48212-Wang, Nian

Nian Wang, PhD

Assistant Professor of Radiology & Imaging Sciences

GH 4100
Indianapolis, IN


Dr. Nian Wang has been a member of the Indiana University School of Medicine Department of Radiology and Imaging Sciences faculty since Oct. 2020. He received his PhD degree at Chinese Academy of Sciences. Before he joined IU, he worked at Duke University, first as a research associate and then as an assistant professor at Center for In Vivo Microscopy (CIVM). Dr. Wang’s interests include developing novel MRI acquisition and reconstruction methods for various brain diseases and musculoskeletal disorders.

Key Publications

a) Brain MRI
1. Wang N, Anderson R, Ashbrook David, Gopalakrishnan V, Park Y, Priebe C, Qi Y, Laoprasert R, Vogelstein J, Williams RW, Johnson GA*. “Variability and heritability of mouse brain structure: microscopic MRI atlases and connectomes for diverse strains”, NeuroImage, 2020, 222, 117274 (Cover Article)
2. Wang N*, White L, Cofer G, Qi Y, Anderson R, Johnson GA*. “Cytoarchitecture of the mouse brain by high resolution diffusion magnetic resonance imaging”, NeuroImage, 2020, 216, 116876
3. Wang N*, Zhang J, Cofer G, Qi Y, Anderson R, Johnson GA*. “Neurite orientation dispersion and density imaging of mouse brain microstructure”, Brain Structure and Function, 2019, 224, 1797-1813
4. Wang N, Zhuang J, Wei HJ, Dibb R, Qi Y, Liu CL*. “Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI”, Journal of Magnetic Resonance Imaging, 2019, 50, 1852-1865
5. Guan X, Huang P, Zeng Q, Liu C, Wei H, Xuan M, Gu Q, Xu X, Wang N, Yu X, Luo X, Zhang M*. “Quantitative susceptibility mapping as a biomarker for evaluating white matter alterations in Parkinson’s disease”, Brain Imaging and Behavior, 2019, 13, 220-231
6. Johnson A#*, Wang N#, Anderson R, Chen M, Cofer G, Gee J, Pratson F, Tustison N, Whilte L. “Whole mouse brain connectivity”, Journal of comparative Neurology, 2019, 527, 2146-2157 (# equal contribution)
7. Wang N, Anderson R, Cofer G, Qi Y, Liu CL, Johnson GA*. “Accelerating 3D high resolution whole brain quantitative susceptibility mapping using compressed sensing”, Physics in Medicine and Biology, 2018, 63, 245002
8. Wang N, Anderson R, Badea A, Cofer G, Dibb R, Qi Y, Johnson GA*. “Whole mouse brain structural connectomics using magnetic resonance histology”, Brain Structure and Function, 2018, 223, 4323-4335
9. Cronin M#, Wang N#, Decker K, Wei H, Zhu W, Liu CL*. “Exploring the origins of TE-dependent QSM measurements in healthy tissue and cerebral microbleeds”, NeuroImage, 2017, 149, 98-113 (# equal contribution)
10. L Wei, Wang N, Yu F, Han H, Cao W, Romero R, Tantiwongkosi B, Duong TQ, Liu CL*. “A method for estimating and removing streaking artifacts in quantitative susceptibility mapping”, NeuroImage, 2015, 103, 111-122
b) Musculoskeletal MRI
1. Wang N, Farid B, Xia Y*. “Resolution-dependent Influences of Compressed Sensing in Quantitative T2 Mapping of Articular Cartilage”, NMR in Biomedicine, 2020, 10, e4260
2. Wang N*, Mirando JA, Cofer G, Qi Y, Hilton JM, Johnson GA. “Characterization Complex Collagen Fiber Architecture in Knee Joint Using High Resolution Diffusion Imaging”, Magnetic Resonance in Medicine, 2020, 84, 908-919.
3. Wang N*, Mirando JA, Cofer G, Qi Y, Hilton JM, Johnson GA. “Diffusion Tractography of the Rat Knee at Microscopic Resolution”, Magnetic Resonance in Medicine, 2019, 81, 3775-3786 (Cover Article)
4. Wang N, Farid B, Xia Y. “Experimental Influences to the Accurate Measurement of Cartilage Thickness in MRI”, Cartilage, 2019, 10, 278-287
5. Wang N, Badar F, Xia Y*. “Quantitative determination of GAG concentration in cartilage by microscopic MRI”, Magnetic Resonance in Medicine, 2018, 79, 3163-3171
6. Wei H, Gibbs E, Zhao P, Wang N, Cofer G, Zhang Y, Johnson G, Liu CL*. “Susceptibility Tensor Imaging and Tractography of Collagen Fibrils in the Articular Cartilage”, Magnetic Resonance in Medicine, 2017, 78, 1683-1690
7. Wei H, Dibb R, Decker K, Wang N, Zhang Y, Zong X, Lin W, Nissman D, Liu CL*. “Investigating magnetic susceptibility of human knee joint at 7 tesla”, Magnetic Resonance in Medicine, 2017, 78, 1933-1943
8. Wang N, Farid B, Xia Y*. “MRI properties of a unique hypo-intense layer in degraded articular cartilage”, Physics in Medicine and Biology, 2015, 60, 8709-8721
9. Wang N, David K, Farid B, Xia Y*. “The molecular origin of a loading-induced black layer in the deep region of articular cartilage at the magic angle”, Journal of Magnetic Resonance Imaging, 2015, 41, 1281-1290
Wang N, Xia Y. Book title: “Biophysics and Biochemistry of Cartilage by NMR and MRI” Invited Chapter: “The Influence of Cartilage Deformation in NMR and MRI,” Royal Society of Chemistry, Y Xia, K Momot (Eds), 2017, ISBN 978-1782621331

Titles & Appointments

  • Assistant Professor of Radiology & Imaging Sciences
  • Education
    2010 PhD Wuhan Institute of Physics & Mathematics of Chinese Academy of Science
    2004 BS Wuhan University
  • Research

    1. Develop compressed sensing (CS) technique to reduce acquisition time for 3D diffusion MRI.

    2. Achieve the highest spatial resolution (25 µm isotropic) of diffusion MRI in Rodents.

    3. Probe tissue microstructure using multi-shell and high b value diffusion MRI acquisition.

    4. Apply novel MRI technologies to various brain diseases, including Autism spectrum disorder, and multiple sclerosis, Alzheimer’s disease, etc.

    5. Investigate 3D collagen fiber network in cartilage, ligament, meniscus, etc.

  • Professional Organizations
    International Society for Magnetic Resonance in Medicine

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