Hyun Cheol Roh, PhD
Assistant Professor of Biochemistry & Molecular Biology
- hyunroh@iu.edu
- Phone
- (317) 274-9622
- Address
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Indiana University School of Medicine
635 Barnhill Dr. Medical Sciences Building Room MS1017A(lab)/MS1021G(office)
Indianapolis, IN 46202-5126 - PubMed:
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Bio
Dr. Roh received his B.S in Genetic Engineering and M.S. in Biochemistry from Korea University. He completed his Ph.D. in Molecular Cell Biology at Washington University in St. Louis with Dr. Kerry Kornfeld, working on homeostatic mechanisms for zinc metabolism using C. elegans. Dr. Roh received his postdoctoral training at Harvard Medical School & Beth Israel Deaconess Medical Center under Dr. Evan Rosen, working on the molecular mechanisms that regulate adipocyte identity in response to physiological stimulations and pathological conditions. He was promoted to Instructor in Medicine at Harvard Medical School in 2018. Dr. Roh joined the faculty of the Department of Biochemistry and Molecular Biology in the fall of 2019.
Key Publications
So J, Taleb S, Wann J, Strobel O, Kim K, Roh HC. Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility. Molecular Metabolism. 2022 Oct 21:101619. doi: 10.1016/j.molmet.2022.101619
Roh HC, Tsai LT, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming induces significant reprogramming of beige, but not brown, adipocyte cellular identity. Cell Metabolism. 2018, 27(5):1121-1137
Shen Y*, Roh HC*, Kumari M, Rosen ED. Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding. Molecular Metabolism. 2017, 6(10):1150-1160
(*co-first authors)
Roh HC, Tsai LT, Lyubetskaya A, Tenen D, Kumari M, Rosen ED. Simultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo. Cell Reports. 2017, 24;18(4):1048-1061
For a complete list of publications, visit PubMed
| Year | Degree | Institution |
|---|---|---|
| 2011 | PhD | Washington University |
| 2005 | MS | Korea University |
| 2003 | BS | Korea University |
We study how to program cellular identity and plasticity to cure metabolic disease
Adipocyte Identity Control and Reprogramming
Adipocytes play a key role in nutrient and energy homeostasis and come in different flavors: white, brown, beige and more. We are looking for ways to control and reprogram adipocyte identity to improve our metabolic health and prevent diseases such as obesity and diabetes.
Cellular Plasticity in Physiology and Human Disease
Once differentiated, somatic cell types maintain cellular identity and fulfill their unique cellular functions, while some cell types have potentials to switch identity. We are exploring how such cellular plasticity contributes to normal physiology in mammals and is implicated in human disease.
Development of Cutting-Edge Epigenomic Techniques
We have established powerful techniques for cell type-specific epigenomic analysis and single cell/nuclei gene expression profiling in vivo. We keep developing new methods that enable us to gain new insights into metabolism research and more.