44012-Hamdouchi, Chafiq
Faculty

Chafiq Hamdouchi, PhD

Senior Research Professor of Pathology & Laboratory Medicine

Address
R2 402
MDEP
IN
Indianapolis, IN

Bio

Dr. Hamdouchi is an accomplished scientific leader in drug discovery & development with extensive experience in advancing small molecules from target identification to clinical proof of concept. His areas of expertise include medicinal chemistry; oncology, diabetes, neuroscience & anti-infective research; strategic planning from target selection to clinical proof-of-concept; due diligence & external collaborations in the USA, Europe, and Asia; portfolio enablement & prioritization; mentoring & talent development.

Throughout his 23-year career at Eli Lilly & Company, he oversaw large global cross-functional drug discovery and development teams, championed the creation of multiple drug discovery strategies, and contributed to the discovery and development of a dozen clinical candidates – encompassing novel treatments in cancer, diabetes, and infectious and neurodegenerative disease.

Furthermore, he was the scientific leader responsible for Lilly’s external research & development strategy and successfully developed international drug discovery as an effective extension of global Eli Lilly & Company research capabilities. He established and led Lilly's first R&D outsourced team in Asia capable of executing a drug discovery process from target selection through clinical proof-of-concept, delivering four high quality clinical candidates. As a member of multiple R&D reviewer committees at Eli Lilly & Company, he routinely participated in setting a strategic direction for the company along with governance of the discovery and early clinical development pipeline.

After 23+ years of experience, he retired from Eli Lilly & Company at the end of 2017. In 2018, he joined the Indiana University School of Medicine where he is contributing to the advancement of the science of therapeutics discovery and translational medicine through research and educational programs. Part of his efforts is focused on building the underlying drug discovery & development capabilities of Indiana University Melvin and Bren Simon Comprehensive Cancer Center, implementing effective preclinical and clinical strategies, to deliver a robust and diverse portfolio. He works at the interface of academic-industrial partnerships, building relationships, consulting, strategizing, negotiating, mentoring, and creating an effective collaborative research environment that stimulates the design and execution of target selection, lead generation, lead optimization, candidate selection, and phases I and II clinical development.

His strong leadership in the field is reflected in numerous patents, publications, invited lectures, and awards. Dr. Hamdouchi has flexibility in both language (French, English, Spanish, Arabic and German) and culture to operate successfully in several professional contexts related to the pharmaceutical business.

Key Publications

PUBLICATIONS (10 Selected)

  • Structural basis for GPR40 allosteric agonism and incretin stimulation. Ho, Joseph D.; Chau, Betty; Rodgers, Logan; Lu, Frances; Wilbur, Kelly L.; Otto, Keith A.; Chen, Yanyun; Song, Min; Riley, Jonathan P.; Hsiu-Chiung, Yang; Reynolds, Nichole A.; Kahl, Steven D.; Patel Lewis, Anjana; Groshong, Christopher; Madsen, Russell E.; Conners, Kris; Lineswala, Jayana P.; Gheyi, Tarun; Decipulo Saflor, Melbert-Brian; Lee, Matthew R.; Benach, Jordi; Baker, Kenton A.; Montrose-Rafizadeh, Chahrzad; Genin, Michael J.; Reifel Miller, Anne; Hamdouchi, Chafiq*Nature Communications (2018), 9: 1645 
  • Discovery of LY3104607: A potent and selective GPR40 agonist with optimized pharmacokinetic properties to support once daily oral treatment in patients with type 2 diabetes mellitus. Hamdouchi, Chafiq*; Maiti, Pranab; Warshawsky, Alan M.; DeBaillie, Amy C.; Otto, Keith A.; Wilbur, Kelly L.; Kahl, Steven D.; Patel Lewis, Anjana; Cardona, Guemalli R.; Zink, Richard W.; Chen, Keyue; Lineswala, Jayana P.; Neathery, Grace L.; Campbell, Alison N.; Sweetana, Stephanie A.; Cabrera, Over; Ma, Xiaosu; Yumibe, Nathan P.; Diseroad, Benjamin A.; Montrose-Rafizadeh, Chahrzad; Chen, Yanyun; Reifel Miller, Anne. Journal of Medicinal Chemistry (2018), 61(3), 934-945. 
  • The discovery, preclinical, and early clinical development of potent and selective GPR40 agonists for the treatment of Type 2 diabetes mellitus (LY2881835, LY2922083, and LY2922470). Hamdouchi, Chafiq*; Kahl, Steven D.; Patel Lewis, Anjana; Cardona, Guemalli R.; Zink, Richard W.; Chen, Keyue; Eessalu, Thomas E.; Ficorilli, James V.; Marcelo, Marialuisa C.; Otto, Keith A.; Wilbur, Kelly L.; Lineswala, Jayana P.; Piper, Jared L.; Coffey, D. Scott; Sweetana, Stephanie A.; Haas, Joseph V.; Brooks, Dawn A.; Pratt, Edward J.; Belin, Ruth M.; Deeg, Mark A.; Ma, Xiaosu; Cannady, Ellen A.; Johnson, Jason T.; Yumibe, Nathan P.; Chen, Qi; Maiti, Pranab; Montrose-Rafizadeh, Chahrzad; Chen, Yanyun; Reifel, Miller Anne. Journal of Medicinal Chemistry (2016), 59(24), 10891–10916. (Selected as 2016 American Chemical Society Editors’ Choice & Featured on the Front Cover of the Journal).
  • Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo, Sonia; Ren, Dongjun; Miller, Richard J.; Henry, Kenneth J.; Lineswala, Jayana; Hamdouchi, Chafiq; Li, Baolin; Monahan, Patrick E.; Chan, David M.; Ripsch, Matthew S.; White, Fletcher A. Molecular Pain (2007), 3:38. 
  • 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism. Gehlert, Donald R.; Cippitelli, Andrea; Thorsell, Annika; Le, Anh Dzung; Hipskind, Philip A.; Hamdouchi, Chafiq; Lu, Jianliang; Hembre, Erik J.; Cramer, Jeffrey; Song, Min; McKinzie, David; Morin, Michelle; Ciccocioppo, Roberto; Heilig, Markus. The Journal of neuroscience (2007), 27(10), 2718-2726. 
  • Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases. Hamdouchi, Chafiq*; Zhong, Boyu; Mendoza, Jose; Collins, Elizabeth; Jaramillo, Carlos; De Diego, Jose Eugenio; Robertson, Daniel; Spencer, Charles D.; Anderson, Bryan D.; Watkins, Scott A.; Zhang, Faming; Brooks, Harold B. Bioorganic & Medicinal Chemistry Letters (2005), 15(7), 1943-1947. (Featured on the Front Cover of the Journal). 
  • The discovery of a new structural class of cyclin-dependent kinase inhibitors aminoimidazo [1,2-a]pyridines. Hamdouchi, Chafiq*; Keyser, Heather; Collins, Elizabeth; Jaramillo, Carlos; De Diego, Jose Eugenio; Spencer, Charles D.; Dempsey, Jack Alan; Anderson, Bryan D.; Leggett, Tillie; Stamm, Nancy B.; Schultz, Richard M.; Watkins, Scott A.; Cocke, Kim; Lemke, Stephanie; Burke, Teresa F.; Beckmann, Richard P.; Dixon, Jeffrey T.; Gurganus, Thomas M.; Rankl, Nancy B.; Houck, Keith A.; Zhang, Faming; Vieth, Michal; Espinosa, Juan; Timm, David E.; Campbell, Robert M.; Patel, Bharvin K. R.; Brooks, Harold B. Molecular Cancer Therapeutics (2004), 3(1), 1-9. (Featured on the Front Cover of the Journal). 
  • Imidazo[1,2-b]pyridazines, novel nucleus with potent and broad spectrum activity against human picornaviruses: design, synthesis, and biological evaluation. Hamdouchi, Chafiq*; Sanchez-Martinez, Concha; Gruber, Joseph; del Prado, Miriam; Lopez, Javier; Rubio, Almudena; Heinz, Beverly A. Journal of Medicinal Chemistry (2003), 46(20), 4333-4341. 
  • 2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a novel class of inhibitors of human rhinovirus: stereospecific synthesis and antiviral activity. Hamdouchi, Chafiq*; De Blas, Jesus; Del Prado, Mirian; Gruber, Joseph; Heinz, Beverly A.; Vance, Lori. Journal of Medicinal Chemistry (1999), 42(1), 50-59.
  • The nature of electron transfer from metal surfaces to the carbon-halogen bond.  Walborsky, Harry; Hamdouchi, ChafiqJournal of the American Chemical Society (1993), 115(14), 6406-8.

Titles & Appointments

  • Senior Research Professor of Pathology & Laboratory Medicine
  • Education
    1990 PhD Louis Pasteur University
    1987 MS Louis Pasteur University
    1986 MS Louis Pasteur University
    1985 BS Louis Pasteur University
  • Research
    • Drug Discovery & Development
    • Medicinal Chemistry
    • Oncology
    • Diabetes
    • Neuroscience
    • Infectious Diseases
    • Strategic Planning from Target Selection to Clinical Proof-of-Concept
    • Due Diligence and External Collaborations in USA, Europe and Asia
    • Portfolio Enablement & Prioritization
    • Biomarkers and Pharmacokinetic / Pharmacodynamic (PK/PD) Relationships
    • Preclinical Safety
    • Competitive Analysis
    • Mentoring and Talent Development

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