Tatsuyoshi Kono, PhD, MSC, BSC

Faculty

Tatsuyoshi Kono, PhD, MSC, BSC

Assistant Research Professor of Pediatrics

Phone (317) 278-9517

Address

VanNuys Med Sci Bldg, Suite 2021
635 Barnhill Dr
MS 2021
Indianapolis, IN 46202-5120

Titles & Appointments

Assistant Research Professor of Pediatrics

Education

2007 PhD Tohoku University

2004 MSC Tohoku University

2002 BSC Tohoku University
Publications

Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic ß cell.
Yamamoto WR; Bone RN; Sohn P; Syed F; Reissaus CA; Mosley AL; Wijeratne AB; True JD; Tong X; Kono T; Evans-Molina C; The Journal of biological chemistry 2018 Nov 12

Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic ß-Cell.
Kono T; Tong X; Taleb S; Bone RN; Iida H; Lee CC; Sohn P; Gilon P; Roe MW; Evans-Molina C; 2018 Aug 21

MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells.
Sims EK; Lakhter AJ; Anderson-Baucum E; Kono T; Tong X; Evans-Molina C; 2017 Mar 9

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation.
Hatanaka M; Anderson-Baucum E; Lakhter A; Kono T; Maier B; Tersey SA; Tanizawa Y; Evans-Molina C; Mirmira RG; Sims EK; 2017 Jun 19

SERCA2 Deficiency Impairs Pancreatic ß-Cell Function in Response to Diet-Induced Obesity.
Tong X; Kono T; Anderson-Baucum EK; Yamamoto W; Gilon P; Lebeche D; Day RN; Shull GE; Evans-Molina C; 2016 Aug 3

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells.
Xiong X; Wang G; Tao R; Wu P; Kono T; Li K; Ding WX; Tong X; Tersey SA; Harris RA; Mirmira RG; Evans-Molina C; Dong XC; Diabetologia 2015 Oct 15

Nitric oxide stress and activation of AMP-activated protein kinase impair ß-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability.
Tong X; Kono T; Evans-Molina C; Cell death & disease 2015 Jun 18

Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet ß cell.
Johnson JS; Kono T; Tong X; Yamamoto WR; Zarain-Herzberg A; Merrins MJ; Satin LS; Gilon P; Evans-Molina C; The Journal of biological chemistry 2014 Sep 30

Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats.
Blue EK; Ballman K; Boyle F; Oh E; Kono T; Quinney SK; Thurmond DC; Evans-Molina C; Haneline LS; Pediatric research 2014 Nov 20

Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors.
Kono TM; Sims EK; Moss DR; Yamamoto W; Ahn G; Diamond J; Tong X; Day KH; Territo PR; Hanenberg H; Traktuev DO; March KL; Evans-Molina C; Stem cells (Dayton, Ohio) 2014 Jul

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains.
Sims EK; Hatanaka M; Morris DL; Tersey SA; Kono T; Chaudry ZZ; Day KH; Moss DR; Stull ND; Mirmira RG; Evans-Molina C; American journal of physiology. Endocrinology and metabolism 2013 Oct 29

Streptozotocin is equally diabetogenic whether administered to fed or fasted mice.
Chaudhry ZZ; Morris DL; Moss DR; Sims EK; Chiong Y; Kono T; Evans-Molina C; Laboratory animals 2013 Jun 10

Thyroid hormone analogues for the treatment of metabolic disorders: new potential for unmet clinical needs?
Shoemaker TJ; Kono T; Mariash CN; Evans-Molina C; Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2012 Nov

PPAR-? activation restores pancreatic islet SERCA2 levels and prevents ß-cell dysfunction under conditions of hyperglycemic and cytokine stress.
Kono T; Ahn G; Moss DR; Gann L; Zarain-Herzberg A; Nishiki Y; Fueger PT; Ogihara T; Evans-Molina C; Molecular endocrinology (Baltimore, Md.) 2012 Jan 12

The role of peroxisome proliferator-activated receptor ? in pancreatic ß cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus.
Gupta D; Kono T; Evans-Molina C; Diabetes, obesity & metabolism 2010 Dec

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.
Evans-Molina C; Robbins RD; Kono T; Tersey SA; Vestermark GL; Nunemaker CS; Garmey JC; Deering TG; Keller SR; Maier B; Mirmira RG; Molecular and cellular biology 2009 Feb 23

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