Tatsuyoshi Kono, MSC, PhD

Faculty

Tatsuyoshi Kono, MSC, PhD

Assistant Research Professor of Pediatrics

Phone (317) 278-9517

Address

VanNuys Med Sci Bldg, Suite 2021
635 Barnhill Dr
MS 2021
Indianapolis, IN 46202-5120

Titles & Appointments

Assistant Research Professor of Pediatrics

Education

2007 PhD Tohoku University

2004 MSC Tohoku University

2002 BSC Tohoku University
Publications

Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion.
Yan S; Conley JM; Reilly AM; Stull ND; Abhyankar SD; Ericsson AC; Kono T; Molosh AI; Kubal CA; Evans-Molina C; Ren H; Cell reports 2022 Jan 4

Cigarette smoke exposure impairs ß-cell function through activation of oxidative stress and ceramide accumulation.
Tong X; Chaudhry Z; Lee CC; Bone RN; Kanojia S; Maddatu J; Sohn P; Weaver SA; Robertson MA; Petrache I; Evans-Molina C; Kono T; Molecular metabolism 2020 Mar 13

Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic ß cell.
Yamamoto WR; Bone RN; Sohn P; Syed F; Reissaus CA; Mosley AL; Wijeratne AB; True JD; Tong X; Kono T; Evans-Molina C; The Journal of biological chemistry 2018 Nov 12

Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic ß-Cell.
Kono T; Tong X; Taleb S; Bone RN; Iida H; Lee CC; Sohn P; Gilon P; Roe MW; Evans-Molina C; 2018 Aug 21

MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells.
Sims EK; Lakhter AJ; Anderson-Baucum E; Kono T; Tong X; Evans-Molina C; 2017 Mar 9

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation.
Hatanaka M; Anderson-Baucum E; Lakhter A; Kono T; Maier B; Tersey SA; Tanizawa Y; Evans-Molina C; Mirmira RG; Sims EK; 2017 Jun 19

SERCA2 Deficiency Impairs Pancreatic ß-Cell Function in Response to Diet-Induced Obesity.
Tong X; Kono T; Anderson-Baucum EK; Yamamoto W; Gilon P; Lebeche D; Day RN; Shull GE; Evans-Molina C; 2016 Aug 3

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells.
Xiong X; Wang G; Tao R; Wu P; Kono T; Li K; Ding WX; Tong X; Tersey SA; Harris RA; Mirmira RG; Evans-Molina C; Dong XC; Diabetologia 2015 Oct 15

Nitric oxide stress and activation of AMP-activated protein kinase impair ß-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability.
Tong X; Kono T; Evans-Molina C; Cell death & disease 2015 Jun 18

Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet ß cell.
Johnson JS; Kono T; Tong X; Yamamoto WR; Zarain-Herzberg A; Merrins MJ; Satin LS; Gilon P; Evans-Molina C; The Journal of biological chemistry 2014 Sep 30

Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats.
Blue EK; Ballman K; Boyle F; Oh E; Kono T; Quinney SK; Thurmond DC; Evans-Molina C; Haneline LS; Pediatric research 2014 Nov 20

Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors.
Kono TM; Sims EK; Moss DR; Yamamoto W; Ahn G; Diamond J; Tong X; Day KH; Territo PR; Hanenberg H; Traktuev DO; March KL; Evans-Molina C; Stem cells (Dayton, Ohio) 2014 Jul

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains.
Sims EK; Hatanaka M; Morris DL; Tersey SA; Kono T; Chaudry ZZ; Day KH; Moss DR; Stull ND; Mirmira RG; Evans-Molina C; American journal of physiology. Endocrinology and metabolism 2013 Oct 29

Streptozotocin is equally diabetogenic whether administered to fed or fasted mice.
Chaudhry ZZ; Morris DL; Moss DR; Sims EK; Chiong Y; Kono T; Evans-Molina C; Laboratory animals 2013 Jun 10

Thyroid hormone analogues for the treatment of metabolic disorders: new potential for unmet clinical needs?
Shoemaker TJ; Kono T; Mariash CN; Evans-Molina C; Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2012 Nov

PPAR-? activation restores pancreatic islet SERCA2 levels and prevents ß-cell dysfunction under conditions of hyperglycemic and cytokine stress.
Kono T; Ahn G; Moss DR; Gann L; Zarain-Herzberg A; Nishiki Y; Fueger PT; Ogihara T; Evans-Molina C; Molecular endocrinology (Baltimore, Md.) 2012 Jan 12

The role of peroxisome proliferator-activated receptor ? in pancreatic ß cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus.
Gupta D; Kono T; Evans-Molina C; Diabetes, obesity & metabolism 2010 Dec

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.
Evans-Molina C; Robbins RD; Kono T; Tersey SA; Vestermark GL; Nunemaker CS; Garmey JC; Deering TG; Keller SR; Maier B; Mirmira RG; Molecular and cellular biology 2009 Feb 23

Store and recoil of elastic energy in slow and fast types of human skeletal muscles.
Bosco C; Tihanyi J; Komi PV; Fekete G; Apor P; Acta physiologica Scandinavica 1982 Dec

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