44795-Lin, Tsai-Yu

Tsai-Yu Lin, PhD

Assistant Professor of Clinical Medical & Molecular Genetics


Dr. Tsai-Yu Lin received his Ph.D. degree from the University of Washington under the mentorship of Dr. Michael Emerman. Subsequently, he worked as a post-doctoral scientist at National Institute of Allergy and Infectious Diseases (NIAID) NIH, University of Massachusetts Medical School, and Indiana University Purdue University Indianapolis (IUPUI). Prior to his IU School of Medicine (IUSM) employment, Dr. Lin has years of experiences as senior researcher in biotech industry where he applied lentiviral vector for gene delivery in the field of gene therapy and immuno-oncology (e.g. CAR-T). Through his training and working experiences, Dr. Lin has equipped himself with expertise in many aspects of medical virology (including HIV, West Nile virus, dengue virus, alphaviruses, and hepatitis B virus), lentiviral vector technology, immuno-oncology, and gene therapy. As Associate Director of Gene Therapy Testing Laboratory at IUSM, Dr. Lin focuses his interests on molecular testing and analysis for gene therapy efficacy and safety.

Key Publications

Lin TY, Ki CS, Lin CC. Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels. Biomaterials. 2014; 35(25):6898-906.

Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, Aker AM, John SP, Sarlah D, Carreira EM, Elledge SJ, Kellam P, Brass AL. Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction. Cell reports. 2013; 5(4):895-908.

Lin TY, Dowd KA, Manhart CJ, Nelson S, Whitehead SS, Pierson TC. A novel approach for the rapid mutagenesis and directed evolution of the structural genes of west nile virus. Journal of virology. 2012; 86(7):3501-12.

Daffis S, Szretter KJ, Schriewer J, Li J, Youn S, Errett J, Lin TY, Schneller S, Zust R, Dong H, Thiel V, Sen GC, Fensterl V, Klimstra WB, Pierson TC, Buller RM, Gale M Jr, Shi PY, Diamond MS. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature. 2010; 468(7322):452-6.

Fuchs A, Lin TY, Beasley DW, Stover CM, Schwaeble WJ, Pierson TC, Diamond MS. Direct complement restriction of flavivirus infection requires glycan recognition by mannose-binding lectin. Cell host & microbe. 2010; 8(2):186-95.

Lin TY, Emerman M. Determinants of cyclophilin A-dependent TRIM5 alpha restriction against HIV-1. Virology. 2008; 379(2):335-41.

Lin TY, Emerman M. Cyclophilin A interacts with diverse lentiviral capsids. Retrovirology. 2006; 3:70.

Titles & Appointments

  • Assistant Professor of Clinical Medical & Molecular Genetics
  • Education
    2008 PhD University of Washington
    2003 MS National Taiwan University
    1998 BS National Taiwan University
  • Research

    Molecular testing and analysis for gene therapy potency and safety.

  • Professional Organizations
    American Association for the Advancement of Science
    American Society for Virology
    American Society of Gene and Cell Therapy

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