4954-Chen, Hanying

Hanying Chen, MD

Associate Research Professor of Medical & Molecular Genetics

IB 252
Indianapolis, IN
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Hanying Chen received his M.D from Tong-Ji Medical University, Wuhan, China and joined as a postdoctoral research fellow in the Herman B Wells Center for Pediatric Research, Indiana University in 2000. In 2014, he became the manager of the Indiana University Mouse Transgenic Core. He introduced CRISPR/Cas9-based gene editing technology to the Core, which has subsequently been used by a number of Core clients and provide technological support of mouse genetic manipulation to all laboratories at Indiana University.

Key Publications

  1.       Qu X, Liu Y, Cao D, Chen J, Liu Z, Ji H, Chen Y, Zhang W, Zhu P, Xiao D, Li X, Shou W, Chen H(correspondence). BMP10 Preserves Cardiac Function Through Its Dual Activation of SMAD-mediated and STAT3-mediated Pathways. J Biol Chem. 2019 Dec 27; 294 (52):19877-19888.
  2.       Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard , Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R,… Miano JM, Burgio G. Reproducibility of CRISPR-Cas9 Methods for Generation of Conditional Mouse Alleles: A Multi-Center Evaluation. Genome Biol. 2019 Aug 26;20 (1):171. doi:10.1186/13059-019-1776-2.
  3.       Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 May;557(7705):439-445.
  4.       Zhang W, Qu X, Chen B, Snyder M, Wang M, Li B, Tang Y, Chen H, Zhu W, Zhan L, Yin N, Li D, Xie L, Liu Y, Zhang JJ, Fu XY, Rubart M, Song LS, Huang XY, Shou W. Critical Roles of STAT3 in β-Adrenergic Functions in the Heart. Circulation. 2016 Jan 5; 133(1) 48-61. PMID: 26628621.
  5.       Xu B, Zhu JX, Huo R, Yan ZY, He JL, Geng L, Wang JX, He J, Qiao GF, Chen H (correspondence), Li BY. Alternations of cardiac IKI and Ito from FKBP12.6 transgenic mouse heart and potential impact of cardiac hypertrophy. Int J Cardiol.2014 Oct 20;176 (3):1017-20.
  6.       Chen H(correspondence), Zhang W, Sun X, Yoshimoto M, Chen Z, Zhu W, Liu J, Shen Y, Yong W, Li D, Zhang J, Lin Y, Li B, VanDusen NJ, Snider P, Schwartz RJ, Conway SJ, Field LJ, Yoder MC, Firulli AB, Carlesso N, Towbin JA, Shou W. Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development. 2013 May;140(9):1946-57.
  7.        Zhang W, Chen H (co-first author), Wang Y, Yong W, Zhu W, Liu Y, Wagner GR, Payne RM, Field LJ, Xin H, Cai CL, Shou W. Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function. J Biol Chem. 2011 Oct 21; 286(42):36820-36829. PMC3196085.
  8.       Maruyama M, Li BY, Chen H(co-first author), Xu X, Song LS, Guatimosim S, Zhu W, Yong W, Zhang W, Bu G, Lin SF, Fishbein MC, Lederer WJ, Schild JH, Field LJ, Rubart M, Chen PS, Shou W. FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res. 2011 Apr 29; 108(9):1042-1052. PMC3092589.
  9.       Chen H, Yong W, Yang Z, Zhou Y, Periyasamy S, Cohn MJ, Sanchez ER, Shou W. Fkbp52 regulates androgen receptor transcriptional activity and male urethra morphogenesis. J Biol Chem. 2010 Sep 3; 285(36):27776-277784. PMC2934645.
  10.       Chen H, Zhang W, Li D, Cordes TM, Payne RM, Shou W. Analysis of ventricular hypertrabeculation and noncompaction using genetically engineered mouse models. Pediatr Cardiol. 2009 Jul; 30(5):626-634. PMC2746357.
  11.       Grego-Bessa J, Luna-Zurita L, del Monte G, Bolós V, Melgar P, Arandilla A, Garratt AN, Zang H, Mukouyama YS, Chen H, Shou W, Ballestar E, Esteller M, Rojas A, Pérez-Pomares JM, de la Pompa JL. Notch signaling is essential for ventricular chamber development. Dev Cell. 2007 Mar; 12(3):415-29.
  12.       Yang Z, Wolf IM, Chen H (co-first author), Periyasamy S, Chen Z, Yong W, Shi S, Zhao W, Xu J, Srivastava A, Sanchez ER, Shou W. FKBP52 is Essential to Uterine Reproductive Physiology Controlled By the Progesterone Receptor A Isoform. Mol Endocrinol. 2006 Nov; 20(11):2682-94.
  13.       Chen H, Yong W, Ren S, Shen W, He Y, Cox KA, Zhu W, Li W, Soonpaa M, Payne RM, Franco D, Field LJ, Rosen V, Wang Y, Shou W. Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth. J Biol Chem. 2006 Sep 15;281(37):27481-91
  14.       Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. Loss of a ventricular Nkx 2.5 pathway leads to defects in trabecular and conduction system myocyte lineage specification and associated congenital heart defects and arrythmogenesis. Cell. 2004 Apr 30; 117(3):373-86.
  15.       Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. BMP-10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May; 131(9):2219-

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