44767-Pasupuleti, Santhosh

Santhosh K. Pasupuleti, PhD

Assistant Research Professor of Pediatrics

R4 169
Indianapolis, IN
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Dr. Santhosh Kumar Pasupuleti received his PhD degree in Biotechnology from Sri Venkateswara Institute of Medical Sciences University, India. In his doctoral training, he expertized in human hematopoietic stem cells (HSCs) and studied the differentiation of erythrocytes, platelets, and hepatocytes from human HSCs. Also, studied drug-resistant BCR-ABL mutant patients with chronic myeloid leukemia as well as polycythemia vera and congenital erythrocytosis. Dr. Pasupuleti further pursued a postdoctoral fellowship in the Department of Pediatrics, IU School of Medicine, Indianapolis, where he studied the role of pre-leukemic or clonal hematopoiesis of indeterminate potential (CHIP) associated mutations (i.e: Dnmt3a, Asxl1, Tet2, and Jak2) in the development of clonal hematopoiesis (CH) or full-blown leukemia such as acute myeloid leukemia (AML) or severe forms of myeloproliferative neoplasms (MPN) in the background of obesity and/or diabetes. Dr. Pasupuleti is currently Assistant Research Professor, Program in Hematologic Malignancies and Stem Cell Biology, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis.

Key Publications


Titles & Appointments

  • Assistant Research Professor of Pediatrics
  • Education
    2019 PhD Sri Venkateswara Institute of Medical Sciences
    2010 MSC Bharathiar University
    2008 BSC Sri Venkateswara University
  • Research
    Dr. Pasupuleti's research interests, include elucidating the role of clonal hematopoiesis of indeterminate potential (CHIP) associated mutations such as TET2, DNMT3a, ASXL1, and JAK2 in blood cell lineages involving the expansion of mutated hematopoietic stem and progenitor cells (HSC/Ps) that leads to an increased risk of hematologic malignancy and cardiovascular disease (CVD). Dr. Pasupuleti’s recent findings that obesity and/or diabetes-induced inflammation promote CHIP driven exacerbated clonal hematopoiesis (CH), leading to severe MPN/AML as well as CVD, via aberrant activation of intracellular calcium (Ca2+) levels and pro-inflammatory cytokines. Dr. Pasupuleti is also, interested in mechanisms of how gain-of-function Shp2E76K/+ mutation drive hematopoietic dysregulation and Juvenile myelomonocytic leukemia (JMML) development. Recently, we show that a combination of MEK inhibitor and hypomethylating agent, 5-azacitidine rescue Shp2-driven JMML. Dr. Pasupuleti was also, involved in Phase I/II trial of augmenting TAK-659 action in relapse/refractory AML by addition of proteasome inhibitor Ixazomib: BTCRC-HEM17-092.
  • Awards
    Org: American Society of Hematology
    Desc: Abstract achievement award
    Scope: National
    Date: 2021-12-12
    Org: Sri Venkateswara Institute of Medical Sciences
    Desc: Endowment Award (Gold medal) for Best Case Report
    Scope: National
    Date: 2019-02-26
    Org: Sri Venkateswara Institute of Medical Sciences
    Desc: Certificate of Appreciation in Teaching
    Scope: National
    Date: 2018-01-26
    Org: Sri Balaji Arogya Varaprasadhini - Sri Venkateswara Institute of Medical Sciences
    Desc: Grant for PhD thesis
    Scope: National
    Date: 2017-08-06
    Org: Sri Venkateswara Veterinary University
    Desc: Best First oral paper presentation award
    Scope: National
    Date: 2017-02-06
    Org: Association of Biotechnology and Pharmacy
    Desc: Young Scientist Award
    Scope: National
    Date: 2016-11-12

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