Howard J. Edenberg, PhD
Distinguished Professor
Phone
(317) 274-2353
Address
635 Barnhill Drive
Medical Science, Room 4063E
Indianapolis, IN 46202-5120
Medical Science, Room 4063E
Indianapolis, IN 46202-5120
Bio
Dr. Edenberg is a molecular biologist and geneticist currently focusing upon complex psychiatric disorders, particularly substance use disorders and bipolar disorder. His early work was on the mechanisms of DNA repair and DNA replication in mammalian cells, and included the development of in vitro systems in which to study them. He became interested in genes involved in alcohol metabolism and cloned several alcohol dehydrogenase genes (ADHs) and studied their regulation in different cell types. He developed the first PCR-based methods for genotyping variants in the ADH and aldehyde dehydrogenase genes, and with colleagues demonstrated that functional variants in three of these genes affected risk for alcoholism. This led to an interest in alcoholism and other complex genetic diseases, and in applying genomics to understand them. He has been a leader in a major family study, the Collaborative Study on the Genetics of Alcoholism, now in its 34th year, and has studied how alcohol exposure affects gene expression in cells and in the brains of rodents and humans. He founded and until recently ran the Center for Medical Genomics, bringing genomic technology to the Indiana University School of Medicine. More recently he is a leader in the Psychiatric Genomics Consortium, a global initiative to carry out meta-analyses of psychiatric and substance-use disorders. He is also carrying out massively parallel reporter assays to determine which genetic variants affect gene expression. He has won several major awards for his work over the decades, including the Distinguished Researcher Award and the Henri Begleiter Excellence in Research Award from the Research Society on Alcohol, and the Valued Colleague Award from the Psychiatric Genomics Consortium.
Key Publications
Edenberg HJ, McClintick JN. (2018) Alcohol dehydrogenases, aldehyde dehydrogenases and alcohol use disorders: a critical review. Alcohol Clin Exp Res. 42, 2281-2297. PMID: 30320893.
Smoller JW, Andreassen OA, Edenberg HJ, Faraone SV, Glatt SJ, Kendler KS. (2019) Psychiatric genetics and the structure of psychopathology. Mol Psychiatry 24, 409-420. PMID: 29317742.
Walters RK, Polimanti R … Gelernter J, Edenberg HJ, Agrawal A. (2018) Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience 21(12):1656–1669. PMID: 30482948.
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Zhou H, Sealock JM … Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J (2020) Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nature Neuroscience 23: 809-818. PMID: 32451486.
Hatoum, A.S., Colbert … Edenberg, H.J., Bogdan, R., & Agrawal, A. (2023) Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. Nat. Mental Health 1, 210–223. PMID: 37250466
Kapoor M, Chao MJ … Edenberg HJ, Marcora E, Agrawal A, Goate A. (2021) Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases. Nat Commun. 12(1):5071. PMID: 34417470.
Thapa KS, Chen AB, Lai D, Xuei X, Wetherill L, Tischfield JA, Liu Y, Edenberg HJ. (2020) Identification of Functional Genetic Variants Associated with Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay. Alcohol Clin Exp Res. 44, 2494 – 2518. PMID: 33119910.
Breen G, Li Q … Sullivan PF, Collier DA, Edenberg HJ. (2016) Translating genome-wide association findings into new therapeutics for psychiatry. Nature Neuroscience 19, 1392-1396. PMID: 27786187.
Peterson R.E., Kuchenbaecker … Edenberg, H. Huang, L.E. Duncan. (2019) Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations. Cell 179, 589-603. PMID: 31607513
Edenberg HJ: Perspective on Beyond Statistical Significance: Finding Meaningful Effects. (2021) Complex Psychiatry 7, 1-8. PMID: 35603094.
Titles & Appointments
- Distinguished Professor
- Chancellor's Professor, IUPUI
- Professor of Biochemistry & Molecular Biology
- Professor of Medical & Molecular Genetics
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Education1973 PhD Stanford University1970 AM Stanford University1968 BA Queens College
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Research
My research focuses on the genetics and genomics of complex genetic disorders, especially alcohol and other substance use disorders. It spans interrelated areas that extend from genome-wide searches for genes affecting the risk for disease to molecular studies of the mechanisms by which associated variants affect gene expression, and from studies of the regulation of individual genes to genome-wide studies of expression using RNAseq and ATAC-seq, and includes the development of high throughput assays to identify functional elements in the genome. My research bridges human, animal and cellular studies to approach these complex disorders from multiple angles. I am one of the founders and leaders of the Substance Use Disorders working group of the Psychiatric Genomics Consortium, which is assembling meta-analyses to find genes affecting risk for alcohol and other substance disorders, and of the Collaborative Study on the Genetics of Alcoholism, which is a family-based study combining GWAS and functional studies to help understand the disorder.
In parallel with genetic and GWAS studies, I have a long record of functional studies. I am examining global gene expression and epigenetics in post-mortem brain tissues and in cell lines derived from alcoholics and unaffected individuals and in rodent models of alcoholism using next-generation RNA sequencing, high-throughput assays, and bioinformatic approaches. My interest in functional genomics led me in 2000 to obtain competitive funding to establish the Center for Medical Genomics, which I directed until September 2016. As part of that, I helped many investigators design, analyze and interpret genomic data. I have explored analytical approaches to reducing noise and multiple-comparison issues in microarray data (relevant also to sequencing data), and contributed to bioinformatics strategies and analyses including ways to detect variants present in a small fraction of the cells (relevant to cancer). I have used these genomic technologies to study how genetics, gene expression and epigenetics are related to risk for alcoholism and other disorders. Integrating studies at these different levels, from individual genetic variations through cell models, animal models, and large-scale human studies is a promising approach toward understanding, preventing and treating devastating complex diseases.
My research on alcohol dehydrogenase genes and alcoholism was recognized by my peers in the form of election as a Fellow of the American Association for the Advancement of Science in 2007 and by my receipt of the Distinguished Researcher Award and the Henri Begleiter Excellence in Research Award, both from the Research Society on Alcohol, and the Valued Colleague Award from the Psychiatric Genomics Consortium.
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PublicationsThe relationship between cannabis and schizophrenia: a genetically informed perspective.
Johnson EC; Hatoum AS; Deak JD; Polimanti R; Murray RM; Edenberg HJ; Gelernter J; Di Forti M; Agrawal A; 2021 May 5Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
Mullins N; Forstner AJ; O'Connell KS; Coombes B; Coleman JRI; Qiao Z; Als TD; Bigdeli TB; Børte S; Bryois J; Charney AW; Drange OK; Gandal MJ; Hagenaars SP; Ikeda M; Kamitaki N; Kim M; Krebs K; Panagiotaropoulou G; Schilder BM; Sloofman LG; Steinberg S; Trubetskoy V; Winsvold BS; Won HH; Abramova L; Adorjan K; Agerbo E; Al Eissa M; Albani D; Alliey-Rodriguez N; Anjorin A; Antilla V; Antoniou A; Awasthi S; Baek JH; Bækvad-Hansen M; Bass N; Bauer M; Beins EC; Bergen SE; Birner A; Bøcker Pedersen C; Bøen E; Boks MP; Bosch R; Brum M; Brumpton BM; Brunkhorst-Kanaan N; Budde M; Bybjerg-Grauholm J; Byerley W; Cairns M; Casas M; Cervantes P; Clarke TK; Cruceanu C; Cuellar-Barboza A; Cunningham J; Curtis D; Czerski PM; Dale AM; Dalkner N; David FS; Degenhardt F; Djurovic S; Dobbyn AL; Douzenis A; Elvsåshagen T; Escott-Price V; Ferrier IN; Fiorentino A; Foroud TM; Forty L; Frank J; Frei O; Freimer NB; Frisén L; Gade K; Garnham J; Gelernter J; Giørtz Pedersen M; Gizer IR; Gordon SD; Gordon-Smith K; Greenwood TA; Grove J; Guzman-Parra J; Ha K; Haraldsson M; Hautzinger M; Heilbronner U; Hellgren D; Herms S; Hoffmann P; Holmans PA; Huckins L; Jamain S; Johnson JS; Kalman JL; Kamatani Y; Kennedy JL; Kittel-Schneider S; Knowles JA; Kogevinas M; Koromina M; Kranz TM; Kranzler HR; Kubo M; Kupka R; Kushner SA; Lavebratt C; Lawrence J; Leber M; Lee HJ; Lee PH; Levy SE; Lewis C; Liao C; Lucae S; Lundberg M; MacIntyre DJ; Magnusson SH; Maier W; Maihofer A; Malaspina D; Maratou E; Martinsson L; Mattheisen M; McCarroll SA; McGregor NW; McGuffin P; McKay JD; Medeiros H; Medland SE; Millischer V; Montgomery GW; Moran JL; Morris DW; Mühleisen TW; O'Brien N; O'Donovan C; Olde Loohuis LM; Oruc L; Papiol S; Pardiñas AF; Perry A; Pfennig A; Porichi E; Potash JB; Quested D; Raj T; Rapaport MH; DePaulo JR; Regeer EJ; Rice JP; Rivas F; Rivera M; Roth J; Roussos P; Ruderfer DM; Sánchez-Mora C; Schulte EC; Senner F; Sharp S; Shilling PD; Sigurdsson E; Sirignano L; Slaney C; Smeland OB; Smith DJ; Sobel Nature genetics 2021 May 17Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts.
Mallard TT; Savage JE; Johnson EC; Huang Y; Edwards AC; Hottenga JJ; Grotzinger AD; Gustavson DE; Jennings MV; Anokhin A; Dick DM; Edenberg HJ; Kramer JR; Lai D; Meyers JL; Pandey AK; Harden KP; Nivard MG; de Geus EJC; Boomsma DI; Agrawal A; Davis LK; Clarke TK; Palmer AA; Sanchez-Roige S; The American journal of psychiatry 2021 May 14Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.
Martin J; Khramtsova EA; Goleva SB; Blokland GAM; Traglia M; Walters RK; Hübel C; Coleman JRI; Breen G; Børglum AD; Demontis D; Grove J; Werge T; Bralten J; Bulik CM; Lee PH; Mathews CA; Peterson RE; Winham SJ; Wray N; Edenberg HJ; Guo W; Yao Y; Neale BM; Faraone SV; Petryshen TL; Weiss LA; Duncan LE; Goldstein JM; Smoller JW; Stranger BE; Davis LK; Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium.; Biological psychiatry 2021 Jan 9The association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences.
Meyers JL; Chorlian DB; Bigdeli TB; Johnson EC; Aliev F; Agrawal A; Almasy L; Anokhin A; Edenberg HJ; Foroud T; Goate A; Kamarajan C; Kinreich S; Nurnberger J; Pandey AK; Pandey G; Plawecki MH; Salvatore JE; Zhang J; Fanous A; Porjesz B; Translational psychiatry 2021 Jan 14Integration of Evidence across Human and Model Organism Studies: A Meeting Report.
Palmer RHC; Johnson EC; Won H; Polimanti R; Kapoor M; Chitre A; Bogue MA; Benca-Bachman CE; Parker CC; Ursu O; Verma A; Reynolds T; Ernst J; Bray M; Kwon SB; Lai D; Quach BC; Gaddis NC; Saba L; Chen H; Hawrylycz M; Zhang S; Zhou Y; Mahaffey S; Fischer C; Sanchez-Roige S; Bandrowski A; Qing L; Shen L; Philip V; Gelernter J; Bierut LJ; Hancock DB; Edenberg HJ; Johnson EO; Nestler EJ; Barr PB; Prins P; Smith DJ; Akbarian S; Thorgeirsson T; Walton D; Baker E; Jacobson D; Palmer AA; Miles M; Chesler EJ; Emerson J; Agrawal A; Martone M; Williams RW; Genes, brain, and behavior 2021 Apr 23A large-scale genome-wide association study meta-analysis of cannabis use disorder.
Johnson EC; Demontis D; Thorgeirsson TE; Walters RK; Polimanti R; Hatoum AS; Sanchez-Roige S; Paul SE; Wendt FR; Clarke TK; Lai D; Reginsson GW; Zhou H; He J; Baranger DAA; Gudbjartsson DF; Wedow R; Adkins DE; Adkins AE; Alexander J; Bacanu SA; Bigdeli TB; Boden J; Brown SA; Bucholz KK; Bybjerg-Grauholm J; Corley RP; Degenhardt L; Dick DM; Domingue BW; Fox L; Goate AM; Gordon SD; Hack LM; Hancock DB; Hartz SM; Hickie IB; Hougaard DM; Krauter K; Lind PA; McClintick JN; McQueen MB; Meyers JL; Montgomery GW; Mors O; Mortensen PB; Nordentoft M; Pearson JF; Peterson RE; Reynolds MD; Rice JP; Runarsdottir V; Saccone NL; Sherva R; Silberg JL; Tarter RE; Tyrfingsson T; Wall TL; Webb BT; Werge T; Wetherill L; Wright MJ; Zellers S; Adams MJ; Bierut LJ; Boardman JD; Copeland WE; Farrer LA; Foroud TM; Gillespie NA; Grucza RA; Harris KM; Heath AC; Hesselbrock V; Hewitt JK; Hopfer CJ; Horwood J; Iacono WG; Johnson EO; Kendler KS; Kennedy MA; Kranzler HR; Madden PAF; Maes HH; Maher BS; Martin NG; McGue M; McIntosh AM; Medland SE; Nelson EC; Porjesz B; Riley BP; Stallings MC; Vanyukov MM; Vrieze S; Psychiatric Genomics Consortium Substance Use Disorders Workgroup.; Davis LK; Bogdan R; Gelernter J; Edenberg HJ; Stefansson K; Børglum AD; Agrawal A; 2020 Oct 20Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay.
Thapa KS; Chen AB; Lai D; Xuei X; Wetherill L; Tischfield JA; Liu Y; Edenberg HJ; 2020 Nov 17Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations.
Lai D; Kapoor M; Wetherill L; Schwandt M; Ramchandani VA; Goldman D; Chao M; Almasy L; Bucholz K; Hart RP; Kamarajan C; Meyers JL; Nurnberger JI; Tischfield J; Edenberg HJ; Schuckit M; Goate A; Scott DM; Porjesz B; Agrawal A; Foroud T; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2020 Jul 11Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Munn-Chernoff MA; Johnson EC; Chou YL; Coleman JRI; Thornton LM; Walters RK; Yilmaz Z; Baker JH; Hübel C; Gordon S; Medland SE; Watson HJ; Gaspar HA; Bryois J; Hinney A; Leppä VM; Mattheisen M; Ripke S; Yao S; Giusti-Rodríguez P; Hanscombe KB; Adan RAH; Alfredsson L; Ando T; Andreassen OA; Berrettini WH; Boehm I; Boni C; Boraska Perica V; Buehren K; Burghardt R; Cassina M; Cichon S; Clementi M; Cone RD; Courtet P; Crow S; Crowley JJ; Danner UN; Davis OSP; de Zwaan M; Dedoussis G; Degortes D; DeSocio JE; Dick DM; Dikeos D; Dina C; Dmitrzak-Weglarz M; Docampo E; Duncan LE; Egberts K; Ehrlich S; Escaramís G; Esko T; Estivill X; Farmer A; Favaro A; Fernández-Aranda F; Fichter MM; Fischer K; Föcker M; Foretova L; Forstner AJ; Forzan M; Franklin CS; Gallinger S; Giegling I; Giuranna J; Gonidakis F; Gorwood P; Gratacos Mayora M; Guillaume S; Guo Y; Hakonarson H; Hatzikotoulas K; Hauser J; Hebebrand J; Helder SG; Herms S; Herpertz-Dahlmann B; Herzog W; Huckins LM; Hudson JI; Imgart H; Inoko H; Janout V; Jiménez-Murcia S; Julià A; Kalsi G; Kaminská D; Karhunen L; Karwautz A; Kas MJH; Kennedy JL; Keski-Rahkonen A; Kiezebrink K; Kim YR; Klump KL; Knudsen GPS; La Via MC; Le Hellard S; Levitan RD; Li D; Lilenfeld L; Lin BD; Lissowska J; Luykx J; Magistretti PJ; Maj M; Mannik K; Marsal S; Marshall CR; Mattingsdal M; McDevitt S; McGuffin P; Metspalu A; Meulenbelt I; Micali N; Mitchell K; Monteleone AM; Monteleone P; Nacmias B; Navratilova M; Ntalla I; O'Toole JK; Ophoff RA; Padyukov L; Palotie A; Pantel J; Papezova H; Pinto D; Rabionet R; Raevuori A; Ramoz N; Reichborn-Kjennerud T; Ricca V; Ripatti S; Ritschel F; Roberts M; Rotondo A; Rujescu D; Rybakowski F; Santonastaso P; Scherag A; Scherer SW; Schmidt U; Schork NJ; Schosser A; Seitz J; Slachtova L; Slagboom PE; Slof-Op't Landt MCT; Slopien A; Sorbi S; Swiatkowska B; Szatkiewicz JP; Tachmazidou I; Tenconi E; Tortorella A; Tozzi F; Treasure J; Tsitsika A; Tyszkiewicz-Nwafor M; Tziouvas K; van Elburg AA; van Furth EF; Wagner G; W Addiction biology 2020 Feb 16A polygenic resilience score moderates the genetic risk for schizophrenia.
Hess JL; Tylee DS; Mattheisen M; Schizophrenia Working Group of the Psychiatric Genomics Consortium.; Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH).; Børglum AD; Als TD; Grove J; Werge T; Mortensen PB; Mors O; Nordentoft M; Hougaard DM; Byberg-Grauholm J; Bækvad-Hansen M; Greenwood TA; Tsuang MT; Curtis D; Steinberg S; Sigurdsson E; Stefánsson H; Stefánsson K; Edenberg HJ; Holmans P; Faraone SV; Glatt SJ; Molecular psychiatry 2019 Sep 6Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders.
Rao X; Thapa KS; Chen AB; Lin H; Gao H; Reiter JL; Hargreaves KA; Ipe J; Lai D; Xuei X; Wang Y; Gu H; Kapoor M; Farris SP; Tischfield J; Foroud T; Goate AM; Skaar TC; Mayfield RD; Edenberg HJ; Liu Y; Molecular psychiatry 2019 Sep 2Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study.
Kinreich S; Meyers JL; Maron-Katz A; Kamarajan C; Pandey AK; Chorlian DB; Zhang J; Pandey G; Subbie-Saenz de Viteri S; Pitti D; Anokhin AP; Bauer L; Hesselbrock V; Schuckit MA; Edenberg HJ; Porjesz B; Molecular psychiatry 2019 Oct 8Development of Alcohol Use Disorder as a Function of Age, Severity, and Comorbidity with Externalizing and Internalizing Disorders in a Young Adult Cohort.
Nurnberger JI Jr; Yang Z; Zang Y; Acion L; Bierut L; Bucholz K; Chan G; Dick DM; Edenberg HJ; Kramer J; Kuperman S; Rice JP; Schuckit M; 2019 Oct 25Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder.
Budde M; Friedrichs S; Alliey-Rodriguez N; Ament S; Badner JA; Berrettini WH; Bloss CS; Byerley W; Cichon S; Comes AL; Coryell W; Craig DW; Degenhardt F; Edenberg HJ; Foroud T; Forstner AJ; Frank J; Gershon ES; Goes FS; Greenwood TA; Guo Y; Hipolito M; Hood L; Keating BJ; Koller DL; Lawson WB; Liu C; Mahon PB; McInnis MG; McMahon FJ; Meier SM; Mühleisen TW; Murray SS; Nievergelt CM; Nurnberger JI Jr; Nwulia EA; Potash JB; Quarless D; Rice J; Roach JC; Scheftner WA; Schork NJ; Shekhtman T; Shilling PD; Smith EN; Streit F; Strohmaier J; Szelinger S; Treutlein J; Witt SH; Zandi PP; Zhang P; Zöllner S; Bickeböller H; Falkai PG; Kelsoe JR; Nöthen MM; Rietschel M; Schulze TG; Malzahn D; 2018 Nov 29Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.
Walters RK; Polimanti R; Johnson EC; McClintick JN; Adams MJ; Adkins AE; Aliev F; Bacanu SA; Batzler A; Bertelsen S; Biernacka JM; Bigdeli TB; Chen LS; Clarke TK; Chou YL; Degenhardt F; Docherty AR; Edwards AC; Fontanillas P; Foo JC; Fox L; Frank J; Giegling I; Gordon S; Hack LM; Hartmann AM; Hartz SM; Heilmann-Heimbach S; Herms S; Hodgkinson C; Hoffmann P; Jan Hottenga J; Kennedy MA; Alanne-Kinnunen M; Konte B; Lahti J; Lahti-Pulkkinen M; Lai D; Ligthart L; Loukola A; Maher BS; Mbarek H; McIntosh AM; McQueen MB; Meyers JL; Milaneschi Y; Palviainen T; Pearson JF; Peterson RE; Ripatti S; Ryu E; Saccone NL; Salvatore JE; Sanchez-Roige S; Schwandt M; Sherva R; Streit F; Strohmaier J; Thomas N; Wang JC; Webb BT; Wedow R; Wetherill L; Wills AG; 23andMe Research Team.; Boardman JD; Chen D; Choi DS; Copeland WE; Culverhouse RC; Dahmen N; Degenhardt L; Domingue BW; Elson SL; Frye MA; Gäbel W; Hayward C; Ising M; Keyes M; Kiefer F; Kramer J; Kuperman S; Lucae S; Lynskey MT; Maier W; Mann K; Männistö S; Müller-Myhsok B; Murray AD; Nurnberger JI; Palotie A; Preuss U; Räikkönen K; Reynolds MD; Ridinger M; Scherbaum N; Schuckit MA; Soyka M; Treutlein J; Witt S; Wodarz N; Zill P; Adkins DE; Boden JM; Boomsma DI; Bierut LJ; Brown SA; Bucholz KK; Cichon S; Costello EJ; de Wit H; Diazgranados N; Dick DM; Eriksson JG; Farrer LA; Foroud TM; Gillespie NA; Goate AM; Goldman D; Grucza RA; Hancock DB; Harris KM; Heath AC; Hesselbrock V; Hewitt JK; Hopfer CJ; Horwood J; Iacono W; Johnson EO; Kaprio JA; Karpyak VM; Kendler KS; Kranzler HR; Krauter K; Lichtenstein P; Lind PA; McGue M; MacKillop J; Madden PAF; Maes HH; Magnusson P; Martin NG; Medland SE; Montgomery GW; Nelson EC; Nöthen MM; Palmer AA; Pedersen NL; Penninx BWJH; Porjesz B; Rice JP; Rietschel M; Riley BP; Rose R; Rujescu D; Shen PH; Silberg J; Stallings MC; Tarter RE; Vanyukov MM; Vrieze S; Wall TL; Whitfield JB; Zhao H; Neale BM; Gelernter J; Edenberg HJ; Agrawal A; 2018 Nov 26Detecting significant genotype-phenotype association rules in bipolar disorder: market research meets complex genetics.
Breuer R; Mattheisen M; Frank J; Krumm B; Treutlein J; Kassem L; Strohmaier J; Herms S; Mühleisen TW; Degenhardt F; Cichon S; Nöthen MM; Karypis G; Kelsoe J; Greenwood T; Nievergelt C; Shilling P; Shekhtman T; Edenberg H; Craig D; Szelinger S; Nurnberger J; Gershon E; Alliey-Rodriguez N; Zandi P; Goes F; Schork N; Smith E; Koller D; Zhang P; Badner J; Berrettini W; Bloss C; Byerley W; Coryell W; Foroud T; Guo Y; Hipolito M; Keating B; Lawson W; Liu C; Mahon P; McInnis M; Murray S; Nwulia E; Potash J; Rice J; Scheftner W; Zöllner S; McMahon FJ; Rietschel M; Schulze TG; 2018 Nov 11Psychiatric genetics and the structure of psychopathology.
Smoller JW; Andreassen OA; Edenberg HJ; Faraone SV; Glatt SJ; Kendler KS; Molecular psychiatry 2018 Jan 9Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Theta Oscillations During a Go/No-Go Task.
Meyers J; McCutcheon VV; Pandey AK; Kamarajan C; Subbie S; Chorlian D; Salvatore J; Pandey G; Almasy L; Anokhin A; Bauer L; Bender A; Dick DM; Edenberg HJ; Hesselbrock V; Kramer J; Kuperman S; Agrawal A; Bucholz K; Porjesz B; 2018 Dec 20Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families.
McCutcheon VV; Agrawal A; Kuo SI; Su J; Dick DM; Meyers JL; Edenberg HJ; Nurnberger JI; Kramer JR; Kuperman S; Schuckit MA; Hesselbrock VM; Brooks A; Porjesz B; Bucholz KK; Addiction (Abingdon, England) 2017 Sep 6Psychiatric Genomics: An Update and an Agenda.
Sullivan PF; Agrawal A; Bulik CM; Andreassen OA; Børglum AD; Breen G; Cichon S; Edenberg HJ; Faraone SV; Gelernter J; Mathews CA; Nievergelt CM; Smoller JW; O'Donovan MC; Psychiatric Genomics Consortium.; The American journal of psychiatry 2017 Oct 3Traumatic Stress Interacts With Bipolar Disorder Genetic Risk to Increase Risk for Suicide Attempts.
Wilcox HC; Fullerton JM; Glowinski AL; Benke K; Kamali M; Hulvershorn LA; Stapp EK; Edenberg HJ; Roberts GMP; Ghaziuddin N; Fisher C; Brucksch C; Frankland A; Toma C; Shaw AD; Kastelic E; Miller L; McInnis MG; Mitchell PB; Nurnberger JI Jr.; Journal of the American Academy of Child and Adolescent Psychiatry 2017 Oct 10Genome-wide association study identifies a novel locus for cannabis dependence.
Agrawal A; Chou YL; Carey CE; Baranger DAA; Zhang B; Sherva R; Wetherill L; Kapoor M; Wang JC; Bertelsen S; Anokhin AP; Hesselbrock V; Kramer J; Lynskey MT; Meyers JL; Nurnberger JI; Rice JP; Tischfield J; Bierut LJ; Degenhardt L; Farrer LA; Gelernter J; Hariri AR; Heath AC; Kranzler HR; Madden PAF; Martin NG; Montgomery GW; Porjesz B; Wang T; Whitfield JB; Edenberg HJ; Foroud T; Goate AM; Bogdan R; Nelson EC; Molecular psychiatry 2017 Nov 7Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.
Andersen AM; Pietrzak RH; Kranzler HR; Ma L; Zhou H; Liu X; Kramer J; Kuperman S; Edenberg HJ; Nurnberger JI Jr; Rice JP; Tischfield JA; Goate A; Foroud TM; Meyers JL; Porjesz B; Dick DM; Hesselbrock V; Boerwinkle E; Southwick SM; Krystal JH; Weissman MM; Levinson DF; Potash JB; Gelernter J; Han S; JAMA psychiatry 2017 Nov 1RareVar: A Framework for Detecting Low-Frequency Single-Nucleotide Variants.
Hao Y; Xuei X; Li L; Nakshatri H; Edenberg HJ; Liu Y; Journal of computational biology : a journal of computational molecular cell biology 2017 May 25Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders.
Cho SB; Aliev F; Clark SL; Adkins AE; Edenberg HJ; Bucholz KK; Porjesz B; Dick DM; Behavior genetics 2017 Mar 25A GABRA2 polymorphism improves a model for prediction of drinking initiation.
Kuperman S; Chan G; Kramer J; Wetherill L; Acion L; Edenberg HJ; Foroud TM; Nurnberger J Jr; Agrawal A; Anokhin A; Brooks A; Hesselbrock V; Hesselbrock M; Schuckit M; Tischfield J; Liu X; Alcohol (Fayetteville, N.Y.) 2017 Jun 28Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.
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McCutcheon VV; Schuckit MA; Kramer JR; Chan G; Edenberg HJ; Smith TL; Bender AK; Hesselbrock V; Hesselbrock M; Bucholz KK; Addiction (Abingdon, England) 2017 Jul 6Substance use disorders in adolescent and young adult relatives of probands with bipolar disorder: What drives the increased risk?
Hulvershorn LA; King J; Monahan PO; Wilcox HC; Mitchell PB; Fullerton JM; Edenberg HJ; Roberts GMP; Kamali M; Glowinski AL; Ghaziuddin N; McInnis M; Iyer-Eimerbrink PA; Nurnberger JI Jr; Comprehensive psychiatry 2017 Jul 27Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study.
Bucholz KK; McCutcheon VV; Agrawal A; Dick DM; Hesselbrock VM; Kramer JR; Kuperman S; Nurnberger JI Jr; Salvatore JE; Schuckit MA; Bierut LJ; Foroud TM; Chan G; Hesselbrock M; Meyers JL; Edenberg HJ; Porjesz B; Alcoholism, clinical and experimental research 2017 Jan 10An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry.
Meyers JL; Zhang J; Wang JC; Su J; Kuo SI; Kapoor M; Wetherill L; Bertelsen S; Lai D; Salvatore JE; Kamarajan C; Chorlian D; Agrawal A; Almasy L; Bauer L; Bucholz KK; Chan G; Hesselbrock V; Koganti L; Kramer J; Kuperman S; Manz N; Pandey A; Seay M; Scott D; Taylor RE; Dick DM; Edenberg HJ; Goate A; Foroud T; Porjesz B; Molecular psychiatry 2017 Jan 10Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism.
Agrawal A; Tillman R; Grucza RA; Nelson EC; McCutcheon VV; Few L; Conner KR; Lynskey MT; Dick DM; Edenberg HJ; Hesselbrock VM; Kramer JR; Kuperman S; Nurnberger JI Jr; Schuckit MA; Porjesz B; Bucholz KK; Journal of affective disorders 2017 Feb 3Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.
Agrawal A; Edenberg HJ; Gelernter J; Journal of studies on alcohol and drugs 2016 SepTranslating genome-wide association findings into new therapeutics for psychiatry.
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Chorlian DB; Rangaswamy M; Manz N; Meyers JL; Kang SJ; Kamarajan C; Pandey AK; Wang JC; Wetherill L; Edenberg H; Porjesz B; International journal of psychophysiology : official journal of the International Organization of Psychophysiology 2016 Nov 12Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures.
Kapoor M; Chou YL; Edenberg HJ; Foroud T; Martin NG; Madden PA; Wang JC; Bertelsen S; Wetherill L; Brooks A; Chan G; Hesselbrock V; Kuperman S; Medland SE; Montgomery G; Tischfield J; Whitfield JB; Bierut LJ; Heath AC; Bucholz KK; Goate AM; Agrawal A; Translational psychiatry 2016 Mar 22CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving.
Shmulewitz D; Meyers JL; Wall MM; Aharonovich E; Frisch A; Spivak B; Weizman A; Edenberg HJ; Gelernter J; Hasin DS; Journal of studies on alcohol and drugs 2016 MarEffects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral Lymphocytes.
Anand A; McClintick JN; Murrell J; Karne H; Nurnberger JI; Edenberg HJ; Molecular neuropsychiatry 2016 Jun 29Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
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Olfson E; Bloom J; Bertelsen S; Budde JP; Breslau N; Brooks A; Culverhouse R; Chan G; Chen LS; Chorlian D; Dick DM; Edenberg HJ; Hartz S; Hatsukami D; Hesselbrock VM; Johnson EO; Kramer JR; Kuperman S; Meyers JL; Nurnberger J; Porjesz B; Saccone NL; Schuckit MA; Stitzel J; Tischfield JA; Rice JP; Goate A; Bierut LJ; Addiction biology 2016 Dec 29A genome wide association study of fast beta EEG in families of European ancestry.
Meyers JL; Zhang J; Manz N; Rangaswamy M; Kamarajan C; Wetherill L; Chorlian DB; Kang SJ; Bauer L; Hesselbrock V; Kramer J; Kuperman S; Nurnberger JI Jr; Tischfield J; Wang JC; Edenberg HJ; Goate A; Foroud T; Porjesz B; International journal of psychophysiology : official journal of the International Organization of Psychophysiology 2016 Dec 28The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood.
Li JJ; Cho SB; Salvatore JE; Edenberg HJ; Agrawal A; Chorlian DB; Porjesz B; Hesselbrock V; COGA Investigators.; Dick DM; Alcoholism, clinical and experimental research 2016 Dec 19A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.
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Hao Y; Zhang P; Xuei X; Nakshatri H; Edenberg HJ; Li L; Liu Y; BMC genomics 2016 Aug 22Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats.
McClintick JN; McBride WJ; Bell RL; Ding ZM; Liu Y; Xuei X; Edenberg HJ; Alcoholism, clinical and experimental research 2016 Apr 8Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
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Bell RL; Hauser SR; McClintick J; Rahman S; Edenberg HJ; Szumlinski KK; McBride WJ; Progress in molecular biology and translational science 2015 Nov 24Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.
Long EC; Aliev F; Wang JC; Edenberg HJ; Nurnberger J Jr; Hesselbrock V; Porjesz B; Dick DM; Journal of studies on alcohol and drugs 2015 MayAre genetic variants for tobacco smoking associated with cannabis involvement?
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Swaminathan S; Koller DL; Foroud T; Edenberg HJ; Xuei X; Niculescu AB 3rd; Bipolar Genome Study (BiGS) Consortium,.; Nurnberger JI Jr; Journal of affective disorders 2015 Mar 14Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
Salvatore JE; Aliev F; Bucholz K; Agrawal A; Hesselbrock V; Hesselbrock M; Bauer L; Kuperman S; Schuckit MA; Kramer J; Edenberg HJ; Foroud TM; Dick DM; Clinical psychological science : a journal of the Association for Psychological Science 2015 MarGender modulates the development of theta event related oscillations in adolescents and young adults.
Chorlian DB; Rangaswamy M; Manz N; Kamarajan C; Pandey AK; Edenberg H; Kuperman S; Porjesz B; Behavioural brain research 2015 Jun 20Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.
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Fullerton JM; Koller DL; Edenberg HJ; Foroud T; Liu H; Glowinski AL; McInnis MG; Wilcox HC; Frankland A; Roberts G; Schofield PR; Mitchell PB; Nurnberger JI; Bipolar High Risk Study Group, BiGS Consortium.; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015 Jul 16Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample.
Aliev F; Wetherill L; Bierut L; Bucholz KK; Edenberg H; Foroud T; COGA Investigators.; Dick DM; Journal of studies on alcohol and drugs 2015 JanRare variants in neuronal excitability genes influence risk for bipolar disorder.
Ament SA; Szelinger S; Glusman G; Ashworth J; Hou L; Akula N; Shekhtman T; Badner JA; Brunkow ME; Mauldin DE; Stittrich AB; Rouleau K; Detera-Wadleigh SD; Nurnberger JI Jr; Edenberg HJ; Gershon ES; Schork N; Bipolar Genome Study.; Price ND; Gelinas R; Hood L; Craig D; McMahon FJ; Kelsoe JR; Roach JC; Proceedings of the National Academy of Sciences of the United States of America 2015 Feb 17Positive Selection on Loci Associated with Drug and Alcohol Dependence.
Sadler B; Haller G; Edenberg H; Tischfield J; Brooks A; Kramer J; Schuckit M; Nurnberger J; Goate A; PloS one 2015 Aug 13Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior.
Salvatore JE; Edwards AC; McClintick JN; Bigdeli TB; Adkins A; Aliev F; Edenberg HJ; Foroud T; Hesselbrock V; Kramer J; Nurnberger JI; Schuckit M; Tischfield JA; Xuei X; Dick DM; Translational psychiatry 2015 Apr 28Evaluation of commercially available RNA amplification kits for RNA sequencing using very low input amounts of total RNA.
Shanker S; Paulson A; Edenberg HJ; Peak A; Perera A; Alekseyev YO; Beckloff N; Bivens NJ; Donnelly R; Gillaspy AF; Grove D; Gu W; Jafari N; Kerley-Hamilton JS; Lyons RH; Tepper C; Nicolet CM; Journal of biomolecular techniques : JBT 2015 AprAssociation of substance dependence phenotypes in the COGA sample.
Wetherill L; Agrawal A; Kapoor M; Bertelsen S; Bierut LJ; Brooks A; Dick D; Hesselbrock M; Hesselbrock V; Koller DL; Le N; Nurnberger JI Jr; Salvatore JE; Schuckit M; Tischfield JA; Wang JC; Xuei X; Edenberg HJ; Porjesz B; Bucholz K; Goate AM; Foroud T; Addiction biology 2014 May 16CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.
Criado JR; Gizer IR; Edenberg HJ; Ehlers CL; Twin research and human genetics : the official journal of the International Society for Twin Studies 2014 Mar 3Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.
Sadler B; Haller G; Agrawal A; Culverhouse R; Bucholz K; Brooks A; Tischfield J; Johnson EO; Edenberg H; Schuckit M; Saccone N; Bierut L; Goate A; Scientific reports 2014 Mar 28An enhancer-blocking element regulates the cell-specific expression of alcohol dehydrogenase 7.
Jairam S; Edenberg HJ; Gene 2014 Jun 24Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
Kapoor M; Wang JC; Wetherill L; Le N; Bertelsen S; Hinrichs AL; Budde J; Agrawal A; Almasy L; Bucholz K; Dick DM; Harari O; Xiaoling X; Hesselbrock V; Kramer J; Nurnberger JI Jr; Rice J; Schuckit M; Tischfield J; Porjesz B; Edenberg HJ; Bierut L; Foroud T; Goate A; Drug and alcohol dependence 2014 Jun 11Identification of pathways for bipolar disorder: a meta-analysis.
Nurnberger JI Jr; Koller DL; Jung J; Edenberg HJ; Foroud T; Guella I; Vawter MP; Kelsoe JR; Psychiatric Genomics Consortium Bipolar Group.; JAMA psychiatry 2014 JunEthanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.
McClintick JN; Brooks AI; Deng L; Liang L; Wang JC; Kapoor M; Xuei X; Foroud T; Tischfield JA; Edenberg HJ; Alcohol (Fayetteville, N.Y.) 2014 Jul 22Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria.
Kilcoyne B; Shmulewitz D; Meyers JL; Aharonovich E; Greenstein E; Frisch A; Weizman A; Spivak B; Edenberg HJ; Gelernter J; Hasin DS; Journal of studies on alcohol and drugs 2014 JulSingle-nucleotide polymorphisms interact to affect ADH7 transcription.
Jairam S; Edenberg HJ; Alcoholism, clinical and experimental research 2014 Feb 11Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.
McClintick JN; McBride WJ; Bell RL; Ding ZM; Liu Y; Xuei X; Edenberg HJ; Pharmacology, biochemistry, and behavior 2014 Dec 24SIBLING family genes and bone mineral density: association and allele-specific expression in humans.
Alam I; Padgett LR; Ichikawa S; Alkhouli M; Koller DL; Lai D; Peacock M; Xuei X; Foroud T; Edenberg HJ; Econs MJ; Bone 2014 Apr 18Genetics of alcoholism.
Edenberg HJ; Foroud T; Handbook of clinical neurology 2014Family-based association analysis of alcohol dependence criteria and severity.
Wetherill L; Kapoor M; Agrawal A; Bucholz K; Koller D; Bertelsen SE; Le N; Wang JC; Almasy L; Hesselbrock V; Kramer J; Nurnberger JI Jr; Schuckit M; Tischfield JA; Xuei X; Porjesz B; Edenberg HJ; Goate AM; Foroud T; Alcoholism, clinical and experimental research 2013 Sep 9Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption.
McBride WJ; Kimpel MW; McClintick JN; Ding ZM; Hyytia P; Colombo G; Liang T; Edenberg HJ; Lumeng L; Bell RL; Alcohol (Fayetteville, N.Y.) 2013 Oct 1DSM-5 cannabis use disorder: a phenotypic and genomic perspective.
Agrawal A; Lynskey MT; Bucholz KK; Kapoor M; Almasy L; Dick DM; Edenberg HJ; Foroud T; Goate A; Hancock DB; Hartz S; Johnson EO; Hesselbrock V; Kramer JR; Kuperman S; Nurnberger JI Jr; Schuckit M; Bierut LJ; Drug and alcohol dependence 2013 Nov 16Genetics and alcoholism.
Edenberg HJ; Foroud T; Nature reviews. Gastroenterology & hepatology 2013 May 28Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats.
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Chambers RA; McClintick JN; Sentir AM; Berg SA; Runyan M; Choi KH; Edenberg HJ; Genes, brain, and behavior 2013 Jun 22Changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats.
McBride WJ; Kimpel MW; McClintick JN; Ding ZM; Edenberg HJ; Liang T; Rodd ZA; Bell RL; Pharmacology, biochemistry, and behavior 2013 Dec 16Stress-response pathways are altered in the hippocampus of chronic alcoholics.
McClintick JN; Xuei X; Tischfield JA; Goate A; Foroud T; Wetherill L; Ehringer MA; Edenberg HJ; Alcohol (Fayetteville, N.Y.) 2013 Aug 24Ethanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects.
Sarmah S; Muralidharan P; Curtis CL; McClintick JN; Buente BB; Holdgrafer DJ; Ogbeifun O; Olorungbounmi OC; Patino L; Lucas R; Gilbert S; Groninger ES; Arciero J; Edenberg HJ; Marrs JA; Biology open 2013 Aug 14Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption.
McBride WJ; Kimpel MW; McClintick JN; Ding ZM; Hyytia P; Colombo G; Edenberg HJ; Lumeng L; Bell RL; Pharmacology, biochemistry, and behavior 2012 May 10Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study.
Plawecki MH; Wetherill L; Vitvitskiy V; Kosobud A; Zimmermann US; Edenberg HJ; O'Connor S; Alcoholism, clinical and experimental research 2012 Jul 20Alt Event Finder: a tool for extracting alternative splicing events from RNA-seq data.
Zhou A; Breese MR; Hao Y; Edenberg HJ; Li L; Skaar TC; Liu Y; BMC genomics 2012 Dec 17Variations in the potassium channel genes KCNK3 and KCNK9 in relation to blood pressure and aldosterone production: an exploratory study.
Jung J; Barrett PQ; Eckert GJ; Edenberg HJ; Xuei X; Tu W; Pratt JH; The Journal of clinical endocrinology and metabolism 2012 Aug 14Genes encoding enzymes involved in ethanol metabolism.
Hurley TD; Edenberg HJ; Alcohol research : current reviews 2012Genes contributing to the development of alcoholism: an overview.
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Edenberg HJ; Biological psychiatry 2011 Sep 15ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.
Bierut LJ; Goate AM; Breslau N; Johnson EO; Bertelsen S; Fox L; Agrawal A; Bucholz KK; Grucza R; Hesselbrock V; Kramer J; Kuperman S; Nurnberger J; Porjesz B; Saccone NL; Schuckit M; Tischfield J; Wang JC; Foroud T; Rice JP; Edenberg HJ; Molecular psychiatry 2011 Oct 4Alteration of gene expression by alcohol exposure at early neurulation.
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Pochareddy S; Edenberg HJ; Alcoholism, clinical and experimental research 2011 Dec 7Convergent functional genomic studies of ?-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.
Le-Niculescu H; Case NJ; Hulvershorn L; Patel SD; Bowker D; Gupta J; Bell R; Edenberg HJ; Tsuang MT; Kuczenski R; Geyer MA; Rodd ZA; Niculescu AB; Translational psychiatry 2011 Apr 26A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.
Herbert BS; Chanoux RA; Liu Y; Baenziger PH; Goswami CP; McClintick JN; Edenberg HJ; Pennington RE; Lipkin SM; Kopelovich L; Oncotarget 2010 OctGABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.
Xuei X; Flury-Wetherill L; Dick D; Goate A; Tischfield J; Nurnberger J Jr; Schuckit M; Kramer J; Kuperman S; Hesselbrock V; Porjesz B; Foroud T; Edenberg HJ; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010 Mar 5Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast.
Staschke KA; Dey S; Zaborske JM; Palam LR; McClintick JN; Pan T; Edenberg HJ; Wek RC; The Journal of biological chemistry 2010 Mar 16Genome-wide association study of alcohol dependence implicates a region on chromosome 11.
Edenberg HJ; Koller DL; Xuei X; Wetherill L; McClintick JN; Almasy L; Bierut LJ; Bucholz KK; Goate A; Aliev F; Dick D; Hesselbrock V; Hinrichs A; Kramer J; Kuperman S; Nurnberger JI Jr; Rice JP; Schuckit MA; Taylor R; Todd Webb B; Tischfield JA; Porjesz B; Foroud T; Alcoholism, clinical and experimental research 2010 Mar 1Identification of genes influencing skeletal phenotypes in congenic P/NP rats.
Alam I; Carr LG; Liang T; Liu Y; Edenberg HJ; Econs MJ; Turner CH; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 JunChanges in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking.
McBride WJ; Kimpel MW; Schultz JA; McClintick JN; Edenberg HJ; Bell RL; Alcohol (Fayetteville, N.Y.) 2010 Jan 29Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats.
Liang T; Kimpel MW; McClintick JN; Skillman AR; McCall K; Edenberg HJ; Carr LG; Genome biology 2010 Feb 3Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women.
Koller DL; Ichikawa S; Lai D; Padgett LR; Doheny KF; Pugh E; Paschall J; Hui SL; Edenberg HJ; Xuei X; Peacock M; Econs MJ; Foroud T; The Journal of clinical endocrinology and metabolism 2010 Feb 17Variation in the ADH1B proximal promoter affects expression.
Pochareddy S; Edenberg HJ; Chemico-biological interactions 2010 Dec 17Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes.
Naguleswaran A; Elias EV; McClintick J; Edenberg HJ; Sullivan WJ Jr; PLoS pathogens 2010 Dec 16Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4).
Pochareddy S; Edenberg HJ; Gene 2010 Apr 2Genetic research: who is at risk for alcoholism.
Foroud T; Edenberg HJ; Crabbe JC; Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 2010Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats.
Alam I; Sun Q; Koller DL; Liu L; Liu Y; Edenberg HJ; Foroud T; Turner CH; Functional & integrative genomics 2009 Oct 15Differentially expressed genes strongly correlated with femur strength in rats.
Alam I; Sun Q; Koller DL; Liu L; Liu Y; Edenberg HJ; Li J; Foroud T; Turner CH; Genomics 2009 May 29Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes.
Hurley JH; Ballard CJ; Edenberg HJ; Alcoholism, clinical and experimental research 2009 Mar 23Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption.
Bell RL; Kimpel MW; McClintick JN; Strother WN; Carr LG; Liang T; Rodd ZA; Mayfield RD; Edenberg HJ; McBride WJ; Pharmacology, biochemistry, and behavior 2009 Aug 8Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.
Wetherill L; Schuckit MA; Hesselbrock V; Xuei X; Liang T; Dick DM; Kramer J; Nurnberger JI Jr; Tischfield JA; Porjesz B; Edenberg HJ; Foroud T; Alcoholism, clinical and experimental research 2008 Sep 25Identification of a linkage disequilibrium block in chromosome 1q associated with BMD in premenopausal white women.
Ichikawa S; Koller DL; Curry LR; Lai D; Xuei X; Pugh EW; Tsai YY; Doheny KF; Edenberg HJ; Hui SL; Foroud T; Peacock M; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 OctCyclic changes in gene expression induced by Peg-interferon alfa-2b plus ribavirin in peripheral blood monocytes (PBMC) of hepatitis C patients during the first 10 weeks of treatment.
Taylor MW; Tsukahara T; McClintick JN; Edenberg HJ; Kwo P; Journal of translational medicine 2008 Nov 5Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism.
Le-Niculescu H; McFarland MJ; Ogden CA; Balaraman Y; Patel S; Tan J; Rodd ZA; Paulus M; Geyer MA; Edenberg HJ; Glatt SJ; Faraone SV; Nurnberger JI; Kuczenski R; Tsuang MT; Niculescu AB; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008 Mar 5A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence.
Edenberg HJ; Wang J; Tian H; Pochareddy S; Xuei X; Wetherill L; Goate A; Hinrichs T; Kuperman S; Nurnberger JI Jr; Schuckit M; Tischfield JA; Foroud T; Human molecular genetics 2008 Mar 4The CHD3 remodeler PICKLE promotes trimethylation of histone H3 lysine 27.
Zhang H; Rider SD Jr; Henderson JT; Fountain M; Chuang K; Kandachar V; Simons A; Edenberg HJ; Romero-Severson J; Muir WM; Ogas J; The Journal of biological chemistry 2008 Jun 6Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats.
Rodd ZA; Kimpel MW; Edenberg HJ; Bell RL; Strother WN; McClintick JN; Carr LG; Liang T; McBride WJ; Pharmacology, biochemistry, and behavior 2008 Feb 26Identifying blood biomarkers for mood disorders using convergent functional genomics.
Le-Niculescu H; Kurian SM; Yehyawi N; Dike C; Patel SD; Edenberg HJ; Tsuang MT; Salomon DR; Nurnberger JI Jr; Niculescu AB; Molecular psychiatry 2008 Feb 26Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in African-Americans.
Jung J; Foroud TM; Eckert GJ; Flury-Wetherill L; Edenberg HJ; Xuei X; Zaidi SA; Pratt JH; The Journal of clinical endocrinology and metabolism 2008 Dec 9Association of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adults.
Ichikawa S; Koller DL; Curry LR; Lai D; Xuei X; Edenberg HJ; Hui SL; Peacock M; Foroud T; Econs MJ; Calcified tissue international 2008 Dec 18Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.
Liu L; Foroud T; Xuei X; Berrettini W; Byerley W; Coryell W; El-Mallakh R; Gershon ES; Kelsoe JR; Lawson WB; MacKinnon DF; McInnis M; McMahon FJ; Murphy DL; Rice J; Scheftner W; Zandi PP; Lohoff FW; Niculescu AB; Meyer ET; Edenberg HJ; Nurnberger JI Jr; Psychiatric genetics 2008 DecCLCN7 polymorphisms and bone mineral density in healthy premenopausal white women and in white men.
Chu K; Koller DL; Ichikawa S; Snyder R; Curry L; Lai D; Austin A; Xuei X; Edenberg HJ; Hui SL; Foroud TM; Peacock M; Econs MJ; Bone 2008 Aug 8Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck.
Alam I; Sun Q; Liu L; Koller DL; Liu Y; Edenberg HJ; Econs MJ; Foroud T; Turner CH; Physiological genomics 2008 Aug 26The tachykinin receptor 3 is associated with alcohol and cocaine dependence.
Foroud T; Wetherill LF; Kramer J; Tischfield JA; Nurnberger JI Jr; Schuckit MA; Xuei X; Edenberg HJ; Alcoholism, clinical and experimental research 2008 Apr 15Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome.
Wang G; Wang X; Wang Y; Yang JY; Li L; Nephew KP; Edenberg HJ; Zhou FC; Liu Y; BMC genomics 2008Using RNase sequence specificity to refine the identification of RNA-protein binding regions.
Wang X; Wang G; Shen C; Li L; Wang X; Mooney SD; Edenberg HJ; Sanford JR; Liu Y; BMC genomics 2008Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers.
Humphreys TL; Li L; Li X; Janowicz DM; Fortney KR; Zhao Q; Li W; McClintick J; Katz BP; Wilkes DS; Edenberg HJ; Spinola SM; Infection and immunity 2007 Sep 24Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase.
Foroud T; Wetherill LF; Dick DM; Hesselbrock V; Nurnberger JI Jr; Kramer J; Tischfield J; Schuckit M; Bierut LJ; Xuei X; Edenberg HJ; Alcoholism, clinical and experimental research 2007 Sep 11The opioid system in alcohol and drug dependence: family-based association study.
Xuei X; Flury-Wetherill L; Bierut L; Dick D; Nurnberger J Jr; Foroud T; Edenberg HJ; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007 Oct 5Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence.
Xuei X; Flury-Wetherill L; Almasy L; Bierut L; Tischfield J; Schuckit M; Nurnberger JI Jr; Foroud T; Edenberg HJ; Addiction biology 2007 Oct 2Association studies of ALOX5 and bone mineral density in healthy adults.
Foroud T; Ichikawa S; Koller D; Lai D; Curry L; Xuei X; Edenberg HJ; Hui S; Peacock M; Econs MJ; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2007 Oct 2Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor.
Travers JB; Edenberg HJ; Zhang Q; Al-Hassani M; Yi Q; Baskaran S; Konger RL; The Journal of investigative dermatology 2007 Oct 11Towards understanding the schizophrenia code: an expanded convergent functional genomics approach.
Le-Niculescu H; Balaraman Y; Patel S; Tan J; Sidhu K; Jerome RE; Edenberg HJ; Kuczenski R; Geyer MA; Nurnberger JI Jr; Faraone SV; Tsuang MT; Niculescu AB; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007 Mar 5Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions.
Kimpel MW; Strother WN; McClintick JN; Carr LG; Liang T; Edenberg HJ; McBride WJ; Alcohol (Fayetteville, N.Y.) 2007 MarChanges in gene expression during pegylated interferon and ribavirin therapy of chronic hepatitis C virus distinguish responders from nonresponders to antiviral therapy.
Taylor MW; Tsukahara T; Brodsky L; Schaley J; Sanda C; Stephens MJ; McClintick JN; Edenberg HJ; Li L; Tavis JE; Howell C; Belle SH; Journal of virology 2007 Jan 31Mapping of trans-acting regulatory factors from microarray data.
McClintick JN; Liu Y; Edenberg HJ; BMC proceedings 2007 Dec 18Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence.
Edenberg HJ; Xuei X; Wetherill LF; Bierut L; Bucholz K; Dick DM; Hesselbrock V; Kuperman S; Porjesz B; Schuckit MA; Tischfield JA; Almasy LA; Nurnberger JI Jr; Foroud T; Human molecular genetics 2007 Dec 12Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver.
Morral N; Edenberg HJ; Witting SR; Altomonte J; Chu T; Brown M; Journal of lipid research 2007 Apr 21Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains.
Carr LG; Kimpel MW; Liang T; McClintick JN; McCall K; Morse M; Edenberg HJ; Alcoholism, clinical and experimental research 2007 Apr 19Association of alcohol craving with alpha-synuclein (SNCA).
Foroud T; Wetherill LF; Liang T; Dick DM; Hesselbrock V; Kramer J; Nurnberger J; Schuckit M; Carr L; Porjesz B; Xuei X; Edenberg HJ; Alcoholism, clinical and experimental research 2007 AprThe genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.
Edenberg HJ; Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 2007The genetics of alcoholism: identifying specific genes through family studies.
Edenberg HJ; Foroud T; Addiction biology 2006 SepCandidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach.
Rodd ZA; Bertsch BA; Strother WN; Le-Niculescu H; Balaraman Y; Hayden E; Jerome RE; Lumeng L; Nurnberger JI Jr; Edenberg HJ; McBride WJ; Niculescu AB; The pharmacogenomics journal 2006 Oct 10Model-based identification of cis-acting elements from microarray data.
Liu Y; Taylor MW; Edenberg HJ; Genomics 2006 May 23Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII.
Rosen ED; Xuei X; Suckow M; Edenberg H; Blood cells, molecules & diseases 2006 Mar 9Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis.
Edenberg HJ; Xuei X; Chen HJ; Tian H; Wetherill LF; Dick DM; Almasy L; Bierut L; Bucholz KK; Goate A; Hesselbrock V; Kuperman S; Nurnberger J; Porjesz B; Rice J; Schuckit M; Tischfield J; Begleiter H; Foroud T; Human molecular genetics 2006 Mar 28Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation.
Dannenberg LO; Chen HJ; Tian H; Edenberg HJ; Alcoholism, clinical and experimental research 2006 JunEpigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation.
Dannenberg LO; Edenberg HJ; BMC genomics 2006 Jul 19Differential gene induction by type I and type II interferons and their combination.
Sanda C; Weitzel P; Tsukahara T; Schaley J; Edenberg HJ; Stephens MA; McClintick JN; Blatt LM; Li L; Brodsky L; Taylor MW; Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2006 JulEffects of filtering by Present call on analysis of microarray experiments.
McClintick JN; Edenberg HJ; BMC bioinformatics 2006 Jan 31Polymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect bone mineral density in white men or women.
Ichikawa S; Johnson ML; Koller DL; Lai D; Xuei X; Edenberg HJ; Hui SL; Foroud TM; Peacock M; Econs MJ; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2006 Jan 24Association of the kappa-opioid system with alcohol dependence.
Xuei X; Dick D; Flury-Wetherill L; Tian HJ; Agrawal A; Bierut L; Goate A; Bucholz K; Schuckit M; Nurnberger J Jr; Tischfield J; Kuperman S; Porjesz B; Begleiter H; Foroud T; Edenberg HJ; Molecular psychiatry 2006 Aug 22Negative regulation of MHC class II gene expression by CXCR4.
Sheridan C; Sadaria M; Bhat-Nakshatri P; Goulet R Jr; Edenberg HJ; McCarthy BP; Chang CH; Srour EF; Nakshatri H; Experimental hematology 2006 AugHuman ALOX12, but not ALOX15, is associated with BMD in white men and women.
Ichikawa S; Koller DL; Johnson ML; Lai D; Xuei X; Edenberg HJ; Klein RF; Orwoll ES; Hui SL; Foroud TM; Peacock M; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 Apr 5Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism.
McClintick JN; Crabb DW; Tian H; Pinaire J; Smith JR; Jerome RE; Edenberg HJ; The Journal of nutritional biochemistry 2005 Sep 19GATA-2 and HNF-3beta regulate the human alcohol dehydrogenase 1A (ADH1A) gene.
Dannenberg LO; Chen HJ; Edenberg HJ; DNA and cell biology 2005 SepCharacterization of a transgenic mouse line lacking photoreceptor development within the ventral retina.
Fong SL; Criswell MH; Belecky-Adams T; Fong WB; McClintick JN; Kao WW; Edenberg HJ; Experimental eye research 2005 OctThe contribution of genetics to addiction therapy approaches.
Edenberg HJ; Kranzler HR; Pharmacology & therapeutics 2005 OctExpression Profiling in Alcoholism Research.
Bergeson SE; Berman AE; Dodd PR; Edenberg HJ; Hitzemann RJ; Lewohl JM; Lodowski KH; Sommer WH; Alcoholism, clinical and experimental research 2005 Jun 1No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample.
Dick DM; Edenberg HJ; Xuei X; Goate A; Hesselbrock V; Schuckit M; Crowe R; Foroud T; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005 Jan 5Alcohol effects on central nervous system gene expression in genetic animal models.
McBride WJ; Kerns RT; Rodd ZA; Strother WN; Edenberg HJ; Hashimoto JG; Wiren KM; Miles MF; Alcoholism, clinical and experimental research 2005 FebGene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats.
Edenberg HJ; Strother WN; McClintick JN; Tian H; Stephens M; Jerome RE; Lumeng L; Li TK; McBride WJ; Genes, brain, and behavior 2005 FebNatural haplotypes in the regulatory sequences affect human alcohol dehydrogenase 1C (ADH1C) gene expression.
Chen HJ; Tian H; Edenberg HJ; Human mutation 2005 FebDescription of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14.
Edenberg HJ; Bierut LJ; Boyce P; Cao M; Cawley S; Chiles R; Doheny KF; Hansen M; Hinrichs T; Jones K; Kelleher M; Kennedy GC; Liu G; Marcus G; McBride C; Murray SS; Oliphant A; Pettengill J; Porjesz B; Pugh EW; Rice JP; Rubano T; Shannon S; Steeke R; Tischfield JA; Tsai YY; Zhang C; Begleiter H; BMC genetics 2005 Dec 30Alternative splicing and promoter use in the human GABRA2 gene.
Tian H; Chen HJ; Cross TH; Edenberg HJ; Brain research. Molecular brain research 2005 Apr 8Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.
Li Y; McClintick J; Zhong L; Edenberg HJ; Yoder MC; Chan RJ; Blood 2004 Sep 9Contribution of the LRP5 gene to normal variation in peak BMD in women.
Koller DL; Ichikawa S; Johnson ML; Lai D; Xuei X; Edenberg HJ; Conneally PM; Hui SL; Johnston CC; Peacock M; Foroud T; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Oct 25High-throughput quantitation of double-stranded DNA using the ABI Prism 7700 sequence detection system.
Tian H; Edenberg HJ; Analytical biochemistry 2004 Mar 15Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.
Edenberg HJ; Dick DM; Xuei X; Tian H; Almasy L; Bauer LO; Crowe RR; Goate A; Hesselbrock V; Jones K; Kwon J; Li TK; Nurnberger JI Jr; O'Connor SJ; Reich T; Rice J; Schuckit MA; Porjesz B; Foroud T; Begleiter H; American journal of human genetics 2004 Mar 12Association of GABRG3 with alcohol dependence.
Dick DM; Edenberg HJ; Xuei X; Goate A; Kuperman S; Schuckit M; Crowe R; Smith TL; Porjesz B; Begleiter H; Foroud T; Alcoholism, clinical and experimental research 2004 JanA genome-wide screen for genes influencing conduct disorder.
Dick DM; Li TK; Edenberg HJ; Hesselbrock V; Kramer J; Kuperman S; Porjesz B; Bucholz K; Goate A; Nurnberger J; Foroud T; Molecular psychiatry 2004 JanGlobal effect of PEG-IFN-alpha and ribavirin on gene expression in PBMC in vitro.
Taylor MW; Grosse WM; Schaley JE; Sanda C; Wu X; Chien SC; Smith F; Wu TG; Stephens M; Ferris MW; McClintick JN; Jerome RE; Edenberg HJ; Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004 FebGene expression profiling of Caco-2 BBe cells suggests a role for specific signaling pathways during intestinal differentiation.
Fleet JC; Wang L; Vitek O; Craig BA; Edenberg HJ; Physiological genomics 2003 Mar 18Coordinate repression of regulators of embryonic identity by PICKLE during germination in Arabidopsis.
Dean Rider S Jr; Henderson JT; Jerome RE; Edenberg HJ; Romero-Severson J; Ogas J; The Plant journal : for cell and molecular biology 2003 JulReproducibility of oligonucleotide arrays using small samples.
McClintick JN; Jerome RE; Nicholson CR; Crabb DW; Edenberg HJ; BMC genomics 2003 Jan 30Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting.
Song J; Koller DL; Foroud T; Carr K; Zhao J; Rice J; Nurnberger JI Jr; Begleiter H; Porjesz B; Smith TL; Schuckit MA; Edenberg HJ; American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003 FebTranscriptional changes in alveolar macrophages during Pneumocystis pneumonia.
Lee CH; Lasbury ME; Xuei X; Jerome RE; Edenberg HJ; Lu D; Durant PJ; Tschang D; The Journal of eukaryotic microbiology 2003Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population.
Carr LG; Foroud T; Stewart T; Castelluccio P; Edenberg HJ; Li TK; American journal of medical genetics 2002 Oct 1Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype.
Dick DM; Nurnberger J Jr; Edenberg HJ; Goate A; Crowe R; Rice J; Bucholz KK; Kramer J; Schuckit MA; Smith TL; Porjesz B; Begleiter H; Hesselbrock V; Foroud T; Alcoholism, clinical and experimental research 2002 OctA retroviral repetitive element confers tissue-specificity to the human alcohol dehydrogenase 1C (ADH1C) gene.
Chen HJ; Carr K; Jerome RE; Edenberg HJ; DNA and cell biology 2002 NovApparent replication of suggestive linkage on chromosome 16 in the NIMH genetics initiative bipolar pedigrees.
Dick DM; Foroud T; Edenberg HJ; Miller M; Bowman E; Rau NL; DePaulo JR; McInnis M; Gershon E; McMahon F; Rice JP; Bierut LJ; Reich T; Nurnberger J Jr; American journal of medical genetics 2002 May 8The collaborative study on the genetics of alcoholism: an update.
Edenberg HJ; Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 2002Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder.
Nurnberger JI Jr; Foroud T; Flury L; Su J; Meyer ET; Hu K; Crowe R; Edenberg H; Goate A; Bierut L; Reich T; Schuckit M; Reich W; The American journal of psychiatry 2001 MayDNA microarray analysis of differential gene expression of 6-year-old rat neural striatal progenitor cells during early differentiation.
Zhou FC; Duguid JR; Edenberg HJ; McClintick J; Young P; Nelson P; Restorative neurology and neuroscience 2001Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping.
Foroud T; Edenberg HJ; Goate A; Rice J; Flury L; Koller DL; Bierut LJ; Conneally PM; Nurnberger JI; Bucholz KK; Li TK; Hesselbrock V; Crowe R; Schuckit M; Porjesz B; Begleiter H; Reich T; Alcoholism, clinical and experimental research 2000 JulSuggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees.
Foroud T; Castelluccio PF; Koller DL; Edenberg HJ; Miller M; Bowman E; Rau NL; Smiley C; Rice JP; Goate A; Armstrong C; Bierut LJ; Reich T; Detera-Wadleigh SD; Goldin LR; Badner JA; Guroff JJ; Gershon ES; McMahon FJ; Simpson S; MacKinnon D; McInnis M; Stine OC; DePaulo JR; Blehar MC; Nurnberger JI Jr; American journal of medical genetics 2000 Feb 7BlastReport: a perl script to facilitate the use of sequence databases for mapping and clustering.
McClintick J; Edenberg HJ; BioTechniques 2000 DecTissue-specific regulatory elements in the human alcohol dehydrogenase 6 gene.
Zhi X; Chan EM; Edenberg HJ; DNA and cell biology 2000 AugRegulation of the mammalian alcohol dehydrogenase genes.
Edenberg HJ; Progress in nucleic acid research and molecular biology 2000A human Raf-responsive zinc-finger protein that binds to divergent sequences.
Zhang L; Zhao J; Edenberg HJ; Nucleic acids research 1999 Jul 15Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression.
Edenberg HJ; Jerome RE; Li M; Pharmacogenetics 1999 FebA quantitative trait locus for alcohol consumption in selectively bred rat lines.
Carr LG; Foroud T; Bice P; Gobbett T; Ivashina J; Edenberg H; Lumeng L; Li TK; Alcoholism, clinical and experimental research 1998 JunRegulation of human alcohol dehydrogenase gene ADH7: importance of an AP-1 site.
Kotagiri S; Edenberg HJ; DNA and cell biology 1998 JulLinkage of an alcoholism-related severity phenotype to chromosome 16.
Foroud T; Bucholz KK; Edenberg HJ; Goate A; Neuman RJ; Porjesz B; Koller DL; Rice J; Reich T; Bierut LJ; Cloninger CR; Nurnberger JI Jr; Li TK; Conneally PM; Tischfield JA; Crowe R; Hesselbrock V; Schuckit M; Begleiter H; Alcoholism, clinical and experimental research 1998 DecA family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence.
Edenberg HJ; Reynolds J; Koller DL; Begleiter H; Bucholz KK; Conneally PM; Crowe R; Goate A; Hesselbrock V; Li TK; Nurnberger JI Jr; Porjesz B; Reich T; Rice JP; Schuckit M; Tischfield JA; Foroud T; Alcoholism, clinical and experimental research 1998 AugA family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism.
Edenberg HJ; Foroud T; Koller DL; Goate A; Rice J; Van Eerdewegh P; Reich T; Cloninger CR; Nurnberger JI Jr; Kowalczuk M; Wu B; Li TK; Conneally PM; Tischfield JA; Wu W; Shears S; Crowe R; Hesselbrock V; Schuckit M; Porjesz B; Begleiter H; Alcoholism, clinical and experimental research 1998 AprFunction of cis-acting elements in human alcohol dehydrogenase 4 (ADH4) promoter and role of C/EBP proteins in gene expression.
Li M; Edenberg HJ; DNA and cell biology 1998 AprFamilial multiple-system tauopathy with presenile dementia is localized to chromosome 17.
Murrell JR; Koller D; Foroud T; Goedert M; Spillantini MG; Edenberg HJ; Farlow MR; Ghetti B; American journal of human genetics 1997 NovInitial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22.
Edenberg HJ; Foroud T; Conneally PM; Sorbel JJ; Carr K; Crose C; Willig C; Zhao J; Miller M; Bowman E; Mayeda A; Rau NL; Smiley C; Rice JP; Goate A; Reich T; Stine OC; McMahon F; DePaulo JR; Meyers D; Detera-Wadleigh SD; Goldin LR; Gershon ES; Blehar MC; Nurnberger JI Jr; American journal of medical genetics 1997 May 31Rapid amplification of uncharacterized transposon-tagged DNA sequences from genomic DNA.
Chun KT; Edenberg HJ; Kelley MR; Goebl MG; Yeast (Chichester, England) 1997 Mar 15Regulation of the seven human alcohol dehydrogenase genes.
Edenberg HJ; Brown CJ; Hur MW; Kotagiri S; Li M; Zhang L; Zhi X; Advances in experimental medicine and biology 1997Gene regulation of alcohol metabolizing enzymes.
Crabb DW; Edenberg HJ; Alcoholism, clinical and experimental research 1996 NovGene expression in a young multigene family: tissue-specific differences in the expression of the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3.
Brown CJ; Zhang L; Edenberg HJ; DNA and cell biology 1996 MarStructure and function of a long alternating purine-pyrimidine sequence in the mouse alcohol dehydrogenase Adh-1 gene.
Yu M; Edenberg HJ; Archives of biochemistry and biophysics 1995 Jan 10Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes.
Kedishvili NY; Bosron WF; Stone CL; Hurley TD; Peggs CF; Thomasson HR; Popov KM; Carr LG; Edenberg HJ; Li TK; The Journal of biological chemistry 1995 Feb 24Cell-specific function of cis-acting elements in the regulation of human alcohol dehydrogenase 5 gene expression and effect of the 5'-nontranslated region.
Hur MW; Edenberg HJ; The Journal of biological chemistry 1995 Apr 14Promoters of the mammalian class III alcohol dehydrogenase genes.
Edenberg HJ; Ho WH; Hur MW; Advances in experimental medicine and biology 1995Tissue-specific differences in the expression of the human ADH2 alcohol dehydrogenase gene and in binding of factors to cis-acting elements in its promoter.
Brown CJ; Zhang L; Edenberg HJ; DNA and cell biology 1994 MarLow frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders.
Thomasson HR; Crabb DW; Edenberg HJ; Li TK; Hwu HG; Chen CC; Yeh EK; Yin SJ; Alcoholism, clinical and experimental research 1994 JunA negative regulatory element upstream from the mouse Adh-1 gene can down-regulate a heterologous promoter.
Yu M; Jerome RE; Edenberg HJ; Gene 1994 Apr 20Alcohol dehydrogenases: molecular biology and gene regulation.
Edenberg HJ; Brown CJ; Zhang L; Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1994A novel negative element in the promoter of the mouse alcohol dehydrogenase gene Adh-1.
Lin Z; Edenberg HJ; Carr LG; The Journal of biological chemistry 1993 May 15Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism.
Thomasson HR; Crabb DW; Edenberg HJ; Li TK; Behavior genetics 1993 MarRegulation of the human alcohol dehydrogenases genes ADH1, ADH2 and ADH3: differences in cis-acting sequences at CTF/NF-I sites.
Edenberg HJ; Brown CJ; Zhang L; Advances in experimental medicine and biology 1993Regulation of human alcohol dehydrogenase genes.
Edenberg HJ; Brown CJ; Pharmacogenetics 1992 OctExpression of the human ADH2 gene: an unusual Sp1-binding site in the promoter of a gene expressed at high levels in liver.
Brown CJ; Baltz KA; Edenberg HJ; Gene 1992 Nov 16Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase.
Hur MW; Edenberg HJ; Gene 1992 Nov 16Molecular cloning of mouse alcohol dehydrogenase-B2 cDNA: nucleotide sequences of the class III ADH genes evolve slowly even for silent substitutions.
Hur MW; Ho WH; Brown CJ; Goldman D; Edenberg HJ; DNA sequence : the journal of DNA sequencing and mapping 1992Cloning and characterization of the murine promoter for the colony-stimulating factor-1-encoding gene.
Harrington MA; Edenberg HJ; Saxman S; Pedigo LM; Daub R; Broxmeyer HE; Gene 1991 Jun 30General base catalysis in a glutamine for histidine mutant at position 51 of human liver alcohol dehydrogenase.
Ehrig T; Hurley TD; Edenberg HJ; Bosron WF; Biochemistry 1991 Jan 29Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
Thomasson HR; Edenberg HJ; Crabb DW; Mai XL; Jerome RE; Li TK; Wang SP; Lin YT; Lu RB; Yin SJ; American journal of human genetics 1991 AprCharacterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51.
Hurley TD; Ehrig T; Edenberg HJ; Bosron WF; Advances in experimental medicine and biology 1991Alcohol dehydrogenase gene expression and cloning of the mouse chi-like ADH.
Edenberg HJ; Brown CJ; Carr LG; Ho WH; Hur MW; Advances in experimental medicine and biology 1991Expression of the human alcohol dehydrogenase genes.
Edenberg HJ; Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1991Expression and kinetic characterization of variants of human beta 1 beta 1 alcohol dehydrogenase containing substitutions at amino acid 47.
Hurley TD; Edenberg HJ; Bosron WF; The Journal of biological chemistry 1990 Sep 25cis-acting sequences involved in protein binding and in vitro transcription of the human alcohol dehydrogenase gene ADH2.
Carr LG; Edenberg HJ; The Journal of biological chemistry 1990 Jan 25Structure and expression of the rat class I alcohol dehydrogenase gene.
Crabb DW; Stein PM; Dipple KM; Hittle JB; Sidhu R; Qulali M; Zhang K; Edenberg HJ; Genomics 1989 NovProtein-DNA interactions in the 5' region of the mouse alcohol dehydrogenase gene Adh-1.
Carr LG; Zhang K; Edenberg HJ; Gene 1989 May 30Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.
Crabb DW; Edenberg HJ; Bosron WF; Li TK; The Journal of clinical investigation 1989 JanNucleotide sequence of the ADH2(3) gene encoding the human alcohol dehydrogenase beta 3 subunit.
Carr LG; Xu Y; Ho WH; Edenberg HJ; Alcoholism, clinical and experimental research 1989 AugEvidence for both a regulatory mutation and a structural mutation in a family with maple syrup urine disease.
Zhang B; Edenberg HJ; Crabb DW; Harris RA; The Journal of clinical investigation 1989 AprHuman alcohol dehydrogenase cDNAs: structure and expression.
Edenberg HJ; Dailey TL; Zhang K; Progress in clinical and biological research 1989cDNA cloning of the E1 alpha subunit of the branched-chain alpha-keto acid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease.
Zhang B; Kuntz MJ; Goodwin GW; Edenberg HJ; Crabb DW; Harris RA; Annals of the New York Academy of Sciences 1989Preirradiation of host cells does not alter blockage of simian virus 40 replication forks by pyrimidine dimers.
Scaria A; Edenberg HJ; Mutation research 1988 JanGenotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification.
Xu YL; Carr LG; Bosron WF; Li TK; Edenberg HJ; Genomics 1988 AprStructure of the mouse Adh-1 gene and identification of a deletion in a long alternating purine-pyrimidine sequence in the first intron of strains expressing low alcohol dehydrogenase activity.
Zhang K; Bosron WF; Edenberg HJ; Gene 1987Cloning and sequencing of a cDNA encoding rat liver alcohol dehydrogenase.
Crabb DW; Edenberg HJ; Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1987Genetic control of liver alcohol dehydrogenase expression in inbred mice.
Patterson LS; Zhang K; Edenberg HJ; Bosron WF; Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1987 -
Professional OrganizationsInternational Behavioural and Neural Genetics SocietyAmerican Association for the Advancement of ScienceAmerican Society for Biochemistry and Molecular BiologyAmerican Society of Human GeneticsInternational Society for Biomedical Research on AlcoholismInternational Society of Psychiatric GeneticsResearch Society on AlcoholismSigma Xi, The Scientific Research Society
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AwardsOrg: Indiana University
Desc: Distinguished Professor
Scope: University
Date: 1905-07-04
Org: American Association for the Advancement of Science
Desc: Fellow (Biological Sciences)
Scope: National
Date: 1905-07-01
Org: American Association for the Advancement of Science
Desc: Elected Fellow
Scope: International
Date:
Org: Research Society on Alcoholism
Desc: Distinguished Researcher Award
Scope: International
Date:
Org: Research Society on Alcoholism
Desc: Tharp Award for Research on Alcoholism
Scope: International
Date:
Org: Indiana University School of Medicine
Desc: Faculty Teaching Award
Scope: School
Date:
Org: Indiana University
Desc: Bicentennial Medal
Scope: University
Date:
Research Labs
Faculty research at IU School of Medicine is transforming health. Details about the medical research being conducted in faculty labs throughout IU School of Medicine are available in the Research section of this site.