families, cancer is a scary diagnosis to hear. We are constantly developing new treatments, changing the face of cancer, and bringing hope.” Dr. Pease specializes in using functional mapping and minimally invasive tools to minimize the impact of surgery on the brain, allowing for faster recovery. As a fellowship trained data scientist, he is pushing cancer care forward through developing new artificial intelligence-based tools to help diagnose and treat cancer more effectively. Dr. Pease’s work has been published in numerous peer-reviewed journals including the Proceedings of the National Academy of Sciences, Neurology, Annals of Neurology, Radiology, Neuro-oncology, Epilepsia and Neurosurgery.

Titles & Appointments

  • Assistant Professor of Neurological Surgery
  • Education
    2015 MD University of Southern California
    2010 BS Duke University

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