John J. Turchi, PhD
Tom and Julie Wood Family Foundation Professor of Lung Cancer Research
Professor of Medicine
Professor of Biochemistry & Molecular Biology
- Address
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Joseph E. Walther Hall, Room C562
980 W. Walnut St.
Indianapolis , IN 46202 - PubMed:
| Year | Degree | Institution |
|---|---|---|
| 1993 | Postdoctoral Training | University of Rochester, Rochester, NY |
| 1990 | PhD | University of Missouri |
| 1985 | BS | Clemson University |
Our research is focused on determining the molecular mechanism by which cisplatin imparts its efficacy. We are involved in the identification and development of agents that target specific proteins involved in cisplatin metabolism with the goal of enhancing cisplatin activity in tumors and cancer types that typically do not respond well to cisplatin. We are also involved in research geared towards understanding the interaction of cisplatin and ionizing radiation and how this treatment regimen influences DNA repair pathways. The goal of this research is to enhance the radiosensitization activity of cisplatin. Our final research goal addresses the identification of markers which are measures of chemotherapeutic responsiveness. In this project we employ proteomic analysis in a cisplatin resistant ovarian cancer model. Link to Turchi DNA Repair Lab
Small-Molecule Inhibitor Screen for DNA Repair Proteins.
Turchi JJ; VanderVere-Carozza PS; Methods in molecular biology (Clifton, N.J.) 2019
Turchi JJ; VanderVere-Carozza PS; Methods in molecular biology (Clifton, N.J.) 2019
Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells.
Keller EJ; Porter M; Garrett JE; Varie M; Wang H; Pollok KE; Turchi JJ; Zaleski JM; Dynlacht JR; Radiation research 2018 May 15
Keller EJ; Porter M; Garrett JE; Varie M; Wang H; Pollok KE; Turchi JJ; Zaleski JM; Dynlacht JR; Radiation research 2018 May 15
Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.
Gavande NS; VanderVere-Carozza P; Mishra AK; Vernon TL; Pawelczak KS; Turchi JJ; Journal of medicinal chemistry 2017 Sep 21
Gavande NS; VanderVere-Carozza P; Mishra AK; Vernon TL; Pawelczak KS; Turchi JJ; Journal of medicinal chemistry 2017 Sep 21
Modulating DNA Repair Pathways to Improve Precision Genome Engineering.
Pawelczak KS; Gavande NS; VanderVere-Carozza PS; Turchi JJ; ACS chemical biology 2017 Dec 20
Pawelczak KS; Gavande NS; VanderVere-Carozza PS; Turchi JJ; ACS chemical biology 2017 Dec 20
DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer.
Sears CR; Cooney SA; Chin-Sinex H; Mendonca MS; Turchi JJ; DNA repair 2016 Mar 3
Sears CR; Cooney SA; Chin-Sinex H; Mendonca MS; Turchi JJ; DNA repair 2016 Mar 3
DNA repair targeted therapy: The past or future of cancer treatment?
Gavande NS; VanderVere-Carozza PS; Hinshaw HD; Jalal SI; Sears CR; Pawelczak KS; Turchi JJ; Pharmacology & therapeutics 2016 Feb 16
Gavande NS; VanderVere-Carozza PS; Hinshaw HD; Jalal SI; Sears CR; Pawelczak KS; Turchi JJ; Pharmacology & therapeutics 2016 Feb 16
Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit.
Woods DS; Sears CR; Turchi JJ; PloS one 2015 May 15
Woods DS; Sears CR; Turchi JJ; PloS one 2015 May 15
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.
Fang F; Munck J; Tang J; Taverna P; Wang Y; Miller DF; Pilrose J; Choy G; Azab M; Pawelczak KS; VanderVere-Carozza P; Wagner M; Lyons J; Matei D; Turchi JJ; Nephew KP; Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Oct 14
Fang F; Munck J; Tang J; Taverna P; Wang Y; Miller DF; Pilrose J; Choy G; Azab M; Pawelczak KS; VanderVere-Carozza P; Wagner M; Lyons J; Matei D; Turchi JJ; Nephew KP; Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Oct 14
Testing the metal of ERCC2 in predicting the response to platinum-based therapy.
Turchi JJ; Woods DS; VanderVere-Carozza P; Cancer discovery 2014 Oct
Turchi JJ; Woods DS; VanderVere-Carozza P; Cancer discovery 2014 Oct
Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer.
Mishra AK; Dormi SS; Turchi AM; Woods DS; Turchi JJ; Biochemical pharmacology 2014 Nov 4
Mishra AK; Dormi SS; Turchi AM; Woods DS; Turchi JJ; Biochemical pharmacology 2014 Nov 4
Exploring a structural protein-drug interactome for new therapeutics in lung cancer.
Peng X; Wang F; Li L; Bum-Erdene K; Xu D; Wang B; Sinn AA; Pollok KE; Sandusky GE; Li L; Turchi JJ; Jalal SI; Meroueh SO; Molecular bioSystems 2014 Jan 9
Peng X; Wang F; Li L; Bum-Erdene K; Xu D; Wang B; Sinn AA; Pollok KE; Sandusky GE; Li L; Turchi JJ; Jalal SI; Meroueh SO; Molecular bioSystems 2014 Jan 9
Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma.
Xu J; Zeng LF; Shen W; Turchi JJ; Zhang ZY; Biochemical and biophysical research communications 2013 Sep 13
Xu J; Zeng LF; Shen W; Turchi JJ; Zhang ZY; Biochemical and biophysical research communications 2013 Sep 13
Extracellular tissue transglutaminase activates noncanonical NF-?B signaling and promotes metastasis in ovarian cancer.
Yakubov B; Chelladurai B; Schmitt J; Emerson R; Turchi JJ; Matei D; Neoplasia (New York, N.Y.) 2013 Jun
Yakubov B; Chelladurai B; Schmitt J; Emerson R; Turchi JJ; Matei D; Neoplasia (New York, N.Y.) 2013 Jun
Chemotherapy induced DNA damage response: convergence of drugs and pathways.
Woods D; Turchi JJ; Cancer biology & therapy 2013 Feb 4
Woods D; Turchi JJ; Cancer biology & therapy 2013 Feb 4
Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways.
Sears CR; Turchi JJ; The Journal of biological chemistry 2012 May 23
Sears CR; Turchi JJ; The Journal of biological chemistry 2012 May 23
DNA repair: from genome maintenance to biomarker and therapeutic target.
Jalal S; Earley JN; Turchi JJ; Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Sep 9
Jalal S; Earley JN; Turchi JJ; Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Sep 9
Identification of Mre11 as a target for heat radiosensitization.
Dynlacht JR; Batuello CN; Lopez JT; Kim KK; Turchi JJ; Radiation research 2011 Jun 23
Dynlacht JR; Batuello CN; Lopez JT; Kim KK; Turchi JJ; Radiation research 2011 Jun 23
Interrogation of nucleotide excision repair capacity: impact on platinum-based cancer therapy.
Earley JN; Turchi JJ; Antioxidants & redox signaling 2011 Jan 23
Earley JN; Turchi JJ; Antioxidants & redox signaling 2011 Jan 23
Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase.
Khanna M; Chelladurai B; Gavini A; Li L; Shao M; Courtney D; Turchi JJ; Matei D; Meroueh S; Molecular cancer therapeutics 2011 Feb 17
Khanna M; Chelladurai B; Gavini A; Li L; Shao M; Courtney D; Turchi JJ; Matei D; Meroueh S; Molecular cancer therapeutics 2011 Feb 17
Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin.
Neher TM; Bodenmiller D; Fitch RW; Jalal SI; Turchi JJ; Molecular cancer therapeutics 2011 Aug 16
Neher TM; Bodenmiller D; Fitch RW; Jalal SI; Turchi JJ; Molecular cancer therapeutics 2011 Aug 16
Identification of novel small molecule inhibitors of the XPA protein using in silico based screening.
Neher TM; Shuck SC; Liu JY; Zhang JT; Turchi JJ; ACS chemical biology 2010 Oct 15
Neher TM; Shuck SC; Liu JY; Zhang JT; Turchi JJ; ACS chemical biology 2010 Oct 15
Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair.
Pawelczak KS; Turchi JJ; DNA repair 2010 Mar 27
Pawelczak KS; Turchi JJ; DNA repair 2010 Mar 27
Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct.
Neher TM; Rechkunova NI; Lavrik OI; Turchi JJ; Biochemistry 2010 Feb 2
Neher TM; Rechkunova NI; Lavrik OI; Turchi JJ; Biochemistry 2010 Feb 2
Targeting the OB-Folds of Replication Protein A with Small Molecules.
Anciano Granadillo VJ; Earley JN; Shuck SC; Georgiadis MM; Fitch RW; Turchi JJ; Journal of nucleic acids 2010 Dec 6
Anciano Granadillo VJ; Earley JN; Shuck SC; Georgiadis MM; Fitch RW; Turchi JJ; Journal of nucleic acids 2010 Dec 6
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ.
Pawelczak KS; Bennett SM; Turchi JJ; Antioxidants & redox signaling 2010 Dec 2
Pawelczak KS; Bennett SM; Turchi JJ; Antioxidants & redox signaling 2010 Dec 2
Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function.
Shuck SC; Turchi JJ; Cancer research 2010 Apr 15
Shuck SC; Turchi JJ; Cancer research 2010 Apr 15
Molecular analysis of Ku redox regulation.
Bennett SM; Neher TM; Shatilla A; Turchi JJ; BMC molecular biology 2009 Aug 28
Bennett SM; Neher TM; Shatilla A; Turchi JJ; BMC molecular biology 2009 Aug 28
A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining.
Pawelczak KS; Turchi JJ; Nucleic acids research 2008 May 31
Pawelczak KS; Turchi JJ; Nucleic acids research 2008 May 31
Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology.
Shuck SC; Short EA; Turchi JJ; Cell research 2008 Jan
Shuck SC; Short EA; Turchi JJ; Cell research 2008 Jan
Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex.
Andrews BJ; Lehman JA; Turchi JJ; The Journal of biological chemistry 2006 Mar 13
Andrews BJ; Lehman JA; Turchi JJ; The Journal of biological chemistry 2006 Mar 13
Nitric oxide and cisplatin resistance: NO easy answers.
Turchi JJ; Proceedings of the National Academy of Sciences of the United States of America 2006 Mar 13
Turchi JJ; Proceedings of the National Academy of Sciences of the United States of America 2006 Mar 13
Org:
Desc: Trustee Teaching Award
Scope: University
Date: 2023-05-01
Desc: Trustee Teaching Award
Scope: University
Date: 2023-05-01
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