
Todd C. Skaar, PhD
Professor of Medicine
950 W Walnut St
R2 419
Indianapolis, IN 46202-5188
Bio
Dr. Skaar is a Professor of Medicine in the Division of Clinical Pharmacology at the Indiana University in Indianapolis, Indiana. He did his graduate work in nutrition at the University of Wisconsin and lactation physiology at the Pennsylvania State University, followed by a postdoc in breast cancer drug resistance at the Lombardi Cancer Center at Georgetown University. Since joining Indiana University, his research is focused on the discovery and implementation of genomic predictors of drug response. More specifically, his studies are focused on genetic variants in the ADME genes. The discovery studies are funded by two NIH grants focused on identifying genetic variants that are associated with clinical drug efficacy and toxicity. Those variants are followed up with laboratory functional studies to understand the mechanisms underlying their association. They also include studies to identify miRNAs that contribute to the drug-induced and developmental changes in hepatic drug metabolism. He also leads an NIH-funded pharmacogenomics implementation study. The goal is to identify and overcome the barriers to using pharmacogenomics to guide clinical drug therapy. The implementation studies include prospectively testing and using pharmacogenetic testing in clinical care. He currently serves as the Chair of the NIH-IGNITE (Implementing Genomics into Practice) network. He has co-authored several CPIC guidelines for using pharmacogenetics to guide clinical drug therapy.
Titles & Appointments
- Professor of Medicine
- Adjunct Professor of Pharmacology & Toxicology
- Adjunct Professor of Medical & Molecular Genetics
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Education1992 PhD Pennsylvania State University1988 MS University of Wisconsin1986 BS South Dakota State University
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Research
Identification of mechanisms in breast cancer cells and patients that alter their responsiveness to endocrine therapies. Dr. Skaar’s research is focused on the discovery and implementation of genomic predictors of drug response. The discovery studies include identifying genetic variants that are associated with clinical drug efficacy and toxicity. Those variants are followed up with laboratory functional studies to understand the mechanisms underlying their association. This also includes identifying miRNAs that contribute to the developmental changes in hepatic drug metabolism. The implementation studies include prospectively testing and using pharmacogenetic testing in clinical care.
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PublicationsImplementation of a Renal Precision Medicine Program: Clinician Attitudes and Acceptance.
Spiech KM; Tripathy PR; Woodcock AM; Sheth NA; Collins KS; Kannegolla K; Sinha AD; Sharfuddin AA; Pratt VM; Khalid M; Hains DS; Moe SM; Skaar TC; Moorthi RN; Eadon MT; Life (Basel, Switzerland) 2020 Mar 26Nephrotoxicity in a Patient With Inadequate Pain Control: Potential Role of Pharmacogenetic Testing for Cytochrome P450 2D6 and Apolipoprotein L1.
Tillman EM; Skaar TC; Eadon MT; Frontiers in pharmacology 2020 Jan 8Cost-effectiveness of CYP2C19-guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data.
Limdi NA; Cavallari LH; Lee CR; Hillegass WB; Holmes AM; Skaar TC; Pisu M; Dillon C; Beitelshees AL; Empey PE; Duarte JD; Diaby V; Gong Y; Johnson JA; Graves J; Garbett S; Zhou Z; Peterson JF; Implementing GeNomics In pracTicE (IGNITE) Network Pharmacogenetic Working Group (IGNITE-PGx).; The pharmacogenomics journal 2020 Feb 11Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders.
Rao X; Thapa KS; Chen AB; Lin H; Gao H; Reiter JL; Hargreaves KA; Ipe J; Lai D; Xuei X; Wang Y; Gu H; Kapoor M; Farris SP; Tischfield J; Foroud T; Goate AM; Skaar TC; Mayfield RD; Edenberg HJ; Liu Y; Molecular psychiatry 2019 Sep 2A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Hicks JK; Bishop JR; Gammal RS; Sangkuhl K; Bousman CA; Leeder JS; Llerena A; Mueller DJ; Ramsey LB; Scott SA; Skaar TC; Caudle KE; Klein TE; Gaedigk A; Clinical pharmacology and therapeutics 2019 Oct 30RegSNPs-intron: a computational framework for predicting pathogenic impact of intronic single nucleotide variants.
Lin H; Hargreaves KA; Li R; Reiter JL; Wang Y; Mort M; Cooper DN; Zhou Y; Zhang C; Eadon MT; Dolan ME; Ipe J; Skaar TC; Liu Y; Genome biology 2019 Nov 28Effects of <i>SLCO1B1</i> polymorphisms on plasma estrogen concentrations in women with breast cancer receiving aromatase inhibitors exemestane and letrozole.
Dempsey JM; Kidwell KM; Gersch CL; Pesch AM; Desta Z; Storniolo AM; Stearns V; Skaar TC; Hayes DF; Henry NL; Rae JM; Hertz DL; Pharmacogenomics 2019 JunAnalytical validity of a genotyping assay for use with personalized antihypertensive and chronic kidney disease therapy.
Collins KS; Pratt VM; Stansberry WM; Medeiros EB; Kannegolla K; Swart M; Skaar TC; Chapman AB; Decker BS; Moorthi RN; Eadon MT; Pharmacogenetics and genomics 2019 JanAnalytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology.
Swart M; Stansberry WM; Pratt VM; Medeiros EB; Kiel PJ; Shen F; Schneider BP; Skaar TC; The Journal of molecular diagnostics : JMD 2019 Feb 20Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers.
Collins KS; Metzger IF; Gufford BT; Lu JB; Medeiros EB; Pratt VM; Skaar TC; Desta Z; Drug metabolism and disposition: the biological fate of chemicals 2019 Dec 30Next generation MicroRNA sequencing to identify coronary artery disease patients at risk of recurrent myocardial infarction.
Kanuri SH; Ipe J; Kassab K; Gao H; Liu Y; Skaar TC; Kreutz RP; Atherosclerosis 2018 Oct 3Report of Confirmation of the rs7853758 and rs885004 Haplotype in SLC28A3.
Stansberry WM; Swart M; Medeiros EB; Skaar TC; Pratt VM; Genetic testing and molecular biomarkers 2018 Oct 23Qualitative study of system-level factors related to genomic implementation.
Zebrowski AM; Ellis DE; Barg FK; Sperber NR; Bernhardt BA; Denny JC; Dexter PR; Ginsburg GS; Horowitz CR; Johnson JA; Levy MA; Orlando LA; Pollin TI; Skaar TC; Kimmel SE; 2018 Nov 23Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Volpi S; Bult CJ; Chisholm RL; Deverka PA; Ginsburg GS; Jacob HJ; Kasapi M; McLeod HL; Roden DM; Williams MS; Green ED; Rodriguez LL; Aronson S; Cavallari LH; Denny JC; Dressler LG; Johnson JA; Klein TE; Leeder JS; Piquette-Miller M; Perera M; Rasmussen-Torvik LJ; Rehm HL; Ritchie MD; Skaar TC; Wagle N; Weinshilboum R; Weitzel KW; Wildin R; Wilson J; Manolio TA; Relling MV; 2018 Mar 30Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes.
Gufford BT; Robarge JD; Eadon MT; Gao H; Lin H; Liu Y; Desta Z; Skaar TC; Pharmacology research & perspectives 2018 Mar 26PASSPORT-seq: A Novel High-Throughput Bioassay to Functionally Test Polymorphisms in Micro-RNA Target Sites.
Ipe J; Collins KS; Hao Y; Gao H; Bhatia P; Gaedigk A; Liu Y; Skaar TC; Frontiers in genetics 2018 Jun 15Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes.
Numanagic I; Malikic S; Ford M; Qin X; Toji L; Radovich M; Skaar TC; Pratt VM; Berger B; Scherer S; Sahinalp SC; 2018 Feb 26CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart.
Skaar TC; Desta Z; Clinical pharmacology and therapeutics 2018 Feb 23Medication Exposure Patterns in Primary Care Patients Prescribed Pharmacogenetically Actionable Opioids.
Knisely MR; Carpenter JS; Broome ME; Holmes AM; Von Ah D; Skaar T; Draucker CB; Qualitative report (Online) 2018 Aug 7Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.
Burgess KS; Ipe J; Swart M; Metzger IF; Lu J; Gufford BT; Thong N; Desta Z; Gaedigk R; Pearce RE; Gaedigk A; Liu Y; Skaar TC; Clinical pharmacology and therapeutics 2017 Sep 27CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids.
Knisely MR; Carpenter JS; Draucker CB; Skaar T; Broome ME; Holmes AM; Von Ah D; 2017 Oct 7Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
Cavallari LH; Lee CR; Beitelshees AL; Cooper-DeHoff RM; Duarte JD; Voora D; Kimmel SE; McDonough CW; Gong Y; Dave CV; Pratt VM; Alestock TD; Anderson RD; Alsip J; Ardati AK; Brott BC; Brown L; Chumnumwat S; Clare-Salzler MJ; Coons JC; Denny JC; Dillon C; Elsey AR; Hamadeh IS; Harada S; Hillegass WB; Hines L; Horenstein RB; Howell LA; Jeng LJB; Kelemen MD; Lee YM; Magvanjav O; Montasser M; Nelson DR; Nutescu EA; Nwaba DC; Pakyz RE; Palmer K; Peterson JF; Pollin TI; Quinn AH; Robinson SW; Schub J; Skaar TC; Smith DM; Sriramoju VB; Starostik P; Stys TP; Stevenson JM; Varunok N; Vesely MR; Wake DT; Weck KE; Weitzel KW; Wilke RA; Willig J; Zhao RY; Kreutz RP; Stouffer GA; Empey PE; Limdi NA; Shuldiner AR; Winterstein AG; Johnson JA; IGNITE Network.; JACC. Cardiovascular interventions 2017 Oct 25Common genetic polymorphisms of adenosine A2A receptor do not influence response to regadenoson.
Berlacher M; Mastouri R; Philips S; Skaar TC; Kreutz RP; Pharmacogenomics 2017 Mar 30Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.
Eadon MT; Hause RJ; Stark AL; Cheng YH; Wheeler HE; Burgess KS; Benson EA; Cunningham PN; Bacallao RL; Dagher PC; Skaar TC; Dolan ME; International journal of molecular sciences 2017 Mar 18The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting.
Cavallari LH; Beitelshees AL; Blake KV; Dressler LG; Duarte JD; Elsey A; Eichmeyer JN; Empey PE; Franciosi JP; Hicks JK; Holmes AM; Jeng L; Lee CR; Lima JJ; Limdi NA; Modlin J; Obeng AO; Petry N; Pratt VM; Skaar TC; Tuteja S; Voora D; Wagner M; Weitzel KW; Wilke RA; Peterson JF; Johnson JA; Clinical and translational science 2017 Mar 14Adherence and Tolerability of Alzheimer's Disease Medications: A Pragmatic Randomized Trial.
Campbell NL; Perkins AJ; Gao S; Skaar TC; Li L; Hendrie HC; Fowler N; Callahan CM; Boustani MA; Journal of the American Geriatrics Society 2017 Mar 14Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients.
Hertz DL; Speth KA; Kidwell KM; Gersch CL; Desta Z; Storniolo AM; Stearns V; Skaar TC; Hayes DF; Henry NL; Rae JM; Breast cancer research and treatment 2017 Jun 22CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study.
Hertz DL; Kidwell KM; Hilsenbeck SG; Oesterreich S; Osborne CK; Philips S; Chenault C; Hartmaier RJ; Skaar TC; Sikora MJ; Rae JM; Breast cancer research and treatment 2017 Jul 20High-Throughput Assays to Assess the Functional Impact of Genetic Variants: A Road Towards Genomic-Driven Medicine.
Ipe J; Swart M; Burgess KS; Skaar TC; Clinical and translational science 2017 Feb 18Multi-site investigation of strategies for the implementation of CYP2C19 genotype-guided antiplatelet therapy.
Empey PE; Stevenson JM; Tuteja S; Weitzel KW; Angiolillo DJ; Beitelshees AL; Coons JC; Duarte JD; Franchi F; Jeng LJB; Johnson JA; Kreutz RP; Limdi NA; Maloney KA; Owusu Obeng A; Peterson JF; Petry N; Pratt VM; Rollini F; Scott SA; Skaar TC; Vesely MR; Stouffer GA; Wilke RA; Cavallari LH; Lee CR; IGNITE Network.; Clinical pharmacology and therapeutics 2017 Dec 26<i>In Vivo</i> siRNA Delivery and Rebound of Renal <i>LRP2</i> in Mice.
Eadon MT; Cheng YH; Hato T; Benson EA; Ipe J; Collins KS; De Luca T; El-Achkar TM; Bacallao RL; Skaar TC; Dagher PC; Journal of drug delivery 2017 Dec 20Implementation of a pharmacogenomics consult service to support the INGENIOUS trial.
Eadon MT; Desta Z; Levy KD; Decker BS; Pierson RC; Pratt VM; Callaghan JT; Rosenman MB; Carpenter JS; Holmes AM; McDonald CA; Benson EA; Patil AS; Vuppalanchi R; Gufford BT; Dave N; Robarge JD; Hyder MA; Haas DM; Kreutz RP; Dexter PR; Skaar TC; Flockhart DA; Clinical pharmacology and therapeutics 2016 Feb 6Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer.
Robarge JD; Desta Z; Nguyen AT; Li L; Hertz D; Rae JM; Hayes DF; Storniolo AM; Stearns V; Flockhart DA; Skaar TC; Henry NL; Breast cancer research and treatment 2016 Dec 9Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK; Sangkuhl K; Swen JJ; Ellingrod VL; Müller DJ; Shimoda K; Bishop JR; Kharasch ED; Skaar TC; Gaedigk A; Dunnenberger HM; Klein TE; Caudle KE; Stingl JC; Clinical pharmacology and therapeutics 2016 Dec 20Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer.
Hertz DL; Kidwell KM; Seewald NJ; Gersch CL; Desta Z; Flockhart DA; Storniolo AM; Stearns V; Skaar TC; Hayes DF; Henry NL; Rae JM; 2016 Aug 23Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study.
Benson EA; Skaar TC; Liu Y; Nephew KP; Matei D; PloS one 2015 Oct 20Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy.
Santa-Maria CA; Blackford A; Nguyen AT; Skaar TC; Philips S; Oesterreich S; Rae JM; Desta Z; Robarge J; Henry NL; Storniolo AM; Hayes DF; Blumenthal RS; Ouyang P; Post WS; Flockhart DA; Stearns V; Consortium on Breast Cancer Pharmacogenomics (COBRA); Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Oct 13Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover.
Oesterreich S; Henry NL; Kidwell KM; Van Poznak CH; Skaar TC; Dantzer J; Li L; Hangartner TN; Peacock M; Nguyen AT; Rae JM; Desta Z; Philips S; Storniolo AM; Stearns V; Hayes DF; Flockhart DA; Breast cancer research and treatment 2015 Nov 4AMPD1 polymorphism and response to regadenoson.
Saab R; Zouk AN; Mastouri R; Skaar TC; Philips S; Kreutz RP; Pharmacogenomics 2015 Nov 10Design and Synthesis of Norendoxifen Analogues with Dual Aromatase Inhibitory and Estrogen Receptor Modulatory Activities.
Lv W; Liu J; Skaar TC; Flockhart DA; Cushman M; Journal of medicinal chemistry 2015 Mar 9Considerations for the Utility of the CPIC Guideline for CYP2D6 Genotype and Codeine Therapy.
Crews KR; Caudle KE; Dunnenberger HM; Sadhasivam S; Skaar TC; Clinical chemistry 2015 Mar 13Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Hicks JK; Bishop JR; Sangkuhl K; Müller DJ; Ji Y; Leckband SG; Leeder JS; Graham RL; Chiulli DL; LLerena A; Skaar TC; Scott SA; Stingl JC; Klein TE; Caudle KE; Gaedigk A; Clinical Pharmacogenetics Implementation Consortium; Clinical pharmacology and therapeutics 2015 Jun 29Cypiripi: exact genotyping of CYP2D6 using high-throughput sequencing data.
Numanagic I; Malikic S; Pratt VM; Skaar TC; Flockhart DA; Sahinalp SC; Bioinformatics (Oxford, England) 2015 Jun 15A translational bioinformatic approach in identifying and validating an interaction between Vitamin A and CYP19A1.
Philips S; Zhou J; Li Z; Skaar TC; Li L; BMC genomics 2015 Jun 11A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice.
Eadon MT; Zhang H; Skaar TC; Hato T; Dagher PC; Gupta SK; Desta Z; Antiviral chemistry & chemotherapy 2015 Jul 30Genotyping concordance in DNA extracted from formalin-fixed paraffin embedded (FFPE) breast tumor and whole blood for pharmacogenetic analyses.
Hertz DL; Kidwell KM; Thibert JN; Gersch C; Regan MM; Skaar TC; Henry NL; Hayes DF; Van Poznak CH; Rae JM; Molecular oncology 2015 Jul 29FDA's draft guidance on laboratory-developed tests increases clinical and economic risk to adoption of pharmacogenetic testing.
Levy KD; Pratt VM; Skaar TC; Vance GH; Flockhart DA; Journal of clinical pharmacology 2015 JulCharacterization of hepatic enzyme activity in older adults with dementia: potential impact on personalizing pharmacotherapy.
Campbell NL; Skaar TC; Perkins AJ; Gao S; Li L; Khan BA; Boustani MA; Clinical interventions in aging 2015 Jan 14Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.
Lv W; Liu J; Skaar TC; O'Neill E; Yu G; Flockhart DA; Cushman M; Journal of medicinal chemistry 2015 Dec 24Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.
Burgess KS; Philips S; Benson EA; Desta Z; Gaedigk A; Gaedigk R; Segar MW; Liu Y; Skaar TC; Clinical pharmacology and therapeutics 2015 AugPooled Analysis of Six Pharmacologic and Nonpharmacologic Interventions for Vasomotor Symptoms.
Guthrie KA; LaCroix AZ; Ensrud KE; Joffe H; Newton KM; Reed SD; Caan B; Carpenter JS; Cohen LS; Freeman EW; Larson JC; Manson JE; Rexrode K; Skaar TC; Sternfeld B; Anderson GL; Obstetrics and gynecology 2015 AugGenome-wide discovery of drug-dependent human liver regulatory elements.
Smith RP; Eckalbar WL; Morrissey KM; Luizon MR; Hoffmann TJ; Sun X; Jones SL; Force Aldred S; Ramamoorthy A; Desta Z; Liu Y; Skaar TC; Trinklein ND; Giacomini KM; Ahituv N; PLoS genetics 2014 Oct 2Systematic review of sleep disorders in cancer patients: can the prevalence of sleep disorders be ascertained?
Otte JL; Carpenter JS; Manchanda S; Rand KL; Skaar TC; Weaver M; Chernyak Y; Zhong X; Igega C; Landis C; Cancer medicine 2014 Nov 30Prerequisites to implementing a pharmacogenomics program in a large health-care system.
Levy KD; Decker BS; Carpenter JS; Flockhart DA; Dexter PR; Desta Z; Skaar TC; Clinical pharmacology and therapeutics 2014 May 7Impact of CYP2D6 polymorphisms on clinical efficacy and tolerability of metoprolol tartrate.
Hamadeh IS; Langaee TY; Dwivedi R; Garcia S; Burkley BM; Skaar TC; Chapman AB; Gums JG; Turner ST; Gong Y; Cooper-DeHoff RM; Johnson JA; Clinical pharmacology and therapeutics 2014 Mar 17Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Crews KR; Gaedigk A; Dunnenberger HM; Leeder JS; Klein TE; Caudle KE; Haidar CE; Shen DD; Callaghan JT; Sadhasivam S; Prows CA; Kharasch ED; Skaar TC; Clinical Pharmacogenetics Implementation Consortium; Clinical pharmacology and therapeutics 2014 Jan 23Report of New Haplotype for ABCC2 Gene: rs17222723 and rs8187718 in cis.
Pratt VM; Beyer BN; Koller DL; Skaar TC; Flockhart DA; Levy KD; Vance GH; The Journal of molecular diagnostics : JMD 2014 Dec 29Incubation of whole blood at room temperature does not alter the plasma concentrations of microRNA-16 and -223.
Benson EA; Skaar TC; Drug metabolism and disposition: the biological fate of chemicals 2013 Jul 25The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration.
Haas DM; Dantzer J; Lehmann AS; Philips S; Skaar TC; McCormick CL; Hebbring SJ; Jung J; Li L; American journal of obstetrics and gynecology 2013 Jan 4Medication use in breast cancer survivors compared to midlife women.
Otte JL; Skaar TC; Wu J; Yu M; Ryker K; Burns DS; Carpenter JS; Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2013 Feb 10Regulation of microRNA expression by rifampin in human hepatocytes.
Ramamoorthy A; Liu Y; Philips S; Desta Z; Lin H; Goswami C; Gaedigk A; Li L; Flockhart DA; Skaar TC; Drug metabolism and disposition: the biological fate of chemicals 2013 Aug 9Histoplasma capsulatum preferentially induces IDO in the lung.
Hage CA; Horan DJ; Durkin M; Connolly P; Desta Z; Skaar TC; Knox KS; Wheat LJ; Medical mycology 2012 Nov 27Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes.
Philips S; Rae JM; Oesterreich S; Hayes DF; Stearns V; Henry NL; Storniolo AM; Flockhart DA; Skaar TC; Frontiers in pharmacology 2012 Mar 30In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4a expression.
Ramamoorthy A; Li L; Gaedigk A; Bradford LD; Benson EA; Flockhart DA; Skaar TC; Drug metabolism and disposition: the biological fate of chemicals 2012 Jan 9Alt Event Finder: a tool for extracting alternative splicing events from RNA-seq data.
Zhou A; Breese MR; Hao Y; Edenberg HJ; Li L; Skaar TC; Liu Y; BMC genomics 2012 Dec 17Functional characterization of a genetic polymorphism in the promoter of the ESR2 gene.
Philips S; Richter A; Oesterreich S; Rae JM; Flockhart DA; Perumal NB; Skaar TC; Hormones & cancer 2012 AprA modulated empirical Bayes model for identifying topological and temporal estrogen receptor a regulatory networks in breast cancer.
Shen C; Huang Y; Liu Y; Wang G; Zhao Y; Wang Z; Teng M; Wang Y; Flockhart DA; Skaar TC; Yan P; Nephew KP; Huang TH; Li L; BMC systems biology 2011 May 9Collection of human genomic DNA from neonates: a comparison between umbilical cord blood and buccal swabs.
Lehmann AS; Haas DM; McCormick CL; Skaar TC; Renbarger JL; American journal of obstetrics and gynecology 2011 Feb 16In silico identification of microRNAs predicted to regulate the drug metabolizing cytochrome P450 genes.
Ramamoorthy A; Skaar TC; Drug metabolism letters 2011 AprResequencing of the vascular endothelial growth factor promoter reveals haplotype structure and functional diversity.
Radovich M; Hancock BA; Kassem N; Mi D; Skaar TC; Schneider BP; Angiogenesis 2010 Jun 16Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays.
Ramamoorthy A; Flockhart DA; Hosono N; Kubo M; Nakamura Y; Skaar TC; Pharmacogenetics and genomics 2010 JulComposite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.
Borges S; Desta Z; Jin Y; Faouzi A; Robarge JD; Philips S; Nguyen A; Stearns V; Hayes D; Rae JM; Skaar TC; Flockhart DA; Li L; Journal of clinical pharmacology 2010 Jan 15Impact of proton pump inhibitors on the effectiveness of clopidogrel after coronary stent placement: the clopidogrel Medco outcomes study.
Kreutz RP; Stanek EJ; Aubert R; Yao J; Breall JA; Desta Z; Skaar TC; Teagarden JR; Frueh FW; Epstein RS; Flockhart DA; Pharmacotherapy 2010 AugIdentification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity.
Arefayene M; Philips S; Cao D; Mamidipalli S; Desta Z; Flockhart DA; Wilkes DS; Skaar TC; Pharmacogenetics and genomics 2009 JunEvaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion.
Carpenter JS; Yu M; Wu J; Von Ah D; Milata J; Otte JL; Johns S; Schneider B; Storniolo AM; Salomon R; Desta Z; Cao D; Jin Y; Philips S; Skaar TC; Menopause (New York, N.Y.) 2009 JulExploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes.
Schneider BP; Radovich M; Flockhart DA; Carpenter JS; Li L; Robarge JD; Storniolo AM; Hancock BA; Skaar TC; Sledge GW; Breast cancer research and treatment 2008 Sep 11Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy.
Jin Y; Hayes DF; Li L; Robarge JD; Skaar TC; Philips S; Nguyen A; Schott A; Hayden J; Lemler S; Storniolo AM; Flockhart DA; Stearns V; Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 Nov 17Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.
Lim YC; Li L; Desta Z; Zhao Q; Rae JM; Flockhart DA; Skaar TC; The Journal of pharmacology and experimental therapeutics 2006 May 11Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
Borges S; Desta Z; Li L; Skaar TC; Ward BA; Nguyen A; Jin Y; Storniolo AM; Nikoloff DM; Wu L; Hillman G; Hayes DF; Stearns V; Flockhart DA; Clinical pharmacology and therapeutics 2006 JulAnalysis of angiogenesis genes from paraffin-embedded breast tumor and lymph nodes.
Schneider BP; Skaar TC; Sledge GW; Badve S; Li L; Flockhart DA; Breast cancer research and treatment 2006 Feb 28