Zeruesenay Desta, PhD
Professor of Medicine
Adjunct Professor of Pharmacology & Toxicology
Associate Division Chief, Clinical Pharmacology
Scientific Director, Clinical Pharmacology Analytical Core
Director, Clinical Pharmacology Training Program
Bio
The goal of effective and safe therapy of many drugs is made difficult by large interindividual variability in response to these drugs and is of major concern for patients, and their caretakers and significantly adversely influences the cost of health care. Our ultimate goals are comprehensive understanding of mechanisms controlling interindividual variability in drug response and then apply this knowledgebase to maximize beneficial and minimize adverse effects of medications for the individual patient. Although potential causes for variable drug effects are multiple, interpatient differences in drug disposition and unpredictable drug-drug interactions (DDIs) are frequent and major determinants of beneficial and adverse drug effects. Thus, our research focuses on identifying factors that contribute to variable drug disposition. Completed and ongoing bench and clinical studies in our laboratory address the impact of altered drug metabolizing enzymes and drug transporters due to genetic polymorphisms and nongenetic factors (e.g., DDIs) on exposure of drugs and (active) metabolites. Our research activities include: developing new analytical tools to measure drugs and their metabolites; profiling of drug metabolites; identification of rate limiting metabolic pathways and the specific enzymes involved; developing and validating novel molecular and clinical tools to study drug disposition and DDIs; assessing the impact of genetic variants and DDIs as well as interplay of them on drug exposure and effect; and developing mathematical models (e.g. static models, PBPK and popPK) to allow mechanistic understanding and quantitative prediction of clinical drug exposure and DDIs from in vitro data. Basic discoveries are made using in vitro model systems. Then, complementary clinical studies are designed in healthy volunteers at the Indiana Clinical Research Center or in patients to verify clinical significance. Dr. Desta has >20 years of experience and extensive publication record (> 130 peer-reviewed) in this area of this research. Our laboratory has made seminal discoveries including new active metabolites (e.g., endoxifen), multiple in vitro and in vivo biochemical, clinical and genetic approaches to study CYPs, and clinical studies that lead to changes in FDA drug labelling (e.g., tamoxifen, pimozide, and efavirenz). We have continuously competed and received funding from the NIH as a PI or Co-I to pursue collaborative research.
Year | Degree | Institution |
---|---|---|
1990 | PhD | Ernst Moritz Arndt University |
1988 | MSC | Martin Luther University |
1982 | BPHARM | Addis Ababa University |
Cheung RW; Willan K; Dickerson J; Bowyer-Crane C; BMJ paediatrics open 2023 Mar
Gufford BT; Metzger IF; Bamfo NO; Benson EA; Masters AR; Lu JBL; Desta Z; The Journal of pharmacology and experimental therapeutics 2022 Jul 7
Shugg T; Ly RC; Rowe EJ; Philips S; Hyder MA; Radovich M; Rosenman MB; Pratt VM; Callaghan JT; Desta Z; Schneider BP; Skaar TC; JCO precision oncology 2022 Feb
Desta Z; El-Boraie A; Gong L; Somogyi AA; Lauschke VM; Dandara C; Klein K; Miller NA; Klein TE; Tyndale RF; Whirl-Carrillo M; Gaedigk A; Clinical pharmacology and therapeutics 2021 Mar 11
Titus-Lay EN; Jaynes HA; Tomaselli Muensterman E; Walroth TA; Ott CA; Desta Z; Williams G; Moe PR; Wilbrandt M; Tisdale JE; Pharmacotherapy 2021 Feb 2
Lima JJ; Thomas CD; Barbarino J; Desta Z; Van Driest SL; El Rouby N; Johnson JA; Cavallari LH; Shakhnovich V; Thacker DL; Scott SA; Schwab M; Uppugunduri CRS; Formea CM; Franciosi JP; Sangkuhl K; Gaedigk A; Klein TE; Gammal RS; Furuta T; Clinical pharmacology and therapeutics 2020 Sep 20
Ipe J; Li R; Metzger IF; Bo Li Lu J; Gufford BT; Desta Z; Liu Y; Skaar TC; Clinical pharmacology and therapeutics 2020 Oct 5
Ingle JN; Cairns J; Suman VJ; Shepherd LE; Fasching PA; Hoskin TL; Singh RJ; Desta Z; Kalari KR; Ellis MJ; Goss PE; Chen BE; Volz B; Barman P; Carlson EE; Haddad TC; Goetz MP; Goodnature B; Cuellar ME; Walters MA; Correia C; Kaufmann SH; Weinshilboum RM; Wang L; Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Feb 25
Liu SN; Gufford BT; Lu JBL; Bushman LR; Anderson PL; Bergstrom RF; Desta Z; Gupta SK; Clinical pharmacology and therapeutics 2019 Nov 1
Dudenkov TM; Liu D; Cairns J; Devarajan S; Zhuang Y; Ingle JN; Buzdar AU; Robson ME; Kubo M; Batzler A; Barman P; Jenkins GD; Carlson EE; Goetz MP; Northfelt DW; Moreno-Aspitia A; Desta Z; Reid JM; Kalari KR; Wang L; Weinshilboum RM; Clinical pharmacology and therapeutics 2019 Mar 18
Dempsey JM; Kidwell KM; Gersch CL; Pesch AM; Desta Z; Storniolo AM; Stearns V; Skaar TC; Hayes DF; Henry NL; Rae JM; Hertz DL; Pharmacogenomics 2019 Jun
Desta Z; Gammal RS; Gong L; Whirl-Carrillo M; Gaur AH; Sukasem C; Hockings J; Myers A; Swart M; Tyndale RF; Masimirembwa C; Iwuchukwu OF; Chirwa S; Lennox J; Gaedigk A; Klein TE; Haas DW; Clinical pharmacology and therapeutics 2019 Jul 5
Liu SN; Lu JBL; Watson CJW; Lazarus P; Desta Z; Gufford BT; Drug metabolism and disposition: the biological fate of chemicals 2019 Feb 25
Fulton CR; Zang Y; Desta Z; Rosenman MB; Holmes AM; Decker BS; Zhang Y; T Callaghan J; Pratt VM; Levy KD; Gufford BT; Dexter PR; Skaar TC; Eadon MT; Pharmacogenomics 2019 Feb 20
Collins KS; Metzger IF; Gufford BT; Lu JB; Medeiros EB; Pratt VM; Skaar TC; Desta Z; Drug metabolism and disposition: the biological fate of chemicals 2019 Dec 30
Liu SN; Desta Z; Gufford BT; CPT: pharmacometrics & systems pharmacology 2019 Dec 23
Wu HY; Shendre A; Zhang S; Zhang P; Wang L; Zeruesenay D; Rocha LM; Shatkay H; Quinney SK; Ning X; Li L; Clinical pharmacology and therapeutics 2019 Dec 21
Metzger IF; Dave N; Kreutz Y; Lu JBL; Galinsky RE; Desta Z; Clinical and translational science 2019 Aug 12
Wu HY; Lu D; Hyder M; Zhang S; Quinney SK; Desta Z; Li L; CPT: pharmacometrics & systems pharmacology 2018 Sep 29
Fulton CR; Swart M; De Luca T; Liu SN; Collins KS; Desta Z; Gufford BT; Eadon MT; The journal for nurse practitioners : JNP 2018 Nov 2
Gufford BT; Robarge JD; Eadon MT; Gao H; Lin H; Liu Y; Desta Z; Skaar TC; Pharmacology research & perspectives 2018 Mar 26
Skaar TC; Desta Z; Clinical pharmacology and therapeutics 2018 Feb 23
Burgess KS; Ipe J; Swart M; Metzger IF; Lu J; Gufford BT; Thong N; Desta Z; Gaedigk R; Pearce RE; Gaedigk A; Liu Y; Skaar TC; Clinical pharmacology and therapeutics 2017 Sep 27
Marcath LA; Deal AM; Van Wieren E; Danko W; Walko CM; Ibrahim JG; Weck KE; Jones DR; Desta Z; McLeod HL; Carey LA; Irvin WJ Jr; Hertz DL; Pharmacogenetics and genomics 2017 Nov
Pierson RC; Gufford BT; Desta Z; Eadon MT; Pharmacogenomics 2017 Jun 8
Hertz DL; Speth KA; Kidwell KM; Gersch CL; Desta Z; Storniolo AM; Stearns V; Skaar TC; Hayes DF; Henry NL; Rae JM; Breast cancer research and treatment 2017 Jun 22
Desta Z; Metzger IF; Thong N; Lu JB; Callaghan JT; Skaar TC; Flockhart DA; Galinsky RE; Antimicrobial agents and chemotherapy 2016 Oct 21
Hertz DL; Deal A; Ibrahim JG; Walko CM; Weck KE; Anderson S; Magrinat G; Olajide O; Moore S; Raab R; Carrizosa DR; Corso S; Schwartz G; Graham M; Peppercorn JM; Jones DR; Desta Z; Flockhart DA; Evans JP; McLeod HL; Carey LA; Irvin WJ Jr; The oncologist 2016 May 25
Kadakia KC; Snyder CF; Kidwell KM; Seewald NJ; Flockhart DA; Skaar TC; Desta Z; Rae JM; Otte JL; Carpenter JS; Storniolo AM; Hayes DF; Stearns V; Henry NL; The oncologist 2016 Mar 23
Masters AR; Gufford BT; Lu JB; Metzger IF; Jones DR; Desta Z; The Journal of pharmacology and experimental therapeutics 2016 Jun 2
Abdelhady AM; Shugg T; Thong N; Lu JB; Kreutz Y; Jaynes HA; Robarge JD; Tisdale JE; Desta Z; Overholser BR; Journal of cardiovascular electrophysiology 2016 Jul 25
Gufford BT; Lu JB; Metzger IF; Jones DR; Desta Z; Drug metabolism and disposition: the biological fate of chemicals 2016 Jan 22
Eadon MT; Desta Z; Levy KD; Decker BS; Pierson RC; Pratt VM; Callaghan JT; Rosenman MB; Carpenter JS; Holmes AM; McDonald CA; Benson EA; Patil AS; Vuppalanchi R; Gufford BT; Dave N; Robarge JD; Hyder MA; Haas DM; Kreutz RP; Dexter PR; Skaar TC; Flockhart DA; Clinical pharmacology and therapeutics 2016 Feb 6
Masters AR; McCoy M; Jones DR; Desta Z; Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2016 Feb 18
Bies R; McDonald C; Desta Z; British journal of clinical pharmacology 2016 Feb
Robarge JD; Desta Z; Nguyen AT; Li L; Hertz D; Rae JM; Hayes DF; Storniolo AM; Stearns V; Flockhart DA; Skaar TC; Henry NL; Breast cancer research and treatment 2016 Dec 9
Robarge JD; Metzger IF; Lu J; Thong N; Skaar TC; Desta Z; Bies RR; Antimicrobial agents and chemotherapy 2016 Dec 27
Hertz DL; Kidwell KM; Seewald NJ; Gersch CL; Desta Z; Flockhart DA; Storniolo AM; Stearns V; Skaar TC; Hayes DF; Henry NL; Rae JM; The pharmacogenomics journal 2016 Aug 23
Benson EA; Eadon MT; Desta Z; Liu Y; Lin H; Burgess KS; Segar MW; Gaedigk A; Skaar TC; Frontiers in pharmacology 2016 Apr 26
Han X; Quinney SK; Wang Z; Zhang P; Duke J; Desta Z; Elmendorf JS; Flockhart DA; Li L; Clinical pharmacology and therapeutics 2015 Sep
Santa-Maria CA; Blackford A; Nguyen AT; Skaar TC; Philips S; Oesterreich S; Rae JM; Desta Z; Robarge J; Henry NL; Storniolo AM; Hayes DF; Blumenthal RS; Ouyang P; Post WS; Flockhart DA; Stearns V; Consortium on Breast Cancer Pharmacogenomics (COBRA); Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Oct 13
Oesterreich S; Henry NL; Kidwell KM; Van Poznak CH; Skaar TC; Dantzer J; Li L; Hangartner TN; Peacock M; Nguyen AT; Rae JM; Desta Z; Philips S; Storniolo AM; Stearns V; Hayes DF; Flockhart DA; Breast cancer research and treatment 2015 Nov 4
Eadon MT; Zhang H; Skaar TC; Hato T; Dagher PC; Gupta SK; Desta Z; Antiviral chemistry & chemotherapy 2015 Jul 30
Cho DY; Shen JH; Lemler SM; Skaar TC; Li L; Blievernicht J; Zanger UM; Kim KB; Shin JG; Flockhart DA; Desta Z; Drug metabolism and pharmacokinetics 2015 Jul 29
Cardoso Jde O; Oliveira RV; Lu JB; Desta Z; Drug metabolism and disposition: the biological fate of chemicals 2015 Dec
Hertz DL; Snavely AC; McLeod HL; Walko CM; Ibrahim JG; Anderson S; Weck KE; Magrinat G; Olajide O; Moore S; Raab R; Carrizosa DR; Corso S; Schwartz G; Peppercorn JM; Evans JP; Jones DR; Desta Z; Flockhart DA; Carey LA; Irvin WJ Jr; British journal of clinical pharmacology 2015 Aug 2
Burgess KS; Philips S; Benson EA; Desta Z; Gaedigk A; Gaedigk R; Segar MW; Liu Y; Skaar TC; Clinical pharmacology and therapeutics 2015 Aug
Metzger IF; Quigg TC; Epstein N; Aregbe AO; Thong N; Callaghan JT; Flockhart DA; Nguyen AT; Stevens CK; Gupta SK; Desta Z; Current therapeutic research, clinical and experimental 2014 Sep 27
Smith RP; Eckalbar WL; Morrissey KM; Luizon MR; Hoffmann TJ; Sun X; Jones SL; Force Aldred S; Ramamoorthy A; Desta Z; Liu Y; Skaar TC; Trinklein ND; Giacomini KM; Ahituv N; PLoS genetics 2014 Oct 2
Kreutz RP; Bitar A; Owens J; Desta Z; Breall JA; von der Lohe E; Sinha A; Vatta M; Nystrom P; Jin Y; Flockhart DA; Journal of thrombosis and thrombolysis 2014 Oct
Levy KD; Decker BS; Carpenter JS; Flockhart DA; Dexter PR; Desta Z; Skaar TC; Clinical pharmacology and therapeutics 2014 May 7
Kreutz RP; Owens J; Lu D; Nystrom P; Jin Y; Kreutz Y; Desta Z; Flockhart DA; Platelets 2014 May 15
Lowenberg D; Thorn CF; Desta Z; Flockhart DA; Altman RB; Klein TE; Pharmacogenetics and genomics 2014 Feb
Ingle JN; Kalari KR; Buzdar AU; Robson ME; Goetz MP; Desta Z; Barman P; Dudenkov TT; Northfelt DW; Perez EA; Flockhart DA; Williard CV; Wang L; Weinshilboum RM; Steroids 2014 Aug 24
Ji Y; Schaid DJ; Desta Z; Kubo M; Batzler AJ; Snyder K; Mushiroda T; Kamatani N; Ogburn E; Hall-Flavin D; Flockhart D; Nakamura Y; Mrazek DA; Weinshilboum RM; British journal of clinical pharmacology 2014 Aug
Henry NL; Chan HP; Dantzer J; Goswami CP; Li L; Skaar TC; Rae JM; Desta Z; Khouri N; Pinsky R; Oesterreich S; Zhou C; Hadjiiski L; Philips S; Robarge J; Nguyen AT; Storniolo AM; Flockhart DA; Hayes DF; Helvie MA; Stearns V; British journal of cancer 2013 Oct 1
Abdelhady AM; Desta Z; Jiang F; Yeo CW; Shin JG; Overholser BR; Journal of clinical pharmacology 2013 Nov 19
Klein DJ; Thorn CF; Desta Z; Flockhart DA; Altman RB; Klein TE; Pharmacogenetics and genomics 2013 Nov
Weng L; Ziliak D; Im HK; Gamazon ER; Philips S; Nguyen AT; Desta Z; Skaar TC; Consortium on Breast Cancer Pharmacogenomics (COBRA); Flockhart DA; Huang RS; Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2013 Mar 18
Xu C; Quinney SK; Guo Y; Hall SD; Li L; Desta Z; Drug metabolism and disposition: the biological fate of chemicals 2013 Jul 11
Jiang F; Desta Z; Shon JH; Yeo CW; Kim HS; Liu KH; Bae SK; Lee SS; Flockhart DA; Shin JG; British journal of clinical pharmacology 2013 Jan
Xu C; Desta Z; Drug metabolism and pharmacokinetics 2013 Feb 5
Love RR; Desta Z; Flockhart D; Skaar T; Ogburn ET; Ramamoorthy A; Uy GB; Laudico AV; Van Dinh N; Quang le H; Van To T; Young GS; Hade E; Jarjoura D; SpringerPlus 2013 Feb 15
Kreutz RP; Owens J; Jin Y; Nystrom P; Desta Z; Kreutz Y; Breall JA; Li L; Chiang C; Kovacs RJ; Flockhart DA; Clinical pharmacology : advances and applications 2013 Dec 9
Ramamoorthy A; Liu Y; Philips S; Desta Z; Lin H; Goswami C; Gaedigk A; Li L; Flockhart DA; Skaar TC; Drug metabolism and disposition: the biological fate of chemicals 2013 Aug 9
Gupta SK; Mi D; Dubé MP; Saha CK; Johnson RM; Stein JH; Clauss MA; Mather KJ; Desta Z; Liu Z; PloS one 2013 Apr 9
Michaud V; Kreutz Y; Skaar T; Ogburn E; Thong N; Flockhart DA; Desta Z; The pharmacogenomics journal 2013 Apr 30
Henry NL; Skaar TC; Dantzer J; Li L; Kidwell K; Gersch C; Nguyen AT; Rae JM; Desta Z; Oesterreich S; Philips S; Carpenter JS; Storniolo AM; Stearns V; Hayes DF; Flockhart DA; Breast cancer research and treatment 2013 Apr 2
Hage CA; Horan DJ; Durkin M; Connolly P; Desta Z; Skaar TC; Knox KS; Wheat LJ; Medical mycology 2012 Nov 27
Desta Z; Moaddel R; Ogburn ET; Xu C; Ramamoorthy A; Venkata SL; Sanghvi M; Goldberg ME; Torjman MC; Wainer IW; Xenobiotica; the fate of foreign compounds in biological systems 2012 May 21
Meyer zu Schwabedissen HE; Oswald S; Bresser C; Nassif A; Modess C; Desta Z; Ogburn ET; Marinova M; Lütjohann D; Spielhagen C; Nauck M; Kroemer HK; Siegmund W; Clinical pharmacology and therapeutics 2012 May 16
Kreutz RP; Nystrom P; Kreutz Y; Miao J; Kovacs R; Desta Z; Flockhart DA; Jin Y; Platelets 2012 Mar 2
Michaud V; Bar-Magen T; Turgeon J; Flockhart D; Desta Z; Wainberg MA; Pharmacological reviews 2012 Jul
Xu C; Ogburn ET; Guo Y; Desta Z; Drug metabolism and disposition: the biological fate of chemicals 2012 Jan 9
Michaud V; Ogburn E; Thong N; Aregbe AO; Quigg TC; Flockhart DA; Desta Z; Clinical pharmacology and therapeutics 2012 Feb 8
Kreutz RP; Nystrom P; Kreutz Y; Miao J; Desta Z; Breall JA; Li L; Chiang C; Kovacs R; Flockhart DA; Jin Y; Clinical pharmacology : advances and applications 2012 Feb 20
Henry NL; Azzouz F; Desta Z; Li L; Nguyen AT; Lemler S; Hayden J; Tarpinian K; Yakim E; Flockhart DA; Stearns V; Hayes DF; Storniolo AM; Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012 Feb 13
Oswald S; Meyer zu Schwabedissen HE; Nassif A; Modess C; Desta Z; Ogburn ET; Mostertz J; Keiser M; Jia J; Hubeny A; Ulrich A; Runge D; Marinova M; Lütjohann D; Kroemer HK; Siegmund W; Clinical pharmacology and therapeutics 2012 Feb 1
Thacker DL; Modak A; Flockhart DA; Desta Z; Journal of breath research 2012 Dec 21
Ji Y; Biernacka JM; Hebbring S; Chai Y; Jenkins GD; Batzler A; Snyder KA; Drews MS; Desta Z; Flockhart D; Mushiroda T; Kubo M; Nakamura Y; Kamatani N; Schaid D; Weinshilboum RM; Mrazek DA; The pharmacogenomics journal 2012 Aug 21
Thacker DL; Modak A; Nguyen PD; Flockhart DA; Desta Z; Chirality 2011 Sep 20
Desta Z; Kreutz Y; Nguyen AT; Li L; Skaar T; Kamdem LK; Henry NL; Hayes DF; Storniolo AM; Stearns V; Hoffmann E; Tyndale RF; Flockhart DA; Clinical pharmacology and therapeutics 2011 Oct 5
Lu WJ; Desta Z; Flockhart DA; Breast cancer research and treatment 2011 Mar 9
Irvin WJ Jr; Walko CM; Weck KE; Ibrahim JG; Chiu WK; Dees EC; Moore SG; Olajide OA; Graham ML; Canale ST; Raab RE; Corso SW; Peppercorn JM; Anderson SM; Friedman KJ; Ogburn ET; Desta Z; Flockhart DA; McLeod HL; Evans JP; Carey LA; Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 Jul 18
Cho DY; Ogburn ET; Jones D; Desta Z; Antimicrobial agents and chemotherapy 2011 Jan 31
Bell LN; Nguyen AT; Li L; Desta Z; Henry NL; Hayes DF; Wolff AC; Stearns V; Storniolo AM; Flockhart DA; Consortium on Breast Cancer Pharmacogenomics (COBRA); Journal of clinical pharmacology 2011 Dec 15
Montenegro MF; Ceron CS; Salgado MC; Desta Z; Flockhart DA; Tanus-Santos JE; Journal of cardiovascular pharmacology 2011 Dec
Kim C; Gupta SK; Green L; Taylor BM; Deuter-Reinhard M; Desta Z; Clauss M; Antiviral therapy 2011
Kamdem LK; Flockhart DA; Desta Z; Drug metabolism and disposition: the biological fate of chemicals 2010 Sep 28
Kamdem LK; Liu Y; Stearns V; Kadlubar SA; Ramirez J; Jeter S; Shahverdi K; Ward BA; Ogburn E; Ratain MJ; Flockhart DA; Desta Z; British journal of clinical pharmacology 2010 Dec