59760-Yuan, Xue

Xue Yuan, PhD

Assistant Professor of Otolaryngology-Head & Neck Surgery

Glick 305T

Indianapolis, IN
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Xue Yuan, PhD, joined Indiana University School of Medicine faculty in 2021 after completing Postdoctoral training in the Department of Surgery at Stanford University.

Dr. Yuan recently received funding from the National Institute of Dental and Craniofacial Research (NIDCR) and is leading research projects to investigate oral epithelial stem cells and head and neck cancers.

Dr. Yuan is most interested to identify adult stem cells because these cells are critical regenerative precursors in the context of wound repair. As stem cells age, their functional ability also deteriorates and reflects as the decline of tissue regenerative ability. In another way, abnormal hyperactive stem cells are considered a high-risk factor for cancer, as they have tumorigenic potential. Therefore, she believes studies of adult stem cells and their regulatory mechanisms hold the promise for therapeutic intervention in regenerative medicine, aging, and cancer. 

Key Publications

Yuan X, Chen J, Gauer J, Xu Q, Van Brunt L, Helms J. "The junctional epithelium is maintained by a stem cell population ". Journal of Dental Research, 2021, 100 (2), 209-216. (Cover)

Yuan X, Chen J, Van Brunt L, Grauer J, Xu Q, Pei X, Wang L, Zhao Y, and Helms J. "Formation and regeneration of a Wnt-responsive junctional epithelium". Journal of Clinical Periodontology, 2020, 47(12), 1476-1484.

Yuan X, Xu Q, Zhang X, Van Brunt L, Ticha P, Helms J. “Regulation of stem cell fate in the oral mucosa by Wnt.” iScience, 2019, 21: 84-94.

Yuan X, Pei X, Zhao Y, Tulu S, Liu B, Helms J. "A Wnt-Responsive PDL Population Effectuates Extraction Socket Healing." Journal of dental research, 2018, 97(7), 803-809.

Yuan X, Cao J, He X, Serra R, Qu J, Cao X, Yang S. "Ciliary IFT80 balances canonical versus non-canonical hedgehog signaling for osteoblast differentiation." Nature Communications 7 (2016).

Titles & Appointments

  • Assistant Professor of Otolaryngology-Head & Neck Surgery
  • Education
    2015 PhD State University of New York at Buffalo
    2009 MS China Pharmaceutical University
    2007 BS China Pharmaceutical University
  • Research

    Oral epithelial stem cell identification, stem cell niche, and stem cell aging

    Head and neck cancer and cancer stem cells

    Periodontium development and periodontitis

    Regenerative medicine and stem cell-based tissue engineering

  • Publications
    Dynamic analyses of a soft tissue-implant interface: Biological responses to immediate versus delayed dental implants.
    Aellos F; Grauer JA; Harder KG; Dworan JS; Fabbri G; Cuevas PL; Yuan X; Liu B; Brunski JB; Helms JA; Journal of clinical periodontology 2024 May 6
    Immediate but Temporal Response: The Role of Distal Epithelial Cells in Wound Healing.
    Thompson T; Flanagan S; Ortega-Gonzalez D; Zhu T; Yuan X; Stem cell reviews and reports 2024 May 17
  • Awards
    Org: International Association for Dental Research (IADR)
    Desc: 2nd Place of Joseph Lister Award
    Scope: International
    Org: American Association for Dental Research (AADR)
    Desc: 1st Place of Joseph Lister Award
    Scope: National
    Org: American Association for Dental Research (AADR)
    Desc: 1st Place of NSRG Dentsply Sirona Restorative Competition
    Scope: National
    Org: University at Buffalo, Dental School
    Desc: James English Research Award for Ph.D. Students
    Scope: School
    Org: American Society for Bone and Mineral Research (ASBMR)
    Desc: Young Investigator Award
    Scope: National
    Org: University at Buffalo, Dental School
    Desc: Excellence in Post-Graduate Research Award
    Scope: School

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