62897-An, Zhibo

Zhibo An, MD, PhD

Assistant Professor of Clinical Medicine

UH 1634
Indianapolis, IN


Dr. An is a board certified gastroenterologist. He received his medical education (Shandong University of TCM) and graduate education (Peking University HSC) in China. Subsequently, he completed his PhD at Vanderbilt University School of Medicine in Tennessee in 2009, where his research focused on glucose metabolism, obesity and type 2 diabetes. He then completed a post-doc research fellowship at University of Cincinnati, where he studied the function of endocrine and digestive system in obesity and diabetes as well as the development of new strategies of weight loss and optimized diabetic treatment. Following his Internal Medicine residency at the Christ Hospital in Cincinnati, Dr. An completed his Gastroenterology fellowship at the University of Iowa Hospitals & Clinics in 2022.  He joined the gastroenterology faculty after his clinical training in Iowa, and currently he is an Assistant Professor of Clinical Medicine in the Department of Medicine at Indiana University. Dr. An has published more than 20 peer-reviewed scientific articles. His patient care interests include gastroesophageal reflux disease, gastric ulcers, GI bleed, constipation, diarrhea, inflammatory bowel disease, etc.

Key Publications

1. An Z, Wang H, Mokadem M: Role of the Autonomic Nervous System in Metabolic Regulation after Bariatric Surgery (review). Frontiers in Neuroscience. DOI=10.3389/fnins.2021.770690, 2021 (PMID: 34024448)

2. An Z, Braseth AL, Sahar N: Acute Cholangitis: Causes, Diagnosis, and Management (review). Gastroenterol Clin of North America. 50(2):403-414, 2021 (PMID: 34024448)

3. Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers, DA, Seeley, RJ, & D’Alessio DA: The Role of beta Cell Glucagon-like Peptide-1 Signaling in Glucose Regulation and Response to Diabetes Drugs. Cell Metabolism 19(6):1050-1057, 2014 (PMID: 24836562)

4. An Z, Prigeon RL, D’Alessio DA: Improved Glycemic Control Enhances the Incretin Effect in Patients with Type 2 Diabetes. J Clin Endocrinol Metab 98(12): 4702-4708, 2013 (PMID: 24092826)

5. Winnick JJ, An Z, Kraft G, Ramnanan CJ, Cherrington AD: Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion. Diabetes 62(1):96-101, 2013 (PMID: 22923473)

6. An Z, Winnick JJ, Moore MC, Farmer B, Cherrington AD: A cGMP Dependent Pathway Can Regulate Net Hepatic Glucose Uptake In Vivo. Diabetes 61(10):2433-41, 2012 (PMID: 22688328)

7. Moore MC, Coate KC, Winnick JJ, An Z, Cherrington AD: Regulation of Hepatic Glucose Uptake and Storage in vivo (review). Advances in Nutrition 3(3):286-94, 2012 (PMID: 22585902)

8. Winnick JJ, An Z, Ramnanan CJ, Smith M, Irimia-Dominguez J, Neal DW, Moore MC, Roach PJ, Cherrington AD: Hepatic Glycogen Supercompensation Activates AMPK, Impairs Insulin Signaling and Reduces Glycogen Deposition in the Liver. Diabetes 60 (2):398-407, 2011 (PMID: 21270252)

9. Rivera N, Ramnanan CJ, An Z, Farmer T, Smith M, Farmer B, Irimia JM, Snead W, Lautz M, Roach PJ and Cherrington AD. Insulin-induced Hypoglycemia Increases Hepatic Sensitivity to Glucagon in Dogs. Journal of Clinical Investigation 120 (12):4425-4435, 2010 (PMID: 21084754)

10. An Z, Winnick JJ, Farmer B, Neal DW, Lautz M, Irimia JM, Roach PJ, Cherrington AD: A Soluble Guanylate Cyclase (sGC) Dependent Mechanism Is Involved in the Regulation of Net Hepatic Glucose Uptake by Nitric Oxide In Vivo. Diabetes 59 (12):2999-3007, 2010 (PMID: 20823104)

11. Winnick JJ, An Z, Moore MC, Ramnanan CJ, Farmer B, Shiota M, Cherrington AD: A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin. American Journal of Physiology 297(8): E358–E366, 2009 (PMID: 19470836)

12. An Z, Moore MC, Winnick JJ, Farmer B, Neal DW, Lautz M, Smith M, Rodewald T, Cherrington AD: Portal Infusion of Escitalopram Enhances Hepatic Glucose Disposal in Conscious Dogs. European Journal of Pharmacology 607(1-3):251-257, 2009 (PMID: 19326481)

13. An Z, DiCostanzo CA, Moore MC, Edgerton DS, Dardevet DP, Neal DW, Cherrington AD: Effects of the Nitric Oxide Donor SIN-1 on Net Hepatic Glucose Uptake in the Conscious Dog. American Journal of Physiology 294(2):E300-306, 2008 (PMID: 18029444)

Titles & Appointments

  • Assistant Professor of Clinical Medicine

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