4795-Liangpunsakul, Suthat

Suthat Liangpunsakul, MD, MPH

Professor of Medicine

Roudebush VA Medical Center, D-3010
1481 W. 10th St.
UH 4100
Indianapolis, IN 46202
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Dr. Liangpunsakul joined the faculty at the Indiana University School of Medicine (IUSM) in July 2003, as an Assistant Professor of Clinical Medicine. He has since held a joint appointment as a clinical staff in the Gastroenterology section at the Roudebush Veterans Administration Medical Center (VAMC). He was promoted to Professor of Medicine, Biochemistry and Molecular Biology in 2017. His research focuses on (i) identification of non-invasive biomarkers to screen for excessive alcohol use, (ii) basic mechanisms and translational studies to determine the pathogenesis of alcohol-associated liver disease (ALD), and (iii) novel therapy for ALD.  He is currently the principal investigator of several research projects funded by the US Department of Veterans Affairs (Merit Review) as well as the National Institute of Health (NIH/NIAAA).

He has written/co-written more than 200 peer-reviewed articles and 6 book chapters. He served as a standing member of the NIH HBPP study section from 2017-2021.  Currently, he serves as an Associate Editor of HEPATOLOGY and a field editor for the journal Alcoholism: Clinical and Experimental Research.  Dr. Liangpunsakul is a fellow of the American Gastroenterological Association (AGA) and the American College of Gastroenterology (ACG). He is also a Fellow of the American Association for the Study of Liver Diseases (AASLD) and currently serves as a steering commitee member, AASLD Special Interest Groups on alcohol-associated liver disease.  He was the past President of the American Federation for Medical Research (AFMR) in 2018. In May 2019, he was appointed as the Associate Chief of Staff for Research at the Roudebush VMAC.

During his tenure at Indiana University, he was awarded the prestigious Indiana University Trustee Teaching Award in 2011, a Showalter Scholar award in 2017, and Department of Medicine Outstanding Mentorship Award in 2022. 

Born in Thailand, Dr. Liangpunsakul completed his medical training at Prince of Songkhla University, Thailand, in 1995, where he was awarded an MD degree, first class honors.  He completed his Internal Medicine Residency at the University of Illinois at Chicago (UIC) in 2000, and Gastroenterology/Hepatology training at the Indiana University School of Medicine in Indianapolis in 2003. In addition, he completed Master of Public Health (MPH) degree from the Indiana University Purdue University in Indianapolis (IUPUI) School of Public Health in 2003.

Key Publications

1. Ma J, Guillot A, Yang Z, Mackowiak B, Hwang S, Park O, Peiffer BJ, Ahmadi AR, Melo L, Kusumanchi P, Huda N, Saxena R, He Y, Guan Y, Feng D, Sancho-Bru P, Zang M, Cameron AM, Bataller R, Tacke F, Sun Z, Liangpunsakul S*, Gao B*. Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure. J Clin Invest. 2022;132(14). Epub 2022/07/16. doi: 10.1172/JCI157780. PubMed PMID: 35838051; PMCID: PMC9282929. *Co-corresponding authors

2. Kusumanchi P, Liang T, Zhang T, Ross RA, Han S, Chandler K, Oshodi A, Jiang Y, Dent AL, Skill NJ, Huda N, Ma J, Yang Z, Liangpunsakul S. Stress-Responsive Gene FK506-Binding Protein 51 Mediates Alcohol-Induced Liver Injury Through the Hippo Pathway and Chemokine (C-X-C Motif) Ligand 1 Signaling. Hepatology. 2021;74(3):1234-50. Epub 2021/03/13. doi: 10.1002/hep.31800. PubMed PMID: 33710653; PMCID: PMC8435051.

3. Yang Z, Smalling RV, Huang Y, Jiang Y, Kusumanchi P, Bogaert W, Wang L, Delker DA, Skill NJ, Han S, Zhang T, Ma J, Huda N, Liangpunsakul S. The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease. JCI Insight. 2021;6(16). Epub 2021/08/24. doi: 10.1172/jci.insight.140687. PubMed PMID: 34423788; PMCID: PMC8410014.

4. Yang Z, Han S, Zhang T, Kusumanchi P, Huda N, Tyler K, Chandler K, Skill NJ, Tu W, Shan M, Jiang Y, Maiers JL, Perez K, Ma J, Liangpunsakul S. Transcriptomic Analysis Reveals the Messenger RNAs Responsible for the Progression of Alcoholic Cirrhosis. Hepatol Commun. 2022. Epub 2022/02/09. doi: 10.1002/hep4.1903. PubMed PMID: 35134262.

5. Liu D, Yang Z, Chandler K, Oshodi A, Zhang T, Ma J, Kusumanchi P, Huda N, Heathers L, Perez K, Tyler K, Ross RA, Jiang Y, Zhang D, Zhang M, Liangpunsakul S. Serum metabolomic analysis reveals several novel metabolites in association with excessive alcohol use - an exploratory study. Transl Res. 2022;240:87-98. Epub 2021/11/08. doi: 10.1016/j.trsl.2021.10.008. PubMed PMID: 34743014.

6. Li M, He Y, Zhou Z, Ramirez T, Gao Y, Gao Y, Ross RA, Cao H, Cai Y, Xu M, Feng D, Zhang P, Liangpunsakul S*, Gao B*. MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47(phox)-oxidative stress pathway in neutrophils. Gut. 2017;66(4):705-15. Epub 2016/09/30. doi: 10.1136/gutjnl-2016-311861. PubMed PMID: 27679493; PMCID: PMC5458746. *Co-coressponding authors

Titles & Appointments

  • Professor of Medicine
  • Professor of Biochemistry & Molecular Biology
  • Adjunct Professor of Anatomy, Cell Biology & Physiology
  • Adjunct Professor, School of Public Health
  • Associate Chief of Staff for Research, Roudebush Veterans Administration Medical Center

Research Labs

Faculty research at IU School of Medicine is transforming health. Details about the medical research being conducted in faculty labs throughout IU School of Medicine are available in the Research section of this site.

Faculty Labs