Samir K. Gupta, MD, MS
David H. Jacobs Professor of Infectious Diseases
Address
1120 West Michigan Street
Gatch Hall, Room 591
Indianapolis, Indian 46202
Gatch Hall, Room 591
Indianapolis, Indian 46202
Bio
Dr. Gupta is a Professor of Medicine and Vice Chair for Research for the Department of Medicine at the Indiana University School of Medicine. He received his medical degree from the University of Pittsburgh and subsequently completed his internal medicine residency and infectious diseases fellowship at Indiana University (Indianapolis). He is an attending physician at the Eskenazi Hospital HIV outpatient clinic and is an active investigator in the general field of HIV therapeutics and complications. Dr. Gupta is funded by the National Institutes of Health to research the effects of HIV and its therapies on cardiovascular diseases.
Titles & Appointments
- David H. Jacobs Professor of Infectious Diseases
- Professor of Medicine
- Director, IU Infectious Diseases Research
- Division Director
- Bell Flower Clinic (BFC) STD Clinic Co-Program Development Director
-
Education2003 MS Indiana University2000 RES Residency, Fellowship, Indiana University School of Medicine, Indianapolis, Indiana1996 MD University of Pittsburgh1992 BS Pennsylvania State University
-
Research
HIV-related renal, cardiovascular, bone, and metabolic diseases; HIV-related mental health; HIV therapeutics and pharmacology
-
PublicationsAssociations of Total, Cognitive/Affective, and Somatic Depressive Symptoms and Antidepressant Use With Cardiovascular Disease-Relevant Biomarkers in HIV: Veterans Aging Cohort Study.
Stewart JC; Polanka BM; So-Armah KA; White JR; Gupta SK; Kundu S; Chang CH; Freiberg MS; Psychosomatic medicine 2020 JunDepression and all-cause mortality risk in HIV-infected and HIV-uninfected US veterans: a cohort study.
So-Armah K; Gupta SK; Kundu S; Stewart JC; Goulet JL; Butt AA; Sico JJ; Marconi VC; Crystal S; Rodriguez-Barradas MC; Budoff M; Gibert CL; Chang CC; Bedimo R; Freiberg MS; HIV medicine 2019 Mar 29GCH1 haplotypes and cardiovascular risk in HIV.
Slaven JE; Haas DW; Liu Z; Stein JH; Brown TT; Gupta SK; AIDS (London, England) 2019 Aug 1Immune reconstitution in ART treated, but not untreated HIV infection, is associated with abnormal beta cell function.
Sims EK; Park G; Mather KJ; Mirmira RG; Liu Z; Gupta SK; PloS one 2018 May 24MMPs/TIMPs imbalances in the peripheral blood and cerebrospinal fluid are associated with the pathogenesis of HIV-1-associated neurocognitive disorders.
Xing Y; Shepherd N; Lan J; Li W; Rane S; Gupta SK; Zhang S; Dong J; Yu Q; Brain, behavior, and immunity 2017 May 6BCL6 represses antiviral resistance in follicular T helper cells.
Amet T; Son YM; Jiang L; Cheon IS; Huang S; Gupta SK; Dent AL; Montaner LJ; Yu Q; Sun J; Journal of leukocyte biology 2017 May 26Bone mineral density reductions after tenofovir disoproxil fumarate initiation and changes in phosphaturia: a secondary analysis of ACTG A5224s.
Gupta SK; Yeh E; Kitch DW; Brown TT; Venuto CS; Morse GD; Ha B; Melbourne K; McComsey GA; The Journal of antimicrobial chemotherapy 2017 Jul 1A randomized, placebo-controlled pilot trial of N-acetylcysteine on oxidative stress and endothelial function in HIV-infected older adults receiving antiretroviral treatment.
Gupta SK; Kamendulis LM; Clauss MA; Liu Z; AIDS (London, England) 2016 Sep 24Plasma and Intracellular Concentrations in HIV-Infected Patients Requiring Hemodialysis Dosed With Tenofovir Disoproxil Fumarate and Emtricitabine.
Slaven JE; Decker BS; Kashuba ADM; Atta MG; Wyatt CM; Gupta SK; Journal of acquired immune deficiency syndromes (1999) 2016 Sep 1Association Between Depressive Disorders and Incident Acute Myocardial Infarction in Human Immunodeficiency Virus-Infected Adults: Veterans Aging Cohort Study.
Khambaty T; Stewart JC; Gupta SK; Chang CH; Bedimo RJ; Budoff MJ; Butt AA; Crane H; Gibert CL; Leaf DA; Rimland D; Tindle HA; So-Armah KA; Justice AC; Freiberg MS; JAMA cardiology 2016 Nov 1Frequency of atazanavir-associated leukocyturia development and renal function decline.
Dbeibo L; Arif S; He F; Gupta SK; AIDS (London, England) 2016 Jun 1A pilot trial of pentoxifylline on endothelial function and inflammation in HIV-infected patients initiating antiretroviral therapy.
Gupta SK; Dubé MP; Stein JH; Clauss MA; Liu Z; AIDS (London, England) 2016 Aug 24Depression and Human Immunodeficiency Virus Infection Are Risk Factors for Incident Heart Failure Among Veterans: Veterans Aging Cohort Study.
White JR; Chang CC; So-Armah KA; Stewart JC; Gupta SK; Butt AA; Gibert CL; Rimland D; Rodriguez-Barradas MC; Leaf DA; Bedimo RJ; Gottdiener JS; Kop WJ; Gottlieb SS; Budoff MJ; Khambaty T; Tindle HA; Justice AC; Freiberg MS; Circulation 2015 Sep 10Switching to tenofovir alafenamide, coformulated with elvitegravir, cobicistat, and emtricitabine, in HIV-infected patients with renal impairment: 48 week results from a single-arm, multi-center, open-label, Phase 3 study.
Pozniak A; Arribas JR; Gathe J; Gupta SK; Post FA; Bloch M; Avihingsanon A; Crofoot G; Benson P; Lichtenstein K; Ramgopal M; Chetchotisakd P; Custodio JM; Abram ME; Wei X; Cheng A; McCallister S; SenGupta D; Fordyce MW; GS-US-292-0112 Study Team; Journal of acquired immune deficiency syndromes (1999) 2015 Nov 30Markers of renal disease and function are associated with systemic inflammation in HIV infection.
Gupta SK; Kitch D; Tierney C; Melbourne K; Ha B; McComsey GA; AIDS Clinical Trials Group Study A5224s Team; HIV medicine 2015 May 20Reductions in Plasma Cystatin C After Initiation of Antiretroviral Therapy Are Associated With Reductions in Inflammation: ACTG A5224s.
Longenecker CT; Kitch D; Sax PE; Daar ES; Tierney C; Gupta SK; McComsey GA; AIDS Clinical Trials Group Study A5224s Team; Journal of acquired immune deficiency syndromes (1999) 2015 Jun 1A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice.
Eadon MT; Zhang H; Skaar TC; Hato T; Dagher PC; Gupta SK; Desta Z; Antiviral chemistry & chemotherapy 2015 Jul 30A randomized, controlled trial of the effect of rilpivirine versus efavirenz on cardiovascular risk in healthy volunteers.
Gupta SK; Slaven JE; Kamendulis LM; Liu Z; The Journal of antimicrobial chemotherapy 2015 Jul 13Blockage of CD59 Function Restores Activities of Neutralizing and Nonneutralizing Antibodies in Triggering Antibody-Dependent Complement-Mediated Lysis of HIV-1 Virions and Provirus-Activated Latently Infected Cells.
Yang K; Lan J; Shepherd N; Hu N; Xing Y; Byrd D; Amet T; Jewell C; Gupta S; Kounga C; Gao J; Yu Q; Journal of virology 2015 Jul 1Endothelial Colony Forming Cells and Inflammatory Monocytes in HIV.
Hays TR; Mund JA; Liu Z; Case J; Ingram DA; Gupta SK; Journal of acquired immune deficiency syndromes (1999) 2015 Jan 5Relationships Between Renal Parameters and Serum and Urine Markers of Inflammation in Those With and Without HIV Infection.
Shinha T; Mi D; Liu Z; Orschell CM; Lederman MM; Gupta SK; AIDS research and human retroviruses 2015 Feb 26A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.
Dahlin A; Wittwer M; de la Cruz M; Woo JM; Bam R; Scharen-Guivel V; Flaherty J; Ray AS; Cihlar T; Gupta SK; Giacomini KM; Pharmacogenetics and genomics 2015 FebEfficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial.
Gupta SK; McComsey GA; Lombaard J; Echevarría J; Orrell C; Avihingsanon A; Osiyemi O; Santoscoy M; Ray N; Stock DA; Joshi SR; Hanna GJ; Lataillade M; The lancet. HIV 2015 Dec 12Differences in Circulating Endothelial Progenitor Cells among Childhood Cancer Survivors Treated with and without Radiation.
Pradhan K; Mund J; Case J; Gupta S; Liu Z; Gathirua-Mwangi W; McDaniel A; Renbarger J; Champion V; Journal of hematology & thrombosis 2015 Aug 5Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients.
Wang T; Green LA; Gupta SK; Amet T; Byrd DJ; Yu Q; Twigg HL 3rd; Clauss M; AIDS research and human retroviruses 2014 Sep 4Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers.
Metzger IF; Quigg TC; Epstein N; Aregbe AO; Thong N; Callaghan JT; Flockhart DA; Nguyen AT; Stevens CK; Gupta SK; Desta Z; Current therapeutic research, clinical and experimental 2014 Sep 27Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV Medicine Association of the Infectious Diseases Society of America.
Lucas GM; Ross MJ; Stock PG; Shlipak MG; Wyatt CM; Gupta SK; Atta MG; Wools-Kaloustian KK; Pham PA; Bruggeman LA; Lennox JL; Ray PE; Kalayjian RC; Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014 Sep 17Changes in proteinuria and albuminuria with initiation of antiretroviral therapy: data from a randomized trial comparing tenofovir disoproxil fumarate/emtricitabine versus abacavir/lamivudine.
Wyatt CM; Kitch D; Gupta SK; Tierney C; Daar ES; Sax PE; Ha B; Melbourne K; McComsey GA; AIDS Clinical Trials Group Study A5224s Team; Journal of acquired immune deficiency syndromes (1999) 2014 Sep 1Antiretroviral treatment initiation.
Gupta SK; The Lancet. Infectious diseases 2014 Nov 17Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction.
Wang T; Green LA; Gupta SK; Kim C; Wang L; Almodovar S; Flores SC; Prudovsky IA; Jolicoeur P; Liu Z; Clauss M; PloS one 2014 Mar 7Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients.
Gupta SK; Anderson AM; Ebrahimi R; Fralich T; Graham H; Scharen-Guivel V; Flaherty JF; Fortin C; Kalayjian RC; Rachlis A; Wyatt CM; PloS one 2014 Mar 20Cystatin C-based renal function changes after antiretroviral initiation: a substudy of a randomized trial.
Gupta SK; Kitch D; Tierney C; Daar ES; Sax PE; Melbourne K; Ha B; McComsey GA; AIDS Clinical Trials Group Study A5224s Team; Open forum infectious diseases 2014 Apr 16Microbial translocation and metabolic and body composition measures in treated and untreated HIV infection.
Timmons T; Shen C; Aldrovandi G; Rollie A; Gupta SK; Stein JH; Dubé MP; AIDS research and human retroviruses 2013 Oct 8Plasma apolipoprotein L1 levels do not correlate with CKD.
Bruggeman LA; O'Toole JF; Ross MD; Madhavan SM; Smurzynski M; Wu K; Bosch RJ; Gupta S; Pollak MR; Sedor JR; Kalayjian RC; Journal of the American Society of Nephrology : JASN 2013 Nov 14HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3.
Green LA; Yi R; Petrusca D; Wang T; Elghouche A; Gupta SK; Petrache I; Clauss M; 2013 Dec 6Pentoxifylline, inflammation, and endothelial function in HIV-infected persons: a randomized, placebo-controlled trial.
Gupta SK; Mi D; Dubé MP; Saha CK; Johnson RM; Stein JH; Clauss MA; Mather KJ; Desta Z; Liu Z; PloS one 2013 Apr 9Worsening endothelial function with efavirenz compared to protease inhibitors: a 12-month prospective study.
Gupta SK; Shen C; Moe SM; Kamendulis LM; Goldman M; Dubé MP; PloS one 2012 Sep 20PPAR? agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes.
Kanakasabai S; Pestereva E; Chearwae W; Gupta SK; Ansari S; Bright JJ; PloS one 2012 Nov 21Pentoxifylline reduces tumor necrosis factor-a and HIV-induced vascular endothelial activation.
Green LA; Kim C; Gupta SK; Rajashekhar G; Rehman J; Clauss M; AIDS research and human retroviruses 2012 May 8Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.
Gupta SK; Shen C; Mather KJ; Agarwal R; Dubé MP; The Journal of infectious diseases 2011 Oct 19Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected Kenyan adults not initially requiring combination antiretroviral therapy.
Gupta SK; Ong'or WO; Shen C; Musick B; Goldman M; Wools-Kaloustian K; Journal of the International AIDS Society 2011 Jun 11Endothelial, inflammatory, coagulation, metabolic effects and safety of etravirine in HIV-uninfected volunteers.
Gupta SK; Mi D; Liu Z; Saha C; AIDS patient care and STDs 2011 Apr 6Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells.
Kim C; Gupta SK; Green L; Taylor BM; Deuter-Reinhard M; Desta Z; Clauss M; Antiviral therapy 2011Bariatric surgery outcomes in HIV-infected subjects: a case series.
Selke H; Norris S; Osterholzer D; Fife KH; DeRose B; Gupta SK; AIDS patient care and STDs 2010 SepDlk1 is necessary for proper skeletal muscle development and regeneration.
Waddell JN; Zhang P; Wen Y; Gupta SK; Yevtodiyenko A; Schmidt JV; Bidwell CA; Kumar A; Kuang S; PloS one 2010 Nov 29Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study.
Gupta SK; Johnson RM; Mather KJ; Clauss M; Rehman J; Saha C; Desta Z; Dubé MP; AIDS (London, England) 2010 Jun 1Relationship of body composition, metabolic status, antiretroviral use, and HIV disease factors to endothelial dysfunction in HIV-infected subjects.
Dubé MP; Shen C; Mather KJ; Waltz J; Greenwald M; Gupta SK; AIDS research and human retroviruses 2010 AugEditorial comment: mixing tenofovir with other nephrotoxins--how safe is this?
Gupta SK; The AIDS reader 2009 JunCan the SMART study data be used to assess risk factors for renal disease?
Gupta SK; Annals of internal medicine 2009 Feb 17Proteinuria, creatinine clearance, and immune activation in antiretroviral-naive HIV-infected subjects.
Gupta SK; Komarow L; Gulick RM; Pollard RB; Robbins GK; Franceschini N; Szczech LA; Koletar SL; Kalayjian RC; The Journal of infectious diseases 2009 Aug 15The effects of HIV type-1 viral suppression and non-viral factors on quantitative proteinuria in the highly active antiretroviral therapy era.
Gupta SK; Smurzynski M; Franceschini N; Bosch RJ; Szczech LA; Kalayjian RC; AIDS Clinical Trials Group Longitudinal Linked Randomized Trials Study Team; Antiviral therapy 2009Serum concentration-dependent hepatotoxicity in individuals receiving oral salsalate.
Juluri R; Gupta S; Vuppalanchi R; Digestive diseases and sciences 2008 Sep 4The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis.
Gupta SK; Rosenkranz SL; Cramer YS; Koletar SL; Szczech LA; Amorosa V; Hall SD; AIDS (London, England) 2008 Oct 1Will there be an epidemic of HIV-related chronic kidney disease in sub-Saharan Africa? Too soon to tell.
Wools-Kaloustian KK; Gupta SK; Kidney international 2008 OctImprovement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study.
Gupta SK; Johnson RM; Saha C; Mather KJ; Greenwald ML; Waltz JS; Rehman J; Dubé MP; AIDS (London, England) 2008 Mar 12Suppression of HIV-1 replication by antiretroviral therapy improves renal function in persons with low CD4 cell counts and chronic kidney disease.
Kalayjian RC; Franceschini N; Gupta SK; Szczech LA; Mupere E; Bosch RJ; Smurzynski M; Albert JM; AIDS (London, England) 2008 Feb 19Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system.
Gupta SK; AIDS patient care and STDs 2008 FebProteinuria and endothelial dysfunction in stable HIV-infected patients. A pilot study.
Gupta SK; Mather KJ; Agarwal R; Saha CK; Considine RV; Dubé MP; Journal of acquired immune deficiency syndromes (1999) 2007 Aug 15Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya.
Wools-Kaloustian K; Gupta SK; Muloma E; Owino-Ong'or W; Sidle J; Aubrey RW; Shen J; Kipruto K; Zwickl BE; Goldman M; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007 AugSuccessful treatment of CMV ventriculitis immune reconstitution syndrome.
Janowicz DM; Johnson RM; Gupta SK; Journal of neurology, neurosurgery, and psychiatry 2005 JunThe effects of highly active antiretroviral therapy on albuminuria in HIV-infected persons: results from a randomized trial.
Gupta SK; Parker RA; Robbins GK; Dubé MP; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005 Aug 16Tenofovir and changes in renal function.
Gupta SK; Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005 Aug 15Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America.
Gupta SK; Eustace JA; Winston JA; Boydstun II; Ahuja TS; Rodriguez RA; Tashima KT; Roland M; Franceschini N; Palella FJ; Lennox JL; Klotman PE; Nachman SA; Hall SD; Szczech LA; Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005 Apr 22The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection.
Szczech LA; Gupta SK; Habash R; Guasch A; Kalayjian R; Appel R; Fields TA; Svetkey LP; Flanagan KH; Klotman PE; Winston JA; Kidney international 2004 SepPrevalence of proteinuria and the development of chronic kidney disease in HIV-infected patients.
Gupta SK; Mamlin BW; Johnson CS; Dollins MD; Topf JM; Dubé MP; Clinical nephrology 2004 JanExogenous cushing syndrome mimicking human immunodeficiency virus lipodystrophy.
Gupta SK; Dubé MP; Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002 Aug 23Evaluation of the Winthrop-University Hospital criteria to identify Legionella pneumonia.
Gupta SK; Imperiale TF; Sarosi GA; Chest 2001 OctThe role of atypical pathogens in community-acquired pneumonia.
Gupta SK; Sarosi GA; The Medical clinics of North America 2001 NovStore and recoil of elastic energy in slow and fast types of human skeletal muscles.
Bosco C; Tihanyi J; Komi PV; Fekete G; Apor P; Acta physiologica Scandinavica 1982 DecStore and recoil of elastic energy in slow and fast types of human skeletal muscles.
Bosco C; Tihanyi J; Komi PV; Fekete G; Apor P; Acta physiologica Scandinavica 1982 Dec -
Professional OrganizationsHIV Medical AssociationInfectious Diseases Society of America
-
Board CertificationsAmerican Board of Internal Medicine - Infectious DiseaseAmerican Board of Internal Medicine - Infectious Disease
-
Clinical Interests
HIV
-
AwardsOrg: Health Foundation of Greater Indianapolis
Desc: Governing body member
Scope: Local
Date: 1905-07-16
Looking for patient care?
To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.