63522-Feldman, Michael
Faculty

Michael Feldman, MD, PhD

Chair, Department of Pathology & Laboratory Medicine

Address
350 West 11th Street
Room, 6016E

Indianapolis, Indian 46202

Bio

My professional interests revolve around the development of institutional biobanking as well as the integration and adoption of information technologies in the discipline of healthcare, and particularly pathology.

My work in the field of tissue banking included being an early funded adopter and tester in the NCI caBIG project, where we partnered on the testing of caTissue with the University of Pittsburgh and were the first cancer center using both caTissue and caTIES. caTIES has now morphed into a multicenter Tissue Collaborative Research Network (TCRN) and is NIH funded.

In the field of digital imaging, I have been developing computer-assisted diagnostic algorithms for machine vision in breast cancer and quantitative scoring of immunohistochemical and immunofluorescent stains of FFPE tissue. Our newest area of investigation is the use of Imaging mass cytometry of pancreas tissues and multispectral imaging for the analysis of multicolor immunohistochemistry and immunofluorescence and the development of a quantitative system for scoring and analyzing at a cytometric level, multicolor immunostaining on surgical pathology slides which was recently used in multiple of breast cancer publications listed below. The efforts have been recognized by the national funding agencies from the NIH, Synergy award from DOD, as well as an industry-sponsored projects.

Key Publications


Google Scholar

  1. Crowley RS, Castine M, Mitchell K, Chavan G, McSherry T, Feldman M. (2010). caTIES: a grid based system for coding and retrieval of surgical pathology reports and tissue specimens in support of translational research. J Am Med Informatics 17(3): 253-64. PMCID: PMC2995710
  2. Jacobson RS, Becich MJ, Bollag RJ, Chavan G, Corrigan J, Dhir R, Feldman MD, Gaudioso C, Legowski E, Maihle NJ, Mitchell K, Murphy M, Sakthivel M, Tseytlin E, Weaver J: A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens. Cancer Res 75(24): 5194-5201, December 2015. PMCID: PMC4683415
  3. Lee, G, Singanamalli, A, Wang, H, Feldman, M, Master, SR, Shih, N, Spangle, E, Rebbeck, T, Tomaszewski, J, & Madabhushi, A. (2015). Supervised multi-view canonical correlation analysis (sMVCCA): integrating histologic and proteomic features for predicting recurrent prostate cancer. IEEE Transactions on Medical Imaging, 34(1), 284-297. PMID: 25203987.
  4. Nirschl JJ, Janowczyk A, Peyster EG, Frank R, Margulies KB, Feldman MD, Madabhushi A: A deep- learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue. PLoS One 3(13), April 2018. PMCID: PMC5882098

Titles & Appointments

  • Chair, Department of Pathology & Laboratory Medicine
  • Manwaring Professor of Pathology & Laboratory Medicine
  • Education
    1992 MD University of Medicine and Dentistry of New Jersey
    1992 PhD University of Medicine and Dentistry of New Jersey
    1984 BS Muhlenberg College
  • Research

    Tissue Banking, methodologies for risk stratification of cancers via computational imaging of digital pathology, methodologies for fusion of imaging-molecular predictors of treatment outcome, methodologies for quantitative staining of tissues

    Ongoing and recently completed projects:

    R01CA202752                        Madabhushi- PI                                

    7/1/16-6/30/22                     

    Cancer Detection and Diagnosis Research

    Role: Co-I/Lead pathologist on translational efforts in image processing

     

    U01CA239055                        Janowczyk- PI                                

    3/1/19-2/28/22                       

    Histo Tools: A suite of digital pathology tools for quality control, annotation and dataset identification

    Role: Co-I/Lead pathologist on the development of new use cases for computational quality control efforts using machine learning

     

    U01DK123594-02                Kaestner-PI                                                 

    9/23/19-8/31/24                  

    The Human Pancreas Analysis Program for Type 2 Diabetes

    Role: Co-I/Lead pathologist overseeing tissue banking

     

    P30 CA016520-45               Vonderheide-PI                                              

    12/1/20 -11/30/25   

    Abramson Cancer Center Support Grant

    Role: Co-Investigator

  • Professional Organizations
    Alpha Omega Alpha Honor Medical Society

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