62443-Tharp, Jeffery

Jeffery M. Tharp, PhD

Assistant Professor of Biochemistry & Molecular Biology

(317) 274-1520
MS 406E
Indianapolis, IN
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Dr. Tharp received his PhD in Chemistry from Texas A&M University in 2018. As a graduate student, he developed technology to install unnatural amino acids into phage-displayed peptide libraries, thereby expanding the utility of phage display for early-stage drug discovery. Dr. Tharp received post-doctoral training in the Department of Molecular Biophysics and Biochemistry at Yale University. As a post-doctoral fellow, his research focused on reprogramming protein synthesis in bacteria to produce genetically encoded biopolymers. Dr. Tharp joined the Department of Biochemistry and Molecular Biology at Indiana University School of Medicine as an Assistant Professor in 2022. Research in the Tharp laboratory is focused on using peptide display technology to identify novel therapeutic peptides. The laboratory is primarily focused on developing therapeutic peptides with anticancer and antiviral properties.  

Tharp Lab Website

Key Publications

J. T. Hampton*, T. J. Lalonde*, J. M. Tharp* Y. Kurra, Y. R. Alugubelli, C. M. Roundy, G. L. Hamer, S. Xu, W. R. Liu, A novel regioselective approach to cyclize phage-displayed peptides in combination with epitope-directed selection to identify a potent neutralizing macrocyclic peptide for SARS-CoV-2. bioRxiv 2022, doi.org/10.1101/2022.07.06.498864. [Link]

J. M. Tharp, O. Vargas-Rodriguez, A. Schepartz, D. Söll, Genetic encoding of three distinct noncanonical amino acids using reprogrammed initiator and nonsense codons. ACS Chem. Biol. 2021, 16 (4), 766–774. [Link]

J. M. Tharp*, J. T. Hampton*, C. A. Reed*, A. Ehnbom, P.-H. C. Chen, J. S. Morse, Y. Kurra, L. M. Pérez, S. Xu, W. R. Liu, An amber obligate active site-directed ligand evolution technique for phage display. Nat. Commun. 2020, 11, 1392. [Link]

J. M. Tharp, O. Ad, K. Amikura, F. R. Ward, E. M. Garcia, J. H. D. Cate, A. Schepartz, D. Söll, Initiation of protein synthesis with noncanonical amino acids in vivo. Angew. Chem. Int. Ed. 2020, 59 (8), 3122–3126. [Link]

* Denotes equal author contribution.

For a complete list of publications, visit PubMed.

Research Labs

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