59877-Shahbazi, Reza

Reza Shahbazi, PhD

Assistant Professor of Medicine

Assistant Professor of Microbiology & Immunology

Adjunct Assistant Professor of Biochemistry & Molecular Biology

(317) 274-3590
R3 C321G
Indianapolis, IN
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Dr. Shahbazi is an Assistant Professor in the Department of Medicine, Division of Hematology/Oncology at Indiana University School of Medicine and joined as an active member of the Brown Center for Immunotherapy in 2021.

Dr. Reza Shahbazi earned his Ph.D. in Nanotechnology and Nanomedicine in 2017 from Hacettepe University, in Ankara, Turkey, where he worked on developing siRNA nanotherapeutics for triple negative breast cancer therapy. Then continued his research as a Postdoctoral Fellow in the field of Stem Cell Gene Editing at the Fred Hutchinson Cancer Research Center, in Seattle. During his Postdoc, Dr. Shahbazi worked on developing CRISPR nanoformulations for in vivo gene editing in hematopoietic stem cells and T cells as a cure for HIV, and beta thalassemia. His research in this field has received a lot of attention and broadcast from different media. Dr. Shahbazi is an active member of the American Society of Gene & Cell Therapy (ASGCT) and has received a meritorious award from the society. His scientific work has resulted in multiple patents that have been licensed. 

Key Publications

Shahbazi R., Sghia-Hughes G., Reid J.L., Kubek S., Haworth K.G., Humbert O., Kiem H.P., Adair J.E., Targeted Homology-Directed Repair in Blood Stem and Progenitor Cells with CRISPR Nanoformulations. Nature Materials, (2019); 18(10): 1124-1132. PMID: 31133730

Adair J.E., Enstrom M.R., Haworth K.G., Schefter L.E., Shahbazi R., Humphrys D.R., Porter S., Tam K., Porteus M.H., Kiem H.P., DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis. Molecular Therapy Methods & Clinical Development, (2020); 17: 796-809. PMID: 32355868

Shahbazi R., Ozpolat B., Ulubayram K. Oligonucleotide Based Theranostic Nanoparticles in Cancer Therapy. Nanomedicine, (2016); 11(10): 1287-1308. PMID: 27102380

Shahbazi R., Asik E., Kahraman N., Turk M., Ozpolat B., Ulubayram K. Modified Gold based siRNA Nanotherapeutics for Targeted Therapy of Triple Negative Breast Cancer. Nanomedicine, (2017), 12(16): 1961-1973. PMID: 28745127

Shahbazi R., Ozcicek I., Ozturk G., Ulubayram K. Functionalized Gold Nanoparticles Manifested As Potent Carriers For Nucleolar Targeting. Nanotechnology, (2017); 28(2): 025103. PMID: 27924783

Arslan M., Shahbazi R., Ulubayram K., Ozpolat B., Targeted Therapies for Pancreatic Cancer and Hurdles Ahead. Anticancer Research, (2018); 38(12): 6591-6606. PMID: 30504367

Sen G.T., Ozkemahli G., Shahbazi R., Erkekoglu P., Ulubayram K., Gumusel B.K., The Effects of Polymer Coating of Gold Nanoparticles on Oxidative Stress and DNA Damage. International Journal of Toxicology, (2020); 39(4): 328-340. PMID: 32483993

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