Amol P. Yadav, PhD

Bio

Amol Yadav, PhD is an Assistant Professor in the Department of Neurological Surgery at Indiana University School of Medicine. He runs the Brain-Spine-Machine Interfaces lab located at the IU Neuroscience Center.

Dr. Yadav completed his PhD in the Dept. of Biomedical Engineering at Duke University under the mentorship of Dr. Miguel Nicolelis - known for his expertise in brain-machine interfaces. In graduate school, Dr. Yadav specialized in neural engineering and developed methods for chronic spinal cord stimulation in rodent models of Parkinson's disease and refractory epilpepsy. During his postdoctoral training, he conducted research in non-human primates and rodents and developed techniques such as closed-loop spinal cord stimulation, brain-spine interfaces, and sensory neuroprosthetics. Prior to joining IU, he worked with surgeons at Duke Neurosurgery to obtain training in clinical translation and developed hardware-software tools for translation of his work in patients.

Yadav Lab Website

Key Publications

Yadav, A.P., Li, S., Krucoff, M.O., Lebedev, M., Abd-El-Barr, M., Nicolelis, M.A.L. (2021) Generating artificial sensations with spinal cord stimulation in primates and rodents. Brain Stimulation,14, 4, doi: https://doi.org/10.1016/j.brs.2021.04.024

Yadav, A.P., Li, D., Nicolelis, M.A.L. (2020), A brain to spine interface for transferring articial sensory information. Scientific Reports, 10, 900, doi: https://doi.org/10.1038/s41598-020-57617-3

Yadav, A.P. and Nicolelis, M. A. L. (2017), Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease. Movement Disorders, 32: 820-832, doi: https://doi.org/10.1002/mds.27033

Titles & Appointments

Assistant Professor of Neurological Surgery

Education

2015 PhD Duke University

2010 MS Duke University

2008 BE University of Mumbai
Research

The brain and the spinal cord constitute a closed-loop sensorimotor system. Injuries or neurological disorders of the nervous system disrupt this closed-loop adaptive system. The Yadav Lab develops novel neuroengineering technologies such as brain-spine-machine interfaces and closed-loop neuromodulation techniques to restore the disrupted brain-spine connection. We use electrophysiological recordings from multiple brain areas, electrical stimulation of the spinal cord, and machine learning-based algorithms to develop therapies to treat neurological disorders. We test our methods in rodent models and in collaboration with neurosurgeons and clinicians conduct pilot studies in human subjects. Our goal is to achieve clinical translation of lab-based neural engineering technologies and provide therapies to patients affected by Parkinson's disease, spinal cord injury, amputation, stroke, and other neurological disorders.

Interests: brain-spine-machine interfaces, neuroprosthetics, spinal cord stimulation, deep brain stimulation, closed-loop control, Parkinson's disease, spinal cord injury

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