51902-Johnson, Travis

Travis S. Johnson, PhD

Agnes Beaudry Investigator in Myeloma Research

HITS 3000
Indianapolis, IN
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Key Publications

Liu, Y., Wang, T., Duggan, B., Huang, K., Zhang, J., Ye, X., Johnson, T.S. (2022). SPCS: A Spatial and Pattern Combined Smoothing Method for Spatial Transcriptomics Expression. Briefings in Bioinformatics.
Sharpnack, M. F.*, Johnson, T. S.*, Chalkley, R., Han, Z., Carbone, D., Huang, K., He, K. (2022). TSAFinder: Exhaustive Tumor Specific Antigen Detection with RNAseq. Bioinformatics.
Johnson, T. S., Christina, Y. Y., Huang, Z., Xu, S., Wang, T., Dong, C., ... & Zhang, Y. (2022). Diagnostic Evidence GAuge of Single cells (DEGAS): A flexible deep-transfer learning framework for prioritizing cells in relation to disease. Genome Medicine,14(1), 1-23.
Huang, X., Huang, K., Johnson, T., Radovich, M., Zhang, J., Ma, J., & Wang, Y. (2021). ParsVNN: parsimony visible neural networks for uncovering cancer-specific and drug-sensitive genes and pathways. NAR Genomics and Bioinformatics3(4), lqab097.
Xu, C., Sun, S., Johnson, T., Qi, R., Zhang, S., Zhang, J., & Yang, K. (2021). The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Cell Reports35(11), 109235.
Wang, T., Johnson, T. S., Shao, W., Lu, Z., Helm, B. R., Zhang, J., & Huang, K. (2019). BERMUDA: a novel deep transfer learning method for single-cell RNA sequencing batch correction reveals hidden high-resolution cellular subtypes. Genome Biology20(1), 1-15.
Johnson, T.S., Wang, T., Huang, Z., Yu, C.Y., Wu, Y., Han, Y., Zhang, Y., Huang, K., Zhang, J. (2019). LAmbDA: Label Ambiguous Domain Adaptation Dataset Integration Reduces Batch Effects and Improves Subtype Detection. Bioinformatics, 35(22), 4696-4706.
Johnson, T.S.
, Li, S., Franz, E., Huang, Z., Li, S.D., Campbell, M.J., Huang, K., Zhang, Y. (2019). PseudoFuN: Deriving functional potentials of pseudogenes from integrative relationships with genes and microRNAs across 32 cancers. Gigascience, 8(5), giz046.

Titles & Appointments

  • Agnes Beaudry Investigator in Myeloma Research
  • Assistant Professor of Biostatistics & Health Data Science
  • Education
    2020 PhD The Ohio State University
    2016 MSPH The Ohio State University
    2015 AS Community College of the Air Force
    2014 BS Ohio University
  • Research

    I am a researcher working at the intersection of data science, medicine, and genetics. My research is focused both on methods development for omics data and collaborative applied omics data analysis. My group develops and applies novel machine learning techniques to single cell RNA sequencing, spatial transcriptomics, bulk RNA sequencing, and multi-omic data. Over the past few years, we have focused on the subfield of machine learning called transfer learning that is used to impart knowledge from one dataset to another. By combining multiple disparate datasets, new insights can be derived and the relative strengths of different datasets harnessed. These projects focus on a wide range of diseases, including diabetes, Alzheimer's disease, breast cancer, and multiple myeloma.

    Aside from methods development, we collaborate with groups at Indiana University School of Medicine, Indiana Biosciences Research Institute, and Eli Lilly and Company by providing bioinformatics and data science support. Vast quantities of cutting-edge biomedical data are being generated in the Indianapolis area and frequently require industry-academic partnerships to generate, access, and identify relevant problems to solve. For these reasons, I believe it is imperative to work in a team science setting of diverse contributors, including clinicians, bench scientists, informaticians, data scientists, and industry partners.
  • Professional Organizations
    American Society of Hematology
    American Society of Human Genetics
    Indiana University Melvin and Bren Simon Comprehensive Cancer Center
    Institute of Electrical and Electronics Engineers
    International Society for Computational Biology
  • Awards
    Org: American Cancer Society
    Desc: Institutional Research Grant
    Scope: National
    Date: 2022-01-01
    Org: Multiple Myeloma Research Foundation
    Desc: Research Fellow Award
    Scope: International
    Date: 2021-12-01
    Org: National Institutes of Health National Library of Medicine
    Desc: National Research Service Award Individual Fellowship (F31)
    Scope: National
    Date: 2019-03-01
    Org: The Ohio State University
    Desc: Multi-Modeling and Integrative Data Analytics Departmental Fellowship (T15)
    Scope: University
    Date: 2016-05-01

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