Kieren J. Mather, MD
Professor of Medicine
Kieren Mather, MD, is a Professor of Medicine in the Department of Internal Medicine at IU School of Medicine. His expertise is in diabetes mellitus and prediabetes, with research efforts ranging from diabetes prevention to metabolic physiology to diabetes treatment. His overarching focus is on the prevention of diabetes-related complications, particularly cardiovascular disease.
Gatch Hall, Suite 365 1120 W. Michigan St.
Indianapolis, IN 46202-5111
Titles & Appointments
- Adjunct Professor of Cellular & Integrative Physiology
Dr Mather is interested in prevention of diabetes-related complications, particularly diabetes-associated cardiovascular disease. This is reflected in three main avenues of investigation. First, he is involved in studies of diabetes prevention including the longstanding Diabetes Prevention Program Outcomes Study, and an ongoing study of methods to improve diabetes prevention by improving insulin production in prediabetes. Second, he is involved in studies of diabetes treatment, overall aimed at improving metabolic control and where possible assessing the effects of these interventions on diabetes complications. These studies include small local proof-of-principle studies, large multicenter NIH-sponsored clinical trials, and industry-sponsored clinical trials. Third, in partnership with Johnathan Tune, Adam Goodwill, and members of the Tune lab (Department of Cellular and Integrative Metabolism) he pursues studies of the effects of diabetes on cardiovascular disease, and effects of diabetes treatments on cardiovascular outcomes. This has included measurements of heart metabolism in vivo in humans and in large animal models, evaluating the integrated effects of metabolic regulators and diabetes treatments on cardiac function and metabolism.
We welcome your participation in these efforts. Please contact me at the above email address to explore your possible involvement.
Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation.
Depressive Symptoms, Antidepressant Medication Use, and Inflammatory Markers in the Diabetes Prevention Program.
Comparison of ß-Cell Function Between Overweight/Obese Adults and Adolescents Across the Spectrum of Glycemia.
Glucagon-Like Peptide 1 Receptor Activation Augments Cardiac Output and Improves Cardiac Efficiency in Obese Swine After Myocardial Infarction.
Effect of Long-Term Metformin and Lifestyle in the Diabetes Prevention Program and Its Outcome Study on Coronary Artery Calcium.
The Confusion Assessment Method for the ICU-7 Delirium Severity Scale: A Novel Delirium Severity Instrument for Use in the ICU.
Review of methods for measuring ß-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium.
Erratum to: "Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the diabetes prevention program" [Metabolism (2016) 65; 764-775].
Retinopathy predicts progression of fasting plasma glucose: An Early Diabetes Intervention Program (EDIP) analysis.
Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism.
Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer.
Changes in Weight and Glucose Can Protect Against Progression in Early Diabetes Independent of Improvements in ß-Cell Function.
Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study.
Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.
Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.
Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program.
Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program.
Treatment-Induced Changes in Plasma Adiponectin Do Not Reduce Urinary Albumin Excretion in the Diabetes Prevention Program Cohort.
Failure of hyperglycemia and hyperinsulinemia to compensate for impaired metabolic response to an oral glucose load.
Profound defects in ß-cell function in screen-detected type 2 diabetes are not improved with glucose-lowering treatment in the Early Diabetes Intervention Program (EDIP).
ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Lifestyle and metformin interventions have a durable effect to lower CRP and tPA levels in the diabetes prevention program except in those who develop diabetes.
Regression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk: results from the Diabetes Prevention Program outcomes study.
Glucagon-like peptide-1 (7-36) but not (9-36) augments cardiac output during myocardial ischemia via a Frank-Starling mechanism.
Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program.
Short and long-term lifestyle coaching approaches used to address diverse participant barriers to weight loss and physical activity adherence.
ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Metabolic syndrome components and their response to lifestyle and metformin interventions are associated with differences in diabetes risk in persons with impaired glucose tolerance.
Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD).
[13C]glucose breath testing provides a noninvasive measure of insulin resistance: calibration analyses against clamp studies.
Restoring Insulin Secretion (RISE): design of studies of ß-cell preservation in prediabetes and early type 2 diabetes across the life span.
Impact of diagnosis of diabetes on health-related quality of life among high risk individuals: the Diabetes Prevention Program outcomes study.
Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (GRADE).
Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus.
Equivalence of arterial and venous blood for [11C]CO2-metabolite analysis following intravenous administration of 1-[11C]acetate and 1-[11C]palmitate.
Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program.
Sex steroid levels and response to weight loss interventions among postmenopausal women in the diabetes prevention program.
Pentoxifylline, inflammation, and endothelial function in HIV-infected persons: a randomized, placebo-controlled trial.
Confirming glycemic status in the Diabetes Prevention Program: implications for diagnosing diabetes in high risk adults.
Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study.
The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.
Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow.
Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program.
Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program.
Brachial artery flow-mediated dilation following exercise with augmented oscillatory and retrograde shear rate.
Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.
Effects of losartan on whole body, skeletal muscle and vascular insulin responses in obesity/insulin resistance without hypertension.
Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans.
Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes.
Influence of motor complete spinal cord injury on visceral and subcutaneous adipose tissue measured by multi-axial magnetic resonance imaging.
Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study.
Intra-individual variability of CO2 breath isotope enrichment compared to blood glucose in the oral glucose tolerance test.
Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study.
Relationship of body composition, metabolic status, antiretroviral use, and HIV disease factors to endothelial dysfunction in HIV-infected subjects.
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Simple modeling allows prediction of steady-state glucose disposal rate from early data in hyperinsulinemic glucose clamps.
Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk.
Effect of progression from impaired glucose tolerance to diabetes on cardiovascular risk factors and its amelioration by lifestyle and metformin intervention: the Diabetes Prevention Program randomized trial by the Diabetes Prevention Program Research Group.
Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus.
Hyperinsulinemia fails to augment ET-1 action in the skeletal muscle vascular bed in vivo in humans.
Relationship between brachial artery flow-mediated dilatation, hyperemic shear stress, and the metabolic syndrome.
Endothelin contributes differently to peripheral vascular tone and blood pressure in human obesity and diabetes.
Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study.
Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes.
No impairment of endothelial function or insulin sensitivity with 4 weeks of the HIV protease inhibitors atazanavir or lopinavir-ritonavir in healthy subjects without HIV infection: a placebo-controlled trial.
Blood pressure response to type A endothelin receptor antagonism in human obesity and diabetes mellitus.
Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance.
Obesity, insulin resistance, and the metabolic syndrome: determinants of endothelial dysfunction in whites and blacks.
Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes.
Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes.
Repeatability characteristics of simple indices of insulin resistance: implications for research applications.
Cyclooxygenase-2 blockade does not impair endothelial vasodilator function in healthy volunteers: randomized evaluation of rofecoxib versus naproxen on endothelium-dependent vasodilatation.
Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome.
Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.
Hyperinsulinemia in polycystic ovary syndrome correlates with increased cardiovascular risk independent of obesity.
Preserved forearm endothelial responses with acute exposure to progesterone: A randomized cross-over trial of 17-beta estradiol, progesterone, and 17-beta estradiol with progesterone in healthy menopausal women.
Maintenance of serum calcium by parathyroid hormone-related peptide during lactation in a hypoparathyroid patient.
American Diabetes Association - Local and Regional community service American Diabetes Association - National Committee service