59881-Holla, Prasida
Faculty

Prasida Holla, PhD

Assistant Research Professor of Pediatrics

Address
R4 402
PIFB
IN
Indianapolis, IN

Bio

Dr Holla’s research focuses on understanding the correlates of protection in chronic infections, with a special focus on malaria in children. She developed an interest in malaria and B lymphocyte dysregulation during her postdoctoral work in Sue Pierce’s lab at the NIAID. Through collaborations with several malaria-focused groups at IU and the Pierce Lab at the NIAID, Dr. Holla aims at understanding how the interplay of innate and adaptive immune cell populations drives immunity to malaria.

Key Publications

1.    Ambegaonkar A*, Holla P*, Dizon B*, Sohn H and Pierce, SK. Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces. Curr Opin Immunol (in press) 
2.    Holla P, Dizon B, Ambegaonkar AA, Rogel N, Goldschmidt E, Boddapati AK, Sohn H, Sturdevant D, Austin JW, Kardava L, Yuesheng L, Liu P, Moir S, Pierce SK and Madi A. Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity. Sci Adv. 2021 May;7(22). PMID: 34039612
3.    Holla P*, Ambegaonkar A*, Sohn H, Pierce SK. Exhaustion may not be in the human B cell vocabulary, at least not in malaria. Immunol Rev. 2019 Nov;292(1):139-148. PubMed PMID: 31553065. 
4.    Holla P, Tran TM. Experience counts in the malaria response. Nat Immunol. 2021 May;22(5):537-539. PubMed PMID: 33888897. 
5.    Kwak K, Quizon N, Sohn H, Saniee A, Manzella-Lapeira J, Holla P, Brzostowski J, Lu J, Xie H, Xu C, Spillane KM, Tolar P, Pierce SK. Intrinsic properties of human germinal center B cells set antigen affinity thresholds. Sci Immunol. 2018 Nov 30;3(29) PubMed Central PMCID: PMC6314460. 
6.    Obeng-Adjei N, Portugal S, Holla P, Li S, Sohn H, Ambegaonkar A, Skinner J, Bowyer G, Doumbo OK, Traore B, Pierce SK, Crompton PD. Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells. PLoS Pathog. 2017 Sep 27;13(9):e1006576. PMID: 28953967; PMCID: PMC5633206.
*Shared first authorship

Titles & Appointments

  • Assistant Research Professor of Pediatrics
  • Education
    2014 PhD International Centre for Genetic Engineering and Biotechnology
    2009 MSC All India Institute of Medical Sciences
    2007 BSC University of Delhi
  • Research
    Malaria, Immunology, transcriptomics, B lymphocyte, B cell receptor (BCR) biology, autoimmunity

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