Tatsuyoshi Kono, PhD
Associate Research Professor of Pediatrics
- Phone
- (317) 278-9517
- Address
-
VanNuys Med Sci Bldg, Suite 2021
635 Barnhill Dr
MS 2021
Indianapolis, IN 46202-5120 - PubMed:
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Bio
Dr. Tatsuyoshi Kono is an Associate Professor in the Pediatrics Department at the Indiana University School of Medicine (IUSM). He earned his Ph.D. at Tohoku University in Japan and completed his postdoctoral training in basic diabetes research at IUSM. Since joining the Diabetes Research Center in 2008, Dr. Kono’s research has centered on understanding pathways that alter β cell function and survival under diabetic conditions.
To date, Dr. Kono has focused on defining the role of β cell endoplasmic reticulum (ER) calcium dyshomeostasis and key calcium regulatory proteins during the progression of diabetes. His research will identify important signaling pathways that synergistically regulate ER, mitochondrial, and Golgi calcium homeostasis and will define new mechanisms that regulate β cell function and health. One of Dr. Kono’s goals is to continue to provide an open environment for education and R&D as a leader in international collaboration in diabetes research.
Full publication list. https://www.researchgate.net/profile/Tatsuyoshi_Kono
Key Publications
*†Tong X, Chaudhry Z, Lee CC, Bone RN, Kanojia S, Maddatu J, Sohn P, Weaver SA, Robertson MA, Petrache I, Evans-Molina C, Kono T.
Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation. Mol Metab. 2020 Mar 13;37:100975. doi:10.1016/j.molmet.2020.100975. Link
*Kono T , Tong X, Taleb S, Bone RN, Iida H, Lee CC, Sohn P, Gilon P, Roe MW, Evans-Molina C.
Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β cell. Diabetes. 2018 Nov;67(11):2293-2304 https://pubmed.ncbi.nlm.nih.gov/30131394/
Year | Degree | Institution |
---|---|---|
2007 | PhD | Tohoku University |
2004 | MSC | Tohoku University |
2002 | BSC | Tohoku University |
Project 1. Effects of endoplasmic reticulum calcium pumps and channels on the pathogenesis of diabetes and role of the SERCA2b gene in β cell function
Project 2. SERCA2-mediated ER calcium homeostasis and insulin processing in mouse models of diabetes and tissues from human diabetics
Project 3. Role of store-operated calcium entry in the pathogenesis of diabetes
Project 4. Golgi calcium pumps and ryanodine receptor function in the pancreatic β cell
Project 5. Cigarette smoke exposure and impaired β-cell function
Yan S; Conley JM; Reilly AM; Stull ND; Abhyankar SD; Ericsson AC; Kono T; Molosh AI; Kubal CA; Evans-Molina C; Ren H; Cell reports 2022 Jan 4
Tong X; Chaudhry Z; Lee CC; Bone RN; Kanojia S; Maddatu J; Sohn P; Weaver SA; Robertson MA; Petrache I; Evans-Molina C; Kono T; Molecular metabolism 2020 Mar 13
Yamamoto WR; Bone RN; Sohn P; Syed F; Reissaus CA; Mosley AL; Wijeratne AB; True JD; Tong X; Kono T; Evans-Molina C; The Journal of biological chemistry 2018 Nov 12
Kono T; Tong X; Taleb S; Bone RN; Iida H; Lee CC; Sohn P; Gilon P; Roe MW; Evans-Molina C; 2018 Aug 21
Sims EK; Lakhter AJ; Anderson-Baucum E; Kono T; Tong X; Evans-Molina C; 2017 Mar 9
Hatanaka M; Anderson-Baucum E; Lakhter A; Kono T; Maier B; Tersey SA; Tanizawa Y; Evans-Molina C; Mirmira RG; Sims EK; 2017 Jun 19
Tong X; Kono T; Anderson-Baucum EK; Yamamoto W; Gilon P; Lebeche D; Day RN; Shull GE; Evans-Molina C; 2016 Aug 3
Xiong X; Wang G; Tao R; Wu P; Kono T; Li K; Ding WX; Tong X; Tersey SA; Harris RA; Mirmira RG; Evans-Molina C; Dong XC; Diabetologia 2015 Oct 15
Tong X; Kono T; Evans-Molina C; Cell death & disease 2015 Jun 18
Johnson JS; Kono T; Tong X; Yamamoto WR; Zarain-Herzberg A; Merrins MJ; Satin LS; Gilon P; Evans-Molina C; The Journal of biological chemistry 2014 Sep 30
Blue EK; Ballman K; Boyle F; Oh E; Kono T; Quinney SK; Thurmond DC; Evans-Molina C; Haneline LS; Pediatric research 2014 Nov 20
Kono TM; Sims EK; Moss DR; Yamamoto W; Ahn G; Diamond J; Tong X; Day KH; Territo PR; Hanenberg H; Traktuev DO; March KL; Evans-Molina C; Stem cells (Dayton, Ohio) 2014 Jul
Sims EK; Hatanaka M; Morris DL; Tersey SA; Kono T; Chaudry ZZ; Day KH; Moss DR; Stull ND; Mirmira RG; Evans-Molina C; American journal of physiology. Endocrinology and metabolism 2013 Oct 29
Chaudhry ZZ; Morris DL; Moss DR; Sims EK; Chiong Y; Kono T; Evans-Molina C; Laboratory animals 2013 Jun 10
Shoemaker TJ; Kono T; Mariash CN; Evans-Molina C; Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2012 Nov
Kono T; Ahn G; Moss DR; Gann L; Zarain-Herzberg A; Nishiki Y; Fueger PT; Ogihara T; Evans-Molina C; Molecular endocrinology (Baltimore, Md.) 2012 Jan 12
Gupta D; Kono T; Evans-Molina C; Diabetes, obesity & metabolism 2010 Dec
Evans-Molina C; Robbins RD; Kono T; Tersey SA; Vestermark GL; Nunemaker CS; Garmey JC; Deering TG; Keller SR; Maier B; Mirmira RG; Molecular and cellular biology 2009 Feb 23
Bosco C; Tihanyi J; Komi PV; Fekete G; Apor P; Acta physiologica Scandinavica 1982 Dec
Desc: Outstanding Paper Award
Scope: International
Date: 2019-05-01
Desc: Showalter Young Investigator Award
Scope: University
Date: 2018-02-01
Desc: NIH T32 Fellowship HL079995
Scope: National
Date: 2009-02-01