6477-Haneline, Laura

Laura S. Haneline, MD

Edwin L. Gresham Professor of Pediatrics

699 Riley Hospital Drive
RR 208

Indianapolis , IN 46202
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Dr. Haneline received a B.S. from Ball State University where she graduated Summa Cum Laude. She received an M.D. from Indiana University School of Medicine followed by Pediatric Residency and Neonatal-Perinatal Medicine Fellowship at the Indiana University School of Medicine.  She is the Edwin L. Gresham Professor of Pediatrics and serves as the Division Chief of Neonatal-Perinatal Medicine.  Dr. Haneline is an established physician-investigator in the Herman B Wells Center for Pediatric Research and conducts basic/translational research.  She has had continuous NIH funding since 1999. She was elected into the American Society for Clinical Investigation and the American Pediatric Society. She has served on 2 NIH study sections (Pregnancy and Neonatology and Molecular and Cellular Hematology) and serves in a variety of roles at national scientific meetings. She has published over 50 scientific manuscripts.  Dr. Haneline is a stem cell biologist whose research focuses on how adverse intrauterine environments impair the function of fetal stem and progenitor cells thereby enhancing risk for hematopoietic, pulmonary, and vascular diseases during childhood.

Key Publications

  1. Ingram DA, Lien IZ, Mead LE, Estes M, Prater DN, Derr-Yellin E, DiMeglio LA, Haneline LS.  In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony-forming cell numbers and function.  Diabetes. 2008 Mar;57(3):724-731. 
  2. Case J, Ingram DA, Haneline LS.  Oxidative Stress Impairs Endothelial Progenitor Cell Function.  Antioxid Redox Signal.  2008 Nov;10(11):1895-1907.  PMCID: PMC2575029
  3. Acosta JC, Haas D, Saha C, DiMeglio LA, Ingram DA, Haneline LS.  Gestational diabetes alters maternal and neonatal circulating endothelial progenitor cell subsets.  Am J Obstet Gynecol. 2011 Mar; 204(3):254.e8-254.e15.
  4. Chang DV, Tiller CJ, Kisling J, Case J, Mund JA, Haneline LS, Ingram DA, Tepper RS. Membrane and Capillary Components of Lung Diffusion and Pro-Angiogenic Cells In Infants. Eur Respir J. 2014,Feb;43(2):497-504.
  5. Blue EK, DiGiuseppe R, Derr-Yellin E, Acosta JC, Mund JA, Case J, Haneline LS. Gestational Diabetes Induces Alterations in the Function of Neonatal Endothelial Colony Forming Cells. Pediatr Res. 2014, Feb;75(2):266-72. 
  6. Assaf S, Chang D, Tiller C, Kisling J, Case J, Mund J, Slaven J, Zhang Sheng Y, Ahlfeld S, Poindexter B, Haneline LS, Ingram D, Tepper R.  Lung Parenchymal Development in Premature Infants without Bronchopulmonary Dysplasia.  Pediatric Pulm. 2014 Dec 2. doi: 10.1002/ppul.23134. [Epub ahead of print]
  7. Blue EK, Ballman K, Boyle F, Oh E, Kono T, Thurmond DC, Evans-Molina C, Haneline LS.  Fetal Hyperglycemia and a High Fat Diet Contribute to Aberrant Glucose Tolerance and Hematopoiesis in Adult Rats. Pediatr Res. 2015 Feb; 77(2):316-25.
  8. Blue EK, Sheehan BM, Nuss ZV, Boyle FA, Hocutt CM, McClintick JN, Haneline LS.  Epigenetic regulation of PLAC8 contributes to altered function of endothelial colony forming cells exposed to intrauterine gestational diabetes mellitus. Diabetes. 2015 Jul;64(7):2664-75.  PMCID:  PMC4477353
  9. Gohn CR, Blue EK, Sheehan BM, Varberg KM, Haneline LS. Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus. J Cell Physiol. 2017 Jul;232(7):1885-1892. Epub 2017 Feb 16.
  10. Varberg KM, Winfree S, Chu C, Tu W, Blue EK, Gohn CR, Dunn KW, Haneline LS.  Kinetic analyses of vasculogenesis inform mechanistic studies. Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C446-C458. Epub 2017 Jan 18.
  11. Varberg KM, Winfree S, Chu C, Dunn KW, Haneline LS.  Kinetic Analysis of Vasculogenesis Quantifies Dynamics of Vasculogenesis and Angiogenesis In Vitro. J Vis Exp. 2017 in press.


Titles & Appointments

  • Edwin L. Gresham Professor of Pediatrics
  • Professor of Microbiology & Immunology
  • Adjunct Professor of Anatomy, Cell Biology & Physiology
  • Professor of Medicine
  • Division Chief, Neonatology
  • Education
    1999 FEL NRSA Research Fellow, Indiana University School of Medicine
    1997 FEL Neonatal-Perinatal Medicine Fellowship, Indiana University School of Medicine
    1994 RES Pediatrics Residency, Indiana University School of Medicine
    1991 MD Indiana University
    1987 BS Ball State University
  • Research

    Dr. Haneline is a Neonatologist and stem cell biologist whose research focuses on how stem and progenitor cell dysfunction impacts the pathogenesis of hematopoietic, pulmonary, and vascular diseases. She is involved in translational studies that examine whether circulating hematopoietic and endothelial progenitor cells are instructive as biomarkers of pediatric and obstetric diseases as well as in the assessment of drug efficacy. She has had continuous NIH funding since 1999. Her early research career elucidated mechanisms involved in the development of bone marrow failure and leukemia in the genetic disease Fanconi anemia using a murine model. Her lab determined that the oxidant-ASK1-p38MAPK pathway has a central role in mediating the stress response of multiple stem and progenitor cell populations. Subsequently, she shifted her scientific focus to neonatal diseases that involve exposure to oxidant stress and that are impacted by dysfunction of stem and progenitor cells. She is particularly interested in understanding basic mechanisms involved in the developmental origins of disease and has recently focused on the effect of prematurity, maternal diabetes mellitus and pre-eclampsia on endothelial and hematopoietic stem/progenitor cell dysfunction, including epigenetic alterations in gene expression and cellular function. National recognition include election into the American Society of Clinical Investigation, an honor society for physician-scientists, and the American Pediatric Society.  She has been active in scientist training throughout her career. She participated in the development of the Morris Green Scholar’s program to enhance the number of pediatric physician-scientists trained at the Indiana University School of Medicine. Her lab has trained MD and PhD post-doctoral fellows as well as graduate and undergraduate students. She has served on several junior faculty mentoring committees to assist with career development, and she was the Training Director on the K12 awarded to the Department of Pediatrics.  Currently, she oversees the Riley Children’s Foundation Scholars program that supports the career development of junior faculty members.

  • Professional Organizations
    American Academy of Pediatrics
    American Pediatric Society
    American Society for Clinical Investigation
    American Society of Hematology
    International Society for Experimental Hematology
    Midwest Society for Pediatric Research
    Perinatal Research Society
    Society for Pediatric Research
  • Board Certifications
    American Board of Pediatrics - Neonatal-Perinatal Medicine
    American Board of Pediatrics - Pediatrics
  • Clinical Interests

    Understanding how impaired function of stem/progenitor cells promotes vascular, pulmonary, and hematopoietic disease.

    Riley Hospital for Children at IU Health
    Eskenazi Health

  • Awards
    Org: Alpha Omega Alpha Honor Medical Society
    Desc: Alpha Omega Alpha
    Scope: National
    Date: 1996-01-01

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