60728-Tayeh, Marwan

Marwan K. Tayeh, PhD

Associate Professor of Clinical Medical & Molecular Genetics

Director, Diagnostic Genomics Laboratory

TK 222
Indianapolis, IN


Marwan Tayeh, PhD, has recently joined Indiana University to establish a Diagnostic Genomics Laboratory. Dr. Tayeh is currently the Director of the IU Diagnostic Genomics Laboratory, and an Associate Professor in the Department of Medical and Molecular Genetics at IU School of Medicine.

Dr. Tayeh has developed, throughout his career, a wide variety of high-throughput diagnostic assays, such as gene-centric comparative genomic hybridization arrays (aCGH), Methylation assays, and next generation sequencing, to help advancing clinical Molecular Genetics and Genomics testing. Dr. Tayeh has also developed bioinformatics tools to improve Next Generation Sequencing (NGS) data analysis, variant calling, and variant annotation for clinical testing and research purposes.

Key Publications

  1. Al-Alami JR, Tayeh MK, Al-Sheyyab MY, El-Shanti HI: Linkage analysis of a large inbred family with congenital megaloblastic Saudi Med J 10: 1251-6, 10/2002. PMID: 12436132
  2. Al-Alami JR, Tayeh MK, Najib DA, Abu-Rubaiha ZA, Majeed HA, Al-Khateeb MS, El-Shanti HI: Familial Mediterranean fever mutation frequencies and carrier rates among a mixed Arabic Saudi Med J 10: 1055-9, 10/2003. PMID: 14578967
  3. Fath MA, Mullins RF, Searby C, Nishimura DY, Wei J, Rahmouni K, Davis RE, Tayeh MK, Andrews M, Yang B, Sigmund CD, Stone EM, Sheffield VC: Mkks-null mice have a phenotype resembling Bardet- Biedl Hum Mol Genet 14(9): 1109-18, 05/2005. PMID: 15772095
  4. Majeed HA, El-Khateeb M, El-Shanti H, Abu Rabaiha ZA, Tayeh MK, Najib D: The spectrum of familial Mediterranean fever gene mutations in Arabs: report of a large Semin Arthritis Rheum 6: 813-818, 06/2005. PMID: 15942916
  5. Ferguson PJ, Chen S, Tayeh MK, Ochoa L, Leal SM, Pelet A, Munnich A, Lyonnet S, Majeed HA, El- Shanti H: Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome). J Med Genet 42 (7): 551-7, 07/2005. PMID: 15994876
  1. Al-Alami JR, Tanner SM, Tayeh MK, de la Chapelle A, El-Shanti H: Homozygous AMN mutation in hereditary selective intestinal malabsorption of vitamin B12 in Saudi Med J 26(7): 1061-4, 07/2005. PMID: 16047053
  1. Yen HJ*, Tayeh MK*, Mullins RF, Stone EM, Sheffield VC, Slusarski DC: Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia Hum Mol Genet 15 (5): 667-77, 03/2006. PMID: 16399798
  2. Chiang AP, Beck JS, Yen HJ, Tayeh MK, Scheetz TE, Swiderski RE, Nishimura DY, Braun TA, Kim KY, Huang J, Elbedour K, Carmi R, Slusarski DC, Casavant TL, Stone EM, Sheffield VC: Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Proc Natl Acad Sci U S A 103(16): 6287-92, 04/2006. PMID: 16606853
  3. Tayeh MK, Yen HJ, Beck JS, Searby CC, Westfall TA, Griesback H, Slusarski DC, Sheffield VC: Genetic interaction between Bardet-Biedl syndrome genes and implications for limb Hum Mol Genet 17 (13): 1956-1967, 07/2008. PMID: 18381349
  4. Ahram D, Sato TS, Kohilan A, Tayeh MK, Chen S, Leal S, Al-Salem M, El-Shanti H: A Homozygous Mutation in ADAMTSL4 Causes Autosomal Recessive Isolated Ectopia Lentis. A J Hum Genet 84: 274-278, 02/2009. PMID: 19200529
  5. Tayeh MK, Chin LH, Miller VR, Bean L, Coffee B, Hegde M: Targeted comparative genomic hybridization (CGH) array for the detection of single- and multi- exon gene deletions and duplications. Genet Med 11 (4): 232-240, 04/2009. PMID: 19282776
  6. Thomas M, Enciso V, Stratton R, Shah S, Winder T, Tayeh MK, Roeder E: Metastatic Medulloblastoma in an Adolescent with Simpson-Golabi-Behmel Syndrome. Am J Med Genet 158A(10): 2534-2536, 10/2012. PMID: 22893378
  7. Thorsson T, Russell WW, El-Kashlan N, Soemedi R, Levine J, Geisler SS, Ackley T, Tomita-Mitchell A, Rosenfeld JA, Topf A, Tayeh MK, Goodship J, Innis JW, Keavney B, Russell MW: Chromosomal imbalances in patients with congenital cardiac defects: a meta-analysis reveals novel potential critical regions involved in heart Congenit Heart Dis. 10(3): 208, 05/2015. PMID: 24720490
  8. Tayeh MK, Rocco T, Ackley T, Ernst L, Glover T, Innis JW: Nine de novo duplications affecting both maternal and paternal chromosomes and an inherited 15q11.2 deletion, in a patient with developmental Clin Case Rep 3(6): 396-401, 06/2015. PMID: 26185636
  9. Ajluni N, Meral R, Neidert AH, Brady GF, Buras E, McKenna B, DiPaola F, Chenevert TL, Horowitz JF, Buggs-Saxton C, Rupani AR, Thomas PE, Tayeh MK, Innis JW, Omary MB, Conjeevaram H, Oral EA: Spectrum of Disease Associated with Partial Lipodystrophy: Lessons from a Trial Cohort. Clinical Endocrinology 86(5): 698-707, 05/2017. PMID: 28199729
  10. Bernat JA, Hershenson MB, Innis JW, Tayeh MK: Compound heterozygosity for CFTR delF508/P750L in two siblings with normal sweat chloride, lung function, growth, and fecal elastase. The Journal of Pulmonary Medicine & Respiratory Research 3(10): 1-5, 06/2017. DOI: 24966/PMRR-0177/100010
  11. Hussain I, Patni N, Ueda M, Sorkina E, Cochran E, Brown RJ, Peeden J, Tikhonovich Y, Tiulpakov A, Stender SR, Klouda E, Tayeh MK, Innis JW, Balow J, Meyer A, Lal P, Adams-Huet B, Rader DJ, Hegele RA, Oral EA, Garg A: A Novel Generalized Lipodystrophy-associated Progeroid Syndrome due to recurrent heterozygous LMNA p.T10I Mutation. J Clin Endocrinol Metab 103(3): 1005-1014, 03/2018. PMID: 29267953
  12. Sahinoz M, Khairi S, Cuttita A, Brady GF, Rupani A, Meral R, Tayeh MK, Thomas P, Riebschleger M, Camelo-Piragua S, Innis JW, Omary MB, Michele D, Oral EA: Potential association of LMNA-associated generalized lipodystrophy with juvenile dermatomyositis. Clin Diabetes Endocrinol 4: 6, 03/2018. PMID: 29610677
  13. Riggs ER, Nelson T, Merz A, Ackley A, Bunke B, Collins CD, Collinson MN, Fan Y, Goodenberger ML, GoldenDM, Haglund-Hazy L, Krgovic D, Lamb AN, Lewis Z, Li G, Liu Y, Meck J, Neufeld-Kaiser W, Runke CR, Sanmann JN, Stavropoulos DJ, Strong E, Su M, Tayeh MK, Vokac NK, Thorland EC , Andersen E, Martin CL: Copy Number Variant Discrepancy Resolution Using the ClinGen Dosage Sensitivity Map Results in Updated Clinical Interpretations in ClinVar. Hum Mutat 39(11): 1650-1659, 11 /2018. PMID: 30095202
  14. del Gaudio D, Shinawi M, Astbury C, Tayeh MK, Deak KL, Raca G.: Diagnostic Testing for Uniparental Disomy, A Points to Consider Statement from the American College of Medical Genetics and Genomics (ACMG). Genet Med 22(7): 1133-1141, 07/2020. PMID: 32296163
  1. Noto FK, Sangodkar J, Adedeji BT, Moody S, McClain CB, Tong M, Ostertag E, Crawford J, Gao X, Hurst L, O'Connor CM, Hanson EN, Izadmehr S, Tohme R, Narla J, LeSueur K, Bhattachary K, Rupani A, Tayeh MK, Innis JW, Galsky MD, Mark Evers BM, DiFeo, A, Narla G, Jamling TY: The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology PLoS One 15(10): e0240169, 10/2020. PMID: 33027304
  1. Jalal Eldin A, Akinci B, da Rocha AM, Rasimcan M, Simsir IY, Adiyaman SC, Ozpelit E, Bhave N, Gen R, Yurekli B, Kutbay NO, Siklar Z, Neidert AH, Hench R, Tayeh MK, Innis JW, Jalife J, Oral H, Oral EA: Cardiac phenotype in familial partial lipodystrophy Clin Endocrinol (OXF) 94(6): 1043-1053, 02/2021. PMID: 33502018
  2. Akinci B, Subauste A, Ajluni N, Esfandiari NH, Meral R, Neidert AH, Eraslan A, Hench R, Rus D, Mckenna B, Hussain HK, Chenevert TL, Tayeh MK, Rupani AR, Innis JW, Mantzoros CS, Conjeevaram HS, Burant CL, Oral EA.: Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two /different clinical Med (N Y): 814-835, 07/2021. PMID: 35291351
  3. PMID: 35291351 Tayeh MK, Gaedigk A, Goetz MP, Klein TE, Lyon E, McMillin GA, Rentas S, Shinawi M, Pratt VM, Scott SA. Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG). Genet Med 24(4):759-768, 04/2022. PMID: 35177334
  4. Tayeh MK, DeVaul J, LeSueur K, Yang C, Bedoyan JK, Thomas P, Hannibal MC, Innis JW. Novel multilocus imprinting disturbances in a child with expressive language delay and intellectual disability. Am J Med Genet 188A: 2209-2216, 04/2022. PMID: 35365979

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