44795-Lin, Tsai-Yu

Tsai-Yu Lin, PhD, MS

Assistant Professor of Clinical Medical & Molecular Genetics

980 W Walnut Street
Room R3 C647

Indianapolis, IN 46202


Dr. Tsai-Yu Lin received his Ph.D. degree from the University of Washington. He subsequently worked as a postdoctoral scientist at the National Institute of Allergy and Infectious Diseases (NIAID), the University of Massachusetts Medical School, and Indiana University Purdue University Indianapolis (IUPUI). Prior to his IU School of Medicine (IUSM) employment, Dr. Lin had many years of experience as a senior researcher in the biotech industry, applying lentiviral vectors to gene delivery in the fields of gene therapy and immuno-oncology (e.g., CAR-T). Through his training and work experience, Dr. Lin has equipped himself with expertise in many aspects of medical virology (e.g., HIV, West Nile virus, dengue virus, alphaviruses, and hepatitis B virus), lentiviral vector technology, immuno-oncology, and gene therapy. As Associate Director of Gene Therapy Testing Laboratory at IUSM, Dr. Lin focuses on molecular testing and analysis of gene and cell therapy product safety.

Key Publications

Lin TY, Ki CS, Lin CC. Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels. Biomaterials. 2014; 35(25):6898-906.

Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, Aker AM, John SP, Sarlah D, Carreira EM, Elledge SJ, Kellam P, Brass AL. Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction. Cell reports. 2013; 5(4):895-908.

Lin TY, Dowd KA, Manhart CJ, Nelson S, Whitehead SS, Pierson TC. A novel approach for the rapid mutagenesis and directed evolution of the structural genes of west nile virus. Journal of virology. 2012; 86(7):3501-12.

Daffis S, Szretter KJ, Schriewer J, Li J, Youn S, Errett J, Lin TY, Schneller S, Zust R, Dong H, Thiel V, Sen GC, Fensterl V, Klimstra WB, Pierson TC, Buller RM, Gale M Jr, Shi PY, Diamond MS. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature. 2010; 468(7322):452-6.

Fuchs A, Lin TY, Beasley DW, Stover CM, Schwaeble WJ, Pierson TC, Diamond MS. Direct complement restriction of flavivirus infection requires glycan recognition by mannose-binding lectin. Cell host & microbe. 2010; 8(2):186-95.

Lin TY, Emerman M. Determinants of cyclophilin A-dependent TRIM5 alpha restriction against HIV-1. Virology. 2008; 379(2):335-41.

Lin TY, Emerman M. Cyclophilin A interacts with diverse lentiviral capsids. Retrovirology. 2006; 3:70.

Titles & Appointments

  • Assistant Professor of Clinical Medical & Molecular Genetics
  • Associate Director of Gene Therapy Testing Laboratory
  • Education
    2008 PhD University of Washington
    2003 MS National Taiwan University
    1998 BS National Taiwan University
  • Research

    Molecular testing and analysis for gene therapy potency and safety.

  • Professional Organizations
    American Association for the Advancement of Science
    American Society for Virology
    American Society of Gene and Cell Therapy

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