47724-Jesudason, Cynthia

Cynthia Jesudason, PhD

Adjunct Clinical Assistant Professor of Medicine

R2 402
Indianapolis, IN
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Cynthia D. Jesudason, Ph.D. earned her BA degree from Oxford University and her doctorate in organic chemistry (on the first asymmetric synthesis of the complete daphnane skeleton) with Prof. Paul Wender at Stanford University in 1995.  Dr. Jesudason joined Lilly Research Laboratories as a medicinal chemist that same year. She has both drug discovery and development experience for a diverse array of central and peripheral targets in neuroscience and endocrinology targeting Alzheimer’s disease, Parkinson’s disease, depression, alcohol abuse, sleep disorders, obesity, diabetes and renal disease resulting in the successful delivery of multiple clinical candidates. She also led a cross functional team at Lilly in the design and development of receptor occupancy and PET tracers to quantitate both preclinical and clinical target engagement and this improve clinical translation, and has advanced several tracers into clinic.

Cynthia holds 26 issued US patents, has 1 pending and has authored 9 peer-reviewed publications and 3 book chapters. She retired from Lilly as a Research Fellow, and joined LGenia Inc in November of 2019 as a Senior Portfolio Director.

Key Publications

Nabulsi, Nabeel B.; Holden Daniel; Zheng, Ming-Qianq; Bois, Frederic; Lin, Shu-Fei; Najafzadeh, Soheila; Gao, Hong; Ropchan, Jim; Lara-Jaime, Teresa; Labaree, David; Shirali, Anupuma; Slieker,  Lawrence J.; Jesudason, Cynthia D.; Barth, Vanessa N.; Navarro, Antonio; Kant, Nancy; Carson, Richard E.; Huang,  Henry. Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman Primates. Journal of Nuclear Medicine, 2019 60,1147-1153.

Soumen, Paul; Haskali, Mohammad B.; Liow, Jeih-San; Zoghbi, Sami S.; Barth, Vanessa N.; Kolodrubetz, Marcy C.; Bond, Michelle R.; Morse, Cheryl L.; Gladding, Robert L.; Frankland, Michael P.; Kant, Nancy; Slieker, Lawrence; Shcherbinin, Sergey; Nuthall, Hugh N.; Zanotti-Fregonara, Paolo; Hanover, John A.; Jesudason, Cynthia; Pike, Victor W. Innis, Robert B.   Evaluation of a novel PET radioligand to image O-GlcNAcase in brain and periphery of rhesus monkey and knock-out mouse. Journal of Nuclear Medicine, 2019, 60, 129-134.

Jesudason, Cynthia D.; DuBois, Susan; Johnson, Megan; Barth, Vanessa N.; Need, Anne B.  ‘In Vivo Receptor Occupancy in Rodents by LC-MS/MS.’ 2017 Mar 9. In: Sittampalam GS, Coussens NP, Brimacombe K, et al., editors.  Assay Guidance Manual. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.  https://www.ncbi.nlm.nih.gov/books/NBK424998/

Fitch, Thomas E.; Benvenga, Mark J.; Jesudason, Cynthia D; Zink, Charity; Vandergriff, Amy B.; Menezes, Michelle M.; Schober, Douglas A.; Rorick-Kehn, Linda M.  ‘LSN 2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy.’  In E-book: Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists.  Frontiers in neuroscience 2014, 8, 5.

Jesudason, Cynthia D.; Baker, James E.; Bryant, Robert D.; Fisher, Jack.; W.; O'Farrell, Libbey S.; Gaich, Gregory A.; He, Minxia M.; Kahl, Steven D.; Kriauciunas, Aidas, V.; Heiman, Mark. L.; Peters, Mary A.; Rito, Christopher J.; Satterwhite, Julie H.; Tinsley, Frank C.; Trankle, William G.; Shuker, Anthony J.  Combination of a Beta Adrenoceptor Modulator and a Norepinephrine-Serotonin Uptake Inhibitor for the Treatment of ObesityACS Medicinal Chemistry Letters 2011, 2, 583-586

Titles & Appointments

  • Adjunct Clinical Assistant Professor of Medicine
  • Education
    1995 PhD Stanford University
    1988 BA University of Oxford

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