4956-Liang, Tiebing

Tiebing Liang, PhD

Associate Research Professor of Medicine

Gatch Hall, Suite 500
1120 W. Michigan St.
CL 500
Indianapolis, IN 46202-5111
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Dr. Liang has training in cell biology and molecular biology, and her research interests have been centered on the study of genetics and molecular mechanism. Dr. Liang’s graduate work focused on the molecular mechanism of vernalization, followed by her research fellowship on DNA and protein interaction at the International Center for Genetic Engineering and Biotechnology (ICGEB) in Italy in 2000. She joined the Department of Medicine at the Indiana University School of Medicine as a postdoctoral fellow in 2001 under Dr. Lucinda Carr and was guided by Ting-Kai Li, Lawrence Lumeng, and Tatiana Foroud. She joined the Indiana University School of Medicine research faculty in 2006, serving as PI of a research lab and as Director of a Genomics and Bioinformatics Core of the Indiana Alcohol Research Center (IARC). Since 2013, she joined the liver research program directed by Dr. Naga Chalasani. Her research interests are the genetics of alcohol use disorder, and metabolic and liver diseases in basic science and clinical research settings.

Key Publications

1) Liang T, Spence J, Liu L, Strother WN, Chang HW, Ellison JA, Lumeng L, Li TK, Foroud T, Carr LG. alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4690-5. doi: 10.1073/pnas.0737182100. Epub 2003 Mar 28. PubMed PMID: 12665621; PubMed Central PMCID: PMC153617.
2) Liang T *, Kimpel MW, McClintick JN, Skillman AR, McCall K, Edenberg HJ, Carr LG. Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. Genome Biol. 2010;11(2):R11. doi: 10.1186/gb-2010-11-2-r11. Epub 2010 Feb 3. PubMed PMID: 20128895; PubMed Central PMCID: PMC2872871. * Corresponding author.
3) Vuppalanchi R, Liang T, Goswami CP, Nalamasu R, Li L, Jones D, Wei R, Liu W, Sarasani V, Janga SC, Chalasani N. Relationship between differential hepatic microRNA expression and decreased hepatic cytochrome P450 3A activity in cirrhosis. PLoS One. 2013;8(9):e74471. doi: 10.1371/journal.pone.0074471. eCollection 2013. PubMed PMID: 24058572; PubMed Central PMCID: PMC3772944. 
4) Liang T, Alloosh M, Bell LN, Fullenkamp A, Saxena R, Van Alstine W, Bybee P, Werling K, Sturek M, Chalasani N, Masuoka HC. Liver injury and fibrosis induced by dietary challenge in the Ossabaw miniature Swine. PLoS One. 2015;10(5):e0124173. doi: 10.1371/journal.pone.0124173. eCollection 2015. PubMed PMID: 25978364; PubMed Central PMCID: PMC4433111.
5) Qiu B, Bell RL, Cao Y, Zhang L, Stewart RB, Graves T, Lumeng L, Yong W, Liang T. Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. J Genet Genomics. 2016 Jul 20;43(7):421-30. doi: 10.1016/j.jgg.2016.04.010. Epub 2016 Apr 29. PubMed PMID: 27461754; PubMed Central PMCID: PMC5055068.
6) Qiu B, Luczak SE, Wall TL, Kirchhoff AM, Xu Y, Eng MY, Stewart RB, Shou W, Boehm SL, Chester JA, Yong W, Liang T. The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans. Int J Mol Sci. 2016 Aug 5;17(8). doi: 10.3390/ijms17081271. PubMed PMID: 27527158; PubMed Central PMCID: PMC5000669.
7) Vilar-Gomez E, Sookoian S, Pirola CJ, Liang T, Gawrieh S, Cummings O, Liu W, Chalasani NP. ADH1B∗2 Is Associated With Reduced Severity of Nonalcoholic Fatty Liver Disease in Adults, Independent of Alcohol Consumption. Gastroenterology. 2020 Sep;159(3):929-943. doi: 10.1053/j.gastro.2020.05.054. Epub 2020 May 23. PubMed PMID: 32454036; PubMed Central PMCID: PMC7502531. 
8) Vilar-Gomez E, Pirola CJ, Sookoian S, Wilson LA, Belt P, Liang T, Liu W, Chalasani N. Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD. Am J Gastroenterol. 2021 May 1;116(5):994-1006. doi: 10.14309/ajg.0000000000001072. PubMed PMID: 33306506; PubMed Central PMCID: PMC8087619.
9) Whitfield JB, Schwantes-An TH, Darlay R, Aithal GP, Atkinson SR, Bataller R, Botwin G, Chalasani NP, Cordell HJ, Daly AK, Day CP, Eyer F, Foroud T, Gleeson D, Goldman D, Haber PS, Jacquet JM, Liang T, Liangpunsakul S, Masson S, Mathurin P, Moirand R, McQuillin A, Moreno C, Morgan MY, Mueller S, Müllhaupt B, Nagy LE, Nahon P, Nalpas B, Naveau S, Perney P, Pirmohamed M, Seitz HK, Soyka M, Stickel F, Thompson A, Thursz MR, Trépo E, Morgan TR, Seth D. A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers. J Hepatol. 2021 Oct 13;. doi: 10.1016/j.jhep.2021.10.005. [Epub ahead of print] PubMed PMID: 34656649. 

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Complete List of Published Work in My Bibliography:


Titles & Appointments

  • Associate Research Professor of Medicine
  • Director, Genomics and Bioinformatics Core of the IARC (2007-2018)

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