44017-Norman, Bryan

Bryan H. Norman, PhD

Adjunct Clinical Assistant Professor of Medicine

Phone
(317) 274-2810
Address
R2 402
MDEP
IN
Indianapolis, IN
PubMed:

Bio

Bryan H. Norman received his Ph.D. in Organic Chemistry at Emory University and was an NIH Postdoctoral Fellow at Penn State University.  After three years at Monsanto/Searle, Bryan joined Eli Lilly and Company in 1993, where he led multiple cross functional drug discovery efforts, many of which culminated in clinical candidates for oncology, endocrine and pain indications.  In addition to his expertise in medicinal chemistry, Bryan has significant cross functional drug discovery experience and expertise in additional disciplines, such as biomarkers, pharmacokinetic/pharmacodynamic (PK/PD) relationships, mechanisms of drug metabolism and toxicology.  He has specific expertise in the mechanisms and mitigation strategies to avoid drug-induced liver injury (DILI).  The breadth of his background has led to his service on many Due Diligence teams to assess potential in-license opportunities.  Retiring after 30 years in Big Pharma, Bryan now consults and teaches short courses on drug discovery topics, with a focus on preclinical safety assessment and mitigation strategies.  He is an Adjunct Assistant Professor at the Indiana University School of Medicine, where he teaches multiple drug discovery topics.  Other scientific activities include service as a Volume Editor and member of the Editorial Board of Burger’s Medicinal Chemistry, Drug Discovery and Development, member of the Board of Directors of the Medicinal and Bioorganic Chemistry Foundation and service on various grant review committees.  He has published over 45 papers in peer-reviewed scientific journals, been named an inventor on over 30 U.S. patents and given many invited lectures at scientific conferences and universities. His most recent research interests have focused on the identification of mechanisms associated with drug-induced liver injury and the discovery of novel analgesic agents for use in chronic pain.

Key Publications

Norman, Bryan H.; Fisher, Matthew J.; Schiffler, Matthew A.; Kuklish, Steven L.; Hughes, Norman E.; Czeskis, Boris A.; Cassidy, Kenneth C.; Abraham, Trent L.; Alberts, Jeffrey J.; Luffer-Atlas, Debra.  Identification of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated due to Clinical Drug-Induced Liver Injury.  J. Med. Chem.  2018, 61, 2041.

Partridge, Katherine; Antonysamy, Stephen; Bhattachar, Shobha; Chandrasekhar, Srinivasan; Fisher, Matthew J.; Fretland, Adrian; Gooding, Karen; Harvey, Anita; Hughes, Norman; Kuklish, Steven; Luz, John; Manninen, Peter; McGee, James; Mudra, Daniel; Navarro, Antonio; Norman, Bryan; Quimby, Steven; Schiffler, Matthew; Sloan, Ashley; Warshawsky, Alan; Weller, Weller; York, Jeremy; Xiao-Peng Yu, Xiao-Peng.  Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.  Bioorg. Med. Chem. Lett., 2017, 27(6), 1478.

Norman, Bryan H.; McDermott, Jeff S.  Targeting the NGF Pathway in Drug Discovery.  Potential Applications to New Therapies for Chronic Pain.  J. Med. Chem., 2017, 60, 66.

Thirunavukkarasu, Kannan; Chambers, Mark G.; Swearingen, Craig A.; Oskins, Jennifer L.; Lin, Chaohua; Bui, Hai H.; Jones, Spencer B.; Pfeifer, Lance A.; Norman, Bryan H.; Mitchell, Peter G.  Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain.  Osteoarthritis and Cart., 2017, 25, 935.

Thirunavukkarasu, Kannan; Tan, Bailin; Swearingen, Craig A.; Rocha, Guilherme; Bui, Hai H.; McCann, Denis J.; Jones, Spencer B.; Norman, Bryan H.; Pfeifer, Lance A.; Saha, Joy K.  Pharmacological characterization of a potent inhibitor of Autotaxin in animal models of inflammatory bowel disease and multiple sclerosis.  J. Pharm. Exper. Ther., 2016, 359, 207.

Kuklish, Steven L.; Antonysamy, Stephen; Bhattachar, Shobha N.; Chandrasekhar, Srinivasan; Fisher, Matthew J.; Fretland, Adrian J.; Gooding, Karen; Harvey, Anita; Hughes, Norman E.; Luz, John G.; Manninen, Peter R.; McGee, James E.; Navarro, Antonio; Norman, Bryan H.; Partridge, Katherine M.; Quimby, Steven J.; Schiffler, Matthew A.; Sloan, Ashley V.; Warshawsky, Alan M.; York, Jeremy S.; Yu, Xiao-Peng.  Characterization of 3,?3-?dimethyl substituted N-?aryl piperidines as potent microsomal prostaglandin E synthase-?1 inhibitors.  Bioorg. Med. Chem. Lett., 2016, 26(19), 4824.

Jones, Spencer B.; Pfeifer, Lance A.; Bleisch, Thomas J.; Beauchamp, Thomas J.; Durbin, Jim D.; Klimkowski, V. Joseph; Hughes, Norman E.; Rito, Christopher J.; Dao, Yen; Gruber, Joseph M.; Bui, Hai; Chambers, Mark G.; Chandrasekhar, Srinivasan; Lin, Chaohua; McCann, Denis J.; Mudra, Daniel R.; Oskins, Jennifer L.; Swearingen, Craig A.; Thirunavukkarasu, Kannan; Norman, Bryan H.  Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.  ACS Med. Chem. Letters, 2016, 7(9), 857.

Hughes, Norman E.; Bleisch, Thomas J.; Jones, Scott A.; Richardson, Timothy I.; Doti, Robert A.; Wang, Yong; Stout, Stephanie L.; Durst, Gregory L.; Chambers, Mark G.; Oskins, Jennifer L.; Lin, Chaohua; Adams, Lisa A.; Page, Todd J.; Barr, Robert J.; Zink, Richard W.; Osborne, Harold; Montrose-Rafizadeh, Chahrzad; Norman, Bryan H.  Identification of potent and selective retinoic acid receptor gamma (RARgamma) antagonists for the treatment of osteoarthritis pain using structure based drug design.  Bioorg. Med. Chem. Lett., 2016, 26(14), 3274.

Chandrasekhar, Srinivasan; Harvey, Anita K.; Yu, Xiao-Peng; Chambers, Mark G.;  Oskins, Jennifer L.; Lin, Chaohua; Seng, Thomas W.; Thibodeaux, Stefan J.; Norman, Bryan H.; Hughes, Norman E.; Schiffler, Matthew A.; Fisher, Matthew J.  Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia.  J. Pharm. Exper. Ther., 2016, 356, 635.

Schiffler, Matthew A.; Antonysamy, Stephen; Bhattachar, Shobha N.; Campanale, Kristina M.; Chandrasekhar, Srinivasan; Condon, Bradley; Desai, Prashant V.; Fisher, Matthew J.; Groshong, Christopher; Harvey, Anita; Hickey, Michael J.; Hughes, Norman E.; Jones, Scott A.; Kim, Euibong J.; Kuklish, Steven L.; Luz, John G.; Norman, Bryan H.; Rathmell, Richard E.; Rizzo, John R.; Seng, Thomas W.; Thibodeaux, Stefan J.; Woods, Timothy A.; York, Jeremy S.; Yu, Xiao-Peng.  Discovery and Characterization of 2-?Acylaminoimidazole Microsomal Prostaglandin E Synthase-?1 Inhibitors. J. Med. Chem., 2016, 59 (1), 194.

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