Dr. Chen received her Ph.D. in Pharmacology from the Vanderbilt University in 2015, under the direction of Dr. Iverson and Dr. Gurevich. There, her research focused on the role of arrestins as key regulators in G protein coupled receptor (GPCR) signaling. Dr. Chen received post-doctoral training under Dr. John Tesmer first at the University of Michigan and then at the Purdue University. There, she studied the phosphorylation step in GPCR signaling pathway and determined the very first structure of a GPCR in complex with its kinase using cryo-electron microscopy (cryo-EM).
Dr. Chen joined the Department of Biochemistry and Molecular Biology at Indiana University School of Medicine in 2022. Her research group centers on mechanisms of GPCR signaling and the development of selective interventions. Her lab uses various structural tools including crystallography, EPR, fluorophore labeling and the cutting-edge cryo-EM.