Bio
Learn more about the Doles lab here!
Professional highlights:
- Vice Chair for Diversity, Equity and Inclusion, Department of Anatomy, Cell Biology and Physiology, IU School of Medicine; 2022-present
- Co-Director/Co-Founder, Leadership in PhD (LeaP) Program (Mayo Clinic); 2021-2022
- Assistant Dean of Diversity and Inclusion, Mayo Clinic Graduate School; 2020-2022
- Associate Program Director, Mayo Clinic Graduate School; 2020-2022
- Co-Leader, Mayo Clinic Post-Baccalaureate Research Education Program (PREP); 2016-2022
- Co-Leader, Mayo Clinic Initiative for Maximizing Student Development (IMSD); 2016-2022
LinkedIn: https://www.linkedin.com/in/jason-doles
Twitter: https://twitter.com/jdoles99
Key Publications
Primary research
Dasgupta A, Arneson-Wissink PC, Schmitt RE, Cho DS, Ducharme AM, Hogenson TL, Krueger EW, Bamlet WR, Zhang L, Razidlo GL, Fernandez-Zapico ME, Doles JD. Anti-cachectic regulator analysis reveals novel Perp-dependent anti-tumorigenic properties of 3-methyladenine in pancreatic cancer. JCI Insight. 2021 Dec 7:e153842. doi: 10.1172/jci.insight.153842.
Arneson-Wissink PC, Doles JD. Disrupted NOS2 metabolism drives myoblast response to wasting-associated cytokines. Exp Cell Res. 2021 Oct 1;407(1):112779. doi: 10.1016/j.yexcr.2021.112779.
Cho DS, Schmitt RE, Dasgupta A, Ducharme AM, Doles JD. Single cell deconstruction of post-sepsis skeletal muscle and adipose tissue microenvironments. Journal of Cachexia, Sarcopenia and Muscle 2020 Jul 8. doi: 10.1002/jcsm.12596.
Arneson PC, Hogan KA, Shin AS, Samani A, Jatoi A, Doles JD. The wasting-associated metabolite succinate disrupts myogenesis and impairs muscle regeneration. JCSM Rapid Communications. 2020 Jun 2. doi: 10.1002/rco2.14.
Arneson PC, Dusharme AM, Doles JD. A novel transplantable model of lung cancer associated tissue loss and disrupted muscle regeneration. Skeletal Muscle. 2020 Mar 9;10(1):6.
Cho DS, Lee B, Doles JD. Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue. Life Sci Alliance. 2019. Nov 25;2(6). pii. e201900561.
Joseph J, Cho DS, Doles JD. Metabolomic Analyses Reveal Extensive Progenitor Cell Deficiencies in a Mouse Model of Duchenne Muscular Dystrophy (2018). Metabolites. Oct 3;8(4). pii: E61. doi: 10.3390/metabo8040061.
Doles JD, Hogan KA, O'Connor J, Wahner Hendrickson AE, Huston O, Jatoi A. Does the Poly (ADP- Ribose) Polymerase Inhibitor Veliparib Merit Further Study for Cancer-Associated Weight Loss? Observations and Conclusions from Sixty Prospectively Treated Patients (2018). J Palliat Med. Sep;21(9):1334-1338. doi: 10.1089/jpm.2018.0023.
Tarrago MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN. A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD+ decline (2018). Cell Metab. May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet. 2018.03.016.
Hogan KA, Cho DS, Arneson P, Samani A, Palines P, Yang Y, Doles JD. Tumor- derived cytokines impair myogenesis and alter the skeletal muscle immune microenvironment (2017). Cytokine. Nov 16. pii: S1043-4666(17)30348-4. DOI: 10.1016/j.cyto.2017.11.006.
Cho DS, Doles JD. Single cell transcriptome analysis of muscle satellite cells reveals widespread transcriptional heterogeneity (2017). Gene. Sep 8. pii: S0378-1119(17)30723-0. DOI: 10.1016/j.gene.2017.09.014.
Reviews/commentaries/book chapters
Joseph J, Doles JD. Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook. Nutr Metab (Lond). 2021 Mar 25;18(1):33. doi: 10.1186/s12986-021-00565-0.
Arneson PC, Doles JD. Impaired Muscle Regeneration in Cancer-Associated Cachexia. Trends Cancer. 2019 Oct;5(10):579-582.
Cho DS, Doles JD. Skeletal Muscle Progenitor Cell Heterogeneity. Adv Exp Med Biol. 2019 Aug;1169:179-193.
Carr RM, Enriquez-Hesles E, Olson RL, Jatoi A, Doles J, Fernandez-Zapico ME. Epigenetics of cancer- associated muscle catabolism (2017). Epigenomics. Sep 25. DOI: 10.2217/epi-2017-0058.
STEM education/career development
Boehmer KR, Boschen De Souza SL, Doles JD, Lachman N, Mays D, Hedin KE, Dornink CA, Maher LJ and Lujan J (2021) Motivating Self-Efficacy in Diverse Biomedical Science Postbaccalaureate and Graduate Students Through Scientific Conference Implementation. Front. Educ. 6:774070. doi: 10.3389/feduc.2021.774070
Titles & Appointments
- Associate Professor of Anatomy, Cell Biology & Physiology
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Education
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Research
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Professional Organizations